Estudio fitoquimico y evaluación de la actividad inhibitoria sobre acetilcolinesterasa en hojas de Piper pesaresanum
64 páginas : gráficas
- Autores:
-
Nitola Torres, Ledy Yolima
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2014
- Institución:
- Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
- Repositorio:
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- Acceso en línea:
- https://repository.udca.edu.co/handle/11158/2025
- Palabra clave:
- Piperaceae
Acetilcolinesterasa
Fitoquímica
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Estudio fitoquimico y evaluación de la actividad inhibitoria sobre acetilcolinesterasa en hojas de Piper pesaresanum |
| title |
Estudio fitoquimico y evaluación de la actividad inhibitoria sobre acetilcolinesterasa en hojas de Piper pesaresanum |
| spellingShingle |
Estudio fitoquimico y evaluación de la actividad inhibitoria sobre acetilcolinesterasa en hojas de Piper pesaresanum Piperaceae Acetilcolinesterasa Fitoquímica |
| title_short |
Estudio fitoquimico y evaluación de la actividad inhibitoria sobre acetilcolinesterasa en hojas de Piper pesaresanum |
| title_full |
Estudio fitoquimico y evaluación de la actividad inhibitoria sobre acetilcolinesterasa en hojas de Piper pesaresanum |
| title_fullStr |
Estudio fitoquimico y evaluación de la actividad inhibitoria sobre acetilcolinesterasa en hojas de Piper pesaresanum |
| title_full_unstemmed |
Estudio fitoquimico y evaluación de la actividad inhibitoria sobre acetilcolinesterasa en hojas de Piper pesaresanum |
| title_sort |
Estudio fitoquimico y evaluación de la actividad inhibitoria sobre acetilcolinesterasa en hojas de Piper pesaresanum |
| dc.creator.fl_str_mv |
Nitola Torres, Ledy Yolima |
| dc.contributor.advisor.spa.fl_str_mv |
Muñoz Cendales, Diego Ricardo, dir. Prieto, Juliet Angélica, dir. |
| dc.contributor.author.spa.fl_str_mv |
Nitola Torres, Ledy Yolima |
| dc.subject.armarc.spa.fl_str_mv |
Piperaceae |
| topic |
Piperaceae Acetilcolinesterasa Fitoquímica |
| dc.subject.agrovoc.spa.fl_str_mv |
Acetilcolinesterasa Fitoquímica |
| description |
64 páginas : gráficas |
| publishDate |
2014 |
| dc.date.issued.spa.fl_str_mv |
2014 |
| dc.date.accessioned.spa.fl_str_mv |
2019-08-26T19:17:58Z |
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2019-08-26T19:17:58Z |
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Trabajo de grado - Pregrado |
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Alpízar-Quesada, C. L.; Morales-Alpízar, C. 2003. La enfermedad de Alzheimer y los inhibidores de la colinesterasa. Acta Médica Costarricense, 45 (2), 50-56. Alzheimer's Association, 2008 Alzheimer’s Disease Facts and Figures. http://www.alz.org/national/documents/report_alzfactsfigures 2008.pdf Arnason J.T., T. Durst y B.J.R Philogene. 2005. Phytochemical discovery of new botanical insecticides. Pp. 37-46. En: Regnault, R.C., Philogene, B.J.j., Vicent C. (eds). Biopesticides of plant origin. Lavoiser and Interept, Ltd., Paris and Andover. 313 p Asprey, G. F.; Thornton, P. 1954. Medicinal plants of Jamaica, 17. West Indies Medicinal Journal, Kingston, Jamaica. Baldoqui D.C., M.J. Kato, A.J. Cavalheiro, et al. 1999. A chromene and prenylated benzoic acid from Piper aduncum. Phytochemistry. 51: 899 – 902. Banerji, A. and Ray, R. 1981. Indian Journal of Chemistry, 2OB, 597. Bourdy, B.; Giménez, A.; Flores, E. N. Conozcan nuestros árboles, nuestras hierbas. 