Evaluación de la actividad antimicrobiana del extracto Hidroalcohólico de matricaria Chamomilla en combinación con el aceite Esencial de melaleuca alternifolia contra la cepa de streptococcus sanguinis una bacteria asociada a periodontitis crónica y la halitosis
84 páginas : gráficas
- Autores:
-
Gómez, Johan Sebastián
Serrano, Danna Marcela
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2019
- Institución:
- Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
- Repositorio:
- Repositorio Institucional UDCA
- Idioma:
- spa
- OAI Identifier:
- oai:repository.udca.edu.co:11158/1956
- Acceso en línea:
- https://repository.udca.edu.co/handle/11158/1956
- Palabra clave:
- Análisis químico de las plantas
Streptococcus
Chamomilla
Extractos vegetales
Antimicrobianos
Melaleuca alternifolia
- Rights
- openAccess
- License
- Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales
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Evaluación de la actividad antimicrobiana del extracto Hidroalcohólico de matricaria Chamomilla en combinación con el aceite Esencial de melaleuca alternifolia contra la cepa de streptococcus sanguinis una bacteria asociada a periodontitis crónica y la halitosis |
| title |
Evaluación de la actividad antimicrobiana del extracto Hidroalcohólico de matricaria Chamomilla en combinación con el aceite Esencial de melaleuca alternifolia contra la cepa de streptococcus sanguinis una bacteria asociada a periodontitis crónica y la halitosis |
| spellingShingle |
Evaluación de la actividad antimicrobiana del extracto Hidroalcohólico de matricaria Chamomilla en combinación con el aceite Esencial de melaleuca alternifolia contra la cepa de streptococcus sanguinis una bacteria asociada a periodontitis crónica y la halitosis Análisis químico de las plantas Streptococcus Chamomilla Extractos vegetales Antimicrobianos Melaleuca alternifolia |
| title_short |
Evaluación de la actividad antimicrobiana del extracto Hidroalcohólico de matricaria Chamomilla en combinación con el aceite Esencial de melaleuca alternifolia contra la cepa de streptococcus sanguinis una bacteria asociada a periodontitis crónica y la halitosis |
| title_full |
Evaluación de la actividad antimicrobiana del extracto Hidroalcohólico de matricaria Chamomilla en combinación con el aceite Esencial de melaleuca alternifolia contra la cepa de streptococcus sanguinis una bacteria asociada a periodontitis crónica y la halitosis |
| title_fullStr |
Evaluación de la actividad antimicrobiana del extracto Hidroalcohólico de matricaria Chamomilla en combinación con el aceite Esencial de melaleuca alternifolia contra la cepa de streptococcus sanguinis una bacteria asociada a periodontitis crónica y la halitosis |
| title_full_unstemmed |
Evaluación de la actividad antimicrobiana del extracto Hidroalcohólico de matricaria Chamomilla en combinación con el aceite Esencial de melaleuca alternifolia contra la cepa de streptococcus sanguinis una bacteria asociada a periodontitis crónica y la halitosis |
| title_sort |
Evaluación de la actividad antimicrobiana del extracto Hidroalcohólico de matricaria Chamomilla en combinación con el aceite Esencial de melaleuca alternifolia contra la cepa de streptococcus sanguinis una bacteria asociada a periodontitis crónica y la halitosis |
| dc.creator.fl_str_mv |
Gómez, Johan Sebastián Serrano, Danna Marcela |
| dc.contributor.advisor.spa.fl_str_mv |
Ramos Rueda, Viviana, dir. |
| dc.contributor.author.spa.fl_str_mv |
Gómez, Johan Sebastián Serrano, Danna Marcela |
| dc.subject.mesh.spa.fl_str_mv |
Análisis químico de las plantas Streptococcus |
| topic |
Análisis químico de las plantas Streptococcus Chamomilla Extractos vegetales Antimicrobianos Melaleuca alternifolia |
| dc.subject.agrovoc.spa.fl_str_mv |
Chamomilla Extractos vegetales Antimicrobianos Melaleuca alternifolia |
| description |
84 páginas : gráficas |
| publishDate |
