Caracterización de eventos adversos de medicamentos antirretrovirales reportados al Programa de farmacovigilancia Bogotá D. C., 2008-2016

The human immunodeficiency virus (HIV) according to WHO, is defined as an infection that attacks the immune system of a living being that will gradually deteriorate called "immunodeficiency", this type of virus can be transmitted by maintaining relationships Vaginal, anal, or oral sex with...

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Autores:
Cruz Montaña, Luis Fernando
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2017
Institución:
Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
Repositorio:
Repositorio Institucional UDCA
Idioma:
spa
OAI Identifier:
oai:repository.udca.edu.co:11158/718
Acceso en línea:
https://repository.udca.edu.co/handle/11158/718
Palabra clave:
Farmacovigilancia
Medicamentos antirretrovirales
Eventos adversos
Programa Distrital de Farmacovigilancia
Antirretrovirales -- Efectos secundarios
Rights
closedAccess
License
Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales
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dc.title.spa.fl_str_mv Caracterización de eventos adversos de medicamentos antirretrovirales reportados al Programa de farmacovigilancia Bogotá D. C., 2008-2016
title Caracterización de eventos adversos de medicamentos antirretrovirales reportados al Programa de farmacovigilancia Bogotá D. C., 2008-2016
spellingShingle Caracterización de eventos adversos de medicamentos antirretrovirales reportados al Programa de farmacovigilancia Bogotá D. C., 2008-2016
Farmacovigilancia
Medicamentos antirretrovirales
Eventos adversos
Programa Distrital de Farmacovigilancia
Antirretrovirales -- Efectos secundarios
title_short Caracterización de eventos adversos de medicamentos antirretrovirales reportados al Programa de farmacovigilancia Bogotá D. C., 2008-2016
title_full Caracterización de eventos adversos de medicamentos antirretrovirales reportados al Programa de farmacovigilancia Bogotá D. C., 2008-2016
title_fullStr Caracterización de eventos adversos de medicamentos antirretrovirales reportados al Programa de farmacovigilancia Bogotá D. C., 2008-2016
title_full_unstemmed Caracterización de eventos adversos de medicamentos antirretrovirales reportados al Programa de farmacovigilancia Bogotá D. C., 2008-2016
title_sort Caracterización de eventos adversos de medicamentos antirretrovirales reportados al Programa de farmacovigilancia Bogotá D. C., 2008-2016
dc.creator.fl_str_mv Cruz Montaña, Luis Fernando
dc.contributor.advisor.spa.fl_str_mv Sabogal Carmona, Juan Sebastián
dc.contributor.author.spa.fl_str_mv Cruz Montaña, Luis Fernando
dc.subject.spa.fl_str_mv Farmacovigilancia
Medicamentos antirretrovirales
Eventos adversos
topic Farmacovigilancia
Medicamentos antirretrovirales
Eventos adversos
Programa Distrital de Farmacovigilancia
Antirretrovirales -- Efectos secundarios
dc.subject.lemb.spa.fl_str_mv Programa Distrital de Farmacovigilancia
Antirretrovirales -- Efectos secundarios
description The human immunodeficiency virus (HIV) according to WHO, is defined as an infection that attacks the immune system of a living being that will gradually deteriorate called "immunodeficiency", this type of virus can be transmitted by maintaining relationships Vaginal, anal, or oral sex with a person infected with HIV, another factor that influences HIV transmission is contaminated blood transfusions or perhaps the sharing of needles, syringes, or other sharp instruments previously in contact with a Positive person in HIV. On the other hand, it can also be transmitted from the mother to the child during the gestation, delivery and breastfeeding process When a patient is diagnosed with HIV, it is essential that they experience an immediate change in their lifestyle, diet, physical exercise and the most appropriate pharmacological treatment. Antiretrovirals are used as chronic treatments to control viral load and improve the immune system, but studies have shown that adverse events reported to the district pharmacovigilance program are high, taking into account that combinations of medications are also used that may increase the possibility Of interactions and adverse events in the patient. In the present study, it was possible to identify certain adverse reactions typical of antiretroviral drugs, which are of vital importance when evaluating and monitoring patients who are receiving antiretroviral treatment, the statistics issued by WHO and UNAIDS on the Prevalence of HIV disease among males. On the other hand it is evidenced that the majority of adverse reactions are of Serious Non-seriousness -Moderado by what is determined that there was the need to intervene professional health without causing greater risks on treated patients. Finally, it is emphasized that it is important that pharmacovigilance and pharmaceutical care programs must be further strengthened in order to propose alternatives that allow safe and effective management of patients who present adverse reactions and thus generate optimization and / Or reducing costs in health care as well as raising awareness and stressing the importance of pharmacy as the main actor in the acquisition, storage and dispensing of medicines as well as ratify the importance of the Pharmaceutical Chemist and his knowledge of the drug which gives The ability to provide support to patients and generate an education about the rational use of medicines.