1999, UMSA-CIPTA-IRD-FONAMA. Cacabelos, R. 1999. Alzheimer’s disease and other dementias. Epidemiology and genetics. Handbook of Neurogeriatrics. Ed. Masson. Barcelona. Crews, P., Rodriguez, J., Jaspars, M., 2010. Organic structure analysis. Oxford University press, 190-220. Darvesh, S.; Hopkins, D. A.; Geula, C. 2003. Neurobiology of butyrylcholinesterase. Nat. Rev. Neuroscience. Pag. 4, 131-138. Davies K, Maloney, A. 1976. Selective loss of central cholinergic neurons in Alzheimer disease. Lancet; 2: 1403-7. De Campos, M., Filho, V., DaSilva, R., Yunes, R., Zacchino, S., Juarez, S., Bella Cruz, R., Bella Cruz A. 2005. Evaluation of antifungal activity of Piper solsianum C. DC. Var. solsianum (Piperaceae). Biological and Pharmaceutical Bulletin. P 28, 8, 1527-1528 De Morais, S. M., Facundo, V. A., Bertini, L. M., Cavalcanti, E. S. B., Anjos Júnior, J. F. d., Ferreira, S. A., de Brito, E. S., de Souza Neto, M. A., 2007. Chemical composition and larvicidal activity of essential oils from Piper species. Biochemical Systematics and Ecology 35, 670 -675 Delgado W., Avella E., Aura M. 1997. Alcaloides bencilisoquinolínicos del tallo de Piper augustum Rudge. Revista Colombiana de química volumen 27 1998. Domínguez, X. A.; Alcorn, J. B. J. 1985. Ethnopharmacol. 13, 139-156 Doody, R. S. 1999. Clinical profile of donepezil in the treatment of Alzheimer's disease. Gerontology. P. 45, 23-32. Eurostat Pocketbooks. 2007. Living conditions in Europe. Data 2002-2005. 2007 edition Farlow RM. 2002. Chlolinesterase inhibitors: relating pharmacological properties to clinical profiles. Int J Clin Pract; Suppl 127: 1-5. Giraldo, A., 2012. Estudio fitoquímico de Piper pesaresanum y Piper crassinervium (Piperaceae). Universidad Tecnológica de Pereira. Facultad de Tecnología. Grossberg, G.; Irwin, P.; Satlin, A.; Mesenbrink, P.; Spiegel, R. 2004. Rivastigmine in Alzheimer disease: efficacy over two years. Am. J. Geriatr. Psychiatry. P, 12, 420-31 Helmer c, Pasquier f, Dartigues Jf. 2006. Epidemiology of alzheimer disease and related disorders. Medecine/science, P. 22:1-18. Homans AL, Fuchs. 1970. Direct bioatography on thin layer chromatography as a method for detecting fungitoxic substances. J Chromatogr 51:327-329. Instituto Nacional de envejecimiento NIH, 2012. Disponible on line http://www.nia.nih.gov/espanol/publicaciones/la-enfermedad-de-alzheimer Jaramillo, A. M., P., 2001. Phylogeny and Patterns of Floral Diversity in the Genus Piper (Piperaceae). American Journal of Botany 88, 706-716. Kuiate T., Ngoupayo J., Liu J., Mitaine A., Tanoli S. 2007. Bioactive aristolactams from Piper Umbellatum. Journal. Disponible online: www.elsevier.com/locate/ phytochem Malaguarnera, M.; Pistone, G.; Vinci, M.; Motta, M.; di Fazio, I.; Rampello, L. 1998. Tacrine treatment of Alzheimer's disease: many expectations, few certainties. Neuropsychobiology. P. 38, 226-31. Marquis, R.J. (2004). Biogeography of neotropical Piper. In: Dyer, L.E. & Palmer, A.D.N. – Piper. A model genus for studies of phytochemistry, ecology and evolutoion. New York, Kluwer Academic/Plenum Publishers, pp. 78-96 Navickiene H.M.D. A.C. Alécio, M.J. Kato, V. da S. Bolzani, M.C.M. Young, Cavalheiro & M. Furlan. 2000. Antifungal amides from Piper hispidum and Piper tuberculatum. Phytochemistry 55:621-626. Ninoska Esther., 2006. Metabolitos secundarios bioactivos de especies del género Piper de la flora boliviana. Pag 25. Disponible online en ftp://tesis.bbtk.ull.es/ccppytec/cp300.pdf. Junio 20 de 2014; 19:30pm. Nussbaum, R. L., Ellis, C. E., 2003. Alzheimer's disease and Parkinson's disease. N. Engl. J. Med., 348, 1356-64. Olof Edhag et al., 2008. Dementia Etiology and Epidemiology. The Swedish Council on Technology Assessment in Health Care. Ortega et al., 2007. The Journal of the Argentine Chemical Society – Vol. 95 - N°(1-2), 1-9 (2007) Orjala, J., Erdelmier, C.A.J., Wright, A. D., Rali, T and Sticher, O., Planta Médica, 1993, 59, 546 Parmar, Virinder, Jain, Subhahs, Bisht, Kirpal, Jain,Rajni, Taneja p, Jha a, Tyagi o, prasad k, Wengel j, Olsen e, Boll m. Phytochemistry of de genus piper en:phytochemistry.1997vol.46p. 597-66 Perry, E. K.; Perry, R. H.; Blessed, G.; Tomlinson, B. E. Changes in brain cholinesterases in senile dementia of Alzheimer type. Neuropathol Appl Neurobiol. 