2019 |
| dc.date.accessioned.spa.fl_str_mv |
2019-08-13T19:58:16Z |
| dc.date.available.spa.fl_str_mv |
2019-08-13T19:58:16Z |
| dc.date.issued.spa.fl_str_mv |
2019 |
| dc.type.spa.fl_str_mv |
Trabajo de grado - Pregrado |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_7a1f |
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QF047 G65e 2019 (205622) |
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https://repository.udca.edu.co/handle/11158/1956 |
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QF047 G65e 2019 (205622) |
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spa |
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spa |
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Abiko, Y., Sato, T., Mayanagi, G., & Takahashi, N. (2010). Profiling of subgingival plaque biofilm microflora from periodontally healthy subjects and from subjects with periodontitis using quantitative real-time PCR. Journal of Periodontal Research, 45(3), 389–395. https://doi.org/10.1111/j.1600- 0765.2009.01250.x DANAYSY, M. S. (2018). ESTUDIO DIAGNÓSTICO DE MICROORGANISMOS PRESENTES EN LA PLACA BACTERIANA DEL PERSONAL QUE BRINDA SERVICIO DE ALIMENTACIÓN A LA UNIVERSIDAD REGIONAL AUTÓNOMA DE LOS ANDES Y SU INFLUENCIA EN LA TRANSMISIÓN HORIZONTAL DE CARIES. UNIVERSIDAD REGIONAL AUTÓNOMA DE LOS ANDES. Abrera, C. R. E. U. C., Ómez, R. O. F. A. G., & Úñiga, A. N. E. D. Z. (2007). La resistencia de bacterias a antibióticos , antisépticos y desinfectantes una manifestación de los mecanismos de supervivencia y adaptación, 38, 149– 158. Amaci, K. (2010). BBL CultureSwab Plus Amies Medium Without Charcoal ve Amies Medium With Charcoal. BASCONES, MARTINEZ, A., & FIGUERO, RUIZ, E. (2005). Las enfermedades periodontales como infecciones bacterianas, 147–156. Bascones, A. (2005a). Factores de riesgo de la enfermedad periodontal: factores genéticos. Scielo, 69–77. Bascones, A. (2005b). Pasado , presente y futuro de la microbiología de la periodontitis, (2), 79–87. Bhatt, A. K., Govila, V., & Sharma, M. (2015). Host modulatory agents in periodontics : A step towards the future. Jorunal of ICDRO Innovations in Destistry, 7(2). https://doi.org/10.4103/2231-0754.164380 Borrell, L. N., Kunzel, C., Lamster, I., & Lalla, E. (2007). Diabetes in the dental office : using NHANES III to estimate the probability of undiagnosed disease. Publmed, 559–565. https://doi.org/10.1111/j.1600-0765.2007.00983.x Brañez Reyes, K., Ramos-Perfecto, D., Castro Luna, A., Piscoche Botello, C., Dávila Paredes, D., & Ruiz Macedo, J. C. (2018). Efecto antibacteriano in vitro del extracto de Stevia rebaudiana sobre Streptococcus sanguinis y Actinomyces viscosus, bacterias iniciadoras en la formación de biopelícula dental. Odontología Sanmarquina, 21(1), 21. https://doi.org/10.15381/os.v21i1.14428 Broek, A. M. W. T. Van Den, Feenstra, L., & Baat, C. De. (2007). A review of the current literature on aetiology and measurement methods of halitosis. Sciencie Direct, 35, 627–635. https://doi.org/10.1016/j.jdent.2007.04.009 C. Page Roy, Seymour, J., & Kenneth, S. K. (2000). Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions. Periodontolgy 2000, 14(23), 216–248. Carson, C. F., Hammer, K. A., & Riley, T. V. (2006). Melaleuca alternifolia ( Tea Tree ) Oil : a Review of Antimicrobial and Other Medicinal Properties. CLINICAL MICROBIOLOGY, 19(1), 50–62. https://doi.org/10.1128/CMR.19.1.50 Carson, C. F., & Riley, T. V. (1995). Antimicrobial activity of the major components of the essential oil of Melaleuca alternifolia. Journal of Applied Bacteriology, 78(3), 264–269. https://doi.org/10.1111/j.1365- 2672.1995.tb05025.x Carvajal, P. (2016). Enfermedades periodontales como un problema de salud pública: el desafío del nivel primario de atención en salud. Revista Clínica de Periodoncia, Implantología y Rehabilitación Oral, 9(2), 177–183. https://doi.org/10.1016/j.piro.2016.07.001 Caufield, P. W., Hsu, J., Hardin, J. M., Pan, Y., Li, Y., & Dasanayake, A. P. (2002). Natural History of Streptococcus sanguinis in the Oral Cavity of Infants: Evidence for a Discrete Window of Infectivity. Infection and Immunity, 68(7), 4018–4023. https://doi.org/10.1128/iai.68.7.4018-4023.2000 Chen, L., Ge, X., Dou, Y., Wang, X., Patel, J. R., & Xu, P. (2011). Identification of hydrogen peroxide productionrelated genes in Streptococcus sanguinis and their functional relationship with pyruvate oxidase. Microbiology, 157(1), 13–20. https://doi.org/10.1099/mic.0.039669-0 Corrales Ramírez, L., Castillo Castañeda, A., & Melo Vargas, A. (2017). Evaluación del potencial antibacterial in vitro de Croton lechleri frente a aislamientos bacterianos de pacientes con úlceras cutáneas. Nova, 11(19), 51. https://doi.org/10.22490/24629448.1018 COSTA, F., MOURA, A., ALMEIDA, F., & BASCONES, A. (2001). Antibioterapia en Periodoncia . Situación actual. Antibióticos Sistémicos, 39– 47. Retrieved from http://scielo.isciii.es/pdf/peri/v13n1/original4.pdf Cotter, P. D., & Hill, C. (2003). Surviving the Acid Test: Responses of GramPositive Bacteria to Low pH. Microbiology and Molecular Biology Reviews, 67(3), 429–453. https://doi.org/10.1128/mmbr.67.3.429-453.2003 Cox, S. D., Mann, C. M., Markham, J. L., Bell, H. C., Gustafson, J. E., Warmington, J. R., & Wyllie, S. G. (2001). The mode of antimicrobial action of the essential oil of Melaleuca alternifolia (tea tree oil). Journal of Applied Microbiology, 88(1), 170–175. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/10735256 Cwikla, C., Schmidt, K., Matthias, A., Bone, K. M., & Lehmann., R. (2009). Investigations into the Antibacterial Activities of Phytotherapeutics against Helicobacter pylori and Campylobacter jejuni. Angiogenesis, 1213(December 2007), 1205–1213. https://doi.org/10.1002/ptr Dramsi, S., Trieu-cuot, P., & Bierne, H. (2005). Sorting sortases : a nomenclature proposal for the various sortases of Gram-positive bacteria, 156, 289–297. https://doi.org/10.1016/j.resmic.2004.10.011 Duque, A. (2016). Implantología y Rehabilitación Oral Prevalencia de periodontitis crónica en Iberoamérica. Revista Clínica de Periodoncia, Implantología y Rehabilitación Oral, 9(2), 208–215. https://doi.org/10.1016/j.piro.2016.07.005 Eke, P. I., Dye, B. A., Wei, L., & Genco, R. J. (2012). Prevalence of Periodontitis in Adults in the United States : 2009 and 2010. Journal of Dental Research, 1–8. https://doi.org/10.1177/0022034512457373 Elavarasu, S., Thangavelu, A., Saravanan, J., & Shereef, M. (2014). Go green periodontics, 2(2), 18–24. Fabri, R. L., Nogueira, M. S., Dutra, L. B., Bouzada, M. L. M., & Scio, E. (2011). Potencial antioxidante e antimicrobiano de espécies da família asteraceae. Revista Brasileira de Plantas Medicinais, 13(2), 183–189. https://doi.org/10.1590/S1516-05722011000200009 Ferreira, S. R. (2007). Prevalence and characteristics associated with metabolic syndrome in Japanese-Brazilians with and without periodontal disease. Scielol, 23(3), 657–668. Flemmig, T. F. (1999). Periodontitis. Periodontolgy Banner, 4(1). Forrer, M., Kulik, E. M., Filippi, A., & Waltimo, T. (2013). The antimicrobial activity of alpha-bisabolol and tea tree oil against Solobacterium moorei, a Gram-positive bacterium associated with halitosis. Archives of Oral Biology, 58(1), 10–16. https://doi.org/10.1016/j.archoralbio.2012.08.001 García, A. M. A., Venero, C. S., & García, B. N. (2014). Infecciones por estreptococo. Medicine, 11(59), 3463–3476. https://doi.org/10.1016/S0304- 5412(14)70802-9 Giacaman, R., C. Muñoz, S., E. Bravo, G., & P. Farfán, C. (2013). Cuantificación de bacterias relacionadas con la caries dental en saliva de adultos y adultos mayores Quantification of caries-associated bacteria from saliva of adults and older adults, 71–74. Graziano, T. S., Calil, C. M., Sartoratto, A., Gilson, C., & Nobre, F. (2016). In