Comparación in vitro de la capacidad de disolución de tejido pulpar humano entre la Azadirachta Indica (Neem) y el hipoclorito de sodio al 5,25 %
Las soluciones irrigantes son un coadyuvante esencial en la terapia endodóntica para la completa desinfección del conducto radicular. Objetivo: Evaluar la capacidad de disolución del tejido pulpar humano utilizando extracto de Azadirachta Indica (Neem) en comparación con una solución de hipoclorito...
- Autores:
-
Vidarte Quintero, Margoli Andrea
Rincón Galindo, Maria Paula
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2024
- Institución:
- Universidad Santo Tomás
- Repositorio:
- Repositorio Institucional USTA
- Idioma:
- spa
- OAI Identifier:
- oai:repository.usta.edu.co:11634/55382
- Acceso en línea:
- http://hdl.handle.net/11634/55382
- Palabra clave:
- Herbal
Endodontic irrigant
Sodium hypochlorite
Neem
Dissolution
Procedimientos odontológicos especializados
Desinfección del conducto radicular
Endodoncia
Análisis de información
Herbal
Irrigante endodóntico
Hipoclorito de sodio
Neem
Disolución
- Rights
- openAccess
- License
- Abierto (Texto Completo)
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| dc.title.spa.fl_str_mv |
Comparación in vitro de la capacidad de disolución de tejido pulpar humano entre la Azadirachta Indica (Neem) y el hipoclorito de sodio al 5,25 % |
| title |
Comparación in vitro de la capacidad de disolución de tejido pulpar humano entre la Azadirachta Indica (Neem) y el hipoclorito de sodio al 5,25 % |
| spellingShingle |
Comparación in vitro de la capacidad de disolución de tejido pulpar humano entre la Azadirachta Indica (Neem) y el hipoclorito de sodio al 5,25 % Herbal Endodontic irrigant Sodium hypochlorite Neem Dissolution Procedimientos odontológicos especializados Desinfección del conducto radicular Endodoncia Análisis de información Herbal Irrigante endodóntico Hipoclorito de sodio Neem Disolución |
| title_short |
Comparación in vitro de la capacidad de disolución de tejido pulpar humano entre la Azadirachta Indica (Neem) y el hipoclorito de sodio al 5,25 % |
| title_full |
Comparación in vitro de la capacidad de disolución de tejido pulpar humano entre la Azadirachta Indica (Neem) y el hipoclorito de sodio al 5,25 % |
| title_fullStr |
Comparación in vitro de la capacidad de disolución de tejido pulpar humano entre la Azadirachta Indica (Neem) y el hipoclorito de sodio al 5,25 % |
| title_full_unstemmed |
Comparación in vitro de la capacidad de disolución de tejido pulpar humano entre la Azadirachta Indica (Neem) y el hipoclorito de sodio al 5,25 % |
| title_sort |
Comparación in vitro de la capacidad de disolución de tejido pulpar humano entre la Azadirachta Indica (Neem) y el hipoclorito de sodio al 5,25 % |
| dc.creator.fl_str_mv |
Vidarte Quintero, Margoli Andrea Rincón Galindo, Maria Paula |
| dc.contributor.advisor.none.fl_str_mv |
Santos Hoyos, Roman Andrés |
| dc.contributor.author.none.fl_str_mv |
Vidarte Quintero, Margoli Andrea Rincón Galindo, Maria Paula |
| dc.subject.keyword.spa.fl_str_mv |
Herbal Endodontic irrigant Sodium hypochlorite Neem Dissolution |
| topic |
Herbal Endodontic irrigant Sodium hypochlorite Neem Dissolution Procedimientos odontológicos especializados Desinfección del conducto radicular Endodoncia Análisis de información Herbal Irrigante endodóntico Hipoclorito de sodio Neem Disolución |
| dc.subject.lemb.spa.fl_str_mv |
Procedimientos odontológicos especializados Desinfección del conducto radicular Endodoncia Análisis de información |
| dc.subject.proposal.spa.fl_str_mv |
Herbal Irrigante endodóntico Hipoclorito de sodio Neem Disolución |
| description |