1978, 4, 273-7. Pogacić, V.; Herrling, P. 2007. List of drugs in development for neurodegenerative diseases. Neurodegener. Dis. 4, 443-486. Pohanka, M. (2011). "Cholinesterases, a target of pharmacology and toxicology." Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 155(3): 219-229. Portal de medicina Alzheimer. Disponible on line http://www.dmedicina.com/enfermedades/neurologicas/alzheimer Portal de datos sistema de información sobre biodiversidad de Colombia SIB., Disponible online en http://data.sibcolombia.net/species/183929. Junio 20 de 2014; 18:10pm. Price, D. L.; Tanzi, R. E.; Borchelt, D. R.; Sisodia, S. S. Alzheimer's disease: genetic studies and transgenic models. Annu Rev Genet. 1998, 32, 461-93 Psicología y neurociencia en español., Disponible online http://psicologiayneurocienciaenespanol.blogspot.com Agosto 15 de 2014; 20:20pm Quijano - Abril, M. A., Callejas - Posada, R., Miranda - Esquivel, D. R., 2006. Areas of endemism and distribution patterns for Neotropical Piper species (Piperaceae). Journal of Biogeography 33, 1266 1278. Quintana, P. G.; Vargas, R. L.; Icona, C.; Bozo, S.; Cuata, C. Guía popular de plantas utilizadas por los Mosetenes de Convendo, Santa Ana y Muchanes (Alto Beni-Bolivia). 1995, FONAMA. Qin W., Huang, S., Li, C Chen, S. & Peng, Z. (2010). Biological activity of the essential oil from the leaves of Piper Sarmentosum Roxb. (Piperaceae) and its chemical constituents on Brontispa longissima (Gesto) (Coleoptera: Hispidae). Pesticide Biochemistry and physiology, 96, 132-139. Rahalison L, Hamburger m, Hostettmann K, Monod M, Frenk E. 1991. A bioautographic agar overlay method for the detection of anti-fungal compounds from higher plants. Phytochem Anal 2: 199-203. Ramaroson H, Helmer c, Barberger- Gateau p, et al. Prévalence de la démence et de la maladie d’alzheimer chez les personnes de 75 ans et plus : données réactualisées de la cohorte paquid. Rev neurol 2003; 159: 405-11. Ramos A., A. Visozo, J. Piloto, et al. 2003. Screening of antimutagenicity via antioxidant activity in Cuban medicinal plants. Journal of Ethnopharmacology. 87: 241 – 246. Ramos M., D.F. Ramos, C.M. Remsberg, et al. 2008. Identification of Polyphenols and Anti-Oxidant Capacity of Piper aduncum L.The Open Bioactive Compounds Journal. 1: 18 – 21. Rogawski, M. A.; Wenk, G. L. The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease. CNS Drug. Rev. 2003, 9, 275- 308. Ruiz de s c; Camargo L, Matallana D, Montañez P ET Al. Una experiencia de 2600 valoraciones y 1918 casos de la clínica de Memoria de la universidad Javeriana Y el Hospital Universitario de San Ignacio. Poster Congreso Colombiano de Neurología (1997a 2009). Solis, P. N.; Olmedo, D.; Nakamura, N.; Calderón, A. I.; Hattori, M.; Gupta, P. M Pharm, Biol. 2005, 43, 378-381. Scarpini, E.; Scheltens, P.; Feldman, H. Treatment of Alzheimer's disease: current status and new perspectives. Lancet Neurol. 2003, 2, 539-47. Schulz, V., 2003. Ginkgo extract or cholinesterase inhibitors in patients with dementia: what clinical trial and guidelines fail to consider. Phytomedicine 10, 74– 79. Singh,Y. N.; Blumenthal, M. Herbalgram (Special Review). 1997, 39, 33 Stebbins, G. L. Flowering plants: evolution above the species level.1974, Arnold Press London, London, 399 Stevens W et al., Flora de Nicaragua. Missouri Botanical Garden Press, 2001, (3):2510 Soltis, P. A., D. E. Soltis, and M. W. Chase. 1999. Angiosperm phylogeny inferred from multiple genes as a tool for comparative biology. Nature 402: 402–404. C, M.; García, A.G.; Marco-Contelles, J.; López, M. G.An update on the pharmacology of galantamine. Expert Opin Investig Drugs. 2007, 16, 1987-98 Wanke, S., Jaramillo, M. A., Borsch, T., Samain, M.