Psicobioma: de la hipótesis experimental a la medicina de precisión en salud mental

In view of the challenges currently shaping the roadmap that links the microbiome with mental health, it is imperative to endow the concept of the psychobiome with greater robustness and precision. No longer merely a “repository” of microbes that influence the brain, the psychobiome should be reconc...

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Autores:: Cuartas-Arias, Mauricio

Tipo de recurso:: Article of journal

Fecha de publicación:: 2025

Institución:: Universidad de San Buenaventura

Repositorio:: Repositorio USB

Idioma:: eng

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dc.title.spa.fl_str_mv	Psicobioma: de la hipótesis experimental a la medicina de precisión en salud mental
dc.title.translated.spa.fl_str_mv	Psicobioma: de la hipótesis experimental a la medicina de precisión en salud mental
title	Psicobioma: de la hipótesis experimental a la medicina de precisión en salud mental
spellingShingle	Psicobioma: de la hipótesis experimental a la medicina de precisión en salud mental Psychobiome Mental Health microbes brain Psicobioma salud mental microbios cerebro
title_short	Psicobioma: de la hipótesis experimental a la medicina de precisión en salud mental
title_full	Psicobioma: de la hipótesis experimental a la medicina de precisión en salud mental
title_fullStr	Psicobioma: de la hipótesis experimental a la medicina de precisión en salud mental
title_full_unstemmed	Psicobioma: de la hipótesis experimental a la medicina de precisión en salud mental
title_sort	Psicobioma: de la hipótesis experimental a la medicina de precisión en salud mental
dc.creator.fl_str_mv	Cuartas-Arias, Mauricio
dc.contributor.author.eng.fl_str_mv	Cuartas-Arias, Mauricio
dc.subject.eng.fl_str_mv	Psychobiome Mental Health microbes brain
topic	Psychobiome Mental Health microbes brain Psicobioma salud mental microbios cerebro
dc.subject.spa.fl_str_mv	Psicobioma salud mental microbios cerebro
description	In view of the challenges currently shaping the roadmap that links the microbiome with mental health, it is imperative to endow the concept of the psychobiome with greater robustness and precision. No longer merely a “repository” of microbes that influence the brain, the psychobiome should be reconceptualised as a complete, malleable, and measurable biological infrastructure that underpins mental health in both basic research and contemporary clinical practice. In this regard, Science emphasises that gut microorganisms—whose gene repertoire far surpasses that of humans—can synthesise neurotransmitters, modulate immune pathways, and even inspire the development of novel drugs for depression, insomnia, and visceral pain (Pennisi, 2020).
publishDate	2025
dc.date.accessioned.none.fl_str_mv	2025-05-22T14:24:40Z 2025-08-22T16:59:38Z
dc.date.available.none.fl_str_mv	2025-05-22T14:24:40Z 2025-08-22T16:59:38Z
dc.date.issued.none.fl_str_mv	2025-05-22
dc.type.spa.fl_str_mv	Artículo de revista
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dc.identifier.doi.none.fl_str_mv	10.21500/20112084.7898
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dc.relation.citationvolume.eng.fl_str_mv	18
dc.relation.ispartofjournal.eng.fl_str_mv	International Journal of Psychological Research
