Glicoterapia para la prevención de enfermedades infecciosas respiratorias de origen bacteriano
24 páginas : gráficas
- Autores:
-
Niviayo Barbosa, Estefanía
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2019
- Institución:
- Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
- Repositorio:
- Repositorio Institucional UDCA
- Idioma:
- spa
- OAI Identifier:
- oai:repository.udca.edu.co:11158/1408
- Acceso en línea:
- https://repository.udca.edu.co/handle/11158/1408
- Palabra clave:
- Enfermedades infecciosas (Veterinaria)
Enfermedades bacterianas en animales
Conejos -- Enfermedades
Medicina Veterinaria
Cúnicula
P.multocida
LPS
Adhesión
Terapia anti adhesiva
Azúcares
Carbohidratos
Patógeno
- Rights
- openAccess
- License
- Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales
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Glicoterapia para la prevención de enfermedades infecciosas respiratorias de origen bacteriano |
| title |
Glicoterapia para la prevención de enfermedades infecciosas respiratorias de origen bacteriano |
| spellingShingle |
Glicoterapia para la prevención de enfermedades infecciosas respiratorias de origen bacteriano Enfermedades infecciosas (Veterinaria) Enfermedades bacterianas en animales Conejos -- Enfermedades Medicina Veterinaria Cúnicula P.multocida LPS Adhesión Terapia anti adhesiva Azúcares Carbohidratos Patógeno |
| title_short |
Glicoterapia para la prevención de enfermedades infecciosas respiratorias de origen bacteriano |
| title_full |
Glicoterapia para la prevención de enfermedades infecciosas respiratorias de origen bacteriano |
| title_fullStr |
Glicoterapia para la prevención de enfermedades infecciosas respiratorias de origen bacteriano |
| title_full_unstemmed |
Glicoterapia para la prevención de enfermedades infecciosas respiratorias de origen bacteriano |
| title_sort |
Glicoterapia para la prevención de enfermedades infecciosas respiratorias de origen bacteriano |
| dc.creator.fl_str_mv |
Niviayo Barbosa, Estefanía |
| dc.contributor.advisor.spa.fl_str_mv |
Gallego López, Carolina, dir. |
| dc.contributor.author.spa.fl_str_mv |
Niviayo Barbosa, Estefanía |
| dc.subject.lemb.spa.fl_str_mv |
Enfermedades infecciosas (Veterinaria) Enfermedades bacterianas en animales Conejos -- Enfermedades Medicina Veterinaria |
| topic |
Enfermedades infecciosas (Veterinaria) Enfermedades bacterianas en animales Conejos -- Enfermedades Medicina Veterinaria Cúnicula P.multocida LPS Adhesión Terapia anti adhesiva Azúcares Carbohidratos Patógeno |
| dc.subject.proposal.spa.fl_str_mv |
Cúnicula P.multocida LPS Adhesión Terapia anti adhesiva Azúcares Carbohidratos Patógeno |
| description |
24 páginas : gráficas |
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2019 |
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2019-05-13T21:09:11Z |
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2019-05-13T21:09:11Z |
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2019 |
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Trabajo de grado - Pregrado |
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MV004 N38g 2019 (205511) |
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spa |
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Al-Haddawi M. H., Jasni S., Zamri-Saad M., Mutalib A. R., Zulkifli I., Son R., & Sheikh-Omar A. R. (2000). In vitro study of Pasteurella multocida adhesion to trachea, lung and aorta of rabbits. Veterinary Journal, 159(3), 274–281. http://doi.org/10.1053/tvjl.1999.0418 Audfray A., Varrot A., & Imberty A. (2013). Bacteria love our sugars: Interaction between soluble lectins and human fucosylated glycans, structures, thermodynamics and design of competing glycocompounds. Comptes Rendus Chimie, 16(5), 482–490. http://doi.org/10.1016/j.crci.2012.11.021 Bavington C., & Page C. (2005). Stopping bacterial adhesion: A novel approach to treating infections. Respiration, 72(4), 335–344. http://doi.org/10.1159/000086243 Campuzano V. M., González A. D., Hernández R., Suárez F., Trigo F. J., & Jaramillo C. J. (2011). Caracterización fenotípica y molecular de cepas de Pasteurella multocida