publishDate 2017
dc.date.accessioned.spa.fl_str_mv 2017-09-08T14:54:21Z
dc.date.available.spa.fl_str_mv 2017-09-08T14:54:21Z
dc.date.issued.spa.fl_str_mv 2017
dc.type.spa.fl_str_mv Trabajo de grado - Pregrado
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dc.coverage.spatial.spa.fl_str_mv Bogotá, Colombia
dc.publisher.faculty.spa.fl_str_mv Facultad de Ciencias
dc.publisher.program.spa.fl_str_mv Química Farmacéutica
institution Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
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spelling Sabogal Carmona, Juan SebastiánCruz Montaña, Luis FernandoBogotá, Colombia2017-09-08T14:54:21Z2017-09-08T14:54:21Z2017https://repository.udca.edu.co/handle/11158/718The human immunodeficiency virus (HIV) according to WHO, is defined as an infection that attacks the immune system of a living being that will gradually deteriorate called "immunodeficiency", this type of virus can be transmitted by maintaining relationships Vaginal, anal, or oral sex with a person infected with HIV, another factor that influences HIV transmission is contaminated blood transfusions or perhaps the sharing of needles, syringes, or other sharp instruments previously in contact with a Positive person in HIV. On the other hand, it can also be transmitted from the mother to the child during the gestation, delivery and breastfeeding process When a patient is diagnosed with HIV, it is essential that they experience an immediate change in their lifestyle, diet, physical exercise and the most appropriate pharmacological treatment. Antiretrovirals are used as chronic treatments to control viral load and improve the immune system, but studies have shown that adverse events reported to the district pharmacovigilance program are high, taking into account that combinations of medications are also used that may increase the possibility Of interactions and adverse events in the patient. In the present study, it was possible to identify certain adverse reactions typical of antiretroviral drugs, which are of vital importance when evaluating and monitoring patients who are receiving antiretroviral treatment, the statistics issued by WHO and UNAIDS on the Prevalence of HIV disease among males. On the other hand it is evidenced that the majority of adverse reactions are of Serious Non-seriousness -Moderado by what is determined that there was the need to intervene professional health without causing greater risks on treated patients. Finally, it is emphasized that it is important that pharmacovigilance and pharmaceutical care programs must be further strengthened in order to propose alternatives that allow safe and effective management of patients who present adverse reactions and thus generate optimization and / Or reducing costs in health care as well as raising awareness and stressing the importance of pharmacy as the main actor in the acquisition, storage and dispensing of medicines as well as ratify the importance of the Pharmaceutical Chemist and his knowledge of the drug which gives The ability to provide support to patients and generate an education about the rational use of medicines.El virus de la inmunodeficiencia humana (VIH) según la OMS, está definido como una infección que ataca el sistema inmunitario de un ser vivo el cual va a presentar un deterioro gradual denominado "inmunodeficiencia", este tipo de virus puede ser transmitido por mantener relaciones sexuales vaginales, anales u orales con una persona infectada de dicho virus, otro factor que influye en la transmisión de VIH son las transfusiones de sangre contaminadas o quizás el uso compartido de agujas, jeringas u otros instrumentos punzantes que previamente hallan estado en contacto con una persona positivo en VIH. Por otra parte también puede transmitirse de la madre al hijo durante el proceso de gestación, el parto y la lactancia Cuando un paciente es diagnosticado con VIH es indispensable que este experimente un cambio inmediato de su estilo de vida, dieta, ejercicio físico y el tratamiento farmacológico más apropiado. Siendo tratamientos crónicos, para controlar la carga viral y mejorar el sistema inmunológico se emplean antiretrovirales, pero estudios han revelado que los eventos adversos reportados al programa distrital de farmacovigilancia son altos, teniendo en cuenta que adicionalmente se utilizan combinaciones de medicamentos que pueden aumentar la posibilidad de interacciones y eventos adversos en el paciente. En el presente trabajo se lograron identificar ciertas reacciones adversas propias de los medicamentos antirretrovirales las cuales son de vital importancia a la hora de evaluar y hacer seguimiento de los pacientes que están en tratamientos antirretrovirales, se confirma las estadísticas emitidas por la OMS y ONUSIDA sobre la prevalencia de la enfermedad VIH sobre el sexo masculino. Por otra parte se evidencia que la mayoría de reacciones adversas son de seriedad No serio –Moderado por lo que se determina que hubo la necesidad de intervenir profesional de la salud sin que causara mayores riesgos sobre los pacientes tratados. Por último se hace énfasis en que es importante que los programas de farmacovigilancia y atención farmacéutica se tienen que seguir fortaleciendo con el fin de proponer alternativas que permitan dar un manejo seguro y eficaz a los pacientes que presenten reacciones adversas y así generar una optimización y/o reducción de los costos en la atención en salud como también generar conciencia y recalcar la importancia de la farmacia como actor principal en la adquisición, almacenamiento y dispensación de medicamentos así como ratificar la importancia del Químico Farmacéutico y su conocimiento del medicamento el cual le da la capacidad para brindar un acompañamiento a los pacientes y generar una educación sobre uso racional de los medicamentos.PregradoQuímico(a) FarmacéuticopdfspaDerechos Reservados - Universidad de Ciencias Aplicadas y Ambientaleshttps://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/closedAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)http://purl.org/coar/access_right/c_14cbFarmacovigilanciaMedicamentos antirretroviralesEventos adversosPrograma Distrital de FarmacovigilanciaAntirretrovirales -- Efectos secundariosCaracterización de eventos adversos de medicamentos antirretrovirales reportados al Programa de farmacovigilancia Bogotá D. 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 incorporada en las Obras Colectivas;
b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda;
c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas.Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).
4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:
a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).
b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.
c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.
d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:
i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.
ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.
e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, Acinpro), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.
5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.
6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.
7. Término.
a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.
b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.
8. Varios.
a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.
b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.
c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.
d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.
