The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents

Colombia

Autores:
Ríos Ospina, Luisa
Soto de León, Sara Cecilia
Camargo, Milena
Sánchez, Ricardo
Mancilla, Cindy Lizeth
Patarroyo, Manuel Elkin
Patarroyo, Manuel Alfonso
Tipo de recurso:
Article of journal
Fecha de publicación:
2016
Institución:
Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
Repositorio:
Repositorio Institucional UDCA
Idioma:
eng
OAI Identifier:
oai:repository.udca.edu.co:11158/2507
Acceso en línea:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0166502
Palabra clave:
Virus ADN
Infecciones por Papillomavirus
Adolescente
Enfermedades de Transmisión Sexual
Virus DNA
Adolescent
Genotype distribution
Papillomavirus Infections
Uterine Cervical Neoplasms
Rights
openAccess
License
Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales
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dc.title.spa.fl_str_mv The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents
title The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents
spellingShingle The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents
Virus ADN
Infecciones por Papillomavirus
Adolescente
Enfermedades de Transmisión Sexual
Virus DNA
Adolescent
Genotype distribution
Papillomavirus Infections
Uterine Cervical Neoplasms
title_short The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents
title_full The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents
title_fullStr The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents
title_full_unstemmed The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents
title_sort The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents
dc.creator.fl_str_mv Ríos Ospina, Luisa
Soto de León, Sara Cecilia
Camargo, Milena
Sánchez, Ricardo
Mancilla, Cindy Lizeth
Patarroyo, Manuel Elkin
Patarroyo, Manuel Alfonso
dc.contributor.author.spa.fl_str_mv Ríos Ospina, Luisa
Soto de León, Sara Cecilia
Camargo, Milena
Sánchez, Ricardo
Mancilla, Cindy Lizeth
Patarroyo, Manuel Elkin
Patarroyo, Manuel Alfonso
dc.subject.mesh.spa.fl_str_mv Virus ADN
Infecciones por Papillomavirus
Adolescente
Enfermedades de Transmisión Sexual
topic Virus ADN
Infecciones por Papillomavirus
Adolescente
Enfermedades de Transmisión Sexual
Virus DNA
Adolescent
Genotype distribution
Papillomavirus Infections
Uterine Cervical Neoplasms
dc.subject.proposal.spa.fl_str_mv Virus DNA
Adolescent
Genotype distribution
Papillomavirus Infections
Uterine Cervical Neoplasms
description Colombia
publishDate 2016
dc.date.issued.spa.fl_str_mv 2016
dc.date.accessioned.spa.fl_str_mv 2019-11-14T20:57:33Z
dc.date.available.spa.fl_str_mv 2019-11-14T20:57:33Z
dc.type.spa.fl_str_mv Artículo de revista
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dc.identifier.citation.spa.fl_str_mv Río-Ospina, L. D., León, S. C. S. -., Camargo, M., Sánchez, R., Mancilla, C. L., Patarroyo, M. E., & Patarroyo, M. A. (2016). The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents. PLoS ONE, 11(11) doi:10.1371/journal.pone.0166502
dc.identifier.uri.spa.fl_str_mv https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0166502
dc.identifier.doi.spa.fl_str_mv 10.1371/journal.pone.0166502
identifier_str_mv Río-Ospina, L. D., León, S. C. S. -., Camargo, M., Sánchez, R., Mancilla, C. L., Patarroyo, M. E., & Patarroyo, M. A. (2016). The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents. PLoS ONE, 11(11) doi:10.1371/journal.pone.0166502
10.1371/journal.pone.0166502
url https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0166502
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv PLoS ONE;Vol.11, No,11, Nov 2016 rticle number e0166502 páginas 1-15
dc.rights.spa.fl_str_mv Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales
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rights_invalid_str_mv Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales
https://creativecommons.org/licenses/by-sa/4.0/
Atribución-CompartirIgual 4.0 Internacional (CC BY-SA 4.0)
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spelling Ríos Ospina, LuisaSoto de León, Sara CeciliaCamargo, MilenaSánchez, RicardoMancilla, Cindy LizethPatarroyo, Manuel ElkinPatarroyo, Manuel Alfonso2019-11-14T20:57:33Z2019-11-14T20:57:33Z2016Río-Ospina, L. D., León, S. C. S. -., Camargo, M., Sánchez, R., Mancilla, C. L., Patarroyo, M. E., & Patarroyo, M. A. (2016). The prevalence of high-risk HPV types and factors determining infection in female colombian adolescents. PLoS ONE, 11(11) doi:10.1371/journal.pone.0166502https://journals.plos.org/plosone/article?id=10.1371/journal.pone.016650210.1371/journal.pone.0166502ColombiaThis study reports six HR-HPV types' infection prevalence discriminated by species and multiple infection in unvaccinated Colombian female adolescents, as well as some factors modulating the risk of infection. HPV DNA for six high-risk viral types was identified in cervical samples taken from 2,134 12-19 year-old females using conventional generic and typespecific PCR. Binomial logistical regression analysis was used for modelling HR-HPV infection and multiple infection risk. The interaction between variables in a stepwise model was also included in such analysis. Viral DNA was detected in 48.97% of the females; 28.52% of them had multiple infections, HPV-16 being the most frequently occurring type (37.44%). Cytological abnormality prevalence was 15.61%. Being over 16 years-old (1.66: 1.01-2.71 95%CI), white ethnicity (4.40: 1.16-16.73 95%CI), having had 3 or more sexual partners (1.77: 1.11-2.81 95%CI) and prior sexually-transmitted infections (STI) (1.65: 1.17-2.32 95%CI) were associated with a greater risk of HPV infection. Having given birth was related to a higher risk of infection by A7 species and antecedent of abortion to less risk of coinfection. Where the females in this study came from also influenced the risk of infection by A7 species as female adolescents from the Andean region had a lower risk of infection (0.42: 0.18-0.99 95%CI). The presence of factors related to risky sexual behaviour in the study population indicated that public health services should pay special attention to female adolescents to modify the risk of infection by high-risk HPV types and decrease their impact on this age group.application/pdfengPLoS ONE;Vol.11, No,11, Nov 2016 rticle number e0166502 páginas 1-15Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientaleshttps://creativecommons.org/licenses/by-sa/4.0/info:eu-repo/semantics/openAccessAtribución-CompartirIgual 4.0 Internacional (CC BY-SA 4.0)http://purl.org/coar/access_right/c_abf2https://www.scopus.com/search/form.uri?display=basichttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0166502Virus ADNInfecciones por PapillomavirusAdolescenteEnfermedades de Transmisión SexualVirus DNAAdolescentGenotype distributionPapillomavirus InfectionsUterine Cervical NeoplasmsThe prevalence of high-risk HPV types and factors determining infection in female colombian adolescentsArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionTexthttp://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85PublicationORIGINALThe Prevalence of High-Risk HPV Types.pdfThe Prevalence of High-Risk HPV Types.pdfapplication/pdf1405738https://repository.udca.edu.co/bitstreams/3e63a4b1-a43d-49c5-9e8b-28781baf6302/download99e0037fbc01fc5e604c8be2c133ee52MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-814775https://repository.udca.edu.co/bitstreams/e87bb007-ba0f-40e4-bb43-92eed73e5a0d/downloadf661acf14bedbf9f5d13897a0387e751MD52TEXTThe Prevalence of High-Risk HPV Types.pdf.txtThe Prevalence of High-Risk HPV Types.pdf.txtExtracted texttext/plain49593https://repository.udca.edu.co/bitstreams/5b436716-c952-49da-b5d9-aeb3925e9696/downloadc24e9e7d05c511e7f44c52ba7c83f4a3MD53THUMBNAILThe Prevalence of High-Risk HPV Types.pdf.jpgThe Prevalence of High-Risk HPV Types.pdf.jpgGenerated Thumbnailimage/jpeg6964https://repository.udca.edu.co/bitstreams/09e79c52-8741-44e7-8f22-efd4201d5bff/download566495765866c89db647c6ab12785340MD5411158/2507oai:repository.udca.edu.co:11158/25072024-05-09 14:23:13.348https://creativecommons.org/licenses/by-sa/4.0/Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientalesopen.accesshttps://repository.udca.edu.coRepositorio - Universidad de Ciencias Aplicadas y Ambientales 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en las Obras Colectivas;
b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda;
c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas.Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).
4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:
a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).
b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.
c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.
d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:
i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.
ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.
e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, Acinpro), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.
5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.
6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.
7. Término.
a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.
b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.
8. Varios.
a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.
b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.
c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.
d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.

