Evaluación de las consecuencias del desabastecimiento de medicamentos oncológicos en los servicios farmacéuticos de Bogotá
132 páginas : gráficas
- Autores:
-
Linares González, Yanis Milena
Aguilar Rodriguez, Argelis Mairena
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2019
- Institución:
- Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
- Repositorio:
- Repositorio Institucional UDCA
- Idioma:
- spa
- OAI Identifier:
- oai:repository.udca.edu.co:11158/1953
- Acceso en línea:
- https://repository.udca.edu.co/handle/11158/1953
- Palabra clave:
- Farmacoterapia oncológica
Agentes neoplásicos
Medicamentos - Abastecimiento y distribución
- Rights
- openAccess
- License
- Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales
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Evaluación de las consecuencias del desabastecimiento de medicamentos oncológicos en los servicios farmacéuticos de Bogotá |
| title |
Evaluación de las consecuencias del desabastecimiento de medicamentos oncológicos en los servicios farmacéuticos de Bogotá |
| spellingShingle |
Evaluación de las consecuencias del desabastecimiento de medicamentos oncológicos en los servicios farmacéuticos de Bogotá Farmacoterapia oncológica Agentes neoplásicos Medicamentos - Abastecimiento y distribución |
| title_short |
Evaluación de las consecuencias del desabastecimiento de medicamentos oncológicos en los servicios farmacéuticos de Bogotá |
| title_full |
Evaluación de las consecuencias del desabastecimiento de medicamentos oncológicos en los servicios farmacéuticos de Bogotá |
| title_fullStr |
Evaluación de las consecuencias del desabastecimiento de medicamentos oncológicos en los servicios farmacéuticos de Bogotá |
| title_full_unstemmed |
Evaluación de las consecuencias del desabastecimiento de medicamentos oncológicos en los servicios farmacéuticos de Bogotá |
| title_sort |
Evaluación de las consecuencias del desabastecimiento de medicamentos oncológicos en los servicios farmacéuticos de Bogotá |
| dc.creator.fl_str_mv |
Linares González, Yanis Milena Aguilar Rodriguez, Argelis Mairena |
| dc.contributor.advisor.spa.fl_str_mv |
Vanegas Escamilla, Egdda Patricia, dir. |
| dc.contributor.author.spa.fl_str_mv |
Linares González, Yanis Milena Aguilar Rodriguez, Argelis Mairena |
| dc.subject.mesh.spa.fl_str_mv |
Farmacoterapia oncológica Agentes neoplásicos Medicamentos - Abastecimiento y distribución |
| topic |
Farmacoterapia oncológica Agentes neoplásicos Medicamentos - Abastecimiento y distribución |
| description |
132 páginas : gráficas |
| publishDate |
2019 |
| dc.date.accessioned.spa.fl_str_mv |
2019-08-12T22:38:25Z |
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2019-08-12T22:38:25Z |
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2019 |
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Trabajo de grado - Pregrado |
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QF045 L35e 2019 (205619) |
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spa |
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Drug shortages roundtable: Minimizing the impact on patient care. Am J Heal Pharm[Internet]. 2018 Jun 1 [cited 2019 Feb 11];75(11):816–20. Available from: https://academic.oup.com/ajhp/article/75/11/816-820/5102302 Servicios Oncológicos en Colombia. Rev Colomb Cancerol. 2013;14(1):52. A ALPS. Título: REPORTE DE CASO DESABASTECIMIENTO Metotrexato 500 mg inyectable Autor / Dependencia: Dirección de Medicamentos y Tecnologías en Salud Ciudad: Bogotá Fecha: 28/12/2017. 2017;28–9. Aguilar Gavira S, Barroso Osuna J. La triangulación de datos como estrategia en investigación educativa. Píxel-Bit, Rev Medios y Educ. 2015; Alevizakos M, Detsis M, Grigoras CA, Machan JT, Mylonakis E. The Impact of Shortages on Medication Prices: Implications for Shortage Prevention. Drugs. 2016;76(16):1551–8. Alruthia YS, Alwhaibi M, Alotaibi MF, Asiri SA, Alghamdi BM, Almuaythir GS, et al. Drug shortages in Saudi Arabia: Root causes and recommendations. Saudi Pharm J [Internet]. 2018;26(7):947–51. Available from: https://doi.org/10.1016/j.jsps.2018.05.002 AlRuthia YS, AlKofide H, AlAjmi R, Balkhi B, Alghamdi A, AlNasser A, et al. Drug shortages in large hospitals in Riyadh: a cross-sectional study. Ann Saudi Med [Internet]. 