aisladas de exudado nasal de bovinos, en dos cuencas lecheras de México. Veterinaria México, 42(1), 1-10. http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0301- 50922011000100001&lng=es&tlng=es. Carrillo M. (2013). Utilización de lectinas en la inhibición de la adhesión de Pasteurella multocida. Revista Medicina Veterinaria, 1(25), 93–107. Retrieved from http://www.scielo.org.co/pdf/rmv/n25/n25a09 Cusumano Z., Klein R., Hultgren S. (2016). Innovative Solutions to Sticky Situations: Antiadhesive Strategies for Treating Bacterial Infections. Microbiol Spectrum 4(2):VMBF-0023-2015. doi:10.1128/microbiolspec.VMBF-0023-2015. Dabo S. M., Confer A., Montelongo M., York P., & Wyckoff J. H. (2008). Vaccination with Pasteurella multocida recombinant OmpA induces strong but non-protective and deleterious Th2-type immune response in mice. Vaccine, 26(34), 4345–4351. http://doi.org/10.1016/j.vaccine.2008.06.029 Dagleish M. P., Finlayson J., Bayne C., MacDonald S., Sales J., & Hodgson J. C. (2010). Characterization and time course of pulmonary lesions in calves after intratracheal infection with Pasteurella multocida A:3. Journal of Comparative Pathology, 142(2–3), 157–169. http://doi.org/10.1016/j.jcpa.2009.10.015 DiGiacomo R.F., Jones C.D., W. C. M. (1987). Transmission of Pasteurella multocida in rabbits. Laboratory Animals Science, 37(5), 621–623. Dziva F., Muhairwa A. P., Bisgaard M., & Christensen H. (2008). Diagnostic and typing options for investigating diseases associated with Pasteurella multocida. Veterinary Microbiology, 128(1–2), 1–22. http://doi.org/10.1016/j.vetmic.2007.10.018 Flannery A., Gerlach JQ, Joshi L., y Kilcoyne M. (2015). Evaluación de las interacciones bacterianas utilizando microarrays basados en carbohidratos. Microarrays (Basilea, Suiza) , 4 (4), 690-713. doi: 10.3390 / microarrays4040690 Gaertner D.J. (1991). Comparison of penicillin and gentamicin for treatment of pasteurellosis in rabbits. Laboratory Animals Science, 41(1), 78–80. Gallego C., Romero S., Esquinas P., Patiño P., Martínez N., y Iregui C. (2017). Evaluación de Pasteurella multocida un lipopolisacárido, como Adhesin en un modelo in vitro de conejo epitelio respiratorio. Veterinaria Internacional , 2017 . https://doi.org/10.1155/2017/8967618 Glorioso J. C., Jones G. W., & Rush H. G. (1982). Adhesion of type A Pasteurella multocida to rabbit pharyngeal cells and its possible role in rabbit respiratory tract infections. Infection and Immunity, 35(3), 1103–1109. Harper M., Boyce JD, y Adler B. (2006). Patogénesis de Pasteurella multocida: 125 años después de Pasteur. Cartas de Microbiología FEMS. https://doi.org/10.1111/j.1574-6968.2006.00442.x Harper M., St.Michael F., John M., Vinogradov E., Steen J. A., van Dorsten L., Boycea J. D. (2013). Pasteurella multocida heddleston serovar 3 and 4 strains share a common lipopolysaccharide biosynthesis locus but display both inter- and intrastrain lipopolysaccharide heterogeneity. Journal of Bacteriology, 195(21), 4854–4864. http://doi.org/10.1128/JB.00779-13 Harper M., St. Michael, F., John M., Vinogradov E., Adler B., Boyce J. D., & Cox A. D. (2011). Pasteurella multocida Heddleston serovars 1 and 14 express different lipopolysaccharide structures but share the same lipopolysaccharide biosynthesis outer core locus. Veterinary Microbiology, 150(3–4), 289–296. http://doi.org/10.1016/j.vetmic.2011.01.028 Johansson E. M. V, Crusz S. A., Kolomiets E., Buts L., Kadam R. U., Cacciarini M., Reymond J. L. (2008). Inhibition and Dispersion of Pseudomonas aeruginosa Biofilms by Glycopeptide Dendrimers Targeting the Fucose-Specific Lectin LecB. Chemistry and Biology, 15(12), 1249–1257. http://doi.org/10.1016/j.chembiol.2008.10.009 Jordan R. W., & Roe J. M. (2004). An experimental mouse model of progressive atrophic rhinitis of swine. Veterinary Microbiology, 103(3), 201–207. http://doi.org/10.1016/j.vetmic.2004.07.006 Lane J. A., Mehra R. K., Carrington S. D. & Hickey R. M. (2010). The food glycome: A source of protection against pathogen colonization in the gastrointestinal tract. International Journal of Food Microbiology, 142(1–2), 