Las soluciones irrigantes son un coadyuvante esencial en la terapia endodóntica para la completa desinfección del conducto radicular. Objetivo: Evaluar la capacidad de disolución del tejido pulpar humano utilizando extracto de Azadirachta Indica (Neem) en comparación con una solución de hipoclorito de sodio al 5,25% en pulpas de terceros molares y premolares sanos extraídos por indicación ortodóntica. Método: Se seleccionaron 24 terceros molares y premolares humanos extraídos, a los cuales se añadieron tres dientes adicionales para el estudio piloto. Posteriormente, se realizaron la instrumentación y se dividieron en tres grupos, cada uno compuesto por 8 terceros molares y premolares. Cada grupo fue tratado con una solución diferente: solución salina, hipoclorito de sodio al 5,25% y extracto de Neem (Azadirachta Indica). Luego, se realizó un corte longitudinal del tejido pulpar y se sumergió en las tres sustancias del estudio. Se llevó a cabo un pesaje inicial (en miligramos), seguido de lecturas a los quince y treinta minutos para evaluar la disminución del peso del tejido pulpar como resultado de la disolución. Los datos obtenidos fueron sometidos a un análisis de varianza estadístico descriptivo con un nivel de significancia establecido en p < 0,05. Resultados: El extracto de Azadirachta Indica disolvió tejido pulpar, aunque el hipoclorito de sodio logró la disolución del tejido pulpar en un tiempo menor. Conclusiones: El extracto de Azadirachta Indica demostró tener la capacidad de disolver el tejido pulpar cuando se utilizó como agente irrigante, lo que sugiere su potencial como alternativa en el proceso de endodoncia. |
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2024 |
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2024-06-06T14:13:42Z |
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2024-06-06T14:13:42Z |
| dc.date.issued.none.fl_str_mv |
2024-06-05 |
| dc.type.local.spa.fl_str_mv |
Trabajo de grado |
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info:eu-repo/semantics/acceptedVersion |
| dc.type.category.spa.fl_str_mv |
Formación de Recurso Humano para la Ctel: Trabajo de grado de Especialización |
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http://purl.org/coar/resource_type/c_7a1f |
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Rincón Galindo, M. P. y Vidarte Quintero, M. A. (2024) Disolución del tejido pulpar entre neem e hipoclorito de sodio, estudio in vitro. [Tesis de postgrado]. Universidad Santo Tomás, Bucaramanga, Colombia |
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http://hdl.handle.net/11634/55382 |
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reponame:Repositorio Institucional Universidad Santo Tomás |
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Rincón Galindo, M. P. y Vidarte Quintero, M. A. (2024) Disolución del tejido pulpar entre neem e hipoclorito de sodio, estudio in vitro. [Tesis de postgrado]. Universidad Santo Tomás, Bucaramanga, Colombia reponame:Repositorio Institucional Universidad Santo Tomás instname:Universidad Santo Tomás repourl:https://repository.usta.edu.co |
| url |
http://hdl.handle.net/11634/55382 |
| dc.language.iso.spa.fl_str_mv |
spa |
| language |
spa |
| dc.relation.references.spa.fl_str_mv |
Agrawal, V., Kapoor, S. and Agrawal, I. (2016). Critical Review on Eliminating Endodontic Dental Infections Using Herbal Products. Journal of Dietary Supplements, 0 (0), 1–12. https://doi.org/10.1080/19390211.2016.1207004 Alkahtani, A., Alkahtany, S. M. and Anil, S. (2014). An in vitro evaluation of the cytotoxicity of varying concentrations of sodium hypochlorite on human mesenchymal stem cells. The Journal of Contemporary Dental Practice, 15(4), 473–481. https://doi.org/10.5005/jp-journals-10024-1565 Arslan, D., Guneser, M. B., Kustarci, A., Er, K. and Siso, S. H. (2015). Pulp tissue dissolution capacity of QMix 2 in1 irrigation solution. European Journal of Dentistry, 9(3), 423–427. https://doi.org/10.4103/1305-7456.163229 Barea, K., Bangel, I., Feijolo, D., Cardoso, M., Soares, F. and Montagner, F. (2019). Calcium hypochlorite solutions – An in vitro evaluation of antimicrobial action and pulp dissolution. European Endodontic Journal, 4(1), 15–20. https://doi.org/10.14744/eej.2018.64936 Bhardwaj, A., Srivastava, N., Rana, V., Adlakha, V. and Asthana, A. (2017). How efficacious are Neem, Tulsi, Guduchi extracts and chlorhexidine as intracanal disinfectants? A comparative exvivo study. International Quarterly Journal of Research in Ayurveda, 38(1), 70. https://doi.org/10.4103/ayu.ayu_72_16 Bhargava, K., Kumar, T., Patil, P., Sanap, A., Zinzarde, S. and Aggarwal, S. (2015). Comparative evaluation of the antimicrobial efficacy of neem, green tea, triphala and sodium hypochlorite: An in vitro study. Journal of Dental Research and Review, 2(1), 13. https://doi.org/10.4103/2348-2915.154638 Baruwa AO, Martins JNR, Maravic T, Mazzitelli C, Mazzoni A, Ginjeira (2022). A. Effect of Endodontic Irrigating Solutions on Radicular Dentine Structure and Matrix Metalloproteinases—A Comprehensive Review. Dentistry Journa, 10(12):219. https://doi.org/10.3390/dj10120219 Bhavsar, B. A., Selvi, T., Paliwal, A., Ansari, F., Beohar, D. S., & Joseph, T. (2022). Effect of Herbal and Chemical Solution in Tissue Dissolution by using Conventional Irrigation and Sonic Irrigation System. Journal of pharmacy & bioallied sciences, 14(1), S863–S867. https://doi.org/10.4103/jpbs.jpbs_28_22 Birring, O. J. S., Viloria, I. L. and Nunez, P. (2015). Anti-microbial efficacy of Allium sativum extract against Enterococcus faecalis biofilm and its penetration into the root dentin: An in vitro study. Indian Journal of Dental Research, 26(5), 477–482. https://doi.org/10.4103/0970-9290.172041 Chatterjee, A., Saluia, M., Singh, N. and Kandwal, A. (2011). To evaluate the antigingivitis and antipalque effect of an Azadirachta indica (neem) mouthrinse on plaque induced gingivitis: A double blind, randomized, controlled trial. Journal of Indian Society of Periodontology, 15(4), 398–401. doi: 10.4103/0972-124X.92578 Datta, S., Chand, G., Sashidhar, K., Sunil, C., Hemadri, M. and Ranga, D. (2016). Evaluation of antimicrobial efficacy of neem and Aloe vera leaf extracts in comparison with 3% sodium hypochlorite and 2% chlorhexidine against E. faecalis and C. albicans. Journal of Health Sciences, 5(2), 104–110. https://doi.org/10.4103/2277-8632.185436 Gomes, B., Aveiro, E., & Kishen, A. (2023). Irrigants and irrigation activation systems in Endodontics. Brazilian dental journal, 34(4), 1–33. https://doi.org/10.1590/0103-6440202305577 Güçlüer, Ö, Akarsu, E., Yavuz, E., Er, K. and Kuştarcı, A. (2020). Human pulp tissue dissolution ability of different extracts of Sapindus mukorossi: An in vitro study. Chinese Herbal Medicines, 12(2), 178–182. https://doi.org/10.1016/j.chmed.2019.11.005 Hadhoud, F., & Abdel-Kader, K. (2019). Comparative evaluation of the tissue dissolution capability of 3% of sodium hypochlorite, 5%pomegranate, and 5%miswak. Egyptian Dental Journal, 65(3), 2867-2873. doi: 10.21608/edj.2019.72683 Iandolo, A., Dagna, A., Poggio, C., Capar, I., Amato, A. and Abdellatif, D. (2019). Evaluation of the actual chlorine concentration and the required time for pulp dissolution using different sodium hypochlorite irrigating solutions. Journal of Conservative Dentistry, 22 (2), 108–113. https://doi.org/10.4103/JCD.JCD_165_19 Jibin, V., Ranjini, M., Swapna, D., Bharathi, M., Nadig, R. and Vedavathi, B. (2022). Evaluation of antimicrobial action, pulp tissue dissolution, and smear layer removal of an experimental irrigant combining salvadora persica and sodium hypochlorite with and without ultrasonic activation: An in vitro study. International. Journal of Preventive and Clinical Dental Research, 9(3), 63–71. https://doi.org/10.4103/ijpcdr.ijpcdr_16_22 Joy, D., Nandha, K., Jaiswal, N., Vasudeva, A., Prabha, S. and Pratap, U. (2017). Antibacterial Effect of Azadirachta indica (Neem) or Curcuma longa (Turmeric) against Enterococcus faecalis Compared with that of 5% Sodium Hypochlorite or 2% Chlorhexidine in vitro. The Bulletin of Tokyo Dental College, 58(2), 103–109. https://doi.org/10.2209/tdcpublication.2015-0029 Lakshmi, T., Krishnan, V., Rajendran, R. and Madhusudhanan, N. (2015). Azadirachta indica: An herbal panacea in dentistry - An update. Pharmacognosy Reviews, 9(17), 41–44. https://doi.org/10.4103/0973-7847.156337 Marne, Y. and Vidyapeeth, B. (2019). Comparative Analysis of Ozonated Oil and Neem Extract as a Root Canal Irrigant-An In-Vitro Study. International Journal of Dental Science and Innovative Research, 2(4), 335 – 343. Martínez, A., Ortega, J. L., Hernández, S. I., Olivas, E. H. and Alba, J. J. (2016). Application of Neem tree in agriculture, industry, medicine, and environment: A review. African Journal of Traditional, Complementary and Alternative Medicines, 13(2), 191–198. https://doi.org/10.4314/ajtcam.v13i2.23 Mistry, K., Sanghvi, Z., Parmar, G. and Shah, S. (2014). The antimicrobial activity of Azadirachta indica, Mimusops elengi, Tinospora cardifolia, Ocimum sanctum and 2% chlorhexidine gluconate on common endodontic pathogens: An in vitro study. European Journal of Dentistry, 8(2), 172–177. DOI: 10.4103/1305-7456.130591. Montealegre, J. M., Zeledón, R., Benavides, M. and Gallardo, C. (2014). Propiedades fisicoquímicas y disolución de tejido pulpar del hipoclorito de sodio utilizado como irrigante endodóntico en tres centros de atención odontológica dela Caja Costarricense del Seguro Social. Revista Científica Odontológica, 10(1), 43–51. Recuperado de http://www.redalyc.org/articulo.oa?id=324233026006 Naveed, N., and Murthykumar, K. (2014). The use of neem in oral health. Research Journal of Pharmacy and Technology, 7 (9), 1060-1064. Nunes, K. S., Feron, L., Montagner, F. and de Melo, T. A. F. (2016). Analysis of root canal organic tissue dissolution capacity according to the type of irrigation solution and agitation technique. Brazilian Journal of Oral Sciences, 15(1), 70–74. https://doi.org/10.20396/bjos.v15i1.8647128 Pashley, E. L., Birdsong, N. L., Bowman, K. and Pashley, D. H. (1985). Cytotoxic effects of NaOCl on vital tissue. Journal of Endodontics, 11(12), 525–528. https://doi.org/10.1016/S0099-2399(85)80197-7 Pravin, P. and Raut, A. (2021). A proposed classification system for herbal endodontic irrigants. Journal of Conservative Dentistry, 24(3), 293–295. https://doi.org/10.4103/jcd.jcd_75_21 Ranjitha, G., Rajesh, S., Kumari, A., Vikram, R., Kumar, N. and Shivekshith, A. (2020). Comparative evaluation of smear layer removal efficacy of three herbal irrigants in the apical third of the root canal: An in vitro scanning electron microscopic study. Journal of Research in Dental Science, 11, 61–65. DOI: 10.4103/srmjrds.srmjrds_2_20 Rao, S. Anitha; Sunitha, Lakkireddy; Rao, B. Nageshwar1; Naik, J. Praveena; Shekar, V. Chandra. (2017). Efficacy of allium sativum extract and sodium hypochlorite on dental pulp dissolution: An in vitro study. Saudi Endodontic Journal. 