Evaluación de nanopartículas de sílice mesoporosa obtenida de la cascarilla de arroz como sistema de liberación controlada del letrozol
El uso de los medicamentos convencionales ha traído consigo diferentes efectos secundarios en el cuerpo humano como resultado a la liberación inmediata del principio activo. Adicionalmente, la cascarilla de arroz es un desecho agrícola generado en grandes cantidades provocando problemas de contamina...
- Autores:
-
García Niño, Laura Milena
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2021
- Institución:
- Universidad Santo Tomás
- Repositorio:
- Repositorio Institucional USTA
- Idioma:
- spa
- OAI Identifier:
- oai:repository.usta.edu.co:11634/34871
- Acceso en línea:
- http://hdl.handle.net/11634/34871
- Palabra clave:
- Controlled release
Letrozole
Mesoporous silica nanoparticles
Rice husk
Arroz - Abonos y fertilizantes
Residuos agrícolas
Cascarilla de arroz
Cascarilla de arroz
Letrozol
Liberación controlada
Nanopartículas de sílice mesoporosa
- Rights
- closedAccess
- License
- Acceso cerrado
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| dc.title.spa.fl_str_mv |
Evaluación de nanopartículas de sílice mesoporosa obtenida de la cascarilla de arroz como sistema de liberación controlada del letrozol |
| title |
Evaluación de nanopartículas de sílice mesoporosa obtenida de la cascarilla de arroz como sistema de liberación controlada del letrozol |
| spellingShingle |
Evaluación de nanopartículas de sílice mesoporosa obtenida de la cascarilla de arroz como sistema de liberación controlada del letrozol Controlled release Letrozole Mesoporous silica nanoparticles Rice husk Arroz - Abonos y fertilizantes Residuos agrícolas Cascarilla de arroz Cascarilla de arroz Letrozol Liberación controlada Nanopartículas de sílice mesoporosa |
| title_short |
Evaluación de nanopartículas de sílice mesoporosa obtenida de la cascarilla de arroz como sistema de liberación controlada del letrozol |
| title_full |
Evaluación de nanopartículas de sílice mesoporosa obtenida de la cascarilla de arroz como sistema de liberación controlada del letrozol |
| title_fullStr |
Evaluación de nanopartículas de sílice mesoporosa obtenida de la cascarilla de arroz como sistema de liberación controlada del letrozol |
| title_full_unstemmed |
Evaluación de nanopartículas de sílice mesoporosa obtenida de la cascarilla de arroz como sistema de liberación controlada del letrozol |
| title_sort |
Evaluación de nanopartículas de sílice mesoporosa obtenida de la cascarilla de arroz como sistema de liberación controlada del letrozol |
| dc.creator.fl_str_mv |
García Niño, Laura Milena |
| dc.contributor.advisor.none.fl_str_mv |
Candela Soto, Angélica María |
| dc.contributor.author.none.fl_str_mv |
García Niño, Laura Milena |
| dc.contributor.corporatename.spa.fl_str_mv |
Universidad Santo Tomás |
| dc.subject.keyword.spa.fl_str_mv |
Controlled release Letrozole Mesoporous silica nanoparticles Rice husk |
| topic |
Controlled release Letrozole Mesoporous silica nanoparticles Rice husk Arroz - Abonos y fertilizantes Residuos agrícolas Cascarilla de arroz Cascarilla de arroz Letrozol Liberación controlada Nanopartículas de sílice mesoporosa |
| dc.subject.lemb.spa.fl_str_mv |
Arroz - Abonos y fertilizantes Residuos agrícolas Cascarilla de arroz |
| dc.subject.proposal.spa.fl_str_mv |
Cascarilla de arroz Letrozol Liberación controlada Nanopartículas de sílice mesoporosa |
| description |
El uso de los medicamentos convencionales ha traído consigo diferentes efectos secundarios en el cuerpo humano como resultado a la liberación inmediata del principio activo. Adicionalmente, la cascarilla de arroz es un desecho agrícola generado en grandes cantidades provocando problemas de contaminación. Por ende, esta propuesta de investigación evaluó la cinética de liberación del letrozol empleando como material de soporte las nanopartículas de sílice mesoporosa obtenidas a partir de la cascarilla de arroz. La síntesis de las nanopartículas se realizó mediante el método Sol-gel y se caracterizó mediante FTIR y TEM. Los resultados obtenidos evidenciaron una liberación controlada con acción prolongada, ajustándose mejor al modelo cinético de primer orden debido a que el letrozol es liberado de forma proporcional al gradiente de concentración. |
| publishDate |
2021 |
| dc.date.accessioned.none.fl_str_mv |
2021-07-13T00:14:50Z |
| dc.date.available.none.fl_str_mv |
2021-07-13T00:14:50Z |
| dc.date.issued.none.fl_str_mv |
2021-07-07 |
| dc.type.local.spa.fl_str_mv |
Trabajo de grado |
| dc.type.version.none.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
| dc.type.category.spa.fl_str_mv |
Formación de Recurso Humano para la Ctel: Trabajo de grado de Pregrado |
| dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_7a1f |
| dc.type.drive.none.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
| format |
http://purl.org/coar/resource_type/c_7a1f |
| status_str |
acceptedVersion |
| dc.identifier.citation.spa.fl_str_mv |
García Niño, L. M. (2021). Evaluación de nanopartículas de sílice mesoporosa de la cascarilla de arroz como sistema de liberación controlada del letrozol. [Tesis de pregrado]. Universidad Santo Tomás, Bucaramanga, Colombia. |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/11634/34871 |
| dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional Universidad Santo Tomás |
| dc.identifier.instname.spa.fl_str_mv |
instname:Universidad Santo Tomás |
| dc.identifier.repourl.spa.fl_str_mv |
repourl:https://repository.usta.edu.co |
| identifier_str_mv |
García Niño, L. M. (2021). Evaluación de nanopartículas de sílice mesoporosa de la cascarilla de arroz como sistema de liberación controlada del letrozol. [Tesis de pregrado]. Universidad Santo Tomás, Bucaramanga, Colombia. reponame:Repositorio Institucional Universidad Santo Tomás instname:Universidad Santo Tomás repourl:https://repository.usta.edu.co |
| url |
http://hdl.handle.net/11634/34871 |
| dc.language.iso.spa.fl_str_mv |
spa |
| language |
spa |
| dc.relation.references.spa.fl_str_mv |
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Candela Soto, Angélica MaríaGarcía Niño, Laura MilenaUniversidad Santo Tomás2021-07-13T00:14:50Z2021-07-13T00:14:50Z2021-07-07García Niño, L. M. (2021). Evaluación de nanopartículas de sílice mesoporosa de la cascarilla de arroz como sistema de liberación controlada del letrozol. [Tesis de pregrado]. Universidad Santo Tomás, Bucaramanga, Colombia.http://hdl.handle.net/11634/34871reponame:Repositorio Institucional Universidad Santo Tomásinstname:Universidad Santo Tomásrepourl:https://repository.usta.edu.coEl uso de los medicamentos convencionales ha traído consigo diferentes efectos secundarios en el cuerpo humano como resultado a la liberación inmediata del principio activo. Adicionalmente, la cascarilla de arroz es un desecho agrícola generado en grandes cantidades provocando problemas de contaminación. Por ende, esta propuesta de investigación evaluó la cinética de liberación del letrozol empleando como material de soporte las nanopartículas de sílice mesoporosa obtenidas a partir de la cascarilla de arroz. La síntesis de las nanopartículas se realizó mediante el método Sol-gel y se caracterizó mediante FTIR y TEM. Los resultados obtenidos evidenciaron una liberación controlada con acción prolongada, ajustándose mejor al modelo cinético de primer orden debido a que el letrozol es liberado de forma proporcional al gradiente de concentración.The use of conventional medications has brought with it different side effects in the human body as a result of the immediate release of the active substance. In addition, rice husk is an agricultural waste generated in large quantities causing pollution problems. Therefore, this research proposal assessed the release kinetics of letrozole using as support material the mesoporous silica nanoparticles obtained from the rice husk. The synthesis of the nanoparticles was performed using the Sol-gel method and characterized by FTIR and TEM. The results obtained showed a controlled release with prolonged action, better adjusting to the first order kinetic model because letrozole is released proportionally to the concentration gradient.Químico Ambientalhttp://www.ustabuca.edu.co/ustabmanga/presentacionPregradoapplication/pdfspaUniversidad Santo TomásPregrado Química AmbientalFacultad de Química AmbientalEvaluación de nanopartículas de sílice mesoporosa obtenida de la cascarilla de arroz como sistema de liberación controlada del letrozolControlled releaseLetrozoleMesoporous silica nanoparticlesRice huskArroz - Abonos y fertilizantesResiduos agrícolasCascarilla de arrozCascarilla de arrozLetrozolLiberación controladaNanopartículas de sílice mesoporosaTrabajo de gradoinfo:eu-repo/semantics/acceptedVersionFormación de Recurso Humano para la Ctel: Trabajo de grado de Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisAcceso cerradoinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbCRAI-USTA BucaramangaAbo-El-Enein, S. 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