FACTORES AMBIENTALES ASOCIADOS CON LABIO O PALADAR HENDIDO NO SINDRÓMICO EN UNA POBLACIÓN DEL MAGDALENA MEDIO COLOMBIANO

Objective: to assess the possible association between environmental factors and the presence of non-syndromic cleft lip and/or palate (CL/P) in children living in the Colombian Magdalena Medio.Methods: a case-control study was carried out with 30 mothers of children with CL/P (cases) and 60 mothers of children without any craniofacial alteration (controls). The cases and controls were obtained from a dental clinic in the region mentioned. The variables analyzed were sociodemographic (age, socioeconomic condition, educational level, place of residence before and during the first trimester); pregnancy background (prenatal examinations, diseases, drugs, alcohol and tobacco consumption, psychoactive substances consumption and pesticide exposure), presence of CL/P in the family. Chi-square and Fisher Exact test, Student t test or U Mann Whitney were performed when appropriate. A logistic regression was done to establish the crude and adjusted odds ratio (OR).Results: the educational level in college category [OR: 0.1 95% CI: 0.01 - 0.70] and the highest socioeconomic condition [OR: 0.07 95% CI: 0.02 - 0.60] were considered as protective factors for CL/P. The results in the logistic regression showed that pesticide exposure [OR: 14.3 95% CI: 4.3 - 47.8] and the presence of CL/P in the family [OR: 5.7 95% CI: 1.3 - 24.9] behaved as risk factor for oral clefts. Diagnostic test for regression model showed a Hosmer-Lemershow test of 4.56 (p=0.1022) indicating a good fit of the model.Conclusions: exposure to pesticides and the presence of CL/P in the family of the affected child increased the risk for non-syndromic oral clefts.

• Autores: Prada Flórez, Andrea Melisa; Eljach Sánchez, Gloria Marcela; Caballero Barbosa, Verónica; Torres Murillo, Ethman Ariel
• Fecha de publicación: 2014
• Institución: Universidad Santo Tomás
• Repositorio: Universidad Santo Tomás
• Idioma: spa
• OAI Identifier: oai:repository.usta.edu.co:11634/37083
• Acceso en línea: http://revistas.ustabuca.edu.co/index.php/USTASALUD_ODONTOLOGIA/article/view/1395; http://hdl.handle.net/11634/37083
• License: Derechos de autor 2018 UstaSalud