Síntesis De Análogos De Curcumina Para La Detección Del pH

Es fundamental desarrollar métodos precisos y sostenibles para la medición de pH en diversas aplicaciones. Los métodos tradicionales como potenciómetros y tiras de pH tienen limitaciones por el uso de materiales tóxicos y la generación de residuos contaminantes. En este contexto, la síntesis de sens...

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Autores:
Fuentes Pérez, Sara Julieth
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2025
Institución:
Universidad Santo Tomás
Repositorio:
Repositorio Institucional USTA
Idioma:
spa
OAI Identifier:
oai:repository.usta.edu.co:11634/59311
Acceso en línea:
http://hdl.handle.net/11634/59311
Palabra clave:
Organic chemistry
Optical sensors
Curcumin analogues
pH detection
UV-Vis spectroscopy
Eco-toxicological tests
Química orgánica
Pruebas de ecotoxicidad
Análisis de información
Curcumina
Espectroscopia
Sensores ópticos
Análogos de curcumina
Detección de pH
Espectroscopía UV-Vis
Pruebas eco-toxicológicas
Rights
openAccess
License
Atribución-NoComercial-CompartirIgual 2.5 Colombia
id SANTOTOMAS_912d88b4d8aa6d62de66da6997467d82
oai_identifier_str oai:repository.usta.edu.co:11634/59311
network_acronym_str SANTOTOMAS
network_name_str Repositorio Institucional USTA
repository_id_str
dc.title.spa.fl_str_mv Síntesis De Análogos De Curcumina Para La Detección Del pH
title Síntesis De Análogos De Curcumina Para La Detección Del pH
spellingShingle Síntesis De Análogos De Curcumina Para La Detección Del pH
Organic chemistry
Optical sensors
Curcumin analogues
pH detection
UV-Vis spectroscopy
Eco-toxicological tests
Química orgánica
Pruebas de ecotoxicidad
Análisis de información
Curcumina
Espectroscopia
Sensores ópticos
Análogos de curcumina
Detección de pH
Espectroscopía UV-Vis
Pruebas eco-toxicológicas
title_short Síntesis De Análogos De Curcumina Para La Detección Del pH
title_full Síntesis De Análogos De Curcumina Para La Detección Del pH
title_fullStr Síntesis De Análogos De Curcumina Para La Detección Del pH
title_full_unstemmed Síntesis De Análogos De Curcumina Para La Detección Del pH
title_sort Síntesis De Análogos De Curcumina Para La Detección Del pH
dc.creator.fl_str_mv Fuentes Pérez, Sara Julieth
dc.contributor.advisor.none.fl_str_mv Rozo Correa, Ciro Eduardo
Osorio Martínez, Carlos Alberto
dc.contributor.author.none.fl_str_mv Fuentes Pérez, Sara Julieth
dc.subject.keyword.spa.fl_str_mv Organic chemistry
Optical sensors
Curcumin analogues
pH detection
UV-Vis spectroscopy
Eco-toxicological tests
topic Organic chemistry
Optical sensors
Curcumin analogues
pH detection
UV-Vis spectroscopy
Eco-toxicological tests
Química orgánica
Pruebas de ecotoxicidad
Análisis de información
Curcumina
Espectroscopia
Sensores ópticos
Análogos de curcumina
Detección de pH
Espectroscopía UV-Vis
Pruebas eco-toxicológicas
dc.subject.lemb.spa.fl_str_mv Química orgánica
Pruebas de ecotoxicidad
Análisis de información
Curcumina
Espectroscopia
dc.subject.proposal.spa.fl_str_mv Sensores ópticos
Análogos de curcumina
Detección de pH
Espectroscopía UV-Vis
Pruebas eco-toxicológicas
description Es fundamental desarrollar métodos precisos y sostenibles para la medición de pH en diversas aplicaciones. Los métodos tradicionales como potenciómetros y tiras de pH tienen limitaciones por el uso de materiales tóxicos y la generación de residuos contaminantes. En este contexto, la síntesis de sensores ópticos basados en análogos de la curcumina es una alternativa prometedora debido a sus propiedades favorables como alta sensibilidad, selectividad, estudio de biocompatibilidad y bajo costo. El objetivo de este proyecto es sintetizar y caracterizar nuevos análogos de curcumina para su uso como indicadores de pH mediante espectroscopía UV-Vis. Los análogos de curcumina en su obtención y optimización de reacciones; se llevará a cabo, mediante diversos procedimientos químicos de síntesis y utilizando literatura reportada y se evaluarán sus respuestas colorimétricas y de fluorescencia en un rango de pH de 0 a 14. Además, se probará la toxicidad de estos compuestos mediante pruebas de ecotoxicidad para determinar su posible impacto en el medio ambiente. La metodología incluye síntesis de sensores, pruebas de calibración y análisis de fluorescencia, así como caracterización estructural mediante técnicas instrumentales como espectroscopia infrarroja y espectroscopia UV-Vis. Se espera que los resultados permitan el desarrollo de sensores ópticos versátiles y eficientes para la medición de pH, con aplicaciones potenciales en las industrias de monitoreo ambiental, atención médica y agricultura. Además, este proyecto impulsará la investigación en síntesis orgánica y detección molecular, proporcionando una alternativa sostenible y eficiente a los métodos tradicionales de determinación del pH.
publishDate 2025
dc.date.accessioned.none.fl_str_mv 2025-01-21T15:56:39Z
dc.date.available.none.fl_str_mv 2025-01-21T15:56:39Z
dc.date.issued.none.fl_str_mv 2025-01-17
dc.type.local.spa.fl_str_mv Trabajo de grado
dc.type.version.none.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.category.spa.fl_str_mv Formación de Recurso Humano para la Ctel: Trabajo de grado de Pregrado
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.drive.none.fl_str_mv info:eu-repo/semantics/bachelorThesis
format http://purl.org/coar/resource_type/c_7a1f
status_str acceptedVersion
dc.identifier.citation.spa.fl_str_mv Fuentes Pérez, S. J. (2025). Síntesis De Análogos De Curcumina Para La Detección Del pH [Trabajo de pregrado]. Universidad Santo Tomás, Bucaramanga, Colombia.
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/11634/59311
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad Santo Tomás
dc.identifier.instname.spa.fl_str_mv instname:Universidad Santo Tomás
dc.identifier.repourl.spa.fl_str_mv repourl:https://repository.usta.edu.co
identifier_str_mv Fuentes Pérez, S. J. (2025). Síntesis De Análogos De Curcumina Para La Detección Del pH [Trabajo de pregrado]. Universidad Santo Tomás, Bucaramanga, Colombia.
