Deterioro Cognitivo tras Administracion de Dosis Subumbrales de Pilocarpina

INTRODUCTION: The present study sought to determine if there is deterioration cognitive function in Wistar rats to which a single subthreshold dose of pilocarpine and that were evaluated using an object recognition test. MATERIAL AND METHODS: Wistar rats (255±34 g) obtained from the National Institu...

Full description

Autores:
Quiñones Espinosa, Liliana Camila
Tipo de recurso:
Tesis
Fecha de publicación:
2016
Institución:
Universidad Antonio Nariño
Repositorio:
Repositorio UAN
Idioma:
spa
OAI Identifier:
oai:repositorio.uan.edu.co:123456789/11680
Acceso en línea:
https://repositorio.uan.edu.co/handle/123456789/11680
Palabra clave:
pilocarpina
status epiléptico
ratas
dosis subumbral
deterioro cognitivo
pilocarpine
status epilepticus
rats
subthreshold dose
cognitive impairment
Rights
License
Acceso abierto
id UAntonioN2_0de46f5699cabbe444ff42ddaf0cca3e
oai_identifier_str oai:repositorio.uan.edu.co:123456789/11680
network_acronym_str UAntonioN2
network_name_str Repositorio UAN
repository_id_str
dc.title.none.fl_str_mv Deterioro Cognitivo tras Administracion de Dosis Subumbrales de Pilocarpina
title Deterioro Cognitivo tras Administracion de Dosis Subumbrales de Pilocarpina
spellingShingle Deterioro Cognitivo tras Administracion de Dosis Subumbrales de Pilocarpina
pilocarpina
status epiléptico
ratas
dosis subumbral
deterioro cognitivo
pilocarpine
status epilepticus
rats
subthreshold dose
cognitive impairment
title_short Deterioro Cognitivo tras Administracion de Dosis Subumbrales de Pilocarpina
title_full Deterioro Cognitivo tras Administracion de Dosis Subumbrales de Pilocarpina
title_fullStr Deterioro Cognitivo tras Administracion de Dosis Subumbrales de Pilocarpina
title_full_unstemmed Deterioro Cognitivo tras Administracion de Dosis Subumbrales de Pilocarpina
title_sort Deterioro Cognitivo tras Administracion de Dosis Subumbrales de Pilocarpina
dc.creator.fl_str_mv Quiñones Espinosa, Liliana Camila
dc.contributor.advisor.none.fl_str_mv Javela González, José Julián
dc.contributor.author.none.fl_str_mv Quiñones Espinosa, Liliana Camila
dc.subject.none.fl_str_mv pilocarpina
status epiléptico
ratas
dosis subumbral
deterioro cognitivo
topic pilocarpina
status epiléptico
ratas
dosis subumbral
deterioro cognitivo
pilocarpine
status epilepticus
rats
subthreshold dose
cognitive impairment
dc.subject.keyword.none.fl_str_mv pilocarpine
status epilepticus
rats
subthreshold dose
cognitive impairment
description INTRODUCTION: The present study sought to determine if there is deterioration cognitive function in Wistar rats to which a single subthreshold dose of pilocarpine and that were evaluated using an object recognition test. MATERIAL AND METHODS: Wistar rats (255±34 g) obtained from the National Institute of Health and kept in the stable in pairs at a constant temperature (24º±1) with water and food ad libitum, they were divided into two experimental groups; Group A (control) to which a single dose of physiological solution was injected (0.9% in 0.5 ml, i.p) and Group B (experimental) to which a single subthreshold dose of pilocarpine (200 mg/kg in 0.5 ml, i.p) long-term memory was evaluated by test object recognition.