vitro effects of Melaleuca alternifolia essential oil on growth and production of volatile sulphur compounds by oral bacteria. Scielo, 24(6), 582–589. Groppo, F. C., Ramacciato, J. C., & Florio, F. M. (2002). Antimicrobial activity of garlic , tea tree oil , and chlorhexidine against oral microorganisms, 433– 437. Hammer, A., Dry, L., Johnson, M., Michalak, E, M., Carson, C, F., & Riley, T, V. (2003). Susceptibility of oral bacteria to Melaleuca alternifolia ( tea tree ) oil in vitro. Oral Microbiology and Inmunology, 1–4. Hammer, K. A., Carson, C. F., & Riley, T. V. (2012). Effects of Melaleuca alternifolia ( Tea Tree ) Essential Oil and the Major Monoterpene Component Terpinen-4-ol on the Development of Single- and Multistep Antibiotic Resistance and Antimicrobial Susceptibility, 909–915. https://doi.org/10.1128/AAC.05741-11 Hart, P. H., Brand, C., Carson, C. F., Riley, T. V, & Prager, R. H. (2000). Terpinen-4-ol , the main component of the essential oil of Melaleuca alternifolia ( tea tree oil ), suppresses inflammatory mediator production by activated human monocytes, 49, 619–626. Inceer, H., & Ozcan, M. (2011). Leaf anatomy as an additional taxonomy tool for 18 taxa of Matricaria L. and Tripleurospermum Sch. Bip. (AnthemideaeAsteraceae) in Turkey, (January 2017). https://doi.org/10.1007/s00606-011- 0487-2 Jenkinson, H. F., & Lamont, R. J. (2001). STREPTOCOCCAL ADHESION AND COLONIZATION. Kazemi, M. (2014). Chemical Composition and Antimicrobial Activity of Essential Oil of Matricaria chamomilla, 3(January), 148–153. Kornman, K. S. (2004). The pathogenesis of human periodontitis : an introduction, 14, 9–11. Kreth, J., Merritt, J., Shi, W., & Qi, F. (2005). Competition and Coexistence between Streptococcus mutans and Streptococcus sanguinis in the Dental Biofilm. Microbiology, 187(21), 7193–7203. https://doi.org/10.1128/JB.187.21.7193 Kushiyama, M., Shimazaki, Y., Murakami, M., & Yamashita, Y. (2009). Relationship Between Intake of Green Tea and Periodontal Disease. Publmed, 80(3). https://doi.org/10.1902/jop.2009.080510 Lopardo, H. (2014). COCOS GRAM POSITIVOS CATALASA NEGATIVOS. Retrieved from http://www.aam.org.ar/descarga-archivos/ParteII.pdf Luis, J., & Cañavate, R. (2005). Fitoterapia de la inflamación, 80–85. Mart, B.-, & Implantol, A. P. (2008). El papel de la genética en la aparición y desarrollo de la periodontitis . 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Detection and prevalence of periodontal pathogens in a Uruguayan population with chronic periodontitis using conventional methodology and metagenomics. Scielo, XVII, 23–33. Petersen, P. Baez, R. (2013). Oral Health Surveys: Basic Methods, 5th ed. World Health Organization PRICE, T., FRENCH, G. L., TALSANIA., H., & PHILLIPS, I. (2016). Differentiation of Streptococcus sanguis and S. mitior by whole-cell rhamnose content and possession of arginine dihydrolase. The Pathological Society of Great Britain and Ireland, 21(1986), 189–197. https://doi.org/10.2139/ssrn.2746477 Prieto, J., & Calvo, A. (2010). Bases microbiológicas en las infecciones bucales y sensibilidad en los antibióticos. Med. Oral Patol. Oral Cir. Bucal, 9(supl 8), 11–18. Rahman, H., & Chandra, A. (2015). Microbiologic Evaluation of Matricaria and Chlorhexidine against E. faecalis and C. albicans. Indian Journal of Dentistry Rebeca, N., Botello, R., Espinosa, A. F., & Castro, M. A. (2011). 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Susceptibility of food-borne bacteria to binary combinations of antimicrobials at selected a w and pH. Journal of Applied Microbiology, 102(2), 486–497. https://doi.org/10.1111/j.1365-2672.2006.03092.x Shelton, D., Zabaras, D., Chohan, S., Wyllie, S. G., Baverstock, P., Leach, D., & Henry, R. (2004). Isolation and partial characterisation of a putative monoterpene synthase from Melaleuca alternifolia. Plant Physiology and Biochemistry, 42(11), 875–882. https://doi.org/10.1016/j.plaphy.2004.10.010 Sk, F., Soma, K., & Ch, S. (2005). Antimicrobial effects of essential oils in combination with chlorhexidine digluconate. Publmed, 221–225. Socransky, S. S., & Haffajee, A. D. (1977). The Bacterial Etiology of Destructive Periodontal Disease: Current Concepts. Journal of Periodontology (Publmed), 322–331. Sokovicx́ , M., Glamočlija, J., Marin, P. D., Brkić, D., & Van Griensven, L. J. L. D. (2010). Antibacterial effects of the essential oils of commonly consumed medicinal herbs using an in vitro model. Molecules, 15(11), 7532–7546. https://doi.org/10.3390/molecules15117532 Soukoulis, S., & Hirsch, R. (2004). The effects of a tea tree oil-containing gel on plaque and chronic gingivitis. Australian Dental Journal, (2), 78–83. Standards, I. C. and laboratory. (2012). MÉTODO DE DETERMINACIÓN DE SENSIBILIDAD ANTIMICROBIANA POR DILUCIÓN. Manual of Antimicrobial Susceptibility Testing (Vol. 32). Takarada, K., Kimizuka, R., Takahashi, N., & Homma, K. (2004). A comparison of the antibacterial efficacies of essential oils againts oral pathogens. Oral Microbiology and Inmunology, 61–64. the International Organization for Standardization. Microbiology of food, animal feed and water — Preparation, production, storage and performance testing of culture media, Pub. L. No. ISO 11133:2014 (2014). Retrieved from https://www.iso.org/obp/ui/#iso:std:iso:11133:ed-1:v2:en Vreven, J. (2005). Antibacterial activity of glass – ionomer cements , compomers and resin composites : relationship between acidity and material setting phase, 1, 368–374 Wiley, J. (2013). Risk factors for periodontal disease. Publmed, 62, 59–94. Zhang, X., Guo, Y., Guo, L., Jiang, H., & Ji, Q. (2018). In Vitro Evaluation of Antioxidant and Antimicrobial Activities of Melaleuca alternifolia Essential Oil . BioMed Research International, 2018, 1–8. https://doi.org/10.1155/2018/2396109 |
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Ramos Rueda, Viviana, dir.Gómez, Johan SebastiánSerrano, Danna Marcela2019-08-13T19:58:16Z2019-08-13T19:58:16Z2019https://repository.udca.edu.co/handle/11158/1956QF047 G65e 2019 (205622)84 páginas : gráficasCurrently the resistance of microorganisms to antimicrobials is a serious health problem throughout the world, because many of the mechanisms can be intrinsic or adaptive. The indiscriminate and irrational use of drugs is the main cause of the seriousness of the situation that is presented today, therefore, the purpose of this study is to evaluate the effect of the essential oil of the plant species Melaleuca alternifolia (tea tree) and the hydroalcoholic extract of Matricaria chamomilla (chamomile) against the microorganism S. sanguinis, which participates in the progression of dental caries and in periodontal disease. Additionally, the antimicrobial activity of the combination of the tea tree and chamomile against S. sanguinis was evaluated. The microdilution method was used to determine the "in vitro" antimicrobial activity of the extracts separately and in combination, this test was carried out with different concentrations of the tea tree essential oil and the hydroalcoholic extract of chamomile according to the indications of Clinical and Laboratory Standars Institute. The microorganism used was Streptococcus sanguinis. The antimicrobial susceptibility tests showed that both plant extracts inhibited the growth of S sanguinis, the effect of the combination of tea tree oil and chamomile potentium the minimum inhibitory concentration increasing its value two dilutions above the minimum inhibitory concentration compared to the minimum individual inhibitory concentration of the two extracts. It is concluded that the combination of plant extracts could be an alternative treatment for the disease of periodontitis caused by S. sanguinisActualmente la resistencia de los microorganismos a los antimicrobianos constituye