Reconstruction of the origin and dispersal of the worldwide dominant Hepatitis B Virus subgenotype D1

Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV). HBV-D1 is the dominant subgenotype in the Mediterranean basin, Eastern Europe, and Asia. However, little is currently known about its evolutionary history and spatio-temporal dynamics. We use Bayesian phylodynamic inference to investigate the temporal history of HBV-D1, for which we calibrate the molecular clock using ancient sequences, and reconstruct the viral global spatial dynamics based, for the first time, on full-length publicly available HBV-D1 genomes from a wide range of sampling dates. We pinpoint the origin of HBV subgenotype D1 before the current era (BCE) in Turkey/Anatolia. The spatial reconstructions reveal global viral transmission with a high degree of mixing. By combining modern-day and ancient sequences, we ensure sufficient temporal signal in HBV-D1 data to enable Bayesian phylodynamic inference using a molecular clock for time calibration. Our results shed light on the worldwide HBV-D1 epidemics and suggest that this originally Middle Eastern virus significantly affects more distant countries, such as those in mainland Europe.

• Autores: Sequeira Trovão, Nídia; Thijssen, Marijn; Vrancken, Bram; Pineda-Peña, Andrea-Clemencia; Mina, Thomas; Amini Bavil Olyaee, Samad; Lemey, Philippe; Baele, Guy; Pourkarim, Mahmoud Reza
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2022
• Institución: Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
• Repositorio: Repositorio Institucional UDCA
• Idioma: eng
• OAI Identifier: oai:repository.udca.edu.co:11158/4771
• Acceso en línea: https://repository.udca.edu.co/handle/11158/4771
• Palabra clave: Teorema de Bayes; Virus de la Hepatitis B
• Rights: openAccess
• License: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.es