1–13. http://doi.org/10.1016/j.ijfoodmicro.2010.05.027 Lennon FE, y Singleton PA. (2011). Papel de las proteínas de unión a hialuronano y hialuronano en la patobiología pulmonar. Revista Americana de Fisiología-Fisiología Celular y Molecular del Pulmón, 301 (2), L137 – L147. https://doi.org/10.1152/ajplung.00071.2010 Lennox A. M., & Kelleher S. (2009). Bacterial and Parasitic Diseases of Rabbits. Veterinary Clinics of North America - Exotic Animal Practice, 12(3), 519–530. http://doi.org/10.1016/j.cvex.2009.06.004 Lu Y., Pakes S. P., Massy L., & Stefanu C. (1987). A potassium thiocyanate extract vaccine prepared from Pasteurella multocida 3:A protects rabbits against homologous challenge. Infection and Immunity, 55(12), 2967–2976. Massacci F. R., Magistrali C. F., Cucco L., Curcio L., Bano L., Mangili P. M., Christensen H. (2018). Characterization of Pasteurella multocida involved in rabbit infections. Veterinary Microbiology, 213, 66–72. https://doi.org/10.1016/j.vetmic.2017.11.023 Moonens K., & Remaut H. (2017). Evolution and structural dynamics of bacterial glycan binding adhesins. Current Opinion in Structural Biology. Elsevier Ltd. https://doi.org/10.1016/j.sbi.2016.12.003 Muto J., Yamasaki K., Taylor K. R., & Gallo R. L. (2009). Engagement of CD44 by hyaluronan suppresses TLR4 signaling and the septic response to LPS. Molecular Immunology, 47(2–3), 449–456. http://doi.org/10.1016/j.molimm.2009.08.026 Nassar S. A., Mohamed A. H., Soufy H., & Nasr S. M. (2013). Protective effect of Egyptian propolis against rabbit pasteurellosis. BioMed Research International, 2013. https://doi.org/10.1155/2013/163724 Ofek I., Hasty D. L., & Sharon N. (2003). Anti-adhesion therapy of bacterial diseases: Prospects and problems. FEMS Immunology and Medical Microbiology. Elsevier. https://doi.org/10.1016/S0928-8244(03)00228-1 Palócz O., Gál J., Clayton P., Dinya Z., Somogyi Z., Juhász C., & Csikó G. (2014). Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits. BMC Veterinary Research, 10(1). https://doi.org/10.1186/s12917-014-0276-6 Praveena P. E., Periasamy S., Kumar A. A., & Singh N. (2010). Cytokine profiles, apoptosis and pathology of experimental Pasteurella multocida serotype A1 infection in mice. Romero, CS (2010). Exposición simultánea y secuencial al lipopolisacárido de Pasteurella multocida ya la bacteria en los cultivos de la fosa nasal de conejo, 97. http://www.bdigital.unal.edu.co/6436/ Sattin S., & Bernardi A. (2016). Glycoconjugates and Glycomimetics as Microbial Anti-Adhesives. Trends in Biotechnology, 34(6), 483–495. http://doi.org/10.1016/j.tibtech.2016.01.004 Snowder G.D., Van Vleck L.D., Cundiff L.V., B. G. L. (2006). Bovine respiratory disease in feedlot cattle: environmental, genetic, and economic factors. Journal of Animal Science, 84(1999–2008). Vera Y.A., Ortiz J.F. (2015). Caracterización de Pasteurella multocida subsp multocida en la neumonía porcina. Facultad de Ingenierías y Arquitectura Universidad de Pamplona. http://revistas.unipamplona.edu.co/ojs_viceinves/index.php/ALIMEN/article/view/1 462/828 Viana D., & Selva L. (2007). Pasteurelosis: principal patología respiratoria en cunicultura industrial. Boletín de Cunicultura, ISSN 1696-6074 - 20061002. https://www.researchgate.net/publication/46246641 Zeng X., Andrade C. A. S., Oliveira M. D. L., & Sun X. L. (2012). Carbohydrateprotein interactions and their biosensing applications. Analytical and Bioanalytical Chemistry. https://doi.org/10.1007/s00216-011-5594-y |
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Gallego López, Carolina, dir.Niviayo Barbosa, Estefanía2019-05-13T21:09:11Z2019-05-13T21:09:11Z2019https://repository.udca.edu.co/handle/11158/1408MV004 N38g 2019 (205511)24 páginas : gráficasEn la mayoría de sistemas de producción, se hallan patógenos oportunistas los cuales son capaces de causar enfermedad, a pesar de ser parte de la microbiota normal del hospedero, llevando a grandes pérdidas económicas. Tal es el caso del sector cunicula el cual es altamente afectado por bacterias como Bordetella bronchiseptica y Pasteurella multocida. En el caso particular de la P.multocida, que es una