reponame:Repositorio Institucional Universidad Santo Tomás
instname:Universidad Santo Tomás
repourl:https://repository.usta.edu.co
url http://hdl.handle.net/11634/59311
dc.language.iso.spa.fl_str_mv spa
language spa
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dc.rights.*.fl_str_mv Atribución-NoComercial-CompartirIgual 2.5 Colombia
Atribución-NoComercial-CompartirIgual 2.5 Colombia
Atribución-NoComercial-CompartirIgual 2.5 Colombia
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spelling Rozo Correa, Ciro EduardoOsorio Martínez, Carlos AlbertoFuentes Pérez, Sara Julieth2025-01-21T15:56:39Z2025-01-21T15:56:39Z2025-01-17Fuentes Pérez, S. J. (2025). Síntesis De Análogos De Curcumina Para La Detección Del pH [Trabajo de pregrado]. Universidad Santo Tomás, Bucaramanga, Colombia.http://hdl.handle.net/11634/59311reponame:Repositorio Institucional Universidad Santo Tomásinstname:Universidad Santo Tomásrepourl:https://repository.usta.edu.coEs fundamental desarrollar métodos precisos y sostenibles para la medición de pH en diversas aplicaciones. Los métodos tradicionales como potenciómetros y tiras de pH tienen limitaciones por el uso de materiales tóxicos y la generación de residuos contaminantes. En este contexto, la síntesis de sensores ópticos basados en análogos de la curcumina es una alternativa prometedora debido a sus propiedades favorables como alta sensibilidad, selectividad, estudio de biocompatibilidad y bajo costo. El objetivo de este proyecto es sintetizar y caracterizar nuevos análogos de curcumina para su uso como indicadores de pH mediante espectroscopía UV-Vis. Los análogos de curcumina en su obtención y optimización de reacciones; se llevará a cabo, mediante diversos procedimientos químicos de síntesis y utilizando literatura reportada y se evaluarán sus respuestas colorimétricas y de fluorescencia en un rango de pH de 0 a 14. Además, se probará la toxicidad de estos compuestos mediante pruebas de ecotoxicidad para determinar su posible impacto en el medio ambiente. La metodología incluye síntesis de sensores, pruebas de calibración y análisis de fluorescencia, así como caracterización estructural mediante técnicas instrumentales como espectroscopia infrarroja y espectroscopia UV-Vis. Se espera que los resultados permitan el desarrollo de sensores ópticos versátiles y eficientes para la medición de pH, con aplicaciones potenciales en las industrias de monitoreo ambiental, atención médica y agricultura. Además, este proyecto impulsará la investigación en síntesis orgánica y detección molecular, proporcionando una alternativa sostenible y eficiente a los métodos tradicionales de determinación del pH.It is essential to develop accurate and sustainable methods for pH measurement in various applications. Traditional methods such as potentiometers and pH strips have limitations due to the use of toxic materials and the generation of polluting waste. In this context, the synthesis of optical sensors based on curcumin analogues is a promising alternative due to their favorable properties such as high sensitivity, selectivity, biocompatibility study and low cost. The objective of this project is to synthesize and characterize new curcumin analogues for use as pH indicators by UV-Vis spectroscopy. The curcumin analogues in their obtaining and optimization of reactions; will be carried out, through various chemical synthesis procedures and using reported literature and their colorimetric and fluorescence responses will be evaluated in a pH range from 0 to 14. In addition, the toxicity of these compounds will be tested by ecotoxicity tests to determine their possible impact on the environment. The methodology includes sensor synthesis, calibration tests and fluorescence analysis, as well as structural characterization using instrumental techniques such as infrared spectroscopy and UV-Vis spectroscopy. The results are expected to enable the development of versatile and efficient optical sensors for pH measurement, with potential applications in the environmental monitoring, healthcare and agricultural industries. In addition, this project will advance research in organic synthesis and molecular