publishDate 2016
dc.date.created.none.fl_str_mv 2016-01-14
dc.date.accessioned.none.fl_str_mv 2024-10-22T15:40:51Z
dc.date.available.none.fl_str_mv 2024-10-22T15:40:51Z
dc.date.issued.none.fl_str_mv 2024-10-22
dc.type.none.fl_str_mv Tesis/Trabajo de grado - Monografía - Pregrado
dc.type.document.none.fl_str_mv Estudio descriptivo
dc.type.version.none.fl_str_mv Versión final del autor, Versión aceptada para publicar
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_46ec
dc.type.redcol.none.fl_str_mv http://purl.org/redcol/resource_type/PIC
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_b1a7d7d4d402bcce
format http://purl.org/coar/resource_type/c_46ec
dc.identifier.uri.none.fl_str_mv https://repositorio.uan.edu.co/handle/123456789/11680
url https://repositorio.uan.edu.co/handle/123456789/11680
dc.language.iso.fl_str_mv spa
language spa
dc.rights.accessrights.none.fl_str_mv Acceso abierto
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv Acceso abierto
http://purl.org/coar/access_right/c_abf2
dc.format.medium.none.fl_str_mv pdf
dc.publisher.none.fl_str_mv Universidad Antonio Nariño
dc.publisher.program.none.fl_str_mv Psicología
dc.publisher.faculty.none.fl_str_mv Facultad de Psicología
dc.publisher.campus.none.fl_str_mv Bogotá - Sur
publisher.none.fl_str_mv Universidad Antonio Nariño
dc.source.none.fl_str_mv instname:Universidad Antonio Nariño
instname_str Universidad Antonio Nariño
institution Universidad Antonio Nariño
dc.source.bibliographicCitation.none.fl_str_mv Abel, T., & Lattal, K. (2001) Molecular mechanisms of memory acquisition, consolidation and retrieval. Current Opinion in Neurobiology, 1, 180–187
Ávila Baray, Héctor Luis. Introducción a la metodología de la investigación. En: Eumed.net.http://www.eumed.net/libros/2006c/203/2f.htm
Aggleton , J. (1985). One-trial object recognition by rats. Quarterly Journal of Experimental Psychology , 37 (B), 279-294
Aggleton J. & Brown, M. (1999). Episodic memory, amnesia and the hippocampalanterior thalamic axis. Behavioural Brain Science, 22 , 425-444.
Adem, A. Jolkkonen, M, Bogdanovic, N. Islam, A. Karlsson, E. (1997). Localization of M1 muscarinic receptors in rat brain using selective muscarinic toxin-1. Brain Res Bull. 44, 597-601.
Andrade, R. Andrade, R.C. Malenka, R.A. Nicoll, (1986). A G protein couples serotonin and GABA receptors to the same channels in hippocampus, Science 234: 1261–1265.
Andrade R y Nicoll, RA (1987). Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro. J Physiol, 394: 99-124
Austin JK, David W, Helena MC, Susan MP, Jaroslaw H, Douglas FR. Recurrent seizure and behavior problems in children with first recognised seizures. Epilepsia. 2002;43:1564–75.
Aznavour N y Zimmer L. (2007) [18F] MPPF as a tool for the in vivo imaging of 5-HT1A receptors in animal and human brain. Neuropharmacology; 52(3):695-707.
Adem, A., Jolkkonen, M., Bogdanovic, N., Islam, A., Karlsson, E., 1997. Localization of M1 muscarinic receptors in rat brain using selective muscarinic toxin-1. Brain Res Bull. 44, 597-601
bitstream.url.fl_str_mv https://repositorio.uan.edu.co/bitstreams/ca9f2fb9-9529-415d-ba47-49523445dcda/download
https://repositorio.uan.edu.co/bitstreams/38d6f492-55d8-42d8-a38e-51615b2e0185/download
bitstream.checksum.fl_str_mv 0bbcd25f20757616380b39840ab8904e
4d54d7f40dc781b4ff0aa8eaefcb22ff
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositorio Institucional UAN
repository.mail.fl_str_mv alertas.repositorio@uan.edu.co
_version_ 1814300396200394752