bacteria gram negativa, patógena oportunista, que inicia la infección en el epitelio respiratorio de muchos animales, causando enfermedades como rinitis y neumonía enzootica especialmente en los conejos. Con ayuda de sus factores de virulencia los cuales expresan genes que efectúan la adhesión con las células epiteliales e inician su respectiva colonización bacteriana, tal es el caso del LPS el factor de virulencia más importante de las células Gram -. Dicha adhesión logro ser evadida en varios estudios con el uso de carbohidratos los cuales son utilizados como terapia antiadhesiva, logrando evitar la interacion entre patógeno y huésped, llevando a la prevención de la enfermedad, Tal es el caso de uso de propoleo egipcio, azúcares GlcNAc, AMeGlc y AMeMan, por otro lado también se han utilizado B-glucanos. Y la terapia antiadhesiva natural la cual es producida por el propio cuerpo. Estas nuevas soluciones ha dado una nueva perspectiva a la medicina y así evitar el uso de antibióticos los cuales dejan residuos en los subproductos de consumo, y reducir la creación de resistencia a los antimicrobianosIn most production systems, the motors of the disease have been described in a timely manner, despite being part of the normal microbiota of the host. Such is the case of the cunicula sector which is highly affected by bacteria such as Bordetella bronchiseptica and Pasteurella multocida. In the particular case of P.multocida, which is a gram-negative, opportunistic pathogen bacterium, which initiates infection in the respiratory epithelium of many animals, causing diseases such as rhinitis and enzootic pneumonia especially in rabbits. With the help of their virulence factors, which express genes that effect the adhesion with epithelial cells and initiate their respective bacterial colonization, as is the case of LPS, the most important virulence factor of gram - cells. The results of the search are based on several studies with the use of carbohydrates, which are used as anti-adhesive therapy, the monitoring of the interaction between the pathogen and the host, the maintenance of the disease, the case of use of Egyptian propolis , sugars GlcNAc, AMeGlc and AMeMan, on the other hand B-glucans have also been used. And natural anti-adhesive therapy which is produced by the body itself. These new solutions have given a new perspective to medicine and at the same time avoid the use of antibiotics waste and residues in consumer by-products, and reduce the creation of resistance to antimicrobials.Incluye bibliografíaPregradoMédico(a) Veterinarioapplication/pdfspaBogotá : Universidad de Ciencias Aplicadas y Ambientales, 2019Facultad de Ciencias AgropecuariasMedicina VeterinariaDerechos Reservados - Universidad de Ciencias Aplicadas y Ambientaleshttps://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)http://purl.org/coar/access_right/c_abf2Glicoterapia para la prevención de enfermedades infecciosas respiratorias de origen bacterianoTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/publishedVersionTexthttp://purl.org/redcol/resource_type/TPhttp://purl.org/coar/version/c_970fb48d4fbd8a85Enfermedades infecciosas (Veterinaria)Enfermedades bacterianas en animalesConejos -- EnfermedadesMedicina VeterinariaCúniculaP.multocidaLPSAdhesiónTerapia anti adhesivaAzúcaresCarbohidratosPatógenoAl-Haddawi M. H., Jasni S., Zamri-Saad M., Mutalib A. R., Zulkifli I., Son R., & Sheikh-Omar A. R. (2000). In vitro study of Pasteurella multocida adhesion to trachea, lung and aorta of rabbits. Veterinary Journal, 159(3), 274–281. http://doi.org/10.1053/tvjl.1999.0418Audfray A., Varrot A., & Imberty A. (2013). Bacteria love our sugars: Interaction between soluble lectins and human fucosylated glycans, structures, thermodynamics and design of competing glycocompounds. Comptes Rendus Chimie, 16(5), 482–490. http://doi.org/10.1016/j.crci.2012.11.021Bavington C., & Page C. (2005). Stopping bacterial adhesion: A novel approach to treating infections. Respiration, 72(4), 335–344. http://doi.org/10.1159/000086243Campuzano V. M., González A. D., Hernández R., Suárez F., Trigo F. J., & Jaramillo