Efecto de la dieta rica en grasa (1%) sobre la aorta y el hígado en conejas ovariectomizadas. II parte

Cause more increased morbidity and mortality in the world. Atherosclerosis is a chronic inflammatory arterial injury exacerbated by an altered lipid metabolism and cardio-vascular risk factors. It was the interests of authors evaluate the effect of a high diet fat on specimen of aorta and liver in an animal model such as the rabbit. Material and Methods. 20 New Zealand rabbits were taken from 2500 to 3000 kg in weight which were divided into 2 groups: Group I (n = 10) 5 control (C), 5 control-fat diet + 1% (C+D) and group II (n = 10) ovariectomized, 5 control (O) and 5 high-fat diet with 1% (O+D). Was evaluated by ultrasonography the abdominal aorta. At the end of the 24 week was sacrificed a rabbit in each group to carried out histological studies of aorta and liver. Was used hematoxylin eosin staining and histological sections for high resolution and fat stain (Fast-Red) Results. In ultrasound the diameter of the aorta between the C and C+D grew by 18.40% in the O and O+D was 12.83%. The intima of the C and C+D grew by 33.33% and between O and O+D controls grew by 15.38%. 50% lower when comparing with controls. The evaluation of the intima between the C1 and O1 increased the diameter in a 14.72% and the thickness of the intima was 33.33%. In the case of C+O and O+D the diameter presented an increase of 0.33% and the adventitia was increased for 275.0%. Histology of the aorta and the hepatocyte shows that the C: had a little increase of fat granules in the intima and in the hepatocyte. C+D: the aorta were seen fat droplets in the intima with thickening of the intima (290 u-390 u). In the liver there was an inflammatory process with moderate hydropic changes and fat droplets inside. O: there was very little change in the intima, small lipid droplets and the diameter is slightly increased (180 u-240 u) compared with controls and inflammatory foci in the liver with hydropic degeneration and fat perilobulillar pericellular in relation to controls. O+D: the aorta showed a large accumulation of fat pericellular with increase in thickness (230 u-360 u) are little larger than the C+D, presents hepatocyte hydropic changes, severe vacuolization and fat perilobulillar strong reaction. Conclusion. The high-fat diet (1%) in a rabbit model produced severe injury to aortic endothelium and the hepatocyte, especially in rabbits with diet and to a lesser extent in the oophorectomised ones.

• Autores: Onatra, W.; Mendoza, R.; Lenis, C.; Forero, G.; Rodríguez, A.; Peña, E.; Laverde, G.; Gallego, C.; Esquinas, P C.; Zúñiga, M.; Ruiz, AI.; Ríos, MT.
• Tipo de recurso: Article of journal
• Fecha de publicación: 2010
• Institución: Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
• Repositorio: Repositorio Institucional UDCA
• Idioma: spa
• OAI Identifier: oai:repository.udca.edu.co:11158/3577
• Acceso en línea: https://encolombia.com/medicina/revistas-medicas/menopausia/volm-163/efectosdeladietaricaengrasa/
• Palabra clave: Dieta; Grasas de la Dieta; Aorta; Conejos; Factor de Crecimiento de Hepatocito
• Rights: openAccess
• License: Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales