Aporte del químico farmacéutico a los desafíos relacionados con el desarrollo de productos de terapias avanzadas en Colombia
76 páginas : gráficas, ilustraciones
- Autores:
-
Jaimes Vega, Nathalia Andrea
Jiménez Cruz, Ronald Andrés
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2019
- Institución:
- Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
- Repositorio:
- Repositorio Institucional UDCA
- Idioma:
- spa
- OAI Identifier:
- oai:repository.udca.edu.co:11158/2748
- Acceso en línea:
- https://repository.udca.edu.co/handle/11158/2748
- Palabra clave:
- Terapéutica
Células Madre
Químicos farmacéuticos
- Rights
- openAccess
- License
- Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales
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Aporte del químico farmacéutico a los desafíos relacionados con el desarrollo de productos de terapias avanzadas en Colombia |
| title |
Aporte del químico farmacéutico a los desafíos relacionados con el desarrollo de productos de terapias avanzadas en Colombia |
| spellingShingle |
Aporte del químico farmacéutico a los desafíos relacionados con el desarrollo de productos de terapias avanzadas en Colombia Terapéutica Células Madre Químicos farmacéuticos |
| title_short |
Aporte del químico farmacéutico a los desafíos relacionados con el desarrollo de productos de terapias avanzadas en Colombia |
| title_full |
Aporte del químico farmacéutico a los desafíos relacionados con el desarrollo de productos de terapias avanzadas en Colombia |
| title_fullStr |
Aporte del químico farmacéutico a los desafíos relacionados con el desarrollo de productos de terapias avanzadas en Colombia |
| title_full_unstemmed |
Aporte del químico farmacéutico a los desafíos relacionados con el desarrollo de productos de terapias avanzadas en Colombia |
| title_sort |
Aporte del químico farmacéutico a los desafíos relacionados con el desarrollo de productos de terapias avanzadas en Colombia |
| dc.creator.fl_str_mv |
Jaimes Vega, Nathalia Andrea Jiménez Cruz, Ronald Andrés |
| dc.contributor.advisor.spa.fl_str_mv |
Jiménez Cruz, Ronald Andrés, dir. |
| dc.contributor.author.spa.fl_str_mv |
Jaimes Vega, Nathalia Andrea Jiménez Cruz, Ronald Andrés |
| dc.subject.mesh.spa.fl_str_mv |
Terapéutica Células Madre |
| topic |
Terapéutica Células Madre Químicos farmacéuticos |
| dc.subject.lemb.spa.fl_str_mv |
Químicos farmacéuticos |
| description |
76 páginas : gráficas, ilustraciones |
| publishDate |
2019 |
| dc.date.issued.spa.fl_str_mv |
2019 |
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2020-02-11T16:27:24Z |
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2020-02-11T16:27:24Z |
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Trabajo de grado - Pregrado |
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QF031 J13a 2019 (205833) |
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https://repository.udca.edu.co/handle/11158/2748 |
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Abbasalizadeh, S., & Baharvand, H. (2013). Technological progress and challenges towards cGMP manufacturing of human pluripotent stem cells based therapeutic products for allogeneic and autologous cell therapies. Biotechnology Advances, 31(8), 1600-1623. https://doi.org/10.1016/j.biotechadv.2013.08.009 Anatol, R., Arcidiacono, J., Bailey, A. M., Durfor, C. N., Fink, D. W., Holobaugh, P., … Witten, C. (2014). The Regulatory Process from Concept to Market. Principles of Tissue Engineering (Fourth Edition). Elsevier. https://doi.org/10.1016/B978-0-12-398358-9.00086-0 Atala, A. (2019). Principles of Tissue Engineering. Campbell-Walsh Urology (Eleventh E). Elsevier Inc. https://doi.org/10.1016/B978-1-4557-7567-5.00020-0 Ausubel, Lara J. Lopez, P. M., & Couture, L. A. (2011). GMP Scale-Up and Banking of Pluripotent Stem Cells for Cellular Therapy Applications. Human Pluripotent Stem Cells, 767, 147-159 Ayala, L. A. (2007). Medicina regenerativa y enfermedades cardiovasculares: Terapia con células madre, 5(2), 38-41. Baghbaderani, B. A., Tian, X., Neo, B. H., Burkall, A., Dimezzo, T., Sierra, G., … Rao, M. S. (2015). Stem Cell Reports. Stem Cell Reports, 5(4), 647-659. https://doi.org/10.1016/j.stemcr.2015.08.015 Ball, O., Robinson, S., Bure, K. I. M., Brindley, D. A., & Mccall, D. (2018). Bioprocessing automation in cell therapy manufacturing : Outcomes of special interest group automation workshop. Cytotherapy, 20(4), 592-599. https://doi.org/10.1016/j.jcyt.2018.01.005 Bravery, C. A., Carmen, J., Fong, T., Oprea, W., Hoogendoorn, K. H., Woda, J., … Hof, W. V. A. N. T. (2013). Potency assay development for cellular therapy products : an ISCT * review of the requirements and experiences in the industry. Journal of Cytotherapy, 15(1), 9-19.e9. https://doi.org/10.1016/j.jcyt.2012.10.008 Brien, F. J. O. (2011). Biomaterials & scaffolds for tissue engineering. 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Cell , tissue and gene products with marketing authorization in 2018 worldwide. Cytotherapy, 20(11), 1401- 1413. https://doi.org/10.1016/j.jcyt.2018.09.010 Detela, G., & Lodge, A. (2016). Manufacturing process development of ATMPs within a regulatory framework for EU clinical trial & marketing authorisation applications. Cell and gene therapy insights, 425-452. https://doi.org/10.18609/cgti.2016.056 Deusen, A. L. Van. (2016). 6 - Compatibility of GxP with Existing Cell Therapy Quality Standards. Guide to Cell Therapy GxP. Elsevier Inc. https://doi.org/10.1016/B978-0-12-803115-5.00006-1 Dotti, G., & Brenner, M. K. (2019). Chapter 100 - T-Cell Therapy of Hematologic Diseases. En Hematology (Seventh Ed, pp. 1568-1574). Elsevier Inc. https://doi.org/10.1016/B978-0-323-35762-3.00100-1 Duvall, C. L., Gersbach, C. A., & Davidson, J. M. (2014). Gene Delivery into Cells and Tissues. https://doi.org/10.1016/B978-0-12-398358-9.00035-5 Eaker, S., Abraham, E., Allickson, J., Brieva, T. A., Baksh, D., Heathman, T. R. J., … Zhang, N. A. N. (2017). Bioreactors for cell therapies : Current status and future advances. Cytotherapy, 19(1), 9-18. https://doi.org/10.1016/j.jcyt.2016.09.011 Fernández Collado, C., & Baptista Lucio, P. (2014). Metodología de la Investigación. (McGrawHill, Ed.) (6a ed.). México, D.F. Foss, D. V, Hochstrasser, M. L., & Wilson, R. C. (2018). Clinical applications of CRISPR-based genome editing and diagnostics. Transfusion, 0, 1-11. https://doi.org/10.1111/trf.15126 Freimark, D., Pino-Grace, P.-, Pohl, S., Weber, C., Wallrapp, C., & Geigle, P. (2010). Use of encapsulated stem cells to overcome the bottleneck of cell availability for cell therapy approaches. Transfusion Medicine Hemotherapy, 37, 66-73. Fundación Mencía. (2017). Fundación Mencía. Recuperado a partir de http://www.fundacionmencia.org/es/enfermedades-geneticas/terapia-genica/ Furth, M. E., Atala, A., Innovations, W. F., & Carolina, N. (2014). Tissue Engineering : Future Perspectives. Principles of Tissue Engineering (Fourth Edition). Elsevier. https://doi.org/10.1016/B978-0-12-398358-9.00006-9 García, S. C. (2012). Gen ajeno o exógeno : transgén, 4, 187-199. Gavin, D. K., & Ph, D. (s. f.). Advanced Topics : Successful Development of Quality Cell and Gene Therapy Products Division of Cellular and Gene Therapies. Gee, A. P. (2009). Cell therapy: cGMP Facilities and Manufacturing. (A. P. Gee, Ed.) (1.a ed.). Houston, TX: Springer US. https://doi.org/10.1007/b102110 Gee, A. P. (2019). Chapter 97 - Graft Engineering and Cell Processing. Hematology (Seventh Ed). Elsevier Inc. https://doi.org/10.1016/B978-0-323-35762-3.00097- 4 Gilbert, T. W., Sellaro, T. L., & Badylak, S. F. (2006). Decellularization of tissues and organs. Biomaterials, 27, 3675-3683. https://doi.org/10.1016/j.biomaterials.2006.02.014 Guzmán Cruz, J. H., & Otálvaro Cifuentes, E. H. (2016). PERSPECTIVA DE TERAPIAS AVANZADAS EN EL MARCO NORMATIVO. Cartagena: INVIMA. Hernández Ramírez, P. (2006). Medicina regenerativa II. Aplicaciones, realidad y perspectivas de la terapia celular. Revista Cubana de Hematología, Inmunología y Hemoterapia, 22(1). Recuperado a partir de http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864- 02892006000100002 Hildebrand, M., & Hochschule, M. (2011). Manufacture of advanced therapies : Academia meets industry, 8(7), 9-10 House of Lords Science and Technology Committee. (2013). Regenerative medicine report. London. Human, T. H. E., Stem, E., Human, T. H. E., & Germ, E. (1998). THE HUMAN EMBRYONIC STEM CELL AND, 11-22 Iglesias-lópez, C., Agustí, A., Obach, M., & Vallano, A. (2019). Regulatory Framework for Advanced Therapy Medicinal Products in Europe and United States, 10(August), 1-14. https://doi.org/10.3389/fphar.2019.00921 Iyer, R. K., Bowles, P. A., Kim, H., & Dulgar-tulloch, A. (2018). Industrializing Autologous Adoptive Immunotherapies : Manufacturing Advances and Challenges, 5(May), 1-9. https://doi.org/10.3389/fmed.2018.00150 Jones, J. (2005). Scaffolds for tissue engineering. En Biomaterials, artificial organs and tissue engineering (pp. 201-214). https://doi.org/10.1533/9781845690861.4.201 Kalra, K., & Tomar, P. C. (s. f.). Stem Cell : Basics , Classification and Applications Karginov, F., & Hannon, G. (2010). The CRISPR System: Small RNA-Guided Defense in Bacteria and Archaea Molecular Cell. Molecular Cell, 37(1), 7-19. https://doi.org/10.1016/j.molcel.2009.12.033 Khademhosseini, A., Karp, J. M., Gerecht-nir, S., Ferreira, L., Annabi, N., Sirabella, D., & Vunjak-novakovic, G. (2014). Embryonic Stem Cells as a Cell Source for Tissue Engineering. Principles of Tissue Engineering (Fourth Edition). Elsevier. https://doi.org/10.1016/B978-0-12-398358-9.00032-X Kulinets, I. (2015). Biomaterials and their applications in medicine. En Regulatory Affairs for Biomaterials and Medical Devices (pp. 1-10). Woodhead Publishing Limited. https://doi.org/10.1533/9780857099204.1 Lindblad, R., Mondoro, T. H., & Wood, D. (2019). INVESTIGATIONAL NEW DRUG – ENABLING PROCESSES FOR CELL-BASED THERAPIES. Hematology (Seventh Ed). Elsevier Inc. https://doi.org/10.1016/B978-0-323- 35762-3.00096-2 Lowry, W. E., & Quan, W. L. (2010). Roadblocks en route to the clinical application of induced pluripotent stem cells. Journal of Cell Science, 123, 643-651. Ma, R., Schaer, M., Hogan, M., Demange, M., & Rodeo, S. A. (2019). Orthobiologics : Clinical Application of Platelet-Rich Plasma and Stem Cell Therapy. DeLee, Drez, and Miller’s Orthopaedic Sports Medicine (Fourth Edi). Elsevier Inc. https://doi.org/10.1016/B978-1-4557-4376-6.00005-6 Manuscript, A. (2013). NIH Public Access, 18(3), 217-222. https://doi.org/10.1111/j.1601-0825.2011.01870.x.The María, D., & Ibarz, T. (s. f.). Desafíos en la Regulación de Nuevos Productos Biológicos : Terapia Génica , Celular y Tisular Terapia Génica , Celular y Tisular Estrategias terapéuticas innovadoras que ofrecen nuevas oportunidades para algunas enfermedades que carecen de. MarketsandMarkets. (2019). Regenerative Medicine Market by Type. US Martin, G. (1981). Isolation of a pluripoten cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc. Natl Acad. Sci. USA, 78. Martin, U. (2017). Therapeutic Application of Pluripotent Stem Cells : Challenges and Risks, 4(December). https://doi.org/10.3389/fmed.2017.00229 Mason, C., & Brindley, D. A. (2011). Cell therapy industry : billion dollar global business with unlimited potential E ditorial. Regenerative Medicine, 6(3), 265- 272 Moffat, K. L., Neal, R. A., Freed, L. E., & Guilak, F. (2014). Engineering Functional Tissues : In Vitro Culture Parameters. Principles of Tissue Engineering (Fourth Edition). 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National Institutes of Health Recuperado a partir de https://stemcells.nih.gov/info/basics.htm United States Adopted Names. (2016). American Medical Association. Recuperado a partir de https://www.ama-assn.org/about/united-states-adopted-names/cellularnoncellular-therapies-naming-scheme Worgall, S., & Crystal, R. G. (2014). Gene Therapy. Principles of Tissue Engineering (Fourth Edition). Elsevier. https://doi.org/10.1016/B978-0-12-398358-9.00034-3 Yu, J., & Thomson, J. A. (2001). 1. embryonic stem cells, 1-12. Zafar, M. S., Ullah, R., Qamar, Z., Fareed, M. A., Amin, F., Khurshid, Z., & Sefat, F. (2019). Properties of dental biomaterials. En F. S. Zohaib Khurshid, Shariq Najeeb, Muhammad Sohail Zafar (Ed.), Advanced Dental Biomaterials (1.a ed., pp. 7-35). Woodhead Publishing Limited. https://doi.org/https://doi.org/10.1016/B978-0-08-102476-8.00002-5 Zakrzewski, W., Dobrzy, M., Szymonowicz, M., & Rybak, Z. (2019). Stem cells : past , present , and future, 5, 1-22. Zhou, W., & Kantardjieff, A. (s. f.). Mammalian Cell Cultures for Biologics Manufacturing. |
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Jiménez Cruz, Ronald Andrés, dir.Jaimes Vega, Nathalia AndreaJiménez Cruz, Ronald Andrés2020-02-11T16:27:24Z2020-02-11T16:27:24Z2019https://repository.udca.edu.co/handle/11158/2748QF031 J13a 2019 (205833)76 páginas : gráficas, ilustracionesEsta investigación busca analizar el aporte del Químico Farmacéutico en el desarrollo de productos de terapias avanzadas en Colombia, identificar los principales desafíos a nivel regulatorio para la implementación de productos de terapiasIncluye bibliografíaPregradoQuímico(a) Farmacéuticoapplication/pdfspaBogotá : Universidad de Ciencias Aplicadas y Ambientales, 2019Facultad de CienciasQuímica FarmacéuticaDerechos Reservados - Universidad de Ciencias Aplicadas y Ambientaleshttps://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)http://purl.org/coar/access_right/c_abf2TerapéuticaCélulas MadreQuímicos farmacéuticosAporte del químico farmacéutico a los desafíos relacionados con el desarrollo de productos de terapias avanzadas en ColombiaTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/publishedVersionTexthttp://purl.org/redcol/resource_type/TPhttp://purl.org/coar/version/c_970fb48d4fbd8a85Abbasalizadeh, S., & Baharvand, H. 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Mammalian Cell Cultures for Biologics Manufacturing.PublicationORIGINALProyecto final para CD.pdfProyecto final para CD.pdfapplication/pdf2219774https://repository.udca.edu.co/bitstreams/88435b6b-3ab1-4773-bc06-1b605b4966b2/download642fd6a5bf798d434d69906918a922acMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-814775https://repository.udca.edu.co/bitstreams/0b0a7864-8728-45d3-896c-e118626d9cd9/downloadf661acf14bedbf9f5d13897a0387e751MD52TEXTProyecto final para CD.pdf.txtProyecto final para CD.pdf.txtExtracted texttext/plain120221https://repository.udca.edu.co/bitstreams/c4e12f76-4a99-47e6-8136-39a0a168b0d8/downloadd60833046d465fd998eed77a2dc1cad8MD53THUMBNAILProyecto final para CD.pdf.jpgProyecto final para CD.pdf.jpgGenerated Thumbnailimage/jpeg3921https://repository.udca.edu.co/bitstreams/4b427c59-577a-4ef7-b268-086f8bb387e3/download630f827aed9b84fe2e61a64143c88cf5MD5411158/2748oai:repository.udca.edu.co:11158/27482024-05-09 14:29:44.96https://creativecommons.org/licenses/by-nc-sa/4.0/Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientalesopen.accesshttps://repository.udca.edu.coRepositorio - Universidad de Ciencias Aplicadas y Ambientales 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en las Obras Colectivas;
b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda;
c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas.Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).
4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:
a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).
b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.
c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.
d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:
i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.
ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.
e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, Acinpro), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.
5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.
6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.
7. Término.
a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.
b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.
8. Varios.
a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.
b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.
c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.
d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.

 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