Desarrollo de emulsiones de limoneno como productos larvicidas para el control de las larvas de mosquitos Aedes aegypti
Los productos naturales han tomado un nuevo impulso en la búsqueda de compuestos capaces de controlar el Aedes aegypti. En esta investigación, los aceites esenciales (AEs) del genero Citrus y sus metabolitos mayoritarios, R-(+) y S-(-)-limoneno, se evaluaron como agentes larvicidas. El S-(-)-limonen...
- Autores:
-
Jaramillo Pérez, Víctor Mario
- Tipo de recurso:
- Masters Thesis
- Fecha de publicación:
- 2021
- Institución:
- Universidad Santo Tomás
- Repositorio:
- Repositorio Institucional USTA
- Idioma:
- spa
- OAI Identifier:
- oai:repository.usta.edu.co:11634/32507
- Acceso en línea:
- http://hdl.handle.net/11634/32507
- Palabra clave:
- Acetylcholinesterase
Aedes aegypti
Danio rerio
Larvicidal activity
R-(+)-limonene
S-(-)-limonene
Emulsion
Larvas de insectos
Insecticidas
Mosquitos
Insectos vectores
Monoterpenos
Emulsiones
Acetilcolinesterasa
Acetilcolinesterasa
Actividad larvicida
Aedes aegypti
Danio rerio
Aedes aegypti
Danio rerio
R-(+)-limoneno
S-(-)-limoneno
R-(+)-limoneno
Actividad larvicida
S-(-)-limoneno
Emulsión
- Rights
- closedAccess
- License
- Acceso cerrado
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| dc.title.spa.fl_str_mv |
Desarrollo de emulsiones de limoneno como productos larvicidas para el control de las larvas de mosquitos Aedes aegypti |
| title |
Desarrollo de emulsiones de limoneno como productos larvicidas para el control de las larvas de mosquitos Aedes aegypti |
| spellingShingle |
Desarrollo de emulsiones de limoneno como productos larvicidas para el control de las larvas de mosquitos Aedes aegypti Acetylcholinesterase Aedes aegypti Danio rerio Larvicidal activity R-(+)-limonene S-(-)-limonene Emulsion Larvas de insectos Insecticidas Mosquitos Insectos vectores Monoterpenos Emulsiones Acetilcolinesterasa Acetilcolinesterasa Actividad larvicida Aedes aegypti Danio rerio Aedes aegypti Danio rerio R-(+)-limoneno S-(-)-limoneno R-(+)-limoneno Actividad larvicida S-(-)-limoneno Emulsión |
| title_short |
Desarrollo de emulsiones de limoneno como productos larvicidas para el control de las larvas de mosquitos Aedes aegypti |
| title_full |
Desarrollo de emulsiones de limoneno como productos larvicidas para el control de las larvas de mosquitos Aedes aegypti |
| title_fullStr |
Desarrollo de emulsiones de limoneno como productos larvicidas para el control de las larvas de mosquitos Aedes aegypti |
| title_full_unstemmed |
Desarrollo de emulsiones de limoneno como productos larvicidas para el control de las larvas de mosquitos Aedes aegypti |
| title_sort |
Desarrollo de emulsiones de limoneno como productos larvicidas para el control de las larvas de mosquitos Aedes aegypti |
| dc.creator.fl_str_mv |
Jaramillo Pérez, Víctor Mario |
| dc.contributor.advisor.spa.fl_str_mv |
Vargas Méndez, Leonor Yamile |
| dc.contributor.author.spa.fl_str_mv |
Jaramillo Pérez, Víctor Mario |
| dc.subject.keyword.spa.fl_str_mv |
Acetylcholinesterase Aedes aegypti Danio rerio Larvicidal activity R-(+)-limonene S-(-)-limonene Emulsion |
| topic |
Acetylcholinesterase Aedes aegypti Danio rerio Larvicidal activity R-(+)-limonene S-(-)-limonene Emulsion Larvas de insectos Insecticidas Mosquitos Insectos vectores Monoterpenos Emulsiones Acetilcolinesterasa Acetilcolinesterasa Actividad larvicida Aedes aegypti Danio rerio Aedes aegypti Danio rerio R-(+)-limoneno S-(-)-limoneno R-(+)-limoneno Actividad larvicida S-(-)-limoneno Emulsión |
| dc.subject.lemb.spa.fl_str_mv |
Larvas de insectos Insecticidas Mosquitos Insectos vectores Monoterpenos Emulsiones |
| dc.subject.proposal.spa.fl_str_mv |
Acetilcolinesterasa Acetilcolinesterasa Actividad larvicida Aedes aegypti Danio rerio Aedes aegypti Danio rerio R-(+)-limoneno S-(-)-limoneno R-(+)-limoneno Actividad larvicida S-(-)-limoneno Emulsión |
| description |
Los productos naturales han tomado un nuevo impulso en la búsqueda de compuestos capaces de controlar el Aedes aegypti. En esta investigación, los aceites esenciales (AEs) del genero Citrus y sus metabolitos mayoritarios, R-(+) y S-(-)-limoneno, se evaluaron como agentes larvicidas. El S-(-)-limoneno, fue el larvicida más activo con CL50 de 13.34; 15.97 y 19.22 ppm sobre las cepas Rockefeller, Piedecuesta y Bucaramanga respectivamente; fue encapsulado con Tween 80 y propilenglicol, formando micelas de tamaño nanométrico, inferior a 10 nm. La evaluación de la emulsión como larvicida dio una CL100 de 30 ppm. Los AEs y los metabolitos fueron capaces de inhibir la acetilcolinesterasa con valores entre 144.5 µg/mL y 256.0 µg/mL. El R-(+)-limoneno fue moderadamente tóxico sobre el organismo no objetivo Danio rerio con CL50 de 22.44 µg/mL. |
| publishDate |
2021 |
| dc.date.accessioned.spa.fl_str_mv |
2021-03-16T21:19:59Z |
| dc.date.available.spa.fl_str_mv |
2021-03-16T21:19:59Z |
| dc.date.issued.spa.fl_str_mv |
2021-03-13 |
| dc.type.local.spa.fl_str_mv |
Tesis de maestría |
| dc.type.version.none.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
| dc.type.category.spa.fl_str_mv |
Formación de Recurso Humano para la Ctel: Trabajo de grado de Maestría |
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http://purl.org/coar/resource_type/c_bdcc |
| dc.type.drive.none.fl_str_mv |
info:eu-repo/semantics/masterThesis |
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http://purl.org/coar/resource_type/c_bdcc |
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acceptedVersion |
| dc.identifier.citation.spa.fl_str_mv |
Jaramillo-Pérez, V. M. (2021). Desarrollo de emulsiones de limoneno como productos larvicidas para el control de las larvas de mosquitos Aedes aegypti [Tesis de maestría]. Universidad Santo Tomás, Bucaramanga, Colombia |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/11634/32507 |
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reponame:Repositorio Institucional Universidad Santo Tomás |
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instname:Universidad Santo Tomás |
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repourl:https://repository.usta.edu.co |
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Jaramillo-Pérez, V. M. (2021). Desarrollo de emulsiones de limoneno como productos larvicidas para el control de las larvas de mosquitos Aedes aegypti [Tesis de maestría]. Universidad Santo Tomás, Bucaramanga, Colombia reponame:Repositorio Institucional Universidad Santo Tomás instname:Universidad Santo Tomás repourl:https://repository.usta.edu.co |
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http://hdl.handle.net/11634/32507 |
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spa |
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spa |
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Journal of Hazardous Materials 334(15), 121–131. https://doi.org/10.1016/j.jhazmat.2017.03.055. Zorro-González, A. F. (2018). Evaluación de la susceptibilidad y la resistencia de mosquitos colectados en Bucaramanga al limoneno y a aceites esenciales de cítricos (Tesis de pregrado en Química Ambiental). Universidad Santo Tómas; Bucaramanga, Colombia (pp. 67 - 68). |
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Vargas Méndez, Leonor YamileJaramillo Pérez, Víctor Mario2021-03-16T21:19:59Z2021-03-16T21:19:59Z2021-03-13Jaramillo-Pérez, V. M. (2021). Desarrollo de emulsiones de limoneno como productos larvicidas para el control de las larvas de mosquitos Aedes aegypti [Tesis de maestría]. Universidad Santo Tomás, Bucaramanga, Colombiahttp://hdl.handle.net/11634/32507reponame:Repositorio Institucional Universidad Santo Tomásinstname:Universidad Santo Tomásrepourl:https://repository.usta.edu.coLos productos naturales han tomado un nuevo impulso en la búsqueda de compuestos capaces de controlar el Aedes aegypti. En esta investigación, los aceites esenciales (AEs) del genero Citrus y sus metabolitos mayoritarios, R-(+) y S-(-)-limoneno, se evaluaron como agentes larvicidas. El S-(-)-limoneno, fue el larvicida más activo con CL50 de 13.34; 15.97 y 19.22 ppm sobre las cepas Rockefeller, Piedecuesta y Bucaramanga respectivamente; fue encapsulado con Tween 80 y propilenglicol, formando micelas de tamaño nanométrico, inferior a 10 nm. La evaluación de la emulsión como larvicida dio una CL100 de 30 ppm. Los AEs y los metabolitos fueron capaces de inhibir la acetilcolinesterasa con valores entre 144.5 µg/mL y 256.0 µg/mL. El R-(+)-limoneno fue moderadamente tóxico sobre el organismo no objetivo Danio rerio con CL50 de 22.44 µg/mL.Botanical products have gained significant momentum in the quest of compounds capable of controlling Aedes aegypti. In this research, essential oils (EOs) from the genus Citrus and their major secondary metabolites, R-(+) and S-(-)-limonene, were evaluated as larvicide agents. S-(-)-limonene was the most active larvicide as it showed LC50 of 13.34; 15.97 and 19.22 ppm over the Rockefeller, Piedecuesta and Bucaramanga Strains, respectively. It was encapsulated with both Tween 80 and Propylene glycol, and as a result, it developed nanometric-scaled emulsions of less than 10 nm. The assessment of the emulsion as a larvicide displayed an LC100 of 30 ppm. The EOs and the secondary metabolites were capable of inhibiting acetylcholinesterase by using values between 144.5 µg/mL and 256.0 µg/mL. R-(+)-limonene had a moderate toxicity of LC50 22.44 µg/mL over the non-target organism Danio rerio.Magister en Ciencias y Tecnologías Ambientaleshttp://www.ustabuca.edu.co/ustabmanga/presentacionMaestríaapplication/pdfspaUniversidad Santo TomásMaestría Ciencias y Tecnologías AmbientalesFacultad de Química AmbientalDesarrollo de emulsiones de limoneno como productos larvicidas para el control de las larvas de mosquitos Aedes aegyptiAcetylcholinesteraseAedes aegyptiDanio rerioLarvicidal activityR-(+)-limoneneS-(-)-limoneneEmulsionLarvas de insectosInsecticidasMosquitosInsectos vectoresMonoterpenosEmulsionesAcetilcolinesterasaAcetilcolinesterasaActividad larvicidaAedes aegyptiDanio rerioAedes aegyptiDanio rerioR-(+)-limonenoS-(-)-limonenoR-(+)-limonenoActividad larvicidaS-(-)-limonenoEmulsiónTesis de maestríainfo:eu-repo/semantics/acceptedVersionFormación de Recurso Humano para la Ctel: Trabajo de grado de Maestríahttp://purl.org/coar/resource_type/c_bdccinfo:eu-repo/semantics/masterThesisAcceso cerradoinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbCRAI-USTA BucaramangaAgilent Technologies. 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