dc.relation.references.eng.fl_str_mv	Bosch, J. A., Hystad, S. W., D'Rovencourt, R., Weiss, J., & Link, A. (2022). Depression, gut microbiota, and ethnicity: A study of six urban ethnic groups. Brain, Behavior, and Immunity, 105, 111–120. https://doi.org/10.1016/j.bbi.2022.06.012 Cryan, J. F., O'Riordan, K. J., Sandhu, K. V., Peterson, V., Dinan, T. G., & Scott, K. A. (2019). The microbiota-gut-brain axis. Physiological Reviews, 99(4), 1877–2013. https://doi.org/10.1152/physrev.00018.2018 Guzmán-Castañeda, S. J., de la Cruz, J., Bedoya, G., & Rojas, W. (2019). Association of ancestry and the gut microbiome in a diverse Colombian cohort. Scientific Reports, 9, Article 19656. https://doi.org/10.1038/s41598-019-56004-9 Huang, L., & Liu, Y. (2024). Efficacy of Bifidobacterium-related preparations on depression: A meta-analysis. Frontiers in Psychiatry, 15, 1463848. https://doi.org/10.3389/fpsyt.2024.1463848 Johnstone, N., Tost, H., & Cohen Kadosh, K. (2023). Anxiolytic effects of a galacto-oligosaccharides prebiotic in habitually anxious young adults: a randomised, placebo-controlled, double-blind study. Scientific Reports, 13, Article 1332. https://doi.org/10.1038/s41598-023-28416-x Kelly, J. R., Borre, Y., O'Brien, C., Patterson, E., El Aidy, S., Deane, J., Kennedy, P. J., Beers, S., Scott, K., Moloney, G., Hoban, A. E., O'Sullivan, O., Cotter, P. D., Ross, R. P., Stanton, C., Clarke, G., Cryan, J. F., & Dinan, T. G. (2016). Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat. Journal of Psychiatric Research, 82, 109–118. https://doi.org/10.1016/j.jpsychires.2016.07.019 Langgartner, D., Weiss, A.-L., Amoroso, M., Sterrett, J. D., Lowry, C. A., & Reber, S. O. (2024). Effects of repeated intragastric administrations of heat-inactivated Mycobacterium aurum DSM 33539 on chronic psychosocial stress-induced colitis in mice. Frontiers in Neuroscience, 18, 1488603. https://doi.org/10.3389/fnins.2024.1488603 Morais, L. H., Boktor, J. C., MahmoudianDehkordi, S., Kaddurah-Daouk, R., & Mazmanian, S. K. (2024). α-Synuclein overexpression and the microbiome shape the gut and brain metabolome in mice. npj Parkinson's Disease, 10, Article 208. https://doi.org/10.1038/s41531-024-00816-w Mosquera, F. E. C., Lizcano Martinez, S., & Liscano, Y. (2024). Effectiveness of psychobiotics in the treatment of psychiatric and cognitive disorders: A systematic review of randomized clinical trials. Nutrients, 16(9), 1352. https://doi.org/10.3390/nu16091352 Needham, B. D., Funabashi, M., Adame, M. D., Wang, Z., Boktor, J. C., Haney, J., Wu, W.-L., Rabut, C., Ladinsky, M. S., Hwang, S.-J., Guo, Y., Zhu, Q., Kim, K., Kor-anantakul, O., Lely-Kubacak, N., Holschneider, D. P., & Mazmanian, S. K. (2022). A gut-derived metabolite alters brain activity and anxiety behaviour in mice. Nature, 602(7898), 647–653. https://doi.org/10.1038/s41586-022-04396-8 Pennisi, E. (2020, 8 de mayo). Meet the psychobiome. Science, 368(6491), 570-573. https://doi.org/10.1126/science.368.6491.570 Tian, P., Chen, Y., Zhu, H., Qian, X., Zou, R., Zhao, J., Zhang, H., & Chen, W. (2022). Bifidobacterium breve CCFM1025 attenuates major depressive disorder via regulating gut microbiome and tryptophan metabolism: A randomized clinical trial. Brain, Behavior, and Immunity, 100, 233–241. https://doi.org/10.1016/j.bbi.2021.11.023 Valles-Colomer, M., Falony, G., Darzi, Y., Tigchelaar, E. F., Wang, J., Tito, R. Y., Schiweck, C., Kurilshikov, A., Joossens, M., Wijmenga, C., Claes, S., Van Oudenhove, L., Zhernakova, A., Vieira-Silva, S., & Raes, J. (2019). The neuroactive potential of the human gut microbiota in quality of life and depression. Nature Microbiology, 4(4), 623–632. https://doi.org/10.1038/s41564-018-0337-x Winder, C. L., Lodhia, A., Basso, M., & Cohen Kadosh, K. (2024). Gut microbiome differences in individuals with PTSD compared to trauma-exposed controls: a systematic review and meta-analysis. Molecular Psychiatry, 29(6), 1845–1856. https://doi.org/10.1038/s41380-024-02465-3 Zhang, Q., Bi, Y., Zhang, B., Jiang, Q., Mou, C. K., Lei, L., Zhang, J., Wu, W., & Zhao, J. (2024). Current landscape of fecal microbiota transplantation in treating depression. Frontiers in Immunology, 15, 1416961. https://doi.org/10.3389/fimmu.2024.1416961 Zhernakova, A., Kurilshikov, A., Bonder, M. J., Tigchelaar, E. F., Schirmer, M., Vatanen, T., Vijos, A., Tigchelaar-Gutter, W., Joossens, M., Goosens, D., ... & Fu, J. (2016). Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity. Science, 352(6285), 565–569. https://doi.org/10.1126/science.aad3369
