Actividad larvicida y efecto residual de piperidinas e insecticidas organofosforados en las proteínas de Aedes aegypti (Díptera: Culicidae)

En esta investigación se determinó la actividad la susceptibilidad y resistencia de las larvas en tercer instar del mosquito Aedes aegypti de la cepa Piedecuesta (colectada en campo), y la cepa Rockefeller a los insecticidas malatión, clorpirifos, y temefos, y a 16 derivados piperidínicos. A ambas c...

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Autores:
Torres Reyes, Erika Amparo
Tipo de recurso:
Masters Thesis
Fecha de publicación:
2021
Institución:
Universidad Santo Tomás
Repositorio:
Repositorio Institucional USTA
Idioma:
spa
OAI Identifier:
oai:repository.usta.edu.co:11634/32506
Acceso en línea:
http://hdl.handle.net/11634/32506
Palabra clave:
Aedes aegypti
Acetylcholinesterase
Enzymatic activity
Organophosphate
Piperidines
Piperidinas
Insecticidas
Compuestos organofosforados
Mosquitos
Insectos vectores
Larvas de insectos
Enzimas - Análisis
Acetilcolinesterasa
Aedes aegypti
Acetilcolinesterasa
Expresión enzimática
Organofosforados
Piperidinas
Rights
closedAccess
License
Acceso cerrado
id SANTOTOMAS_591ac3a0ac601963c3416a51a0b571b8
oai_identifier_str oai:repository.usta.edu.co:11634/32506
network_acronym_str SANTOTOMAS
network_name_str Repositorio Institucional USTA
repository_id_str
dc.title.spa.fl_str_mv Actividad larvicida y efecto residual de piperidinas e insecticidas organofosforados en las proteínas de Aedes aegypti (Díptera: Culicidae)
title Actividad larvicida y efecto residual de piperidinas e insecticidas organofosforados en las proteínas de Aedes aegypti (Díptera: Culicidae)
spellingShingle Actividad larvicida y efecto residual de piperidinas e insecticidas organofosforados en las proteínas de Aedes aegypti (Díptera: Culicidae)
Aedes aegypti
Acetylcholinesterase
Enzymatic activity
Organophosphate
Piperidines
Piperidinas
Insecticidas
Compuestos organofosforados
Mosquitos
Insectos vectores
Larvas de insectos
Enzimas - Análisis
Acetilcolinesterasa
Aedes aegypti
Acetilcolinesterasa
Expresión enzimática
Organofosforados
Piperidinas
title_short Actividad larvicida y efecto residual de piperidinas e insecticidas organofosforados en las proteínas de Aedes aegypti (Díptera: Culicidae)
title_full Actividad larvicida y efecto residual de piperidinas e insecticidas organofosforados en las proteínas de Aedes aegypti (Díptera: Culicidae)
title_fullStr Actividad larvicida y efecto residual de piperidinas e insecticidas organofosforados en las proteínas de Aedes aegypti (Díptera: Culicidae)
title_full_unstemmed Actividad larvicida y efecto residual de piperidinas e insecticidas organofosforados en las proteínas de Aedes aegypti (Díptera: Culicidae)
title_sort Actividad larvicida y efecto residual de piperidinas e insecticidas organofosforados en las proteínas de Aedes aegypti (Díptera: Culicidae)
dc.creator.fl_str_mv Torres Reyes, Erika Amparo
dc.contributor.advisor.spa.fl_str_mv Vargas Méndez, Leonor Yamile
dc.contributor.author.spa.fl_str_mv Torres Reyes, Erika Amparo
dc.subject.keyword.spa.fl_str_mv Aedes aegypti
Acetylcholinesterase
Enzymatic activity
Organophosphate
Piperidines
topic Aedes aegypti
Acetylcholinesterase
Enzymatic activity
Organophosphate
Piperidines
Piperidinas
Insecticidas
Compuestos organofosforados
Mosquitos
Insectos vectores
Larvas de insectos
Enzimas - Análisis
Acetilcolinesterasa
Aedes aegypti
Acetilcolinesterasa
Expresión enzimática
Organofosforados
Piperidinas
dc.subject.lemb.spa.fl_str_mv Piperidinas
Insecticidas
Compuestos organofosforados
Mosquitos
Insectos vectores
Larvas de insectos
Enzimas - Análisis
Acetilcolinesterasa
dc.subject.proposal.spa.fl_str_mv Aedes aegypti
Acetilcolinesterasa
Expresión enzimática
Organofosforados
Piperidinas
description En esta investigación se determinó la actividad la susceptibilidad y resistencia de las larvas en tercer instar del mosquito Aedes aegypti de la cepa Piedecuesta (colectada en campo), y la cepa Rockefeller a los insecticidas malatión, clorpirifos, y temefos, y a 16 derivados piperidínicos. A ambas cepas se le cuantificaron las proteínas totales y las colinesterasas. A las larvas previamente expuestas a una concentración sub-letal de los insecticidas, se les determinó la actividad colinérgica residual, y el tipo de inhibición causada sobre la AChE. Los resultados mostraron la cepa silvestre fue altamente resistente a malatión y clorpirifos, y que catorce de las piperidinas evaluadas son una alternativa promisoria para controlar las poblaciones de larvas por su elevada toxicidad, comportándose como inhibidores colinérgicos de tipo mixto.
publishDate 2021
dc.date.accessioned.spa.fl_str_mv 2021-03-16T20:40:39Z
dc.date.available.spa.fl_str_mv 2021-03-16T20:40:39Z
dc.date.issued.spa.fl_str_mv 2021-03-15
dc.type.local.spa.fl_str_mv Tesis de maestría
dc.type.version.none.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.category.spa.fl_str_mv Formación de Recurso Humano para la Ctel: Trabajo de grado de Maestría
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_bdcc
dc.type.drive.none.fl_str_mv info:eu-repo/semantics/masterThesis
format http://purl.org/coar/resource_type/c_bdcc
status_str acceptedVersion
dc.identifier.citation.spa.fl_str_mv Torres-Reyes, E. A. (2021). Actividad larvicida y efecto residual de piperidinas e insecticidas organofosforados en las proteínas de Aedes aegypti (Díptera: Culicidae). [Tesis de maestría]. Universidad Santo Tomás, Bucaramanga, Colombia
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/11634/32506
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad Santo Tomás
dc.identifier.instname.spa.fl_str_mv instname:Universidad Santo Tomás
dc.identifier.repourl.spa.fl_str_mv repourl:https://repository.usta.edu.co
identifier_str_mv Torres-Reyes, E. A. (2021). Actividad larvicida y efecto residual de piperidinas e insecticidas organofosforados en las proteínas de Aedes aegypti (Díptera: Culicidae). [Tesis de maestría]. Universidad Santo Tomás, Bucaramanga, Colombia
reponame:Repositorio Institucional Universidad Santo Tomás
instname:Universidad Santo Tomás
repourl:https://repository.usta.edu.co
url http://hdl.handle.net/11634/32506
dc.language.iso.spa.fl_str_mv spa
language spa
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spelling Vargas Méndez, Leonor YamileTorres Reyes, Erika Amparo2021-03-16T20:40:39Z2021-03-16T20:40:39Z2021-03-15Torres-Reyes, E. A. (2021). Actividad larvicida y efecto residual de piperidinas e insecticidas organofosforados en las proteínas de Aedes aegypti (Díptera: Culicidae). [Tesis de maestría]. Universidad Santo Tomás, Bucaramanga, Colombiahttp://hdl.handle.net/11634/32506reponame:Repositorio Institucional Universidad Santo Tomásinstname:Universidad Santo Tomásrepourl:https://repository.usta.edu.coEn esta investigación se determinó la actividad la susceptibilidad y resistencia de las larvas en tercer instar del mosquito Aedes aegypti de la cepa Piedecuesta (colectada en campo), y la cepa Rockefeller a los insecticidas malatión, clorpirifos, y temefos, y a 16 derivados piperidínicos. A ambas cepas se le cuantificaron las proteínas totales y las colinesterasas. A las larvas previamente expuestas a una concentración sub-letal de los insecticidas, se les determinó la actividad colinérgica residual, y el tipo de inhibición causada sobre la AChE. Los resultados mostraron la cepa silvestre fue altamente resistente a malatión y clorpirifos, y que catorce de las piperidinas evaluadas son una alternativa promisoria para controlar las poblaciones de larvas por su elevada toxicidad, comportándose como inhibidores colinérgicos de tipo mixto.The purpose of this research was to determine the activity, susceptibility, and resistance of larvae on third instar of mosquito Aedes aegypti to insecticides known as Malathion, Chlorpyrifos, and Temephos, as well as to 16 piperidine derivates. To accomplish the purpose of this study, Piedecuesta strain (collected in the field) and Rockefeller strain were used. In both cases, the total proteins and cholinesterase rates were quantified. In the case of the larvae that had been previously exposed to sublethal concentration of the insecticides, residual cholinergic activity was determined, as well as the type of inhibition caused by the AChE. The results of the research showed that the wild-type strain was highly resistant to Malathion and Chlorpyrifos; it was also registered that 14 of the tested piperidines, by acting as mixed-type cholinergic inhibitors, are a promising alternative to control the populations of larvae due to their high toxicity.Magister en Ciencias y Tecnologías Ambientaleshttp://www.ustabuca.edu.co/ustabmanga/presentacionMaestríaapplication/pdfspaUniversidad Santo TomásMaestría Ciencias y Tecnologías AmbientalesFacultad de Química AmbientalActividad larvicida y efecto residual de piperidinas e insecticidas organofosforados en las proteínas de Aedes aegypti (Díptera: Culicidae)Aedes aegyptiAcetylcholinesteraseEnzymatic activityOrganophosphatePiperidinesPiperidinasInsecticidasCompuestos organofosforadosMosquitosInsectos vectoresLarvas de insectosEnzimas - AnálisisAcetilcolinesterasaAedes aegyptiAcetilcolinesterasaExpresión enzimáticaOrganofosforadosPiperidinasTesis de maestríainfo:eu-repo/semantics/acceptedVersionFormación de Recurso Humano para la Ctel: Trabajo de grado de Maestríahttp://purl.org/coar/resource_type/c_bdccinfo:eu-repo/semantics/masterThesisAcceso cerradoinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbCRAI-USTA BucaramangaAhmed, M., Rocha, J. B. T., Mazzanti, C. M., Morsch, A. L. B., Cargnelutti, D., Correa, M., Loro, V., Morsch, V. M., Schetinger, M. R. C. (2007). Malathion, carbofuran and paraquat inhibit Bungarus sindanus (krait) venom acetylcholinesterase and human serum butyrylcholinesterase in vitro. Ecotoxicology, 16 (4), 363-369. Doi: 10.1007/s10646-007-0137-1.Aiki, Y., Kozaki, T., Mizuno, H. & Kono, Y. (2005). Amino acid substitution in Ace paralogous acetylcholinesterase accompanied by organophosphate resistance in the spider mite Tetranychus kanzawai. Pesticide Biochemistry and Physiology, 82(2), 154-161. Doi: 10.1016/j.pestbp.2005.02.004.Aguirre-Obando, O. A., Dalla Bona, A. C., Duque, J. E. & Navarro-Silva, M. A. (2015). Insecticide resistance and genetic variability in natural populations of Aedes (Stegomyia) aegypti (Diptera: Culicidae) from Colombia. Zoología, 32(1), 14-22. Doi: 10.1590/S1984-46702015000100003.Aguirre-Obando, O. A., Pietrobon, A. J., Dalla Bona, A. C. & Navarro-Silva, M. A. (2016). Contrasting patterns of insecticide resistance and knockdown resistance (kdr) in Aedes aegypti populations from Jacarezihno (Brazil) after a dengue outbreak. Revista Brasileira de Entomologia, 60(1), 94-100. Doi: 10.1016/j.rbe.2015.11.009.Allaby, M. (2014). Oviposition. A dictionary of zoology. Oxford: Oxford University Press. [En línea]. Consultado el 30 de diciembre de 2020 de la fuente: http://www.oxfordreference.com/view/10.1093/acref/9780199684274.001.0001/acref-9780199684274-e-9864Alout, H., Berthomieu, A., Hadjivassilis, A. & Weill, M. (2007). A new amino-acid substitution in acetylcholinesterase 1 confers insecticide resistance to Culex pipiens mosquitoes from Cyprus. Insect Biochemistry and Molecular Biology, 37(1), 41-47. Doi: 10.1016/j.ibmb.2006.10.001.Alvarado, A. C. 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