sensing, providing a sustainable and efficient alternative to traditional pH determination methods.Químico Ambientalhttps://www.ustabuca.edu.co/Pregradoapplication/pdfspaUniversidad Santo TomásPregrado Química AmbientalFacultad de Química AmbientalAtribución-NoComercial-CompartirIgual 2.5 ColombiaAtribución-NoComercial-CompartirIgual 2.5 ColombiaAtribución-NoComercial-CompartirIgual 2.5 Colombiahttp://creativecommons.org/licenses/by-nc-sa/2.5/co/Abierto (Texto Completo)info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Síntesis De Análogos De Curcumina Para La Detección Del pHOrganic chemistryOptical sensorsCurcumin analoguespH detectionUV-Vis spectroscopyEco-toxicological testsQuímica orgánicaPruebas de ecotoxicidadAnálisis de informaciónCurcuminaEspectroscopiaSensores ópticosAnálogos de curcuminaDetección de pHEspectroscopía UV-VisPruebas eco-toxicológicasTrabajo de gradoinfo:eu-repo/semantics/acceptedVersionFormación de Recurso Humano para la Ctel: Trabajo de grado de Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisCRAI-USTA BucaramangaAl-Noor, T., Ali, A., Al-Sarray, A., Al-Obaidi, O., Obeidat, A., & Habash, R. (2022). A Short Review: Chemistry of Curcumin and Its Metal Complex Derivatives. Journal of University of Anbar for Pure Science, 16(1), 20-26. https://juaps.uoanbar.edu.iq/article_174832.htmlAliouche, H. (2019, febrero 26). News medical life sciences. Retrieved from https://www.news-medical.net/life-sciences/Importance-of-Measuring-pH-in-Industry.aspxArafa, A.A., Nada, A.A., Ibrahim, A.Y., Zahran, M.K., Hakeim, O.A. (2021). Greener therapeutic pH-sensing wound dressing based on Curcuma Longa and cellulose hydrogel, European Polymer Journal, 159, 110744, ISSN 0014-3057, https://doi.org/10.1016/j.eurpolymj.2021.110744.Beganovic, S., Wittmann, Ch. (2024). Medical properties, market potential, and microbial production of golden polyketide curcumin for food, biomedical, and cosmetic applications, Current Opinion in Biotechnology, 87, 103112, ISSN 0958-1669, https://doi.org/10.1016/j.copbio.2024.103112.Casas, J.A., ; Castillo, H.J., ; Noy, J.M., ; Palomares, A.N.,; Rodríguez, R.L. 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Colorimetric sensing of heavy metals on metal doped metal oxide nanocomposites: A review, Trends in Environmental Analytical Chemistry, 37, e00187, ISSN 2214-1588, https://doi.org/10.1016/j.teac.2022.e00187.THUMBNAIL2025FuentesSara.pdf.jpg2025FuentesSara.pdf.jpgIM Thumbnailimage/jpeg5138https://repository.usta.edu.co/bitstream/11634/59311/12/2025FuentesSara.pdf.jpg42e83473fabdc3a027f889f2018879c3MD512open access2025FuentesSara2.pdf.jpg2025FuentesSara2.pdf.jpgIM Thumbnailimage/jpeg8593https://repository.usta.edu.co/bitstream/11634/59311/13/2025FuentesSara2.pdf.jpg4214e3ae73c9e38c1890f86bd5e2cbbbMD513open access2025FuentesSara1.pdf.jpg2025FuentesSara1.pdf.jpgIM Thumbnailimage/jpeg7038https://repository.usta.edu.co/bitstream/11634/59311/14/2025FuentesSara1.pdf.jpg761a123dd6a40c0bc5920ded2bd48e96MD514open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-8807https://repository.usta.edu.co/bitstream/11634/59311/11/license.txtaedeaf396fcd827b537c73d23464fc27MD511open accessCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81037https://repository.usta.edu.co/bitstream/11634/59311/10/license_rdf1487462a1490a8fc01f5999ce7b3b9ccMD510open accessORIGINAL2025FuentesSara.pdf2025FuentesSara.pdfTrabajo de gradoapplication/pdf2265803https://repository.usta.edu.co/bitstream/11634/59311/4/2025FuentesSara.pdffe886191724893bfed96c39681620079MD54open access2025FuentesSara2.pdf2025FuentesSara2.pdfAcuerdo de publicaciónapplication/pdf136100https://repository.usta.edu.co/bitstream/11634/59311/6/2025FuentesSara2.pdf062779767048bfda2282217eb49cd8c2MD56metadata only access2025FuentesSara1.pdf2025FuentesSara1.pdfAprobación de facultadapplication/pdf53815https://repository.usta.edu.co/bitstream/11634/59311/9/2025FuentesSara1.pdf8d685c52530340019e577757629ad272MD59metadata only access11634/59311oai:repository.usta.edu.co:11634/593112025-01-22 03:20:04.241metadata only accessRepositorio Universidad Santo Tomásrepositorio@usta.edu.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