- S., Quandt, D., Neinhuis, C., 2007. Evolution of Piperales —matK gene and trnK intron sequence data reveal lineage specific resolution contrast. Molecular Phylogenetics and Evolution 42, 477- 497 Weggen S., M. Roger & J. Eriksen. 2007. NSAIDs: small molecules for prevention of Alzheimer’s disease or precursors for future drug development. Trends in Pharmacological Sciences.28(10): 536 – 543. Williams, L. A. D.; Vasquez, E. A.; Milan, P.; Zebitz, C,; Kraus, W. Proceedings of the phytochemical society of Europe, 2002, 47, 221-227 World Alzheimer Report 2010, The economic impact of dementia Disponible online: www.biovirtual.unal.edu.co/ICN/?controlador=ShowObject&accion=show&id=1196 29 Zaa Carlos., Valdivia Martha, Marcelo A. (2012). Efecto neuroprotector del extracto hidroalcohólico de Piper aduncum “matico” en un modelo in vitro de neurodegeneración. Zi, X; Simoneau, A. R Cancer Reseach. 2005, 65,8, 3479-3486. |
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Muñoz Cendales, Diego Ricardo, dir.Prieto, Juliet Angélica, dir.Nitola Torres, Ledy Yolima2019-08-26T19:17:58Z2019-08-26T19:17:58Z2014https://repository.udca.edu.co/handle/11158/2025QI004 N37e 2014 (204477)64 páginas : gráficasLa presente investigación relaciona el estudio fitoquímico y de actividad inhibitoria sobre acetilcolinesterasa mediante método bioatuográfico con el fin de contribuir al estudio químico y de la actividad bilógica del género Piper. A partir del extracto etanólico de las hojas de la especie vegetal Piper pesarenasum y su respectivo fraccionamiento y purificación por CLV y CF, se llegó a al aislamiento y caracterización de un derivado de ácido benzoico identificado como ácido 4-metoxi-3,5-di(3’-metil-2’-butenil) benzoico. El estudio fitoquímico preliminar realizado al extracto total etanólico permitió detectar cualitativamente la presencia de terpenos, esteroides, flavonoides, taninos y cumarinas, siendo estos metabolitos destacados en esté género. Se realizó la evaluación de la actividad inhibitoria sobre la acetilcolinesterasa mediante el método de bioautográfico empleando el método de Ellman, con las fracciones derivadas de la fracción EdP y al compuesto obtenido logrando identificar zonas de inhibición de la enzima. El compuesto obtenido se aisló a través del fraccionamiento por cromatografía en columna de la fracción de éter de petróleo de Piper pesarenasum, logrando ser elucidado por técnicas espectroscópicas de RMN 1H y 13C de 1 y 2 dimensionesThis research relates the phytochemical and acetylcholinesterase inhibitory activity by bioatuográfico study method in order to contribute to the chemical and bilógica activity of the genus Piper. From the ethanolic extract of the leaves of the plant species and its respective Piper pesaresanum fractionation and purification by GLC and CF, was reached isolation and characterization of a benzoic acid derivative identified as 4-Methoxy-3,5-di (3'-methyl-2'-butenyl) benzoic acid. The preliminary phytochemical study conducted by ethanolic total extract allowed qualitatively detect the presence of terpenes, steroids, flavonoids, tannins, coumarins, and these are highlighted in gender metabolites. Evaluation of acetylcholinesterase inhibitory activity was performed by using the method bioautográfico Ellman method with fractions derived from the EdP and the compound obtained fraction succeeded in identifying zones of inhibition of the enzyme. The obtained compound was isolated via column chromatography fractionation of petroleum ether fraction Piper pesaresanum, achieving be elucidated by spectroscopic techniques 1H and 13C NMR of 1D and 2D.Incluye bibliografíaPregradoQuímico(a)application/pdfspaBogotá : Universidad de Ciencias Aplicadas y Ambientales, 2014Facultad de CienciasQuímicaDerechos Reservados - Universidad de Ciencias Aplicadas y