IFNL4 genotype influences the rate of HIV-1 seroconversion in men who have sex with men

Individuals lacking interferon lambda 4 (IFNL4) protein due to a common null mutation (rs368234815) in the IFNL4 gene display higher resistance against several infections. The influence of IFNL4 on HIV-1 infection is still under discussion and conflicting results have been reported. This study intended to corroborate or refute the association of the null allele of IFNL4 and HIV-1 predisposition in a cohort of men who have sex with men (MSM). IFNL4 null genotype was assessed on 619 HIV-1-seronegative MSM who were followed for 36 months during a trial of a prophylactic vaccine against HIV-1. Of those, 257 individuals seroconverted during this period. A logistic regression model was constructed including demographic and IFNL4 genotype. In addition, a meta-analysis using data from the current study and other European populations was conducted. The null IFNL4 genotypes were correlated with lower HIV-1 seroconversion (Adjusted OR = 0.4 [95%CI: 0.2–0.8], P = 0.008) and longer time to seroconversion (889 vs. 938 days, P= 0.01). These results were validated by a meta-analysis incorporating data from other European populations and the result yielded a significant association of the IFNL4 null genotype under a dominant model with a lower probability of HIV-1 infection (OR=0.4 [95% CI: 0.3-0.6]; P= 1.3 x 10E-5). © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

• Autores: Meza Barreto, Giovanna; Galián, Fátima; Jaimes Bernal, Claudia Patricia; Márquez, Francisco J.; Sinangil, Faruk M.; Scagnolari, Carolina; Real, Luis Miguel; Forthal, Donald; Caruz, Antonio
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2022
• Institución: Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
• Repositorio: Repositorio Institucional UDCA
• Idioma: eng
• OAI Identifier: oai:repository.udca.edu.co:11158/4667
• Acceso en línea: https://repository.udca.edu.co/handle/11158/4667
• Palabra clave: Serodiagnóstico del SIDA; Sida
• Rights: openAccess
• License: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.es