C. J. (2011). Caracterización fenotípica y molecular de cepas de Pasteurella multocida aisladas de exudado nasal de bovinos, en dos cuencas lecheras de México. Veterinaria México, 42(1), 1-10. http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0301- 50922011000100001&lng=es&tlng=es.Carrillo M. (2013). Utilización de lectinas en la inhibición de la adhesión de Pasteurella multocida. Revista Medicina Veterinaria, 1(25), 93–107. Retrieved from http://www.scielo.org.co/pdf/rmv/n25/n25a09Cusumano Z., Klein R., Hultgren S. (2016). Innovative Solutions to Sticky Situations: Antiadhesive Strategies for Treating Bacterial Infections. Microbiol Spectrum 4(2):VMBF-0023-2015. doi:10.1128/microbiolspec.VMBF-0023-2015.Dabo S. M., Confer A., Montelongo M., York P., & Wyckoff J. H. (2008). Vaccination with Pasteurella multocida recombinant OmpA induces strong but non-protective and deleterious Th2-type immune response in mice. Vaccine, 26(34), 4345–4351. http://doi.org/10.1016/j.vaccine.2008.06.029Dagleish M. P., Finlayson J., Bayne C., MacDonald S., Sales J., & Hodgson J. C. (2010). Characterization and time course of pulmonary lesions in calves after intratracheal infection with Pasteurella multocida A:3. Journal of Comparative Pathology, 142(2–3), 157–169. http://doi.org/10.1016/j.jcpa.2009.10.015DiGiacomo R.F., Jones C.D., W. C. M. (1987). Transmission of Pasteurella multocida in rabbits. Laboratory Animals Science, 37(5), 621–623.Dziva F., Muhairwa A. P., Bisgaard M., & Christensen H. (2008). Diagnostic and typing options for investigating diseases associated with Pasteurella multocida. Veterinary Microbiology, 128(1–2), 1–22. http://doi.org/10.1016/j.vetmic.2007.10.018Flannery A., Gerlach JQ, Joshi L., y Kilcoyne M. (2015). Evaluación de las interacciones bacterianas utilizando microarrays basados en carbohidratos. Microarrays (Basilea, Suiza) , 4 (4), 690-713. doi: 10.3390 / microarrays4040690Gaertner D.J. (1991). Comparison of penicillin and gentamicin for treatment of pasteurellosis in rabbits. Laboratory Animals Science, 41(1), 78–80.Gallego C., Romero S., Esquinas P., Patiño P., Martínez N., y Iregui C. (2017). Evaluación de Pasteurella multocida un lipopolisacárido, como Adhesin en un modelo in vitro de conejo epitelio respiratorio. Veterinaria Internacional , 2017 . https://doi.org/10.1155/2017/8967618Glorioso J. C., Jones G. W., & Rush H. G. (1982). Adhesion of type A Pasteurella multocida to rabbit pharyngeal cells and its possible role in rabbit respiratory tract infections. Infection and Immunity, 35(3), 1103–1109.Harper M., Boyce JD, y Adler B. (2006). Patogénesis de Pasteurella multocida: 125 años después de Pasteur. Cartas de Microbiología FEMS. https://doi.org/10.1111/j.1574-6968.2006.00442.xHarper M., St.Michael F., John M., Vinogradov E., Steen J. A., van Dorsten L., Boycea J. D. (2013). 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en las Obras Colectivas;
b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda;
c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas.Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).
4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:
a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).
b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.
c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.
d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:
i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.
ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.
e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, Acinpro), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.
5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.
6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.
7. Término.
a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.
b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.
8. Varios.
a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.
b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.
c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.
d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.

 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