un grave problema de salud en todo el mundo, debido a que muchos de los mecanismos pueden ser intrínsecos o adaptativos. El uso indiscriminado e irracional de fármacos constituye la principal causa de la gravedad de la situación que hoy se presenta, por tanto, el propósito de este estudio es evaluar el efecto del aceite esencial de la especie vegetal Melaleuca alternifolia (árbol de té) y del extracto hidroalcohólico de Matricaria chamomilla (manzanilla) frente al microorganismo S. sanguinis, el cual participa en la progresión de la caries dental y en la enfermedad periodontal. Adicionalmente se evaluó la actividad antimicrobiana de la combinación del árbol de te y manzanilla frente a S. sanguinis. Se utilizó el método de microdilución para determinar la actividad antimicrobiana “in vitro” de los extractos por separado y en combinación, esta prueba se realizó con diferentes concentraciones del aceite esencial de árbol de te y del extracto hidroalcohólico de manzanilla según las indicaciones de Clinical and Laboratory Standars Institute. El microorganismo empleado fue Streptococcus sanguinis. Los ensayos de susceptibilidad antimicrobiana demostraron que ambos extractos vegetales inhibieron el crecimiento del S sanguinis, el efecto de la combinación del aceite de árbol de té y manzanilla potencio la concentración mínima inhibitoria incrementando su valor dos diluciones por encima de la concentración mínima inhibitoria en comparación con la concentración mínima inhibitoria individual de los dos extractos. Se concluye que la combinación de los extractos vegetales podría ser una alternativa de tratamiento para la enfermedad de periodontitis causada por S. sanguinis.Incluye bibliografíaPregradoQuímico(a) Farmacéuticoapplication/pdfspaBogotá : Universidad de Ciencias Aplicadas y Ambientales, 2019Facultad de CienciasQuímica FarmacéuticaDerechos Reservados - Universidad de Ciencias Aplicadas y Ambientaleshttps://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)http://purl.org/coar/access_right/c_abf2Análisis químico de las plantasStreptococcusChamomillaExtractos vegetalesAntimicrobianosMelaleuca alternifoliaEvaluación de la actividad antimicrobiana del extracto Hidroalcohólico de matricaria Chamomilla en combinación con el aceite Esencial de melaleuca alternifolia contra la cepa de streptococcus sanguinis una bacteria asociada a periodontitis crónica y la halitosisTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/publishedVersionTexthttp://purl.org/redcol/resource_type/TPhttp://purl.org/coar/version/c_970fb48d4fbd8a85Abiko, Y., Sato, T., Mayanagi, G., & Takahashi, N. 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en las Obras Colectivas;
b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda;
c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas.Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).
4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:
a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).
b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.
c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.
d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:
i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.
ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.
e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, Acinpro), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.
5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.
6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.
7. Término.
a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.
b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.
8. Varios.
a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.
b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.
c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.
d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.

 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