2017 Sep [cited 2019 Feb 11];37(5):375–85. Available from: http://www.annsaudimed.net/index.php/vol37/vol37iss5/4657.html Alsheikh M, Seoane-Vazquez E, Rittenhouse B, Fox ER, Fanikos J. A Comparison of Drug Shortages in the Hospital Setting in the United States and Saudi Arabia: An Exploratory Analysis. Hosp Pharm [Internet]. 2016;51(5):370–5. Available from: http://journals.sagepub.com/doi/10.1310/hpj5105-370 American College of Medical Toxicology, American Academy of Clinical Toxicology. Antidote Shortages in the USA: Impact and Response. J Med Toxicol. 2015;11(1):144–6. Asamblea Mundial de la Salud 70. La escasez mundial de medicamentos y vacunas y el acceso a ellos: informe de la Secretaría. 2017;2:1–9. Available from: http://apps.who.int/iris/handle/10665/274800%0Ahttp://apps.who.int/iris/bitstream/10665/274800/1/A70_20-sp.pdf Bigdeli M, Jacobs B, Tomson G, Laing R, Ghaffar A, Dujardin B, et al. Access to medicines from a health system perspective. Health Policy Plan. 2013; Bochenek T, Abilova V, Alkan A, Asanin B, Beriain I de M, Besovic Z, et al. Systemic measures and legislative and organizational frameworks aimed at preventing or mitigating drug shortages in 28 European and Western Asian Countries. Front Pharmacol. 2018;8(JAN). Brennan AT, Bor J, Davies MA, Conradie F, Maskew M, Long L, et al. Tenofovir stock shortages have limited impact on clinic- and patient-level HIV treatment outcomes in public sector clinics in South Africa. Trop Med Int Heal. 2017; Cáncer DEL. Plan Decena Para El Control Del Cáncer En Colombia 2012-2021 [Internet]. 2012. 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Clinical, Economic and Policy Implications of Drug Shortages in the European Union. Appl Health Econ Health Policy. 2017;15(4):441–5. De Weerdt E, Simoens S, Casteels M, Huys I. Toward a European definition for a drug shortage: A qualitative study. Front Pharmacol. 2015; de Weerdt E, Simoens S, Casteels M, Huys I. Clinical, Economic and Policy Implications of Drug Shortages in the European Union. Appl Health Econ Health Policy. 2016;1–5. De Weerdt E, Simoens S, Hombroeckx L, Casteels M, Huys I. Causes of drug shortages in the legal pharmaceutical framework. Regul Toxicol Pharmacol [Internet]. 2015;71(2):251–8. Available from: http://dx.doi.org/10.1016/j.yrtph.2015.01.005 De I. Informe de gestión del desabastecimiento de medicamentos en Colombia 2013-2018. 2018; Dranitsaris G, Jacobs I, Kirchhoff C, Popovian R, Shane LG. Drug tendering: Drug supply and shortage implications for the uptake of biosimilars. ClinicoEconomics and Outcomes Research. 2017. Estadístico De Datos A, Franco TL, Hidalgo R. Análisis Estadístico de Datos de Caracterización Morfológica de Recursos Fitogenéticos. Boletin Técnico Nro 8, Instituto Internacional de Recursos Fitogenéticos IPGRI. 2003 Fecha M, Suministro D, Esmeralda ASA, Regulatory AM, Manager A, M- I, et al. Título: REPORTE DE CASO DESABASTECIMIENTO FOLINATO DE CALCIO TABLETAS Autor / Dependencia: Dirección de Medicamentos y Tecnologías en Salud Ciudad: Bogotá Fecha: 08/09/2016. 2016; FEDERACIÓN INTERNACIONAL DE FARMACIA. Informe De La Cumbre Internacional Sobre Desabastecimiento De Medicamentos. FIP- Toronto Canadá [Internet]. 2013;1–26. Available from: https://www.fip.org/files/fip/publications/P02595_FIP_Summit_on_Medicines_Shortage-Spaans_TAB_V3_LOS.pdf Fox ER, McLaughlin MM. ASHP guidelines on managing drug product shortages. Am J Heal Pharm. 2018; Fox ER, Pugh MJ, Karnad AB, Parsons HM, Liang Y, Schmidt S. ReCAP: Association Between the Number of Suppliers for Critical Antineoplastics and Drug Shortages: Implications for Future Drug Shortages and Treatment. J Oncol Pract. 2016; Fox ER, Sweet B V., Jensen V. Drug shortages: A complex health care crisis. Mayo Clinic Proceedings. 2014. Fox ER, Tyler LS. Potential Association between Drug Shortages and High-Cost Medications. Pharmacotherapy [Internet]. 2016; Available from: http://www.ncbi.nlm.nih.gov/pubmed/27891635 Frey NP, Davis EP. Launch and commissioning the deep space climate observatory. Adv Astronaut Sci. 2016;157(February):999–1010 Giovanella, L., Feo, O., Faria, M., Tobar S. Sistemas de Salud en Suramérica [Internet]. UNASUR,Instituto Suramericano de Gobierno en Salud. 2012. 854 p. Available from: http://www.isags-unasur.org/uploads/biblioteca/2/bb[8]ling[2]anx[9].pdf Goldsack JC, Reilly C, Bush C, McElligott S, Bristol MN, Motanya UN, et al. Impact of shortages of injectable oncology drugs on patient care. Am J Heal Pharm. 2014; Group AP. Why drug shortages occur. Drug Ther Bull [Internet]. 2015;53(3):33–6. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84929429250&doi=10.1136%2Fdtb.2015.3.0316&partnerID=40&md5=856988f7216a695184ada98b06229765%0Ahttp://dtb.bmj.com/cgi/doi/10.1136/dtb.2015.3.0316 GUERRERO J. ASPECTOS TEÓRICOS PARA EL ESTABLECIMIENTO DE POSIBLES ESTRATEGIAS DE MEJORAMIENTO PARA LA PRESTACIÓN DEL SERVICIO DE SALUD EN COLOMBIA BASADO EN LA LEY ESTATUTARIA EN SALUD 1751 DEL 2015. 2018; Guerrero R, Gallego AI, Becerril-Montekio V, Vásquez J. Sistema de salud de Colombia. Salud Publica Mex. 2011;53(SUPPL. 2). Guillén Ponces, Carmen (Servicio de Oncología Médica. Hospital Ramón y Cajal. Madrid); Molina Garrido MJ( S de OMHV de la LC. Qué es, cómo funciona y tipos de quimioterapia. SEOM “Sociedad Española de Oncología Médica.” 2014 Harris RC, Dodd PJ, White RG. The potential impact of BCG vaccine supply shortages on global paediatric tuberculosis mortality. BMC Med. 2016; Hedlund NG, Isgor Z, Zwanziger J, Rondelli D, Crawford SY, Hynes DM, et al. Drug Shortage Impacts Patient Receipt of Induction Treatment. Health Serv Res. 2018; Hernandez Sampieri R, Fernandez Collado C, Baptista Lucio M del P. Metodología de La Investigación. Quinta Edición. Metodol la Investig. 2010; Hipocrate E, Hoffman B, Schorge J, Cunningham F, Carol U, București D, et al. Williams Ginecologie Tratat și atlas color de tehnici chirurgicale Cuprinsul lucr ării. 2015; Investigación y Ciencia. Manual de Procedimientos. Med Soc. 2005;126(5):419–22. ISAGS. Situation of Essential Medicines at Risk of Supply Shortage with Emphasis on South American Countries. Rio de Janeiro; 2017. ISAGS-UNASUR. Situación de medicamentos esenciales con riesgo de desabastecimiento con énfasis en los países Suramericanos. 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Drug Shortages and Patient Safety: An Overview of Essential Information for the Infusion Nurse. J Infus Nurs. 2015;38(3):205–8. Meloni ST, Chaplin B, Idoko J, Agbaji O, Akanmu S, Imade G, et al. Drug resistance patterns following pharmacy stock shortage in Nigerian Antiretroviral Treatment Program. AIDS Res Ther. 2017; Melorose J, Perroy R, Careas S. DECRETO NÚMERO 677 DE 1995. Statew Agric L Use Baseline 2015. 2015; MINISTERIO DE LA PROTECCIÓN SOCIAL. RESOLUCION 1043 de 2006. Minist la Protección Soc. 2006; Ministerio de Salud y Protección Social. Resolucion 2003 de 2014. Minist La Protección Soc. 2014; Ministerio de Salud y Protección Social. Repúlica de Colombia. Sistema de Información de Precios de Medicamentos (SISMED). 2015; Morris S. Editorial: Medicine shortages in Australia - what are we doing about them? Aust Prescr. 2018;41(5):136–7. Murcia E, Aguilera J, Wiesner C, Pardo C. Oncology services supply in Colombia. Colomb Med. 2018;49(1):89–96. N.J. N, T.H. L. The drug shortage crisis in the united states: impact on cancer pharmaceutical safety. Cancer Treatment and Research. 2019. Neff MP, Wagner D, Phillips BJ, Shanks A, Thompson A, Wilkins K, et al. Propofol drug shortage associated with worse postoperative nausea and vomiting outcomes despite a mitigation strategy. AANA J. 2018; Nonzee NJ, Luu TH. Cancer Policy: Pharmaceutical Safety [Internet]. Vol. 171. Springer International Publishing; 2019. 75–92 p. Available from: http://link.springer.com/10.1007/978-3-319-43896-2 Oscanoa TJ. Acceso y usabilidad de medicamentos: propuesta para una definición operacional. Rev Peru Med Exp Salud Publica. 2012 Otzen T, Manterola C. Técnicas de Muestreo sobre una Población a Estudio. Int J Morphol. 2017; Paparella SF. Drug Shortages in the Emergency Department: Managing a Threat to Patient Safety. J Emerg Nurs. 2012; Pauwels K, Huys I, Casteels M, Simoens S. 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How Drug Shortages Affect Clinical Care: The Case of the Surgical Anesthetic Propofol. Hosp Pharm. 2015; Rose AJ. Targeted approaches to improve outcomes for highest-cost patients. Isr J Health Policy Res. 2017;6(1):6–8. Saedi S, Erhun Kundakcioglu O, Henry AC. Mitigating the impact of drug shortages for a healthcare facility: An inventory management approach. Eur J Oper Res [Internet]. 2016;251(1):107–23. Available from: http://dx.doi.org/10.1016/j.ejor.2015.11.017 Schwartzberg E, Ainbinder D, Vishkauzan A, Gamzu R. Drug shortages in Israel : regulatory perspectives , challenges and solutions. 2017;1–8. Scott JC, Shah N, Porco T, Flood J. Cost resulting from anti-tuberculosis drug shortages in the United States: A hypothetical cohort study. PLoS One. 2015; Secretaría I De. La escasez mundial de medicamentos y la seguridad y accesibilidad de los medicamentos pediátricos. 2016;2:153–4. Setayesh S, Mackey TK. Addressing the impact of economic sanctions on Iranian drug shortages in the joint comprehensive plan of action: Promoting access to medicines and health diplomacy. Global Health. 2016; Skelton Duke M, Chambliss WG, Gardner KN, Norris DM. Mitigating the impact of medication shortages on public health. J Am Pharm Assoc. 2011; Steers WD. Falling Short: Causes and Implications of Drug Shortages in the United States. J Urol. 2014; Storey MA, Weber RJ, Besco K, Beatty S, Aizawa K, Mirtallo JM. Evaluation of Parenteral Nutrition Errors in an Era of Drug Shortages. Nutr Clin Pract. 2016;31(2):211–7. Tan YX, Moles RJ, Chaar BB. Medicine shortages in Australia: causes, impact and management strategies in the community setting. Int J Clin Pharm. 2016;38(5):1133–41. Tapella E. El mapeo de actores claves. Efectos de la biodiversidad funcional sobre procesos ecosistémicos, servicios ecosistémicos y sustentabilidad en las Américas: un abordaje interdisciplinario. 2007 Therapeutic Goods Administration T. Medicine Shortages Information Initiative [Internet]. 2019 [cited 2019 Apr 2]. Available from: https://apps.tga.gov.au/prod/MSI/search#furtherinformation Ventola CL. The Drug Shortage Crisis in the United States Causes , Impact , and Management Strategies. 2011;36(11). Videau M, Lebel D, Bussières JF. Drug shortages in Canada: Data for 2016–2017 and perspectives on the problem. Ann Pharm Fr [Internet]. 2019; Available from: https://doi.org/10.1016/j.pharma.2018.11.007 WHO. WHOCC - ATC DDD Index. WHO Collab Cent Drug Stat Methodol. 2018; Ziesenitz VC, Fox E, Zocchi M, Samiee-Zafarghandy S, van den Anker JN, Mazer-Amirshahi M. Prescription Drug Shortages: Impact on Neonatal Intensive Care. Neonatology [Internet]. 2019 [cited 2019 Feb 11];108–15. 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Vanegas Escamilla, Egdda Patricia, dir.Linares González, Yanis MilenaAguilar Rodriguez, Argelis MairenaBogotá, Colombia2019-08-12T22:38:25Z2019-08-12T22:38:25Z2019https://repository.udca.edu.co/handle/11158/1953QF045 L35e 2019 (205619)132 páginas : gráficasEl desabastecimiento de medicamentos ha generado un problema de salud mundial que se ha evidenciado en un gran número de países, esto ha tenido consecuencias negativas en la calidad y la eficiencia en la atención de los pacientes. La Organización Mundial de la Salud -OMS establece que el desabastecimiento se produce cuando el suministro de medicamentos esenciales en un sistema de salud se considera insuficiente para satisfacer las necesidades de salud pública y de los pacientes. En Colombia, el INVIMA define el desabastecimiento como la situación en la cual se presenta una insuficiente oferta para satisfacer la demanda de un producto farmacéutico que ya ha sido aprobado por el INVIMA y comercializado en el país; las causas de la escasez se han analizado en varios países y numerosos estudios; dentro de las cuales se han identificado: aspectos regulatorios, problemas de producción, inadecuada gestión logística y problemas específicos de oferta y demanda. Actualmente en Colombia y en Latinoamérica no se han evidenciado investigaciones acerca de las consecuencias generadas por el desabastecimiento. Este estudio tiene como objetivo establecer las consecuencias del desabastecimiento de medicamentos oncológicos en los servicios farmacéuticos de Bogotá. Con el fin de identificar y documentar las consecuencias, se planteó realizar una investigación de carácter mixto, donde se realizaron entrevistas semi-estructuradas a expertos que han tenido contacto con el fenómeno del desabastecimiento con el fin de obtener información preliminar acerca de las consecuencias generadas a causa del desabastecimiento, posteriormente se diseñó y distribuyo una encuesta a los servicios farmacéuticos de Bogotá que ofrecen servicios de quimioterapia y se realizó un análisis estadístico a las encuestas realizadas para determinar la ocurrencia de los eventos evidenciados, finalmente se determinó el efecto del desabastecimiento de medicamentos oncológicos de los servicios farmacéuticos de Bogotá a través de un constructo. De acuerdo con los resultados se identificaron consecuencias como aumento de costos administrativos en procesos de compra 76%, aumento de los costos del servicio farmacéutico 34%, aumentos de costos de hospitalización 21%, aumento de costos por el tiempo del personal 38%, aumento significativo en el precio de los medicamentos 72%, a nivel institucional las entidades se han visto afectadas por imagen y PQR 28%, cambios entre contratación de IPS y EPS 45%, por el aumento del tiempo del personal del servicio farmacéutico, atraso en las tareas asignadas al personal 31% y generación de nuevos procesos 10% , en cuanto a afectación en la salud se identificaron complicaciones que requieren hospitalización 24%, nuevos exámenes clínicos 21% y reingresos al hospital 10%, el uso de alternativas terapéuticas menos efectivas, 28%, cambios en protocolos, 14%, interrupción y cambios en el tratamiento, 10%, sustitución de medicamentos 69%, errores de medicación 31%, cambios en la formulación que causan problemas de seguridad en los pacientes 62%, efectos negativos en los resultados de la terapia 31%, mortalidad 45% y finalmente los medicamentos que son desabastecidos con frecuencia 5-fluoracilo 24%, metrotexato 22%, calcio folinato 22%, Cisplatino 12%, letrosol 8% y doxorrubicina 4% en forma farmacéutica afectada inyectable 82% y Orales 8%.The shortage of medicines has generated a global health problem that has been evident in a large number of countries, this has had negative consequences on the quality and efficiency of patient care. The World Health Organization - OMS states that the shortage occurs when the supply of essential drugs in a health system is considered insufficient to meet the needs of public health and patients. In Colombia, INVIMA defines shortages as the situation in which an insufficient supply is presented to meet the demand for a pharmaceutical product that has already been approved by INVIMA and marketed in the country; The causes of the shortage have been analyzed in several countries and numerous studies; Within which have been identified: regulatory aspects, production problems, inadequate logistics management and specific supply and demand problems. Currently, in Colombia and Latin America there have been no investigations into the consequences generated by the shortage. This study aims to establish the consequences of the shortage of oncological drugs in the pharmaceutical services of Bogotá. In order to identify and document the consequences, a mixed investigation was carried out, where semi-structured interviews were conducted with experts who had contact with the phenomenon of shortage in order to obtain preliminary information about the consequences generated by Because of the shortage, a survey was designed and distributed to the pharmaceutical services of Bogotá that offer chemotherapy services and a statistical analysis was carried out to the surveys carried out to determine the occurrence of the evidenced events, finally the effect of the shortage of medicines was determined oncology of the pharmaceutical services of Bogotá through a construct. According to the results, consequences were identified such as an increase in administrative costs in purchasing processes 76%, increase in the costs of the pharmaceutical service 34%, increases in hospitalization costs 21%, increase in costs due to staff time 38%, increase Significant in the price of medicines 72%, at institutional level the entities have been affected by image and PQR 28%, changes between hiring IPS and EPS 45%, due to the increase in the time of the personnel of the pharmaceutical service, delay in the tasks assigned to staff 31% and generation of new processes 10%, in terms of health involvement complications were identified that require 24% hospitalization, new clinical exams 21% and re-hospitalizations 10%, the use of less effective therapeutic alternatives, 28%, changes in protocols, 14%, interruption and changes in treatment, 10%, medication substitution 69%, medication errors 31%, changes in the form ulation that cause safety problems in patients 62%, negative effects on the results of therapy 31%, mortality 45% and finally medications that are frequently depleted 5-fluoracil 24%, metrotexate 22%, calcium folinate 22%, Cisplatin 12%, letrosol 8% and doxorubicin 4% in affected pharmaceutical form 82% injectable and Oral 8%.Incluye bibliografíaPregradoQuímico(a) Farmacéuticoapplication/pdfspaBogotá : Universidad de Ciencias Aplicadas y Ambientales, 2019Facultad de CienciasQuímica FarmacéuticaDerechos Reservados - Universidad de Ciencias Aplicadas y Ambientaleshttps://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)http://purl.org/coar/access_right/c_abf2Farmacoterapia oncológicaAgentes neoplásicosMedicamentos - Abastecimiento y distribuciónEvaluación de las consecuencias del desabastecimiento de medicamentos oncológicos en los servicios farmacéuticos de BogotáTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/publishedVersionTexthttp://purl.org/redcol/resource_type/TPhttp://purl.org/coar/version/c_970fb48d4fbd8a85Drug shortages roundtable: Minimizing the impact on patient care. 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Available from: https://www.karger.com/Article/FullText/493119PublicationORIGINALTRABAJO PROYECTO DE GRADO UDCA 28-07-2019.pdfTRABAJO PROYECTO DE GRADO UDCA 28-07-2019.pdfapplication/pdf2963667https://repository.udca.edu.co/bitstreams/c8c88cb2-68e5-4230-b249-e14cc08b6e7a/download75aa1534b86cd9e04b57f68924ff47a9MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-814775https://repository.udca.edu.co/bitstreams/3cc59eeb-075d-4c32-bd23-737974afae48/downloadf661acf14bedbf9f5d13897a0387e751MD52TEXTTRABAJO PROYECTO DE GRADO UDCA 28-07-2019.pdf.txtTRABAJO PROYECTO DE GRADO UDCA 28-07-2019.pdf.txtExtracted texttext/plain248059https://repository.udca.edu.co/bitstreams/7e59a220-7889-4d6d-b602-f824cccf1317/downloadba1441070c4defb4c00ac5d8bc43c259MD53THUMBNAILTRABAJO PROYECTO DE GRADO UDCA 28-07-2019.pdf.jpgTRABAJO PROYECTO DE GRADO UDCA 28-07-2019.pdf.jpgGenerated 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en las Obras Colectivas;
b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda;
c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas.Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).
4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:
a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).
b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.
c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.
d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:
i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.
ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.
e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, Acinpro), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.
5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.
6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.
7. Término.
a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.
b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.
8. Varios.
a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.
b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.
c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.
d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.

 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