Efecto de la dieta rica en grasa (1%) sobre el perfil lipídico en conejas ovariectomizadas. I parte

Introduction: Cardiovascular disease is the main cause of morbility and mortality in developed and underveloped countries around the World. Instead of that ethiology is multifactorial, one of the most important factor is the use of saturated fats and its effect on lipoproteins and atherosclerosis. The aim of the authors was to assess the effect of the fat rich diet on the lipid profile of a rabbit experimental model. Methods: 20 female New Zealand rabbits with 2.500 t0 3 000 kg 0f weight were divided in two groups: Group I (n 10) : 5 controls (C) and 5 rich fat 1% diet (C+D) and group II (n 10) ovariectomized: 5 controls (O) and 5 rich fat 1% diet (O+D). At 3 and 6 months we avaluated the following parameters: weight, GLYCEMIA, total cholesterol TC, Triglycerides TG, HDL lipoproteins, low density lipoproteins LDL and estradiol E2. We use parametric and non parametric measures incluiding the Keuskall-Wallis tests to statistic evaluation. Results: The weight increase progressively in all the 4 groups but higher in the C+D (54%) (p <0.001) y O+D (61%) (p<0.001). Glycemia decrease at 3 and 6 months in controls (-56%) (p<0.002) with a higher decrease in O+D group (-64.67%)(p<0.043). HDL shown a decreased trend with not significant differences at 3 or 6 months. (p0.116 an p<0.609). LDL shown a non statistic significant decrease (p<0.754). TG shown an significant increase (p<0.011) at 3 months in the C+D group(p<0.012) and in ovariectomized (p<0.007). Estradiol had an increase in controls of 13% and 93% in the C+D group (p<0.001). Conclusion: This model is useful in assessing the lipid profile with a high-fat diet (1%) showing severe metabolic effects in ovariectomized rabbits.

• Autores: Onatra, W; Mendoza, R; Lenis, C; Forero, G; Rodríguez, A; Peña, E; Laverde, G; Gallego, C; Esquinas, Pc; Zúñiga, M; Ruiz, A; Ríos, Mt
• Tipo de recurso: Article of journal
• Fecha de publicación: 2009
• Institución: Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
• Repositorio: Repositorio Institucional UDCA
• Idioma: spa
• OAI Identifier: oai:repository.udca.edu.co:11158/3487
• Acceso en línea: https://encolombia.com/medicina/revistas-medicas/menopausia/vm-153/efectodedietaricaengrasas/
• Palabra clave: Grasas de la Dieta; Enfermedades Cardiovasculares; Conejos
• Rights: openAccess
• License: Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales