PREVENCIÓN DE LA MUCOSITIS ORAL SECUNDARIA A TRATAMIENTOS ONCOLÓGICOS EN ADULTOS CON CÁNCER: REVISIÓN SISTEMÁTICA

Objective: To evaluate the effectiveness of interventions for the prevention of oral mucositis in cancer patients antineoplasic treated.Methods: The Cochrane Oral Health Group Trials Register, MEDLINE LILACS y SCIELO were searched. Randomized clinical trials were selected. The preventive measures must have been begun the first day of the antineoplasic treatment. Only were include the studies publish in the last 10 years. Review the title and abstract of each result of the search and extracted the outcome measures and results in duplicate. Meta-analysis was performed when two or more studies use the same intervention and was comparable. The statistical analysis was made by EPIDAT y RevMan 5.Results: Forty six studies were eligible, 24 were excluded. Fifteen interventions were evaluated, of the included interventions in this study nine showed evidence of some benefit for either preventing or reducing the severity of mucositis, three interventions were present in more than one study and comparable for performing meta-analysis: amifostine, laser He/Ne y zinc. The meta-analysis of zinc was the only one that showed beneficial effect in preventing moderate and severe mucositis.Conclusions: Especially administration of zinc, honey and sucralfate had showed some benefit at preventing or reducing the severity of mucositis associated with cancer treatment. Nevertheless the quality and the sample size of these studies are not enough for recommend and specific intervention instead of another.

• Autores: Otero Wandurraga, Johanna Alejandra; Torres Pinzón, Harold; Pedraza Flechas, Ana María; González Vélez, Abel Ernesto
• Fecha de publicación: 2011
• Institución: Universidad Santo Tomás
• Repositorio: Repositorio Institucional USTA
• Idioma: spa
• OAI Identifier: oai:repository.usta.edu.co:11634/37021
• Acceso en línea: http://revistas.ustabuca.edu.co/index.php/USTASALUD_ODONTOLOGIA/article/view/1146; http://hdl.handle.net/11634/37021
• License: Derechos de autor 2018 UstaSalud