Biología de redes del interactoma de las estatinas

Statins are a group of drugs that act by inhibiting HMG-CoA reductase, an enzyme essential for the synthesis of cholesterol; medications used as first-line treatment for atherosclerotic and cardiovascular diseases as well as for secondary prevention of cardiovascular diseases. The description of the pleiotropic effects that have been the subject of attention in the scientific community due to its controversy has been evidenced. To date an integrated network of statins is not described and where it acts on proteins, their consequent actions and effects within the human being, by means of bioinformatic tools how to relate the pleiotropic effects, according to the results of biological function within the protein-protein interaction network and the statin molecule. The objective of this work is to build a network of protein - protein interaction with specific data of the molecular structure of statins. The subnets of six statins were reconstructed using STITCH 5.0 and were integrated into Cytoscape 3.5.1 using the Merge function. The integrated network was analyzed using the Network Ramdomizer plugin. Statistical degree (k), intermediation (BC), centrality (CC), Strees and Clustering Coefficient were obtained using the NetworkAnalyzer plugin. The degree of functional richness was determined using the MCODE and BiNGO plugins. It was determined that the networks obtained for each statin can interact with about 30 human protein proteins each; The integrated network consisted of 34 nodes and 124 connections. Statins act in the regulation of lipid metabolism, possible secondary targets were identified that could be involved in cellular processes such as vasodilation, anticoagulation, apoptosis, cell differentiation, cell cycle control, immunomodulation.As conclusions of the study, statins affect biological processes beyond lipid metabolism, acting on vasodilation, anticoagulation and cellular apoptosis, indicating that they may be related to the pleiotropic effects of the pharmacological group.

• Autores: Torres Sierra, Juan Sebastián
• Tipo de recurso: Trabajo de grado de pregrado
• Fecha de publicación: 2017
• Institución: Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
• Repositorio: Repositorio Institucional UDCA
• Idioma: spa
• OAI Identifier: oai:repository.udca.edu.co:11158/823
• Acceso en línea: https://repository.udca.edu.co/handle/11158/823
• Palabra clave: Estatinas; Interactoma; Biología de redes; Ateroesclerosis; Pleiotropicos; Estatinas (Agentes cardiovasculares) -- Investigaciones; Aterosclerosis -- Tratamiento; Aterosclerosis -- Investigaciones; Medicina
• Rights: closedAccess
• License: Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales