Efectos de nmda intrahipocampal sobre re-extinción de una tarea de memoria emocional aversiva

Se sabe que los receptores de tipo N-metil-D-Aspartato (NMDA) están involucrados en procesos de aprendizaje y memoria. Se ha demostrado que el hipocampo ventral es una estructura crucial en la formación de recuerdos emocionales principalmente relacionados con miedo y ansiedad. El objetivo de la pres...

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Autores:
Gómez Ordoñez , Daisy Marili
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Fecha de publicación:
2014
Institución:
Universidad de San Buenaventura
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Repositorio USB
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spa
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Palabra clave:
150 - Psicología
NMDA
Memoria
Adquisición
Consolidación
Evocación
Reinstalación
re-extención
Hipocampo
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dc.title.spa.fl_str_mv Efectos de nmda intrahipocampal sobre re-extinción de una tarea de memoria emocional aversiva
title Efectos de nmda intrahipocampal sobre re-extinción de una tarea de memoria emocional aversiva
spellingShingle Efectos de nmda intrahipocampal sobre re-extinción de una tarea de memoria emocional aversiva
150 - Psicología
NMDA
Memoria
Adquisición
Consolidación
Evocación
Reinstalación
re-extención
Hipocampo
title_short Efectos de nmda intrahipocampal sobre re-extinción de una tarea de memoria emocional aversiva
title_full Efectos de nmda intrahipocampal sobre re-extinción de una tarea de memoria emocional aversiva
title_fullStr Efectos de nmda intrahipocampal sobre re-extinción de una tarea de memoria emocional aversiva
title_full_unstemmed Efectos de nmda intrahipocampal sobre re-extinción de una tarea de memoria emocional aversiva
title_sort Efectos de nmda intrahipocampal sobre re-extinción de una tarea de memoria emocional aversiva
dc.creator.fl_str_mv Gómez Ordoñez , Daisy Marili
dc.contributor.advisor.none.fl_str_mv Cárdenas Parra, Luis Fernando
dc.contributor.author.none.fl_str_mv Gómez Ordoñez , Daisy Marili
dc.subject.ddc.none.fl_str_mv 150 - Psicología
topic 150 - Psicología
NMDA
Memoria
Adquisición
Consolidación
Evocación
Reinstalación
re-extención
Hipocampo
dc.subject.proposal.spa.fl_str_mv NMDA
Memoria
Adquisición
Consolidación
Evocación
Reinstalación
re-extención
Hipocampo
description Se sabe que los receptores de tipo N-metil-D-Aspartato (NMDA) están involucrados en procesos de aprendizaje y memoria. Se ha demostrado que el hipocampo ventral es una estructura crucial en la formación de recuerdos emocionales principalmente relacionados con miedo y ansiedad. El objetivo de la presente investigación es identificar el efecto de la estimulación de receptores de tipo NMDA en el hipocampo ventral sobre la re-extinción de una respuesta de miedo condicionado. Para esto, se aplicó bilateralmente, de forma local en hipocampo ventral, NMDA (0.2 ug/µl; 0.2 µl) a un grupo experimental y solución salina (0.9 %; 0.2 µl) a un grupo control de ratas macho Wistar, antes de la sesión de re-instalación del condicionamiento. El grupo experimental estuvo conformado por 10 animales y el grupo control por 9 sujetos. Los resultados demostraron que la activación de los receptores de tipo NMDA del hipocampo ventral ocasiona un aumento del tiempo para la re-extinción del condicionamiento de miedo, indicando con ello un efecto de fortalecimiento sobre la re-instalación de la respuesta de miedo.
publishDate 2014
dc.date.issued.none.fl_str_mv 2014
dc.date.accessioned.none.fl_str_mv 2023-07-26T18:15:07Z
dc.date.available.none.fl_str_mv 2023-07-26T18:15:07Z
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.content.spa.fl_str_mv Text
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
status_str acceptedVersion
dc.identifier.instname.spa.fl_str_mv instname:Universidad de San Buenaventura
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad de San Buenaventura
dc.identifier.repourl.spa.fl_str_mv repourl:https://bibliotecadigital.usb.edu.co/
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10819/11993
identifier_str_mv instname:Universidad de San Buenaventura
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dc.language.iso.none.fl_str_mv spa
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dc.relation.references.none.fl_str_mv Abumaria, N., Yin, B., Zhang, L., Li, X. Y., Chen, T., Descalzi, G. et al. (2011). Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral amygdala. J.Neurosci., 31, 14871-14881.
Akirav, I. (2007). NMDA Partial agonist reverses blocking of extinction of aversive memory by GABA(A) agonist in the amygdala. Neuropsychopharmacology, 32, 542-550.
Akirav, I. & Maroun, M. (2006). Ventromedial prefrontal cortex is obligatory for consolidation and reconsolidation of object recognition memory. Cereb.Cortex, 16, 1759-1765.
Albrechet-Souza, L., Borelli, K. G., Almada, R. C., & Brandao, M. L. (2011). Midazolam reduces the selective activation of the rhinal cortex by contextual fear stimuli. Behav.Brain Res, 216, 631-638.
Andres, A. L., Regev, L., Phi, L., Seese, R. R., Chen, Y., Gall, C. M. et al. (2013). NMDA receptor activation and calpain contribute to disruption of dendritic spines by the stress neuropeptide CRH. J Neurosci, 33, 16945-16960.
Baratti, C. M., Boccia, M. M., & Blake, M. G. (2009). Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation. Braz.J Med Biol.Res, 42, 148-154.
Bliss, T. V. & Lomo, T. (1973). Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol, 232, 331-356.Arriada, N., Otero, E., & Corona, T. (1999). Conceptos actuales sobre cerebelo y cognición. Revista de Neurologia, 29, 1075-1082.
Bo, T., Jiang, Y., Cao, H., Wang, J., & Wu, X. (2004). Long-term effects of seizures in neonatal rats on spatial learning ability and N-methyl-D-aspartate receptor expression in the brain. Brain Res Dev.Brain Res, 152, 137-142.
Buhot, M. C., Martin, S., & Segu, L. (2000). Role of serotonin in memory impairment. Ann.Med, 32, 210-221.
Butcher, S. P., Hamberger, A., & Morris, R. G. (1991). Intracerebral distribution of DL2-amino-phosphonopentanoic acid (AP5) and the dissociation of different types of learning. Exp.Brain Res, 83, 521-526.
Chambless, D. L. & Ollendick, T. H. (2001). Empirically supported psychological interventions: controversies and evidence. Annu.Rev Psychol., 52, 685-716.
Clugnet, M. C. & LeDoux, J. E. (1990). Synaptic plasticity in fear conditioning circuits: induction of LTP in the lateral nucleus of the amygdala by stimulation of the medial geniculate body. J Neurosci, 10, 2818-2824.
Coleman, B. R., Carlezon, W. A., Jr., & Myers, K. M. (2013). Extinction of conditioned opiate withdrawal in rats is blocked by intracerebroventricular infusion of an NMDA receptor antagonist. Neurosci Lett, 541, 39-42.
Collingridge, G. L. (1992). The Sharpey-Schafer Prize Lecture. The mechanism of induction of NMDA receptor-dependent long-term potentiation in the hippocampus. Exp.Physiol, 77, 771-797.
De Oliveira, A. L., Genro, B. P., Diehl, F., & Quillfeldt, J. A. (2008). Differential role of the hippocampal endocannabinoid system in the memory consolidation and retrieval mechanisms. Neurobiol.Learn.Mem., 90, 1-9.
Elvander-Tottie, E., Eriksson, T. M., Sandin, J., & Ogren, S. O. (2006). N-methyl-Daspartate receptors in the medial septal area have a role in spatial and emotional learning in the rat. Neuroscience, 142, 963-978.
Fanselow, M. S. & Bolles, R. C. (1979). Naloxone and shock-elicited freezing in the rat. J Comp Physiol Psychol., 93, 736-744.
Fanselow, M. S., Kim, J. J., Yipp, J., & De, O. B. (1994). Differential effects of the Nmethyl-D-aspartate antagonist DL-2-amino-5-phosphonovalerate on acquisition of fear of auditory and contextual cues. Behav.Neurosci, 108, 235- 240.
Fanselow, M. S. & LeDoux, J. E. (1999). Why we think plasticity underlying Pavlovian fear conditioning occurs in the basolateral amygdala. Neuron, 23, 229-232.
Fiorenza, N. G., Rosa, J., Izquierdo, I., & Myskiw, J. C. (2012). Modulation of the extinction of two different fear-motivated tasks in three distinct brain areas. Behav.Brain Res, 232, 210-216.
Forcato, C., Argibay, P. F., Pedreira, M. E., & Maldonado, H. (2009). Human reconsolidation does not always occur when a memory is retrieved: the relevance of the reminder structure. Neurobiol.Learn.Mem., 91, 50-57.
Fuster, J. M. (2000). Prefrontal neurons in networks of executive memory. Brain Res Bull., 52, 331-336.
Golchin, L., Golchin, L., Vahidi, A. A., & Shabani, M. (2013). Hippocampus and cerebellum function following imipenem treatment in male and female rats: evaluation of sex differences during developmental stage. Pak.J Biol.Sci., 16, 151-159.
Holmes, N. M. & Westbrook, R. F. (2013). Extinction of reinstated or ABC renewed fear responses renders them resistant to subsequent ABA renewal. J Exp.Psychol.Anim Behav.Process, 39, 208-220.
Izquierdo, I. & Medina, J. H. (1997). Memory formation: the sequence of biochemical events in the hippocampus and its connection to activity in other brain structures. Neurobiol.Learn.Mem., 68, 285-316.
Izquierdo, L. A., Barros, D. M., da Costa, J. C., Furini, C., Zinn, C., Cammarota, M. et al. (2007). A link between role of two prefrontal areas in immediate memory and in long-term memory consolidation. Neurobiol.Learn.Mem., 88, 160-166.
Keller, E. A., Borghese, C. M., Carrer, H. F., & Ramirez, O. A. (1992). The learning capacity of high or low performance rats is related to the hippocampus NMDA receptors. Brain Res, 576, 162-164.
Langton, J. M. & Richardson, R. (2009). The role of context in the re-extinction of learned fear. Neurobiol.Learn.Mem., 92, 496-503.Ji, J. & Maren, S. (2008). Lesions of the entorhinal cortex or fornix disrupt the contextdependence of fear extinction in rats. Behav.Brain Res, 194, 201-206.
Laurent, V., Marchand, A. R., & Westbrook, R. F. (2008). The basolateral amygdala is necessary for learning but not relearning extinction of context conditioned fear. Learn.Mem., 15, 304-314.
Laurent, V. & Westbrook, R. F. (2009). Infusion of the NMDA receptor antagonist, DLAPV, into the basolateral amygdala disrupts learning to fear a novel and a familiar context as well as relearning to fear an extinguished context. Learn.Mem., 16, 96-105.
LeDoux, J. (2003). The emotional brain, fear, and the amygdala. Cell Mol.Neurobiol., 23, 727-738.
LeDoux, J. E. (1992). Brain mechanisms of emotion and emotional learning. Curr.Opin.Neurobiol., 2, 191-197.
LeDoux, J. E. (1993a). Emotional memory systems in the brain. Behav.Brain Res, 58, 69-79.
LeDoux, J. E. (1993b). Emotional memory: in search of systems and synapses. Ann.N.Y.Acad.Sci., 702, 149-157.
Lehner, M., Wislowska-Stanek, A., Skorzewska, A., Maciejak, P., Szyndler, J., Turzynska, D. et al. (2011). Expression of N-methyl-D-aspartate (R)(GluN2B) - subunits in the brain structures of rats selected for low and high anxiety. J.Physiol Pharmacol., 62, 473-482.