Ambientaleshttps://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/closedAccessAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)http://purl.org/coar/access_right/c_14cbEstudio fitoquimico y evaluación de la actividad inhibitoria sobre acetilcolinesterasa en hojas de Piper pesaresanumTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/publishedVersionTexthttp://purl.org/redcol/resource_type/TPhttp://purl.org/coar/version/c_970fb48d4fbd8a85Alpízar-Quesada, C. L.; Morales-Alpízar, C. 2003. La enfermedad de Alzheimer y los inhibidores de la colinesterasa. Acta Médica Costarricense, 45 (2), 50-56.Alzheimer's Association, 2008 Alzheimer’s Disease Facts and Figures. http://www.alz.org/national/documents/report_alzfactsfigures 2008.pdfArnason J.T., T. Durst y B.J.R Philogene. 2005. Phytochemical discovery of new botanical insecticides. Pp. 37-46. En: Regnault, R.C., Philogene, B.J.j., Vicent C. (eds). Biopesticides of plant origin. Lavoiser and Interept, Ltd., Paris and Andover. 313 pAsprey, G. F.; Thornton, P. 1954. Medicinal plants of Jamaica, 17. West Indies Medicinal Journal, Kingston, Jamaica.Baldoqui D.C., M.J. Kato, A.J. Cavalheiro, et al. 1999. A chromene and prenylated benzoic acid from Piper aduncum. Phytochemistry. 51: 899 – 902.Banerji, A. and Ray, R. 1981. Indian Journal of Chemistry, 2OB, 597.Bourdy, B.; Giménez, A.; Flores, E. N. Conozcan nuestros árboles, nuestras hierbas. 1999, UMSA-CIPTA-IRD-FONAMA.Cacabelos, R. 1999. Alzheimer’s disease and other dementias. Epidemiology and genetics. Handbook of Neurogeriatrics. Ed. Masson. Barcelona.Crews, P., Rodriguez, J., Jaspars, M., 2010. Organic structure analysis. Oxford University press, 190-220.Darvesh, S.; Hopkins, D. A.; Geula, C. 2003. Neurobiology of butyrylcholinesterase. Nat. Rev. Neuroscience. Pag. 4, 131-138.Davies K, Maloney, A. 1976. Selective loss of central cholinergic neurons in Alzheimer disease. Lancet; 2: 1403-7.De Campos, M., Filho, V., DaSilva, R., Yunes, R., Zacchino, S., Juarez, S., Bella Cruz, R., Bella Cruz A. 2005. Evaluation of antifungal activity of Piper solsianum C. DC. Var. solsianum (Piperaceae). Biological and Pharmaceutical Bulletin. P 28, 8, 1527-1528De Morais, S. M., Facundo, V. A., Bertini, L. M., Cavalcanti, E. S. B., Anjos Júnior, J. F. d., Ferreira, S. A., de Brito, E. S., de Souza Neto, M. A., 2007. Chemical composition and larvicidal activity of essential oils from Piper species. Biochemical Systematics and Ecology 35, 670 -675Delgado W., Avella E., Aura M. 1997. Alcaloides bencilisoquinolínicos del tallo de Piper augustum Rudge. Revista Colombiana de química volumen 27 1998.Domínguez, X. A.; Alcorn, J. B. J. 1985. Ethnopharmacol. 13, 139-156Doody, R. S. 1999. Clinical profile of donepezil in the treatment of Alzheimer's disease. Gerontology. P. 45, 23-32.Eurostat Pocketbooks. 2007. Living conditions in Europe. Data 2002-2005. 2007 editionFarlow RM. 2002. Chlolinesterase inhibitors: relating pharmacological properties to clinical profiles. Int J Clin Pract; Suppl 127: 1-5.Giraldo, A., 2012. Estudio fitoquímico de Piper pesaresanum y Piper crassinervium (Piperaceae). Universidad Tecnológica de Pereira. Facultad de Tecnología.Grossberg, G.; Irwin, P.; Satlin, A.; Mesenbrink, P.; Spiegel, R. 2004. Rivastigmine in Alzheimer disease: efficacy over two years. Am. J. Geriatr. Psychiatry. P, 12, 420-31Helmer c, Pasquier f, Dartigues Jf. 2006. Epidemiology of alzheimer disease and related disorders. Medecine/science, P. 22:1-18.Homans AL, Fuchs. 