Nuevo método de ayuda diagnóstica con geometría fractal para células preneoplásicas del epitelio escamoso cervical

Fractal geometry allows the mathematical description of autosimilar, sibisemejants and wild objects. Fractal analysis application to cancer has been able to show changes in the fractal measures of tissues and cells associated in some cases to neoplasic evolution. A new diagnostic methodology for pre-neoplasic cells in cervical cytologies was developed, beginning with the digital photographies of 8 cells, 4 healthy cells, -3 superficials and 1 intermediate-, 2 AsCUs and 2 L-sIL, diagnosed according to conventional parameters. Fractal dimensions from three objects, nucleus, cytoplasm without nucleus and totality, were calculated with Box-Counting method, estimating variability and cellular intrinsic mathematical harmony of fractal dimensions. Mathematical differences between healthy and L-sIL cells were found, making evident that AsCUs cells can have both healthy or L-sIL associated values. This new methodology constitutes the first objective and quantitative evaluation of preventive diagnosis and clinical application for pre-neoplasic cervical injuries. Making quantitatively evident the degree of evolution from normal cells to L-sIL, this methodology gives a solution to diagnostic indetermination of AsCUs cells.

• Autores: Rodríguez, Javier O.
• Tipo de recurso: Article of journal
• Fecha de publicación: 2011
• Institución: Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
• Repositorio: Repositorio Institucional UDCA
• Idioma: spa
• OAI Identifier: oai:repository.udca.edu.co:11158/2137
• Acceso en línea: https://revistas.udca.edu.co/index.php/ruadc/article/view/752
• Palabra clave: Cáncer de cuello uterino; Geometría fractal; Citología; Citología; Cuello uterino - Cáncer
• Rights: openAccess
• License: Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales