Caracterización clínica, histopatológica e histoquímica del papiloma cutáneo en bovinos (Bos taurus) del departamento de Córdoba, Colombia
The objective of this study was to study the clinical, histopathological and histochemical aspects of cutaneous papillomatosis (CP) in cattle (Bos taurus) of the department of Córdoba, Colombia. This study was descriptive, not probabilistic, in animals of convenience. Were used Twenty - four bovines...
- Autores:
-
Cardona Álvarez, José
Montes Vergara, Donicer
Álvarez Peñate, Jaime
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2018
- Institución:
- Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
- Repositorio:
- Repositorio Institucional UDCA
- Idioma:
- spa
- OAI Identifier:
- oai:repository.udca.edu.co:11158/1446
- Acceso en línea:
- https://revistas.udca.edu.co/index.php/ruadc/article/view/672
https://doi.org/10.31910/rudca.v21.n1.2018.672
- Palabra clave:
- Tumor
Papilomavirus
Dermopatología
Hiperqueratosis
Bos taurus
Tumores animales
Histopatología
- Rights
- openAccess
- License
- Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales, 2018
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Caracterización clínica, histopatológica e histoquímica del papiloma cutáneo en bovinos (Bos taurus) del departamento de Córdoba, Colombia |
| dc.title.alternative.eng.fl_str_mv |
Clinical, histopathological and histochemical characterization of cutaneous papillomatosis in bovine (Bos taurus) of Córdoba department, Colombia |
| title |
Caracterización clínica, histopatológica e histoquímica del papiloma cutáneo en bovinos (Bos taurus) del departamento de Córdoba, Colombia |
| spellingShingle |
Caracterización clínica, histopatológica e histoquímica del papiloma cutáneo en bovinos (Bos taurus) del departamento de Córdoba, Colombia Tumor Papilomavirus Dermopatología Hiperqueratosis Bos taurus Tumores animales Histopatología |
| title_short |
Caracterización clínica, histopatológica e histoquímica del papiloma cutáneo en bovinos (Bos taurus) del departamento de Córdoba, Colombia |
| title_full |
Caracterización clínica, histopatológica e histoquímica del papiloma cutáneo en bovinos (Bos taurus) del departamento de Córdoba, Colombia |
| title_fullStr |
Caracterización clínica, histopatológica e histoquímica del papiloma cutáneo en bovinos (Bos taurus) del departamento de Córdoba, Colombia |
| title_full_unstemmed |
Caracterización clínica, histopatológica e histoquímica del papiloma cutáneo en bovinos (Bos taurus) del departamento de Córdoba, Colombia |
| title_sort |
Caracterización clínica, histopatológica e histoquímica del papiloma cutáneo en bovinos (Bos taurus) del departamento de Córdoba, Colombia |
| dc.creator.fl_str_mv |
Cardona Álvarez, José Montes Vergara, Donicer Álvarez Peñate, Jaime |
| dc.contributor.author.spa.fl_str_mv |
Cardona Álvarez, José Montes Vergara, Donicer Álvarez Peñate, Jaime |
| dc.subject.proposal.spa.fl_str_mv |
Tumor Papilomavirus Dermopatología Hiperqueratosis |
| topic |
Tumor Papilomavirus Dermopatología Hiperqueratosis Bos taurus Tumores animales Histopatología |
| dc.subject.agrovoc.spa.fl_str_mv |
Bos taurus Tumores animales Histopatología |
| description |
The objective of this study was to study the clinical, histopathological and histochemical aspects of cutaneous papillomatosis (CP) in cattle (Bos taurus) of the department of Córdoba, Colombia. This study was descriptive, not probabilistic, in animals of convenience. Were used Twenty - four bovines with BCP diagnosed clinically and histopathologically. In describing the lesions exophytic and hyperpigmented masses were observed in some cases, pedicled or in the form of cauliflower in others and even in the flat papillomas showed the pedicles to the compression. Similarly, large pendulum papillomas were surgically removed, which when dissected revealed epithelial hyperplasia, hyperkeratosis and the projection of the epidermis to the dermis. At head level, the largest presentation was given in mouth, ears, forehead and eyelids. Histopathologically in the H-E staining, were observed epithelial hyperplasia, acanthosis, digital projections to the dermis and hyperkeratosis. In the T-G staining, marked dermal proliferation of disorganized collagen with little diffuse connective tissue was present, and in the P-R / P staining, marked areas of reddish birefringence and scarce birefringence were observed. The definitive diagnosis of the disease was based on the clinical characteristics, differential diagnosis and histopathological findings, being conclusive as diagnostic methods for CP in bovines in the Department of Córdoba. |
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2018 |
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2018-01 |
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2019-05-20T21:04:24Z |
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2019-05-20T21:04:24Z |
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Artículo de revista |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_6501 |
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info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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Text |
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0123-4226 |
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https://revistas.udca.edu.co/index.php/ruadc/article/view/672 |
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https://doi.org/10.31910/rudca.v21.n1.2018.672 |
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307048 |
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https://revistas.udca.edu.co/index.php/ruadc/article/view/672 https://doi.org/10.31910/rudca.v21.n1.2018.672 |
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spa |
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spa |
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Revista UDCA : Actualidad & Divulgación Científica (Bogotá). -- Vol. 21, No. 1 (Ene.-Jun. 2018). -- páginas 137-146 |
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Agricultura |
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Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales, 2018 |
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Córdoba (Colombia) |
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Bogotá : Universidad de Ciencias Aplicadas y Ambientales, 2018 |
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Cardona Álvarez, JoséMontes Vergara, DonicerÁlvarez Peñate, JaimeCórdoba (Colombia)2019-05-20T21:04:24Z2019-05-20T21:04:24Z2018-010123-4226https://revistas.udca.edu.co/index.php/ruadc/article/view/672https://doi.org/10.31910/rudca.v21.n1.2018.672307048The objective of this study was to study the clinical, histopathological and histochemical aspects of cutaneous papillomatosis (CP) in cattle (Bos taurus) of the department of Córdoba, Colombia. This study was descriptive, not probabilistic, in animals of convenience. Were used Twenty - four bovines with BCP diagnosed clinically and histopathologically. In describing the lesions exophytic and hyperpigmented masses were observed in some cases, pedicled or in the form of cauliflower in others and even in the flat papillomas showed the pedicles to the compression. Similarly, large pendulum papillomas were surgically removed, which when dissected revealed epithelial hyperplasia, hyperkeratosis and the projection of the epidermis to the dermis. At head level, the largest presentation was given in mouth, ears, forehead and eyelids. Histopathologically in the H-E staining, were observed epithelial hyperplasia, acanthosis, digital projections to the dermis and hyperkeratosis. In the T-G staining, marked dermal proliferation of disorganized collagen with little diffuse connective tissue was present, and in the P-R / P staining, marked areas of reddish birefringence and scarce birefringence were observed. The definitive diagnosis of the disease was based on the clinical characteristics, differential diagnosis and histopathological findings, being conclusive as diagnostic methods for CP in bovines in the Department of Córdoba.El objetivo de este trabajo fue estudiar los aspectos clínicos, histopatológicos e histoquímicos de la papilomatosis cutánea (PC) en bovinos (Bos taurus), del departamento de Córdoba, Colombia. Dicho estudio fue de tipo descriptivo, no probabilístico, en animales de conveniencia. Se utilizaron 24 bovinos con PCB, diagnosticados clínica e histopatológicamente. Las lesiones, se observaron a modo de masas exofíticas e hiperpigmentadas; en algunos casos, pediculadas o en forma de coliflor; en otros e inclusive en los papilomas planos, se evidenciaron los pedículos a la compresión . De igual forma, los papilomas de gran tamaño pendulantes fueron extraídos quirúrgicamente que, al ser diseccionados, se evidenció la hiperplasia epitelial, la hiperqueratosis y la pro- yección de la epidermis hacia la dermis. A nivel de cabeza, la mayor presentación se dio en boca, en orejas, en frente y en párpados . Histopatológicamente, en la coloración de H-E, se observó hiperplasia epitelial, acantosis, proyecciones digitales hacía la dermis e hiperqueratosis. En la coloración de T-G, se observó marcada proliferación dérmica de colágeno desorganizado, con escasa presencia de tejido conjuntivo difuso y en la coloración de P-R/P, se observaron marcadas áreas de birrefringencia rojiza y escasa birrefringencia verde amarillenta . El diagnóstico definitivo de la enfermedad, se fundamentó en las características clínicas, diagnóstico diferencial y en los hallazgos histopatológicos, siendo concluyentes, como métodos de diagnóstico de la PC en bovinos, del Departamento de Córdoba.Incluye referencias bibliográficasapplication/pdfspaBogotá : Universidad de Ciencias Aplicadas y Ambientales, 2018Revista UDCA : Actualidad & Divulgación Científica (Bogotá). -- Vol. 21, No. 1 (Ene.-Jun. 2018). -- páginas 137-146AgriculturaDerechos Reservados - Universidad de Ciencias Aplicadas y Ambientales, 2018https://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)http://purl.org/coar/access_right/c_abf2Caracterización clínica, histopatológica e histoquímica del papiloma cutáneo en bovinos (Bos taurus) del departamento de Córdoba, ColombiaClinical, histopathological and histochemical characterization of cutaneous papillomatosis in bovine (Bos taurus) of Córdoba department, ColombiaArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionTexthttp://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85TumorPapilomavirusDermopatologíaHiperqueratosisBos taurusTumores animalesHistopatologíaPublicationORIGINAL672-Texto del artículo-1717-2-10-20180925.pdf672-Texto del artículo-1717-2-10-20180925.pdfapplication/pdf1122067https://repository.udca.edu.co/bitstreams/44ce69b4-2454-49d9-a319-85c2fe131e2a/download107f2984333f9ffe9b09548f248b23beMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-814775https://repository.udca.edu.co/bitstreams/af348723-65c6-4576-a722-23477f177844/downloadf661acf14bedbf9f5d13897a0387e751MD52TEXT672-Texto del artículo-1717-2-10-20180925.pdf.txt672-Texto del artículo-1717-2-10-20180925.pdf.txtExtracted 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 nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.
d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:
i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.
ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.
e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, Acinpro), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.
5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.
6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.
7. Término.
a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.
b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.
8. Varios.
a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.
b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.
c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.
d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.

 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