Genetics components related with anterior cruciate ligament rupture: sports implications

This review presents a replication analysis that seeks to look at single nucleotide genetic polymorphisms (SNPs) that have been associated with anterior cruciate ligament rupture (ACLR) in more than two independent cohorts. We presented a genotypic map and established the alleles that may play a protective role in the injury. Similarly, components such as predisposition and heritability to the lesion reported in the literature are observed. The information was obtained from the Scopus, Pubmed, and EBSCO Host (Sportdiscus) databases. Seven SNPs associated with ACLR were identified in two and more independent cohorts (COL1A1 rs1800012, COL3A1 rs1800255, COL5A1 rs12722, COL12A1 rs970547, KDR rs2071559, ACAN rs1516797 y VEGFA rs2010963). On the other hand, the evidence found shows a heritability of 69% for the injury; however, more studies are needed to verify this high percentage because only one study was reported, and it was conducted in a non-athlete population. Likewise, the probability of suffering an ACLR is established between 12% and 30%, when a first-degree relative presented the injury. The genetic component should have a more significant influence in the prediction, follow-up, inclusion in programs, and optimization of post-injury rehabilitation and therapy of athletes at high hereditary risk. © 2024 Didactic Asociation Andalucia

• Autores: ARROYO MOYA, WILSON; Rodríguez Buitrago, Jeansy Alonso; Buitrago Espitia, Jorge Enrique; Prieto Mondragon, Laura del Pilar; Ordoñez-Saavedra, Néstor; Araújo, Duarte
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2024
• Institución: Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
• Repositorio: Repositorio Institucional UDCA
• Idioma: spa
• OAI Identifier: oai:repository.udca.edu.co:11158/6006
• Acceso en línea: https://repository.udca.edu.co/handle/11158/6006; https://doi.org/10.58727/jshr.97526
• Palabra clave: 570 - Biología::576 - Genética y evolución; Polimorfismo Genético; Genética deportiva; Heridas y Lesiones; Heredabilidad; Predisposición genética
• Rights: openAccess
• License: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.es