Prevalencia de agentes transmisibles por transfusión y factores asociados en un banco de sangre de Córdoba- Colombia 2014-2016
Transfusion therapy is an important therapeutic alternative; the risk of transmitting infections in this way constitutes a clinical and public health problem, with magnitude and as-sociated heterogeneous factors according to the reference population of each blood bank. The objective of the study was...
- Autores:
-
Ruiz Mendoza, Leyand
Villegas Gracia, Rossana
Cardona Arias, Jaiberth
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2018
- Institución:
- Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
- Repositorio:
- Repositorio Institucional UDCA
- Idioma:
- spa
- OAI Identifier:
- oai:repository.udca.edu.co:11158/1477
- Acceso en línea:
- https://revistas.udca.edu.co/index.php/ruadc/article/view/969
https://doi.org/10.31910/rudca.v21.n2.2018.969
- Palabra clave:
- Transfusión de sangre
Bancos de sangre
Bancos de sangre
Transfusión sanguínea
Infecciones
Prevalencia
- Rights
- openAccess
- License
- Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales, 2018
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dc.title.spa.fl_str_mv |
Prevalencia de agentes transmisibles por transfusión y factores asociados en un banco de sangre de Córdoba- Colombia 2014-2016 |
dc.title.alternative.spa.fl_str_mv |
Prevalence of transmissible agents by transfusion and associated factors in a blood bank from Córdoba-Colombia 2014-2016 |
title |
Prevalencia de agentes transmisibles por transfusión y factores asociados en un banco de sangre de Córdoba- Colombia 2014-2016 |
spellingShingle |
Prevalencia de agentes transmisibles por transfusión y factores asociados en un banco de sangre de Córdoba- Colombia 2014-2016 Transfusión de sangre Bancos de sangre Bancos de sangre Transfusión sanguínea Infecciones Prevalencia |
title_short |
Prevalencia de agentes transmisibles por transfusión y factores asociados en un banco de sangre de Córdoba- Colombia 2014-2016 |
title_full |
Prevalencia de agentes transmisibles por transfusión y factores asociados en un banco de sangre de Córdoba- Colombia 2014-2016 |
title_fullStr |
Prevalencia de agentes transmisibles por transfusión y factores asociados en un banco de sangre de Córdoba- Colombia 2014-2016 |
title_full_unstemmed |
Prevalencia de agentes transmisibles por transfusión y factores asociados en un banco de sangre de Córdoba- Colombia 2014-2016 |
title_sort |
Prevalencia de agentes transmisibles por transfusión y factores asociados en un banco de sangre de Córdoba- Colombia 2014-2016 |
dc.creator.fl_str_mv |
Ruiz Mendoza, Leyand Villegas Gracia, Rossana Cardona Arias, Jaiberth |
dc.contributor.author.spa.fl_str_mv |
Ruiz Mendoza, Leyand Villegas Gracia, Rossana Cardona Arias, Jaiberth |
dc.subject.lemb.spa.fl_str_mv |
Transfusión de sangre Bancos de sangre |
topic |
Transfusión de sangre Bancos de sangre Bancos de sangre Transfusión sanguínea Infecciones Prevalencia |
dc.subject.proposal.spa.fl_str_mv |
Bancos de sangre Transfusión sanguínea Infecciones Prevalencia |
description |
Transfusion therapy is an important therapeutic alternative; the risk of transmitting infections in this way constitutes a clinical and public health problem, with magnitude and as-sociated heterogeneous factors according to the reference population of each blood bank. The objective of the study was to determine the prevalence of transmissible agents by transfusion and associated factors in a blood bank of Cór-doba-Colombia 2014-2016. A prevalence study was carried out in all blood bank donors, the global prevalence of reac-tivity was estimated and the agent was specified, the associated factors were studied with chi-square, prevalence ratios and odds ratios adjusted to a regression model. multivariate logistics. 39,825 donors were included. The overall preva-lence of positivity was 1.4%. The prevalence for Treponema pallidum was 0.43%, Trypanosoma cruzi 0.39%, hepatitis B virus core 0.32% and Hepatitis B Surface Antigen 0.05%, Human Immunodeficiency Virus 0.14% , Human T-cell Lym-photropic Virus 0.08%, Hepatitis C Virus 0.04% and Plasmo-dium spp. 0% .In the overall prevalence, T. pallidum infec-tions, positivity for the antibody against the central antigen of the hepatitis virus B and Lymphotropic Human T Cell Virus were statistically higher in women, older people, residents of other departments different from Córdoba, housewives, pensioners, farmers and ranchers, administrators and other professions, military and health workers. The prevalence of infections was low, however, the finding of subgroups with statistically significant prevalences allows to guide new re-search and epidemiological surveillance interventions. |
publishDate |
2018 |
dc.date.issued.spa.fl_str_mv |
2018-07 |
dc.date.accessioned.spa.fl_str_mv |
2019-05-31T14:14:45Z |
dc.date.available.spa.fl_str_mv |
2019-05-31T14:14:45Z |
dc.type.spa.fl_str_mv |
Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_6501 |
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info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
dc.type.content.spa.fl_str_mv |
Text |
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http://purl.org/redcol/resource_type/ART |
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dc.identifier.issn.spa.fl_str_mv |
0123-4226 |
dc.identifier.uri.spa.fl_str_mv |
https://revistas.udca.edu.co/index.php/ruadc/article/view/969 |
dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.31910/rudca.v21.n2.2018.969 |
dc.identifier.local.spa.fl_str_mv |
307380 |
identifier_str_mv |
0123-4226 307380 |
url |
https://revistas.udca.edu.co/index.php/ruadc/article/view/969 https://doi.org/10.31910/rudca.v21.n2.2018.969 |
dc.language.iso.spa.fl_str_mv |
spa |
language |
spa |
dc.relation.ispartofseries.spa.fl_str_mv |
Revista UDCA : Actualidad & Divulgación Científica (Bogotá). -- Vol. 21, No. 2 (Jul.-Dic. 2018). -- páginas 297-308 |
dc.rights.spa.fl_str_mv |
Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales, 2018 |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