spelling Javela González, José JuliánQuiñones Espinosa, Liliana Camila2024-10-22T15:40:51Z2024-10-22T15:40:51Z2016-01-142024-10-22https://repositorio.uan.edu.co/handle/123456789/11680INTRODUCTION: The present study sought to determine if there is deterioration cognitive function in Wistar rats to which a single subthreshold dose of pilocarpine and that were evaluated using an object recognition test. MATERIAL AND METHODS: Wistar rats (255±34 g) obtained from the National Institute of Health and kept in the stable in pairs at a constant temperature (24º±1) with water and food ad libitum, they were divided into two experimental groups; Group A (control) to which a single dose of physiological solution was injected (0.9% in 0.5 ml, i.p) and Group B (experimental) to which a single subthreshold dose of pilocarpine (200 mg/kg in 0.5 ml, i.p) long-term memory was evaluated by test object recognition.INTRODUCCION: El presente estudio busco determinar si existe deterioro cognitivo en ratas Wistar a las cuales se les administró una única dosis subumbral de pilocarpina y que fueron evaluadas mediante test de reconocimiento de objetos. MATERIAL Y METODOS: Ratas Wistar (255±34 g) obtenidas del Instituto Nacional De Salud y mantenidas en el estabulario de la en parejas a una temperatura constante (24º±1) con agua y comida ad libitum, fueron divididos en dos grupos experimentales; Grupo A (control) a los cuales se inyecto una única dosis de solución fisiológica (0.9% en 0.5 ml, i.p) y Grupo B (experimental) a los cuales se inyecto una única dosis subumbral de pilocarpina (200 mg/kg en 0.5 ml, i.p) memoria a largo plazo fue evaluado mediante test de reconocimiento de objetos.finalPsicólogo(a)PregradoPresencialMonografíapdfUniversidad Antonio NariñoPsicologíaFacultad de PsicologíaBogotá - Surinstname:Universidad Antonio NariñoAbel, T., & Lattal, K. (2001) Molecular mechanisms of memory acquisition, consolidation and retrieval. Current Opinion in Neurobiology, 1, 180–187Ávila Baray, Héctor Luis. Introducción a la metodología de la investigación. En: Eumed.net.http://www.eumed.net/libros/2006c/203/2f.htmAggleton , J. (1985). One-trial object recognition by rats. Quarterly Journal of Experimental Psychology , 37 (B), 279-294Aggleton J. & Brown, M. (1999). Episodic memory, amnesia and the hippocampalanterior thalamic axis. Behavioural Brain Science, 22 , 425-444.Adem, A. Jolkkonen, M, Bogdanovic, N. Islam, A. Karlsson, E. (1997). Localization of M1 muscarinic receptors in rat brain using selective muscarinic toxin-1. Brain Res Bull. 44, 597-601.Andrade, R. Andrade, R.C. Malenka, R.A. Nicoll, (1986). A G protein couples serotonin and GABA receptors to the same channels in hippocampus, Science 234: 1261–1265.Andrade R y Nicoll, RA (1987). Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro. J Physiol, 394: 99-124Austin JK, David W, Helena MC, Susan MP, Jaroslaw H, Douglas FR. Recurrent seizure and behavior problems in children with first recognised seizures. Epilepsia. 2002;43:1564–75.Aznavour N y Zimmer L. (2007) [18F] MPPF as a tool for the in vivo imaging of 5-HT1A receptors in animal and human brain. Neuropharmacology; 52(3):695-707.Adem, A., Jolkkonen, M., Bogdanovic, N., Islam, A., Karlsson, E., 1997. Localization of M1 muscarinic receptors in rat brain using selective muscarinic toxin-1. Brain Res Bull. 44, 597-601pilocarpinastatus epilépticoratasdosis subumbraldeterioro cognitivopilocarpinestatus epilepticusratssubthreshold dosecognitive impairmentDeterioro Cognitivo tras Administracion de Dosis Subumbrales de PilocarpinaTesis/Trabajo de grado - Monografía - PregradoEstudio descriptivoVersión final del autor, Versión aceptada para publicarhttp://purl.org/coar/resource_type/c_46echttp://purl.org/redcol/resource_type/PIChttp://purl.org/coar/version/c_b1a7d7d4d402bcceEspecializadaAcceso abiertohttp://purl.org/coar/access_right/c_abf2spaORIGINAL2016_LilianaCamilaQuiñonesEspinosa2016_LilianaCamilaQuiñonesEspinosaTrabajo de gradoapplication/pdf1491752https://repositorio.uan.edu.co/bitstreams/ca9f2fb9-9529-415d-ba47-49523445dcda/download0bbcd25f20757616380b39840ab8904eMD512016_LilianaCamilaQuiñonesEspinosa_Autorizacion2016_LilianaCamilaQuiñonesEspinosa_AutorizacionAutorizaciónapplication/pdf1005803https://repositorio.uan.edu.co/bitstreams/38d6f492-55d8-42d8-a38e-51615b2e0185/download4d54d7f40dc781b4ff0aa8eaefcb22ffMD52123456789/11680oai:repositorio.uan.edu.co:123456789/116802024-10-22 15:40:54.067open.accesshttps://repositorio.uan.edu.coRepositorio Institucional UANalertas.repositorio@uan.edu.co

Publicaciones similares