7(1):36-39. | DOI: 10.4103/1658-5984.197986 Ravishankar, T., Kaur, R., Kaur, S. and Bhattacharyya, S. (2018). Neem (Azadirachta indica): An Elixir in Dentistry. Chronicles of Dental Research, 7(1), 7–17. Recuperado de www.cdronline .org Reshma RV., Varma, R., Sureshkumar, J., Kumaran, P., Xavier, A. and Madhavan, M. (2020). Comparison of cytotoxicity and smear layer removal efficacy of triphala (an Indian ayurvedic herbal formulation) and 5.25% sodium hypochlorite as root canal irrigants: An in vitro study. Journal of Indian Society of Pedodontics and Preventive Dentistry, 38(4), 343–349. https://doi.org/10.4103/JISPPD.JISPPD_297_20 Saxena, D., Saha, S. G., Saha, M. K., Dubey, S. and Khatri, M. (2015). An in vitro evaluation of antimicrobial activity of five herbal extracts and comparison of their activity with 2.5% sodium hypochlorite against Enterococcus faecalis. Indian Journal of Dental Research, 26(5), 524–527. https://doi.org/10.4103/0970-9290.172080 Silva, L. H., Gomes, N., Silva, L., Neutziling, A., Giadino, L., Souza, E. and Pappen, F. (2013). Pulp tissue dissolution capacity of sodium hypochlorite combined with cetrimide and polypropylene glycol. Brazilian Dental Journal, 24(5), 477–481. https://doi.org/10.1590/0103-6440201302041 Só, M. V. R., Vier-Pelisser, F. V., Darcie, M. S., Smaniotto, D. G. R., Montagner, F., & Kuga, M. C. (2011). Pulp tissue dissolution when the use of sodium hypochlorite and EDTA alone or associated. Revista de Odontología y Ciencia, 26(2), 156-160. Recuperado de https://www.scielo.br/j/roc/a/WvpSqhBFnkNGHJpYBJY9RXq/?format=pdf&lang=en Srinivasan, S., Kumarappan, S. K., Ramachandran, A., Honap, M. N., Kadandale, S., & Rayar, S. (2020). Comparative evaluation of pulp tissue dissolution ability of sodium hypochlorite by various activation techniques: An in vitro study. Journal of conservative dentistry, 23(3), 304–308. https://doi.org/10.4103/JCD.JCD_425_20 Sundaram, D., Narayanan, R. K. and Vadakkepurayil, K. (2016). A comparative evaluation on antimicrobial effect of honey, neem leaf extract and sodium hypochlorite as intracanal irrigant: An ex-vivo study. Journal of Clinical and Diagnostic Research, 10(8), ZC88–ZC91. https://doi.org/10.7860/JCDR/2016/19268.8311 Tartari, T., Bachmann, L., Maliza, A. G., Andrade, F. B., Duarte, M. A., & Bramante, C. M. (2016). Tissue dissolution and modifications in dentin composition by different sodium hypochlorite concentrations. Journal of Applied Oral Science, 24(3), 291–298. https://doi.org/10.1590/1678-775720150524 Teja, K. V., Janani, K., Srivastava, K. C., Shrivastava, D., Jose, J., Marya, A., & Karobari, M. I. (2021). Comparison of Herbal Agents with Sodium Hypochlorite as Root Canal Irrigant: A Systematic Review of In Vitro Studies. Evidence-based complementary and alternative medicine: eCAM, 2021, 8967219. https://doi.org/10.1155/2021/8967219 Tyagi, S., Sinha, D., Garg, P., Singh, U., Mishra, C. and Nagpal, R. (2013). Comparison of antimicrobial efficacy of propolis, Morinda citrifolia, Azadirachta indica (Neem) and 5% sodium hypochlorite on Candida albicans biofilm formed on tooth substrate: An in-vitro study. Journal of Conservative Dentistry, 16(6), 532–535. https://doi.org/10.4103/0972-0707.120973 Wahjuningrum, D., Elizabeth, M. K., Puteri, F., Mardiyah, A. and Subiyanto, A. (2019). Cytotoxicity assay of sodium hypochlorite and QMix on cultured human periodontal ligament fibroblast cells. Journal of International Oral Health, 11(4), 204. https://doi.org/10.4103/jioh.jioh_48_19 |