Liang, W. G., Xu, S. T., & Ou, Y. Q. (1992). [Role of N-methyl-D-aspartate receptor in the maintenance of learning-dependent long-term potentiation in rat hippocampal CA3 area]. Sheng Li Xue.Bao., 44, 333-339.
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Lonsdorf, T. B., Haaker, J., & Kalisch, R. (2014). Long-term expression of human contextual fear and extinction memories involves amygdala, hippocampus and ventromedial prefrontal cortex: a reinstatement study in two independent samples. Soc.Cogn Affect.Neurosci.
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dc.format.extent.none.fl_str_mv 46 páginas
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dc.publisher.spa.fl_str_mv Universidad de San Buenaventura
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dc.publisher.faculty.spa.fl_str_mv Facultad de Psicología
dc.publisher.program.spa.fl_str_mv Maestría en Neuropsicología Clínica
institution Universidad de San Buenaventura
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spelling Cárdenas Parra, Luis Fernando1ebe87fa-0af9-4237-8531-9e95406d8e02-1Gómez Ordoñez , Daisy Marili3aa5e8b4-fb29-4bfd-ab46-0fb2e3d71f9e-12023-07-26T18:15:07Z2023-07-26T18:15:07Z2014Se sabe que los receptores de tipo N-metil-D-Aspartato (NMDA) están involucrados en procesos de aprendizaje y memoria. Se ha demostrado que el hipocampo ventral es una estructura crucial en la formación de recuerdos emocionales principalmente relacionados con miedo y ansiedad. El objetivo de la presente investigación es identificar el efecto de la estimulación de receptores de tipo NMDA en el hipocampo ventral sobre la re-extinción de una respuesta de miedo condicionado. Para esto, se aplicó bilateralmente, de forma local en hipocampo ventral, NMDA (0.2 ug/µl; 0.2 µl) a un grupo experimental y solución salina (0.9 %; 0.2 µl) a un grupo control de ratas macho Wistar, antes de la sesión de re-instalación del condicionamiento. El grupo experimental estuvo conformado por 10 animales y el grupo control por 9 sujetos. Los resultados demostraron que la activación de los receptores de tipo NMDA del hipocampo ventral ocasiona un aumento del tiempo para la re-extinción del condicionamiento de miedo, indicando con ello un efecto de fortalecimiento sobre la re-instalación de la respuesta de miedo.N-Methyl-D-aspartate (NMDA) receptors are involved in learning and memory. It is known that ventral hippocampus is a crucial structure involved in emotional memory formation mainly for fear and anxiety situations. The aim of this research is to identify the effect of the stimulation of ventral hipocampal NMDA receptors on the reextinction of an aversive emotional memory task. NMDA (0.2 ug/µl; 0.2 µl) or saline (0.9 %; 0.2 µl) was bilateral and locally administered in the ventral hippocampus of male Wistar rats, before the re-instatement trial. The experimental group consisted of 10 animals and the control group by 9 subjects. The results suggest that the activation of ventral hipocampal NMDA receptors induces an increase in the time needed to re-extinguish the conditioned fear, suggesting a possible potentiating effect on re-installationMaestríaMagíster en Neuropsicología Clínica46 páginasapplication/pdfinstname:Universidad de San Buenaventurareponame:Repositorio Institucional Universidad de San Buenaventurarepourl:https://bibliotecadigital.usb.edu.co/https://hdl.handle.net/10819/11993spaUniversidad de San BuenaventuraBogotáFacultad de PsicologíaMaestría en Neuropsicología ClínicaAbumaria, N., Yin, B., Zhang, L., Li, X. Y., Chen, T., Descalzi, G. et al. (2011). Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral amygdala. J.Neurosci., 31, 14871-14881.Akirav, I. (2007). NMDA Partial agonist reverses blocking of extinction of aversive memory by GABA(A) agonist in the amygdala. Neuropsychopharmacology, 32, 542-550.Akirav, I. & Maroun, M. (2006). Ventromedial prefrontal cortex is obligatory for consolidation and reconsolidation of object recognition memory. Cereb.Cortex, 16, 1759-1765.Albrechet-Souza, L., Borelli, K. G., Almada, R. C., & Brandao, M. L. (2011). Midazolam reduces the selective activation of the rhinal cortex by contextual fear stimuli. Behav.Brain Res, 216, 631-638.Andres, A. L., Regev, L., Phi, L., Seese, R. R., Chen, Y., Gall, C. M. et al. (2013). NMDA receptor activation and calpain contribute to disruption of dendritic spines by the stress neuropeptide CRH. J Neurosci, 33, 16945-16960.Baratti, C. M., Boccia, M. M., & Blake, M. G. (2009). Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation. Braz.J Med Biol.Res, 42, 148-154.Bliss, T. V. & Lomo, T. (1973). Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol, 232, 331-356.Arriada, N., Otero, E., & Corona, T. (1999). Conceptos actuales sobre cerebelo y cognición. Revista de Neurologia, 29, 1075-1082.Bo, T., Jiang, Y., Cao, H., Wang, J., & Wu, X. (2004). Long-term effects of seizures in neonatal rats on spatial learning ability and N-methyl-D-aspartate receptor expression in the brain. Brain Res Dev.Brain Res, 152, 137-142.Buhot, M. C., Martin, S., & Segu, L. (2000). Role of serotonin in memory impairment. Ann.Med, 32, 210-221.Butcher, S. P., Hamberger, A., & Morris, R. G. (1991). Intracerebral distribution of DL2-amino-phosphonopentanoic acid (AP5) and the dissociation of different types of learning. Exp.Brain Res, 83, 521-526.Chambless, D. L. & Ollendick, T. H. (2001). Empirically supported psychological interventions: controversies and evidence. Annu.Rev Psychol., 52, 685-716.Clugnet, M. C. & LeDoux, J. E. (1990). Synaptic plasticity in fear conditioning circuits: induction of LTP in the lateral nucleus of the amygdala by stimulation of the medial geniculate body. J Neurosci, 10, 2818-2824.Coleman, B. R., Carlezon, W. A., Jr., & Myers, K. M. (2013). Extinction of conditioned opiate withdrawal in rats is blocked by intracerebroventricular infusion of an NMDA receptor antagonist. Neurosci Lett, 541, 39-42.Collingridge, G. L. (1992). The Sharpey-Schafer Prize Lecture. The mechanism of induction of NMDA receptor-dependent long-term potentiation in the hippocampus. Exp.Physiol, 77, 771-797.De Oliveira, A. L., Genro, B. P., Diehl, F., & Quillfeldt, J. A. (2008). Differential role of the hippocampal endocannabinoid system in the memory consolidation and retrieval mechanisms. Neurobiol.Learn.Mem., 90, 1-9.Elvander-Tottie, E., Eriksson, T. M., Sandin, J., & Ogren, S. O. (2006). N-methyl-Daspartate receptors in the medial septal area have a role in spatial and emotional learning in the rat. Neuroscience, 142, 963-978.Fanselow, M. S. & Bolles, R. C. (1979). Naloxone and shock-elicited freezing in the rat. J Comp Physiol Psychol., 93, 736-744.Fanselow, M. S., Kim, J. J., Yipp, J., & De, O. B. (1994). Differential effects of the Nmethyl-D-aspartate antagonist DL-2-amino-5-phosphonovalerate on acquisition of fear of auditory and contextual cues. Behav.Neurosci, 108, 235- 240.Fanselow, M. S. & LeDoux, J. E. (1999). Why we think plasticity underlying Pavlovian fear conditioning occurs in the basolateral amygdala. Neuron, 23, 229-232.Fiorenza, N. G., Rosa, J., Izquierdo, I., & Myskiw, J. C. (2012). Modulation of the extinction of two different fear-motivated tasks in three distinct brain areas. Behav.Brain Res, 232, 210-216.Forcato, C., Argibay, P. F., Pedreira, M. E., & Maldonado, H. (2009). 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