1970. Direct bioatography on thin layer chromatography as a method for detecting fungitoxic substances. J Chromatogr 51:327-329.Instituto Nacional de envejecimiento NIH, 2012. Disponible on line http://www.nia.nih.gov/espanol/publicaciones/la-enfermedad-de-alzheimerJaramillo, A. M., P., 2001. Phylogeny and Patterns of Floral Diversity in the Genus Piper (Piperaceae). American Journal of Botany 88, 706-716.Kuiate T., Ngoupayo J., Liu J., Mitaine A., Tanoli S. 2007. Bioactive aristolactams from Piper Umbellatum. Journal. Disponible online: www.elsevier.com/locate/ phytochemMalaguarnera, M.; Pistone, G.; Vinci, M.; Motta, M.; di Fazio, I.; Rampello, L. 1998. Tacrine treatment of Alzheimer's disease: many expectations, few certainties. Neuropsychobiology. P. 38, 226-31.Marquis, R.J. (2004). Biogeography of neotropical Piper. In: Dyer, L.E. & Palmer, A.D.N. – Piper. A model genus for studies of phytochemistry, ecology and evolutoion. New York, Kluwer Academic/Plenum Publishers, pp. 78-96Navickiene H.M.D. A.C. Alécio, M.J. Kato, V. da S. Bolzani, M.C.M. Young, Cavalheiro & M. Furlan. 2000. Antifungal amides from Piper hispidum and Piper tuberculatum. Phytochemistry 55:621-626.Ninoska Esther., 2006. Metabolitos secundarios bioactivos de especies del género Piper de la flora boliviana. Pag 25. Disponible online en ftp://tesis.bbtk.ull.es/ccppytec/cp300.pdf. Junio 20 de 2014; 19:30pm.Nussbaum, R. L., Ellis, C. E., 2003. Alzheimer's disease and Parkinson's disease. N. Engl. J. Med., 348, 1356-64.Olof Edhag et al., 2008. Dementia Etiology and Epidemiology. The Swedish Council on Technology Assessment in Health Care.Ortega et al., 2007. The Journal of the Argentine Chemical Society – Vol. 95 - N°(1-2), 1-9 (2007)Orjala, J., Erdelmier, C.A.J., Wright, A. D., Rali, T and Sticher, O., Planta Médica, 1993, 59, 546Parmar, Virinder, Jain, Subhahs, Bisht, Kirpal, Jain,Rajni, Taneja p, Jha a, Tyagi o, prasad k, Wengel j, Olsen e, Boll m. Phytochemistry of de genus piper en:phytochemistry.1997vol.46p. 597-66Perry, E. K.; Perry, R. H.; Blessed, G.; Tomlinson, B. E. Changes in brain cholinesterases in senile dementia of Alzheimer type. Neuropathol Appl Neurobiol. 1978, 4, 273-7.Pogacić, V.; Herrling, P. 2007. List of drugs in development for neurodegenerative diseases. Neurodegener. Dis. 4, 443-486.Pohanka, M. (2011). "Cholinesterases, a target of pharmacology and toxicology." Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 155(3): 219-229.Portal de medicina Alzheimer. Disponible on line http://www.dmedicina.com/enfermedades/neurologicas/alzheimerPortal de datos sistema de información sobre biodiversidad de Colombia SIB., Disponible online en http://data.sibcolombia.net/species/183929. Junio 20 de 2014; 18:10pm.Price, D. L.; Tanzi, R. E.; Borchelt, D. R.; Sisodia, S. S. Alzheimer's disease: genetic studies and transgenic models. Annu Rev Genet. 1998, 32, 461-93Psicología y neurociencia en español., Disponible online http://psicologiayneurocienciaenespanol.blogspot.com Agosto 15 de 2014; 20:20pmQuijano - Abril, M. A., Callejas - Posada, R., Miranda - Esquivel, D. R., 2006. Areas of endemism and distribution patterns for Neotropical Piper species (Piperaceae). Journal of Biogeography 33, 1266 1278.Quintana, P. G.; Vargas, R. L.; Icona, C.; Bozo, S.; Cuata, C. Guía popular de plantas utilizadas por los Mosetenes de Convendo, Santa Ana y Muchanes (Alto Beni-Bolivia). 1995, FONAMA.Qin W., Huang, S., Li, C Chen, S. & Peng, Z. (2010). Biological activity of the essential oil from the leaves of Piper Sarmentosum Roxb. (Piperaceae) and its chemical constituents on Brontispa longissima (Gesto) (Coleoptera: Hispidae). Pesticide Biochemistry and physiology, 96, 132-139.Rahalison L, Hamburger m, Hostettmann K, Monod M, Frenk E. 1991. A bioautographic agar overlay method for the detection of anti-fungal compounds from higher plants. Phytochem Anal 2: 199-203.Ramaroson H, Helmer c, Barberger- Gateau p, et al. Prévalence de la démence et de la maladie d’alzheimer chez les personnes de 75 ans et plus : données réactualisées de la cohorte paquid. Rev neurol 2003; 159: 405-11.Ramos A., A. Visozo, J. Piloto, et al. 2003. Screening of antimutagenicity via antioxidant activity in Cuban medicinal plants. Journal of Ethnopharmacology. 87: 241 – 246.Ramos M., D.F. Ramos, C.M. Remsberg, et al. 2008. Identification of Polyphenols and Anti-Oxidant Capacity of Piper aduncum L.The Open Bioactive Compounds Journal. 1: 18 – 21.Rogawski, M. A.; Wenk, G. L. The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease. CNS Drug. Rev. 2003, 9, 275- 308.Ruiz de s c; Camargo L, Matallana D, Montañez P ET Al. Una experiencia de 2600 valoraciones y 1918 casos de la clínica de Memoria de la universidad Javeriana Y el Hospital Universitario de San Ignacio. Poster Congreso Colombiano de Neurología (1997a 2009).Solis, P. N.; Olmedo, D.; Nakamura, N.; Calderón, A. I.; Hattori, M.; Gupta, P. M Pharm, Biol. 2005, 43, 378-381.Scarpini, E.; Scheltens, P.; Feldman, H. Treatment of Alzheimer's disease: current status and new perspectives. Lancet Neurol. 2003, 2, 539-47.Schulz, V., 2003. Ginkgo extract or cholinesterase inhibitors in patients with dementia: what clinical trial and guidelines fail to consider. Phytomedicine 10, 74– 79.Singh,Y. N.; Blumenthal, M. Herbalgram (Special Review). 1997, 39, 33Stebbins, G. L. Flowering plants: evolution above the species level.1974, Arnold Press London, London, 399Stevens W et al., Flora de Nicaragua. Missouri Botanical Garden Press, 2001, (3):2510Soltis, P. A., D. E. Soltis, and M. W. Chase. 1999. Angiosperm phylogeny inferred from multiple genes as a tool for comparative biology. Nature 402: 402–404.C, M.; García, A.G.; Marco-Contelles, J.; López, M. G.An update on the pharmacology of galantamine. Expert Opin Investig Drugs. 2007, 16, 1987-98Wanke, S., Jaramillo, M. A., Borsch, T., Samain, M.- S., Quandt, D., Neinhuis, C., 2007. Evolution of Piperales —matK gene and trnK intron sequence data reveal lineage specific resolution contrast. Molecular Phylogenetics and Evolution 42, 477- 497Weggen S., M. Roger & J. Eriksen. 2007. NSAIDs: small molecules for prevention of Alzheimer’s disease or precursors for future drug development. Trends in Pharmacological Sciences.28(10): 536 – 543.Williams, L. A. D.; Vasquez, E. A.; Milan, P.; Zebitz, C,; Kraus, W. Proceedings of the phytochemical society of Europe, 2002, 47, 221-227World Alzheimer Report 2010, The economic impact of dementiaDisponible online: www.biovirtual.unal.edu.co/ICN/?controlador=ShowObject&accion=show&id=1196 29Zaa Carlos., Valdivia Martha, Marcelo A. (2012). Efecto neuroprotector del extracto hidroalcohólico de Piper aduncum “matico” en un modelo in vitro de neurodegeneración.Zi, X; Simoneau, A. 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en las Obras Colectivas;
b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda;
c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas.Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).
4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:
a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).
b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.
c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.
d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:
i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.
ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.
e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, Acinpro), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.
5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.
6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.
7. Término.
a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.
b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.
8. Varios.
a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.
b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.
c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.
d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.

 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