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Santos Hoyos, Roman AndrésVidarte Quintero, Margoli AndreaRincón Galindo, Maria Paula2024-06-06T14:13:42Z2024-06-06T14:13:42Z2024-06-05Rincón Galindo, M. P. y Vidarte Quintero, M. A. (2024) Disolución del tejido pulpar entre neem e hipoclorito de sodio, estudio in vitro. [Tesis de postgrado]. Universidad Santo Tomás, Bucaramanga, Colombiahttp://hdl.handle.net/11634/55382reponame:Repositorio Institucional Universidad Santo Tomásinstname:Universidad Santo Tomásrepourl:https://repository.usta.edu.coLas soluciones irrigantes son un coadyuvante esencial en la terapia endodóntica para la completa desinfección del conducto radicular. Objetivo: Evaluar la capacidad de disolución del tejido pulpar humano utilizando extracto de Azadirachta Indica (Neem) en comparación con una solución de hipoclorito de sodio al 5,25% en pulpas de terceros molares y premolares sanos extraídos por indicación ortodóntica. Método: Se seleccionaron 24 terceros molares y premolares humanos extraídos, a los cuales se añadieron tres dientes adicionales para el estudio piloto. Posteriormente, se realizaron la instrumentación y se dividieron en tres grupos, cada uno compuesto por 8 terceros molares y premolares. Cada grupo fue tratado con una solución diferente: solución salina, hipoclorito de sodio al 5,25% y extracto de Neem (Azadirachta Indica). Luego, se realizó un corte longitudinal del tejido pulpar y se sumergió en las tres sustancias del estudio. Se llevó a cabo un pesaje inicial (en miligramos), seguido de lecturas a los quince y treinta minutos para evaluar la disminución del peso del tejido pulpar como resultado de la disolución. Los datos obtenidos fueron sometidos a un análisis de varianza estadístico descriptivo con un nivel de significancia establecido en p < 0,05. Resultados: El extracto de Azadirachta Indica disolvió tejido pulpar, aunque el hipoclorito de sodio logró la disolución del tejido pulpar en un tiempo menor. Conclusiones: El extracto de Azadirachta Indica demostró tener la capacidad de disolver el tejido pulpar cuando se utilizó como agente irrigante, lo que sugiere su potencial como alternativa en el proceso de endodoncia.Irrigating solutions are an essential component in endodontic therapy for complete disinfection of the root canal. Objective: To evaluate the solubility of human pulp tissue using Azadirachta Indica (Neem) extract compared to a 5.25% solution of sodium hypochlorite in pulps of healthy third molars and premolars extracted by orthodontic indication. Method: 24 extracted human third molars and premolars were selected along with three additional teeth were added for the pilot study. Subsequently, the instrumentation was carried out and they were divided into three groups, each consisting of 8 third molars and premolars. Each group was treated with a different solution: saline solution, 5.25% sodium hypochlorite and Neem extract (Azadirachta Indica). A longitudinal cut of the pulp tissue was then carried out and the three substances in the study were immersed. An initial weighing (in milligrams) was carried out, followed by measuremen every fifteen and thirty minutes to assess the decrease in the weight of the pulp tissue because of the dissolution. The data obtained were subjected to a descriptive statistical variance analysis with a level of significance set at p < 0.05. Results: The Azadirachta Indica extract dissolved pulp tissue, although sodium hypochlorite achieved dissolution of the pulp tissue in a shorter time. Conclusions: Azadirachta Indica extract has been shown to have the ability to dissolve pulp tissue when used as irrigating agent, suggesting its potential as an alternative irrigating agent.Especialista en Endodonciahttps://www.ustabuca.edu.co/Especializaciónapplication/pdfspaUniversidad Santo TomásEspecialización EndodonciaFacultad de OdontologíaComparación in vitro de la capacidad de disolución de tejido pulpar humano entre la Azadirachta Indica (Neem) y el hipoclorito de sodio al 5,25 %HerbalEndodontic irrigantSodium hypochloriteNeemDissolutionProcedimientos odontológicos especializadosDesinfección del conducto radicularEndodonciaAnálisis de informaciónHerbalIrrigante endodónticoHipoclorito de sodioNeemDisoluciónTrabajo de gradoinfo:eu-repo/semantics/acceptedVersionFormación de Recurso Humano para la Ctel: Trabajo de grado de Especializaciónhttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisAbierto (Texto Completo)info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2CRAI-USTA BucaramangaAgrawal, V., Kapoor, S. and Agrawal, I. 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Journal of International Oral Health, 11(4), 204. https://doi.org/10.4103/jioh.jioh_48_19THUMBNAIL2024RincónMariaPaula.pdf.jpg2024RincónMariaPaula.pdf.jpgIM Thumbnailimage/jpeg8820https://repository.usta.edu.co/bitstream/11634/55382/5/2024Rinc%c3%b3nMariaPaula.pdf.jpg5eb3ad1588a23067c2a6694e3c5d83eeMD55open access2024RinconMariaPaula1.pdf.jpg2024RinconMariaPaula1.pdf.jpgIM Thumbnailimage/jpeg8163https://repository.usta.edu.co/bitstream/11634/55382/6/2024RinconMariaPaula1.pdf.jpg0da6e6dded775859b420c77b305d2f10MD56open access2024RinconMariaPaula2.pdf.jpg2024RinconMariaPaula2.pdf.jpgIM Thumbnailimage/jpeg9119https://repository.usta.edu.co/bitstream/11634/55382/7/2024RinconMariaPaula2.pdf.jpgf6dfbbe04f63daf96e24057b2ceaf5c3MD57open accessORIGINAL2024RincónMariaPaula.pdf2024RincónMariaPaula.pdfTrabajo de gradoapplication/pdf289617https://repository.usta.edu.co/bitstream/11634/55382/1/2024Rinc%c3%b3nMariaPaula.pdf4b114e42f6d11a49a0e35459d524403fMD51open access2024RinconMariaPaula1.pdf2024RinconMariaPaula1.pdfCarta de facultadapplication/pdf123732https://repository.usta.edu.co/bitstream/11634/55382/3/2024RinconMariaPaula1.pdf96b3b94f4de8500d87022e0fe5c2236cMD53metadata only access2024RinconMariaPaula2.pdf2024RinconMariaPaula2.pdfAcuerdo de publicacionapplication/pdf246464https://repository.usta.edu.co/bitstream/11634/55382/2/2024RinconMariaPaula2.pdfb9f07e23e96f9a517d946870bea73dabMD52metadata only accessLICENSElicense.txtlicense.txttext/plain; charset=utf-8807https://repository.usta.edu.co/bitstream/11634/55382/4/license.txtaedeaf396fcd827b537c73d23464fc27MD54open access11634/55382oai:repository.usta.edu.co:11634/553822024-06-07 03:01:09.227open accessRepositorio Universidad Santo Tomásrepositorio@usta.edu.coQXV0b3Jpem8gYWwgQ2VudHJvIGRlIFJlY3Vyc29zIHBhcmEgZWwgQXByZW5kaXphamUgeSBsYSBJbnZlc3RpZ2FjacOzbiwgQ1JBSS1VU1RBCmRlIGxhIFVuaXZlcnNpZGFkIFNhbnRvIFRvbcOhcywgcGFyYSBxdWUgY29uIGZpbmVzIGFjYWTDqW1pY29zIGFsbWFjZW5lIGxhCmluZm9ybWFjacOzbiBpbmdyZXNhZGEgcHJldmlhbWVudGUuCgpTZSBwZXJtaXRlIGxhIGNvbnN1bHRhLCByZXByb2R1Y2Npw7NuIHBhcmNpYWwsIHRvdGFsIG8gY2FtYmlvIGRlIGZvcm1hdG8gY29uCmZpbmVzIGRlIGNvbnNlcnZhY2nDs24sIGEgbG9zIHVzdWFyaW9zIGludGVyZXNhZG9zIGVuIGVsIGNvbnRlbmlkbyBkZSBlc3RlCnRyYWJham8sIHBhcmEgdG9kb3MgbG9zIHVzb3MgcXVlIHRlbmdhbiBmaW5hbGlkYWQgYWNhZMOpbWljYSwgc2llbXByZSB5IGN1YW5kbwptZWRpYW50ZSBsYSBjb3JyZXNwb25kaWVudGUgY2l0YSBiaWJsaW9ncsOhZmljYSBzZSBsZSBkw6kgY3LDqWRpdG8gYWwgdHJhYmFqbyBkZQpncmFkbyB5IGEgc3UgYXV0b3IuIERlIGNvbmZvcm1pZGFkIGNvbiBsbyBlc3RhYmxlY2lkbyBlbiBlbCBhcnTDrWN1bG8gMzAgZGUgbGEKTGV5IDIzIGRlIDE5ODIgeSBlbCBhcnTDrWN1bG8gMTEgZGUgbGEgRGVjaXNpw7NuIEFuZGluYSAzNTEgZGUgMTk5Mywg4oCcTG9zIGRlcmVjaG9zCm1vcmFsZXMgc29icmUgZWwgdHJhYmFqbyBzb24gcHJvcGllZGFkIGRlIGxvcyBhdXRvcmVz4oCdLCBsb3MgY3VhbGVzIHNvbgppcnJlbnVuY2lhYmxlcywgaW1wcmVzY3JpcHRpYmxlcywgaW5lbWJhcmdhYmxlcyBlIGluYWxpZW5hYmxlcy4K |