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Atribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0) |
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Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales, 2018 https://creativecommons.org/licenses/by-nc-sa/4.0/ Atribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0) http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
dc.coverage.spatial.spa.fl_str_mv |
Córdoba (Colombia) |
dc.publisher.spa.fl_str_mv |
Bogotá : Universidad de Ciencias Aplicadas y Ambientales, 2018 |
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Universidad de Ciencias Aplicadas y Ambientales U.D.C.A |
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spelling |
Ruiz Mendoza, LeyandVillegas Gracia, RossanaCardona Arias, JaiberthCórdoba (Colombia)2019-05-31T14:14:45Z2019-05-31T14:14:45Z2018-070123-4226https://revistas.udca.edu.co/index.php/ruadc/article/view/969https://doi.org/10.31910/rudca.v21.n2.2018.969307380Transfusion therapy is an important therapeutic alternative; the risk of transmitting infections in this way constitutes a clinical and public health problem, with magnitude and as-sociated heterogeneous factors according to the reference population of each blood bank. The objective of the study was to determine the prevalence of transmissible agents by transfusion and associated factors in a blood bank of Cór-doba-Colombia 2014-2016. A prevalence study was carried out in all blood bank donors, the global prevalence of reac-tivity was estimated and the agent was specified, the associated factors were studied with chi-square, prevalence ratios and odds ratios adjusted to a regression model. multivariate logistics. 39,825 donors were included. The overall preva-lence of positivity was 1.4%. The prevalence for Treponema pallidum was 0.43%, Trypanosoma cruzi 0.39%, hepatitis B virus core 0.32% and Hepatitis B Surface Antigen 0.05%, Human Immunodeficiency Virus 0.14% , Human T-cell Lym-photropic Virus 0.08%, Hepatitis C Virus 0.04% and Plasmo-dium spp. 0% .In the overall prevalence, T. pallidum infec-tions, positivity for the antibody against the central antigen of the hepatitis virus B and Lymphotropic Human T Cell Virus were statistically higher in women, older people, residents of other departments different from Córdoba, housewives, pensioners, farmers and ranchers, administrators and other professions, military and health workers. The prevalence of infections was low, however, the finding of subgroups with statistically significant prevalences allows to guide new re-search and epidemiological surveillance interventions.La terapia transfusional es una importante alternativa terapéutica, pero el riesgo de transmitir infecciones por esta vía constituye un problema clínico y de salud pública, con magnitud y factores asociados heterogéneos, según la población de referencia de cada banco de sangre. El objetivo del estudio fue determinar la prevalencia de agentes transmisibles por transfusión y factores asociados en un banco de sangre de Córdoba-Colombia 2014-2016. Se realizó un estudio de prevalencia en la totalidad de donantes del banco de sangre, se estimó la prevalencia global de reactividad y específica por agente. Los factores asociados, se estudiaron con chi cuadrado, razones de prevalencia y razones de odds, ajustados a un modelo de regresión logística multivariante. Se incluyeron 39.825 donantes. La prevalencia global de positividad fue 1,4%. La prevalencia para Treponema pallidum fue 0,43%; Tripanosoma cruzi, 0,39%; virus de la hepatitis B core, 0,32% y Antígeno de Superficie de la Hepatitis B, 0,05%; Virus de la Inmunodeficiencia Humana, 0,14%; Virus Linfotrópico de Células T Humana, 0,08%; Virus de la Hepatitis C, 0,04% y Plasmodium spp., 0%. En la prevalencia global, las infecciones por Treponema pallidum, positividad para el anticuerpo contra el antígeno central del virus de hepatitis B y Virus Linfotrópico de Células T Humana, fueron estadísticamente mayor en mujeres, personas de mayor edad, residentes de otros departamentos diferente de Córdoba, amas de casa, pensionados, agricultores y ganaderos, administradores y otras profesiones, militares y trabajadores de la salud. La prevalencia de infecciones fue baja; sin embargo, el hallazgo de subgrupos con prevalencias estadísticamente significativa permite orientar nuevas investigaciones e intervenciones de vigilancia epidemiológica.Incluye referencias bibliográficasapplication/pdfspaBogotá : Universidad de Ciencias Aplicadas y Ambientales, 2018Revista UDCA : Actualidad & Divulgación Científica (Bogotá). -- Vol. 21, No. 2 (Jul.-Dic. 2018). -- páginas 297-308Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales, 2018https://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)http://purl.org/coar/access_right/c_abf2Prevalencia de agentes transmisibles por transfusión y factores asociados en un banco de sangre de Córdoba- Colombia 2014-2016Prevalence of transmissible agents by transfusion and associated factors in a blood bank from Córdoba-Colombia 2014-2016Artículo de 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 nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.
d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:
i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.
ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.
e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, Acinpro), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.
5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.
6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.
7. Término.
a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.
b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.
8. Varios.
a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.
b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.
c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.
d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.

 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