Toxoplasma gondii in small ruminants in northeastern areas of Colombia: Seroprevalence and risk factors

Sheep and goats are susceptible to infections with Toxoplasma gondii and could play an important role in the transmission of the zoonotic parasite to human. We conducted a cross sectional study to estimate the seroprevalence and to assess the risk factors for T. gondii seropositivity in small rumina...

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Autores:
Martínez Rodríguez, Lorena C.
Tafur Gómez, Gabriel Andres
Guzmán Barragán, Blanca Lisseth
Tipo de recurso:
Article of journal
Fecha de publicación:
2020
Institución:
Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
Repositorio:
Repositorio Institucional UDCA
Idioma:
eng
OAI Identifier:
oai:repository.udca.edu.co:11158/3214
Acceso en línea:
https://udca.elogim.com:2119/science/article/pii/S2405673120300167/pdfft?md5=c6a1372678fbea0dcc385a297b6a2e3e&pid=1-s2.0-S2405673120300167-main.pdf
Palabra clave:
Goat
Risk factors
Seroprevalence
Sheep
Toxoplasma gondii
Cabra
Oveja
Toxoplasma gondii
Factores de riesgo
Rights
openAccess
License
Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales
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dc.title.spa.fl_str_mv Toxoplasma gondii in small ruminants in northeastern areas of Colombia: Seroprevalence and risk factors
title Toxoplasma gondii in small ruminants in northeastern areas of Colombia: Seroprevalence and risk factors
spellingShingle Toxoplasma gondii in small ruminants in northeastern areas of Colombia: Seroprevalence and risk factors
Goat
Risk factors
Seroprevalence
Sheep
Toxoplasma gondii
Cabra
Oveja
Toxoplasma gondii
Factores de riesgo
title_short Toxoplasma gondii in small ruminants in northeastern areas of Colombia: Seroprevalence and risk factors
title_full Toxoplasma gondii in small ruminants in northeastern areas of Colombia: Seroprevalence and risk factors
title_fullStr Toxoplasma gondii in small ruminants in northeastern areas of Colombia: Seroprevalence and risk factors
title_full_unstemmed Toxoplasma gondii in small ruminants in northeastern areas of Colombia: Seroprevalence and risk factors
title_sort Toxoplasma gondii in small ruminants in northeastern areas of Colombia: Seroprevalence and risk factors
dc.creator.fl_str_mv Martínez Rodríguez, Lorena C.
Tafur Gómez, Gabriel Andres
Guzmán Barragán, Blanca Lisseth
dc.contributor.author.spa.fl_str_mv Martínez Rodríguez, Lorena C.
Tafur Gómez, Gabriel Andres
Guzmán Barragán, Blanca Lisseth
dc.subject.proposal.spa.fl_str_mv Goat
Risk factors
Seroprevalence
Sheep
Toxoplasma gondii
topic Goat
Risk factors
Seroprevalence
Sheep
Toxoplasma gondii
Cabra
Oveja
Toxoplasma gondii
Factores de riesgo
dc.subject.agrovoc.spa.fl_str_mv Cabra
Oveja
Toxoplasma gondii
Factores de riesgo
description Sheep and goats are susceptible to infections with Toxoplasma gondii and could play an important role in the transmission of the zoonotic parasite to human. We conducted a cross sectional study to estimate the seroprevalence and to assess the risk factors for T. gondii seropositivity in small ruminants under traditional husbandry systems. This study was carried out from November 2015 to April 2016 in randomly selected small ruminants (n = 1038) from 48 farms located in Colombia, in the departments of northern Cesar in the north and La Guajira in the south. An indirect ELISA was used to detect IgG antibodies to T. gondii in the animals. A standardized questionnaire was used to obtain information on putative risk factors. We conducted the association analyses by using univariable and multivariate logistic regression and report odds ratios (OR) with 95% confidence interval (C.I). The overall seroprevalence in small ruminants was 23.5% (C.I: 21–26.2%). Sheep showed a higher seroprevalence (25.1% C.I: 22.4–28.6%) than goats (18.4% C.I: 22.4–28.6%). The association analysis recognized as risk factors for T. gondii seropositivity farming pigs in addition to small ruminants (OR = 1.96 C.I: 1.414–2.743), the inexistence of manure heap (OR = 2.254 C.I: 1.480–3.433) and drinking water from locally aqueducts (OR = 1.489 C.I: 1.006–2.204). The results of the study confirmed that exposure to T. gondii is common in sheep and goats in dry Caribbean regions of Colombia.
publishDate 2020
dc.date.accessioned.spa.fl_str_mv 2020-05-04T17:24:38Z
dc.date.available.spa.fl_str_mv 2020-05-04T17:24:38Z
dc.date.issued.spa.fl_str_mv 2020
dc.type.spa.fl_str_mv Artículo de revista
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dc.identifier.citation.spa.fl_str_mv Martínez-Rodriguez, L.C., Tafur-Gómez, G.A., Guzman-Barragan, B.L. Toxoplasma gondii in small ruminants in northeastern areas of Colombia: Seroprevalence and risk factors (2020) Parasite Epidemiology and Control, 10, art. no. e00147, .
dc.identifier.uri.spa.fl_str_mv https://udca.elogim.com:2119/science/article/pii/S2405673120300167/pdfft?md5=c6a1372678fbea0dcc385a297b6a2e3e&pid=1-s2.0-S2405673120300167-main.pdf
dc.identifier.doi.spa.fl_str_mv 10.1016/j.parepi.2020.e00147
identifier_str_mv Martínez-Rodriguez, L.C., Tafur-Gómez, G.A., Guzman-Barragan, B.L. Toxoplasma gondii in small ruminants in northeastern areas of Colombia: Seroprevalence and risk factors (2020) Parasite Epidemiology and Control, 10, art. no. e00147, .
10.1016/j.parepi.2020.e00147
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dc.relation.ispartofseries.spa.fl_str_mv Parasite Epidemiology and Control;Vol. 10, Ago 2020, Article number e00147
dc.relation.indexed.spa.fl_str_mv Agricultura
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spelling Martínez Rodríguez, Lorena C.Tafur Gómez, Gabriel AndresGuzmán Barragán, Blanca LissethColombia2020-05-04T17:24:38Z2020-05-04T17:24:38Z2020Martínez-Rodriguez, L.C., Tafur-Gómez, G.A., Guzman-Barragan, B.L. Toxoplasma gondii in small ruminants in northeastern areas of Colombia: Seroprevalence and risk factors (2020) Parasite Epidemiology and Control, 10, art. no. e00147, .https://udca.elogim.com:2119/science/article/pii/S2405673120300167/pdfft?md5=c6a1372678fbea0dcc385a297b6a2e3e&pid=1-s2.0-S2405673120300167-main.pdf10.1016/j.parepi.2020.e00147Sheep and goats are susceptible to infections with Toxoplasma gondii and could play an important role in the transmission of the zoonotic parasite to human. We conducted a cross sectional study to estimate the seroprevalence and to assess the risk factors for T. gondii seropositivity in small ruminants under traditional husbandry systems. This study was carried out from November 2015 to April 2016 in randomly selected small ruminants (n = 1038) from 48 farms located in Colombia, in the departments of northern Cesar in the north and La Guajira in the south. An indirect ELISA was used to detect IgG antibodies to T. gondii in the animals. A standardized questionnaire was used to obtain information on putative risk factors. We conducted the association analyses by using univariable and multivariate logistic regression and report odds ratios (OR) with 95% confidence interval (C.I). The overall seroprevalence in small ruminants was 23.5% (C.I: 21–26.2%). Sheep showed a higher seroprevalence (25.1% C.I: 22.4–28.6%) than goats (18.4% C.I: 22.4–28.6%). The association analysis recognized as risk factors for T. gondii seropositivity farming pigs in addition to small ruminants (OR = 1.96 C.I: 1.414–2.743), the inexistence of manure heap (OR = 2.254 C.I: 1.480–3.433) and drinking water from locally aqueducts (OR = 1.489 C.I: 1.006–2.204). 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 nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.
d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:
i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.
ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.
e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, Acinpro), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.
5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.
6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.
7. Término.
a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.
b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.
8. Varios.
a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.
b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.
c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.
d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.