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spelling	Cuartas-Arias, Mauricio2025-05-22T14:24:40Z2025-08-22T16:59:38Z2025-05-22T14:24:40Z2025-08-22T16:59:38Z2025-05-22In view of the challenges currently shaping the roadmap that links the microbiome with mental health, it is imperative to endow the concept of the psychobiome with greater robustness and precision. No longer merely a “repository” of microbes that influence the brain, the psychobiome should be reconceptualised as a complete, malleable, and measurable biological infrastructure that underpins mental health in both basic research and contemporary clinical practice. In this regard, Science emphasises that gut microorganisms—whose gene repertoire far surpasses that of humans—can synthesise neurotransmitters, modulate immune pathways, and even inspire the development of novel drugs for depression, insomnia, and visceral pain (Pennisi, 2020).application/pdf10.21500/20112084.78982011-79222011-2084https://hdl.handle.net/10819/29005https://doi.org/10.21500/20112084.7898engUniversidad San Buenaventura - USB (Colombia)https://revistas.usb.edu.co/index.php/IJPR/article/download/7898/566651118International Journal of Psychological ResearchBosch, J. A., Hystad, S. W., D'Rovencourt, R., Weiss, J., & Link, A. (2022). Depression, gut microbiota, and ethnicity: A study of six urban ethnic groups. Brain, Behavior, and Immunity, 105, 111–120. https://doi.org/10.1016/j.bbi.2022.06.012 Cryan, J. F., O'Riordan, K. J., Sandhu, K. V., Peterson, V., Dinan, T. G., & Scott, K. A. (2019). The microbiota-gut-brain axis. Physiological Reviews, 99(4), 1877–2013. https://doi.org/10.1152/physrev.00018.2018 Guzmán-Castañeda, S. J., de la Cruz, J., Bedoya, G., & Rojas, W. (2019). Association of ancestry and the gut microbiome in a diverse Colombian cohort. Scientific Reports, 9, Article 19656. https://doi.org/10.1038/s41598-019-56004-9 Huang, L., & Liu, Y. (2024). Efficacy of Bifidobacterium-related preparations on depression: A meta-analysis. Frontiers in Psychiatry, 15, 1463848. https://doi.org/10.3389/fpsyt.2024.1463848 Johnstone, N., Tost, H., & Cohen Kadosh, K. (2023). Anxiolytic effects of a galacto-oligosaccharides prebiotic in habitually anxious young adults: a randomised, placebo-controlled, double-blind study. Scientific Reports, 13, Article 1332. https://doi.org/10.1038/s41598-023-28416-x Kelly, J. R., Borre, Y., O'Brien, C., Patterson, E., El Aidy, S., Deane, J., Kennedy, P. J., Beers, S., Scott, K., Moloney, G., Hoban, A. E., O'Sullivan, O., Cotter, P. D., Ross, R. P., Stanton, C., Clarke, G., Cryan, J. F., & Dinan, T. G. (2016). Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat. Journal of Psychiatric Research, 82, 109–118. https://doi.org/10.1016/j.jpsychires.2016.07.019 Langgartner, D., Weiss, A.-L., Amoroso, M., Sterrett, J. D., Lowry, C. A., & Reber, S. O. (2024). Effects of repeated intragastric administrations of heat-inactivated Mycobacterium aurum DSM 33539 on chronic psychosocial stress-induced colitis in mice. Frontiers in Neuroscience, 18, 1488603. https://doi.org/10.3389/fnins.2024.1488603 Morais, L. H., Boktor, J. C., MahmoudianDehkordi, S., Kaddurah-Daouk, R., & Mazmanian, S. K. (2024). α-Synuclein overexpression and the microbiome shape the gut and brain metabolome in mice. npj Parkinson's Disease, 10, Article 208. https://doi.org/10.1038/s41531-024-00816-w Mosquera, F. E. C., Lizcano Martinez, S., & Liscano, Y. (2024). Effectiveness of psychobiotics in the treatment of psychiatric and cognitive disorders: A systematic review of randomized clinical trials. Nutrients, 16(9), 1352. https://doi.org/10.3390/nu16091352 Needham, B. D., Funabashi, M., Adame, M. D., Wang, Z., Boktor, J. C., Haney, J., Wu, W.-L., Rabut, C., Ladinsky, M. S., Hwang, S.-J., Guo, Y., Zhu, Q., Kim, K., Kor-anantakul, O., Lely-Kubacak, N., Holschneider, D. P., & Mazmanian, S. K. (2022). A gut-derived metabolite alters brain activity and anxiety behaviour in mice. Nature, 602(7898), 647–653. https://doi.org/10.1038/s41586-022-04396-8 Pennisi, E. (2020, 8 de mayo). Meet the psychobiome. Science, 368(6491), 570-573. https://doi.org/10.1126/science.368.6491.570 Tian, P., Chen, Y., Zhu, H., Qian, X., Zou, R., Zhao, J., Zhang, H., & Chen, W. (2022). Bifidobacterium breve CCFM1025 attenuates major depressive disorder via regulating gut microbiome and tryptophan metabolism: A randomized clinical trial. Brain, Behavior, and Immunity, 100, 233–241. https://doi.org/10.1016/j.bbi.2021.11.023 Valles-Colomer, M., Falony, G., Darzi, Y., Tigchelaar, E. F., Wang, J., Tito, R. Y., Schiweck, C., Kurilshikov, A., Joossens, M., Wijmenga, C., Claes, S., Van Oudenhove, L., Zhernakova, A., Vieira-Silva, S., & Raes, J. (2019). The neuroactive potential of the human gut microbiota in quality of life and depression. Nature Microbiology, 4(4), 623–632. https://doi.org/10.1038/s41564-018-0337-x Winder, C. L., Lodhia, A., Basso, M., & Cohen Kadosh, K. (2024). Gut microbiome differences in individuals with PTSD compared to trauma-exposed controls: a systematic review and meta-analysis. Molecular Psychiatry, 29(6), 1845–1856. https://doi.org/10.1038/s41380-024-02465-3 Zhang, Q., Bi, Y., Zhang, B., Jiang, Q., Mou, C. K., Lei, L., Zhang, J., Wu, W., & Zhao, J. (2024). Current landscape of fecal microbiota transplantation in treating depression. Frontiers in Immunology, 15, 1416961. https://doi.org/10.3389/fimmu.2024.1416961 Zhernakova, A., Kurilshikov, A., Bonder, M. J., Tigchelaar, E. F., Schirmer, M., Vatanen, T., Vijos, A., Tigchelaar-Gutter, W., Joossens, M., Goosens, D., ... & Fu, J. (2016). Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity. Science, 352(6285), 565–569. https://doi.org/10.1126/science.aad3369info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.http://creativecommons.org/licenses/by-nc-nd/4.0https://revistas.usb.edu.co/index.php/IJPR/article/view/7898PsychobiomeMental HealthmicrobesbrainPsicobiomasalud mentalmicrobioscerebroPsicobioma: de la hipótesis experimental a la medicina de precisión en salud mentalPsicobioma: de la hipótesis experimental a la medicina de precisión en salud mentalArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Textinfo:eu-repo/semantics/articleJournal articleinfo:eu-repo/semantics/publishedVersionPublicationOREORE.xmltext/xml2537https://bibliotecadigital.usb.edu.co/bitstreams/e9fe2283-f5bd-407a-aa28-0321af459dc7/download4971a5acd1ed1404b376513848dbdab6MD5110819/29005oai:bibliotecadigital.usb.edu.co:10819/290052025-08-22 11:59:38.929http://creativecommons.org/licenses/by-nc-nd/4.0https://bibliotecadigital.usb.edu.coRepositorio Institucional Universidad de San Buenaventura Colombiabdigital@metabiblioteca.com

Psicobioma: de la hipótesis experimental a la medicina de precisión en salud mental

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