Monitoreo de la Concentración de la Glucosa Plasmática en Pacientes en Cuidados Intensivos usando Mediciones de Glucosa Intersticial

The glucose homeostasis is responsible for regulating the blood glucose concentration around 100 mg / dl. As soon as this mechanism is broken due to the inability of the pancreas to produce insulin, the blood glucose levels increase and patients are diagnosed with Type 1 Diabetes Mellitus (T1DM). Research has been directed towards the creation of an artificial pancreas allowing the regulation of glucose levels in blood. However, one of the main difficulties is that not all internal variables of the mathematical model can be measured directly, preventing the implementation of automatic controllers. Therefore, it is necessary to use estimation schemes to reconstruct the unknown states by using the available measurements. In the case of T1DM, the delay between the blood glucose and the interstitial glucose has a negative effect on the performance of state estimators, so the treatment of this delay is necessary either from the modeling process or by a modification of the estimation techniques. Two scenarios are discussed in this contribution. First, the is assumed to be measured from continuous glucose monitors (CGM) which introduces a measurement delay affecting the performance of the studied filter. Then, in a second scenario, the dynamic relationship between and is added to prevent the filter to deal directly with the measurement delay, then giving better results.

• Autores: Aguirre-Zapata, Estefanía; García-Tirado, José Fernando
• Fecha de publicación: 2016
• Institución: Universidad de San Buenaventura
• Repositorio: Repositorio USB
• Idioma: spa
• OAI Identifier: oai:bibliotecadigital.usb.edu.co:10819/6689
• Acceso en línea: http://hdl.handle.net/10819/6689
• Palabra clave: EKF; State estimation; Glucose homeostasis; insulin; Mathematical mode; T1DM; DMT1; Estimación de estado; FKE; Homeostasis de la glucosa; Insulina; Modelo matemático; Diabetes Mellitus
• License: Atribución-NoComercial-SinDerivadas 2.5 Colombia