Revisión de la Importancia de la Actividad física en la Secreción de Interleuquina 6 para la Reducción del Tejido Adiposo en la Obesidad
66 páginas
- Autores:
-
Baracaldo Fuentes, Diego Alejandro
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
- Repositorio:
- Repositorio Institucional UDCA
- Idioma:
- spa
- OAI Identifier:
- oai:repository.udca.edu.co:11158/3396
- Acceso en línea:
- https://repository.udca.edu.co/handle/11158/3396
- Palabra clave:
- Actividad Motora
Obesidad
Ejercicio Físico
Tejido Adiposo
- Rights
- openAccess
- License
- Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales
| id |
RepoUDCA2_00e7483d10be2784c903146705582765 |
|---|---|
| oai_identifier_str |
oai:repository.udca.edu.co:11158/3396 |
| network_acronym_str |
RepoUDCA2 |
| network_name_str |
Repositorio Institucional UDCA |
| repository_id_str |
|
| dc.title.spa.fl_str_mv |
Revisión de la Importancia de la Actividad física en la Secreción de Interleuquina 6 para la Reducción del Tejido Adiposo en la Obesidad |
| title |
Revisión de la Importancia de la Actividad física en la Secreción de Interleuquina 6 para la Reducción del Tejido Adiposo en la Obesidad |
| spellingShingle |
Revisión de la Importancia de la Actividad física en la Secreción de Interleuquina 6 para la Reducción del Tejido Adiposo en la Obesidad Actividad Motora Obesidad Ejercicio Físico Tejido Adiposo |
| title_short |
Revisión de la Importancia de la Actividad física en la Secreción de Interleuquina 6 para la Reducción del Tejido Adiposo en la Obesidad |
| title_full |
Revisión de la Importancia de la Actividad física en la Secreción de Interleuquina 6 para la Reducción del Tejido Adiposo en la Obesidad |
| title_fullStr |
Revisión de la Importancia de la Actividad física en la Secreción de Interleuquina 6 para la Reducción del Tejido Adiposo en la Obesidad |
| title_full_unstemmed |
Revisión de la Importancia de la Actividad física en la Secreción de Interleuquina 6 para la Reducción del Tejido Adiposo en la Obesidad |
| title_sort |
Revisión de la Importancia de la Actividad física en la Secreción de Interleuquina 6 para la Reducción del Tejido Adiposo en la Obesidad |
| dc.creator.fl_str_mv |
Baracaldo Fuentes, Diego Alejandro |
| dc.contributor.advisor.spa.fl_str_mv |
Tavares, Paula Cristina, dir. Sánchez Rodríguez, Diego Alonso, dir. |
| dc.contributor.author.spa.fl_str_mv |
Baracaldo Fuentes, Diego Alejandro |
| dc.subject.mesh.spa.fl_str_mv |
Actividad Motora Obesidad Ejercicio Físico Tejido Adiposo |
| topic |
Actividad Motora Obesidad Ejercicio Físico Tejido Adiposo |
| description |
66 páginas |
| publishDate |
2020 |
| dc.date.accessioned.spa.fl_str_mv |
2020-06-25T22:33:55Z |
| dc.date.available.spa.fl_str_mv |
2020-06-25T22:33:55Z |
| dc.date.issued.spa.fl_str_mv |
2020-06 |
| dc.type.spa.fl_str_mv |
Trabajo de grado - Pregrado |
| dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_7a1f |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.content.spa.fl_str_mv |
Text |
| dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/TP |
| format |
http://purl.org/coar/resource_type/c_7a1f |
| status_str |
publishedVersion |
| dc.identifier.uri.spa.fl_str_mv |
https://repository.udca.edu.co/handle/11158/3396 |
| url |
https://repository.udca.edu.co/handle/11158/3396 |
| dc.language.iso.spa.fl_str_mv |
spa |
| language |
spa |
| dc.relation.references.spa.fl_str_mv |
AACE/ACE. (1998). Position statement on the prevention, diagnosis and treatment of obesity. Endoncrine Practice, 4, 297-330. Aranceta, J., Serra, L., Foz, M., & Moreno, B. (2005). Prevalencia de Obesidad en España. Medicina Clinica, 460 - 466. Arrizabalaga, J. J., Masmiquel, L., Vidal, J., Calanas Continente, A., Días Fernández, J. M., García Luna, P. P., . . . Cordido, F. (2004). Recomendaciones y algoritmo de tratamiento del sobrepeso y la obesidaden personas adultas. Medicina Clínica, 122(3), 104-110. Barbany, M., & Foz, M. (2002). Obesidad: concepto, clasificación y diagnostico. Anales del Sistema Sanitario de Navara, 25, 7-16. Blair, S. N., Archer, E., & Hand, G. A. (2013). Commentary: Luke and Cooper are wrong: physical activity has a crucial role in weight management and determinants of obesity. International Journal of epidemiology, 42(6), 1836- 1838. Bruun, J., Helge, J. W., Richelsen, B., & Stallknecht, B. (2006). Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. American journal of Physiology Endocrinology and Metabolism, 290, 961-967. Dębska, M., Mynarsky, W., Biernat, E., Nawrocka, A., & Bergier, B. (2019). Compliance with physical activity health recommendations in members of non-governmental organizations promoting active lifestyle. Annals of agricultural and environment medicine, 26(1), 109-113. Fisher, C. P. (2006). Interleukin-6 in acute exercise and training: what is the biological relevance? Exercise Immunology review, 12, 6-33. Fonseca-Junior, S. J., Avelar de Bustamante, C. G., Ferreira Rodriguez, P., Oliveira, A. J., & Fernandes-Filho, J. (2013). Physical exercise and morbid obesity: a systematic review. ABCD, Arquivos Brasileiros de Cirugia Digestiva, 26(1). Fried, S., Bunkin, D., & Greenberg, A. (1998). Omental and subcutaneous adipose tissues of obese subjects release interleukin-6 depot difference and regulation by glucocorticoid. J Clin Endocrinol Metabol, 83(3), 847-850. Grasdalmoen, M., Eriksen, H. R., Lonning, K. J., & Silversten, B. (2019). Physical exercise and body-mass index in young adults: a national survey of Norwegian university students. BMC Public Health, 19(1354). Haskell, W., Lee, M., Pate, R., Powell, K., Blair, S., Franklin, B., . . . Bauman, A. (2007). Physical Activity and Public Health: Updated Recommendation for Adults From the American College of Sports Medicine and the American Heart Association. Circulation, 116(9), 1081-1093. He, Z., Tian, Y., Valenzuela, P., Huang, C., Zhao, J., Hong, P., . . . Lucia, A. (2018). Miokine Response to High-Intensity Interval vs. Resistance Exercise: A Individual Approach. Frontiers in Physiology, 9(1735). Hernández, R. (2014). Metodología de la Investigación . México: Mc Graw Hill Education. Keller, C., Steensberg, A., Pilegaard, H., Osada, T., Saltin, B., Pedersen, B. K., & Neufer, P. (2001). Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content. FASEB J, 15, 2748-2750. Laredo Aguilera, J. A., Cobo Cuenca, A. I., Santacruz, E., Martins, M. M., Rodríguez, M. A., López Soto, P. J., & Carmona, J. M. (2019). Levels of Physical activity, obesity and related factors in young adults aged 18-30 during 2009-2017. International Journal of environmental research and public health, 16(20), 4033. Leon, H., Melo Moreno, C., & Ramirez, J. (2012). Role of the miokynes production through the exercise . Journal of Sport and Health Research, 4(2), 157-166. López Chicharro, J., & Fernández Vaquero, A. (2006). Fisiología del ejercicio (Tercera ed.). Madrid: Panamericana. Marie, N., Fleming, T., Robinson, M., Thomson, B., Graetz, N., Margono, C., . . . Gakidou, E. (2014). Global, regional and national prevalence of overweight and obesity in children and adults 1980-2013: A systematic analysis. The Lancet, 384(9945), 766-781. Martinez Lopez, E., Zagalaz Sanchez, M., & Latorre, P. (2005). Respuestas a la demanda social de Actividad física. Madrid Gymnos. Mavi, N. K., Nikbakht, H., Gaieni, A. A., & Ghazalian, F. (2015). Effects of High Intensity Interval Training (HIIT) on Interleukin 6 (IL-6) in Young Inactive Women . Advances in Environmental Biology, 9(3), 806-810. Moreno, M. (2014). Definition and classification of obesity. Medicine clinical condes, 2(23), 124-128. National Institutes of Health, National Hearth, Lung and Blood Institute e North American Association for the study of Obesity. (2000). The practical Guide: identification, evaluation and treatment of overweight and obesity in adults. Retrieved novembro 4, 2019, from http://www.nhlbi.nih.gov/guidelines/obesity/practgde.htm OMS. (2019, 12 5). Worl Health Organization. Retrieved from Obesidad y sobrepeso: https://www.who.int/es/news-room/fact-sheets/detail/obesityand-overweight OMS. (2019, 12 5). World Health Organization. Retrieved from Actividad física: https://www.who.int/dietphysicalactivity/pa/en/ OMS. (2019, 12 5). World Health Organization. Retrieved from Inactividad: https://www.who.int/dietphysicalactivity/factsheet_inactivity/es/ Ostrowski, K., Rohde, T., Asp, S., Schjerling, P., & Pedersen, B. K. (1999). Pro- and anti-inflammatory cytokine balance in strenuous exercise in humans. Journal of Physiology, 515, 287-291. Ostrowski, K., Schjerling, P., & Pedersen, B. K. (2000). Physical activity and plasma interleukin-6 in humans-effect of intensity of exercise. European Journal of Applied Physiology, 83(6), 512-515. Pedersen, B. (2013). Muscle as a Secretory Organ. American physiological society, 3(3). Pedersen, B. K. (2009). Edward F. Adolph Distinguished Lecture: Muscle as an endocrine organ: IL-6 and other myokines. Journal of applied physiology, 107(4), 1006-1014. Pedersen, B. K. (2009). The diseasome of physical inactivity – and the role of myokines in muscle–fat cross talk. The Journal of physiology, 587(23), 5559- 5568. Pedersen, B. K. (2010). Muscles and their myokines. The Journal of Experimental Biology, 337-346. Pedersen, B. K. (2011). Exercise-induced myokines and their role in chronic diseases. Brain, behavior, and Inmunity, 25(5), 811-816. Pedersen, B. K., & Febbraio, M. A. (2008). Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6. Physiological reviews, 88, 1379-1406. Pedersen, B. K., & Toft, A. D. (2000). Effects of Exercise on lymphocytes and cytokines. Britsh Journal of Sports Medicine, 246-251. Pedersen, B., & Febbrairo, M. (2012). Muscles, excercise and obesity: skeletal muscle as a secretory organ. Nature Reviews Endocrinology, 8, 457-465. Pedersen, B., & Fischer, C. (2007). Beneficial health effects of exercise: the role of IL-6 as a myokine. Trends Pharmacol Sci, 28, 152-156. Plomagaard, P., Penkowa, M., & Pedersen, B. (2005). Fiber type specific expression of TNF-alpha, IL-6 and IL-18 in human skeletal muscles. Exerc Immunol Rev, 11, 53-63. Ramirez Alvarado, M., & Sánchez Roitz, C. (2012). Tumor necrosis factor-α, insulin resistance, the lipoprotein metabolism and obesity in humans. Nutrición hospitalaria, 27(6), 1752-1757. Raschke, S., & Eckel, J. (2013). Adipo-Myokines: Two Sides of the Same Coin— Mediators of Inflammation and mediators of the exercise. Hindawi Publishing Corporation, 1-16. Rexrode, K., Carey, V., Henmakens, C., Walters, E., Colditz, G., Stampfer, M., & Manson, J. (1998). Abdominal adiposity and coronary heart disease in woman. Journal of the American Medical Association, 280, 1843-1848. Rosenkilde, M., Auerbach, P., Reichkendler, M. H., Ploug, T., Stallknecht, B. M., & Sjodin, A. (2012). Body fat loss and compensatory mechanisms in response to different doses of aerobic exercise – a randomized controlled trial in overweight sedentary males. American Journal of physiology, regulatory, integrative and comparative physiology, 303, 571-579. Saavedra, P., Vásquez, G., & González, L. (2011). Interleucina-6 ¡amiga o enemiga? Bases para comprender su utilizan como objetivo terapéutico. IATREIA Revista Médica Universidad de Antioquia , 157-166. Sarelius, I., & Pohl, U. (2010). Control of muscle blood flow guring exercise: local factors and integrative mechanisms. Acta Physiologica, 349-365. Silva Forjan, C., Salvador Rodriguez, F. J., & Fruhbeck Martínez, G. (2004). Obesidad. Concepto. Clasificación. Implicaciones fisiopatológicas. Complicaciones asociadas. Valoración clínica. Medicine: Programa de formación Médica Continuada Acreditado, 9(19), 1167-1175. Retrieved from https://dialnet.unirioja.es/servlet/articulo?codigo=1283492 Subbotina, E., Sierra, A., Zhu, Z., Gao, Z., Krishna, S., Reyes , S., . . . Zingman, L. (2005). Musclin is an activity-stimuled myokine that enhaces physical endurance . PNAS Early Edition, 1-6. Tencio , J., Alpizar, D., Camacho , S., Muñoz, J., & Morales, G. (2017). Miquinas: Mediadoras de los efectos del ejercicio fisico en la salud. Revista Medica de la Universidad de Costa Rica , 10(2), 32-43. Van Hall, G., Steensberg, A., Sachetti, M., Fischer, C., Keller, C., Shcjerling, P., . . . Pedersen, B. (2003). Interleukin-6 stimulates lipolysis and fat oxidation in humans. The Journal of clinical endocrinology and metabolism, 88(7), 3005- 3010. Weyer, C., Snitcker, S., Rising, R., Ravussin, E., & Bogardus, C. (1999). Determinants of energy expenditure and fuel utilization in man: effects on body composition, age, sex, ethnicity, and glucose tolerance in 916 subjects. International Journal of obesity, 203, 715-722. Zárate, A., Basurto, L., & Saucedo, R. (2001). La obesidad: Conceptos actuales sobre fisiopatologia y tratamiento. Unidad de Investigación Médica en Enfermedades Endocrinas, Hospital de especialiddade, Centro Médico Nacional, 44(2), 66-70. |
| dc.rights.spa.fl_str_mv |
Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales |
| dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| dc.rights.uri.spa.fl_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.creativecommons.spa.fl_str_mv |
Atribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0) |
| rights_invalid_str_mv |
Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales https://creativecommons.org/licenses/by-nc-sa/4.0/ Atribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0) http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.mimetype.spa.fl_str_mv |
application/pdf |
| dc.publisher.spa.fl_str_mv |
Bogotá : Universidad de Ciencias Aplicadas y Ambientales, 2020 |
| dc.publisher.faculty.spa.fl_str_mv |
Facultad de Ciencias de la Salud |
| dc.publisher.program.spa.fl_str_mv |
Ciencias del Deporte |
| institution |
Universidad de Ciencias Aplicadas y Ambientales U.D.C.A |
| bitstream.url.fl_str_mv |
https://repository.udca.edu.co/bitstreams/77475e92-b446-4169-9dd6-194235335815/download https://repository.udca.edu.co/bitstreams/add117de-ba6a-4cc0-9cc9-1dff900f74a2/download https://repository.udca.edu.co/bitstreams/a42a644f-4526-4509-bca8-0a843c477b19/download https://repository.udca.edu.co/bitstreams/ccf98dc9-cbc4-448b-8235-325a74164a8d/download https://repository.udca.edu.co/bitstreams/c8270706-53ba-4990-a54f-5ba62258d43c/download https://repository.udca.edu.co/bitstreams/85901c39-59f4-4f25-a546-1f2efa04c0a9/download https://repository.udca.edu.co/bitstreams/c920f897-aca0-4d5c-bb5d-59d205486c57/download https://repository.udca.edu.co/bitstreams/7e89b0b4-816a-4e5f-90b7-6a90bc73a17a/download https://repository.udca.edu.co/bitstreams/7ff936b2-d9f9-448c-84e2-bd0e22b6600c/download https://repository.udca.edu.co/bitstreams/e4d3a636-93eb-4ed4-9156-c452c3d03458/download |
| bitstream.checksum.fl_str_mv |
7a2ead5e6b452aa04ffa1671fcaf5cf6 337d0bfaa7b52fcf70d3826941c786fa b5b115046d460a36d669a0d9d2b9b189 f661acf14bedbf9f5d13897a0387e751 e006dee5b06b994422f839dfec413b8c 4e7bb887d39932f5b138191b5cf237b3 e1c06d85ae7b8b032bef47e42e4c08f9 ed3bb084401796b42ae6d4640d2eb8c4 8d42f4b7a71fe93f1aebb34850491a58 f3d1daa66babb69819dccef7ca358de3 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositorio - Universidad de Ciencias Aplicadas y Ambientales UDCA. |
| repository.mail.fl_str_mv |
bdigital@metabiblioteca.com |
| _version_ |
1814213369571311616 |
| spelling |
Tavares, Paula Cristina, dir.Sánchez Rodríguez, Diego Alonso, dir.Baracaldo Fuentes, Diego Alejandro2020-06-25T22:33:55Z2020-06-25T22:33:55Z2020-06https://repository.udca.edu.co/handle/11158/339666 páginasObesity and overweight have become a very important research topic for decades as it is a public health problem that affects thousands of people around the world, the mismatch between calories consumed and calories spent leads to the accumulation of population. excess fat in the body, this can lead to musculoskeletal, cerebrovascular health problems, diabetes, including death. Low levels of physical activity are a major cause of obesity and overweight in the world population, good levels of physical activity generate energy expenditure and many other health benefits for people, but physical exercise is a controlled activity repetitive and with the purpose of improving the physical capacities has a better benefit to the health of the population. It has recently been found that skeletal muscle is an organ that secretes different substances, one of which is mytokines, these cytokines are produced as a response to physical exercise in muscle contraction, interlucin-6 (IL-6) has a positive relationship with metabolism. of lipids. The main purpose is to identify the relationship between physical exercise and interleukin 6 secretion as an essential myokin for the reduction of adipose tissue in obesity.La obesidad y el sobrepeso se ha convertido en un tema de investigación muy importante en las últimas décadas, debido a que es un problema de salud pública que afecta a millones de personas en el mundo, la errónea relación entre las calorías consumidas y las calorías gastadas genera en la población a acumular exceso de grasa en el cuerpo, esto puede desencadenar problemas de salud a nivel osteomuscular, cerebrovascular diabetes e inclusive la muerte. Los bajos niveles de actividad física es una de las dos principales causantes de obesidad y sobrepeso en la población mundial, buenos niveles de actividad física generan un gasto energético y muchos otros beneficios para la salud de las personas, más el ejercicio físico que es una actividad controlada, repetitiva y con el fin de mejorar las capacidades físicas y obtener beneficios para la salud. Recientemente se encontró que el músculo esquelético es un órgano que segrega diferentes sustancias, una de ellas son las mioquinas, estas son citoquinas y péptidos que son producidas como respuesta al ejercicio físico en la contracción muscular, la interleuquina 6 (IL-6) tiene una relación positiva con el metabolismo de los lípidos. El propósito principal es identificar la relación del ejercicio físico y la secreción de interleuquina 6 como mioquina esencial para la reducción del tejido adiposo en la obesidad.Incluye bibliografíaPregradoProfesional en Ciencias del Deporteapplication/pdfspaBogotá : Universidad de Ciencias Aplicadas y Ambientales, 2020Facultad de Ciencias de la SaludCiencias del DeporteDerechos Reservados - Universidad de Ciencias Aplicadas y Ambientaleshttps://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)http://purl.org/coar/access_right/c_abf2Actividad MotoraObesidadEjercicio FísicoTejido AdiposoRevisión de la Importancia de la Actividad física en la Secreción de Interleuquina 6 para la Reducción del Tejido Adiposo en la ObesidadTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/publishedVersionTexthttp://purl.org/redcol/resource_type/TPhttp://purl.org/coar/version/c_970fb48d4fbd8a85AACE/ACE. (1998). Position statement on the prevention, diagnosis and treatment of obesity. Endoncrine Practice, 4, 297-330.Aranceta, J., Serra, L., Foz, M., & Moreno, B. (2005). Prevalencia de Obesidad en España. Medicina Clinica, 460 - 466.Arrizabalaga, J. J., Masmiquel, L., Vidal, J., Calanas Continente, A., Días Fernández, J. M., García Luna, P. P., . . . Cordido, F. (2004). Recomendaciones y algoritmo de tratamiento del sobrepeso y la obesidaden personas adultas. Medicina Clínica, 122(3), 104-110.Barbany, M., & Foz, M. (2002). Obesidad: concepto, clasificación y diagnostico. Anales del Sistema Sanitario de Navara, 25, 7-16.Blair, S. N., Archer, E., & Hand, G. A. (2013). Commentary: Luke and Cooper are wrong: physical activity has a crucial role in weight management and determinants of obesity. International Journal of epidemiology, 42(6), 1836- 1838.Bruun, J., Helge, J. W., Richelsen, B., & Stallknecht, B. (2006). Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. American journal of Physiology Endocrinology and Metabolism, 290, 961-967.Dębska, M., Mynarsky, W., Biernat, E., Nawrocka, A., & Bergier, B. (2019). Compliance with physical activity health recommendations in members of non-governmental organizations promoting active lifestyle. Annals of agricultural and environment medicine, 26(1), 109-113.Fisher, C. P. (2006). Interleukin-6 in acute exercise and training: what is the biological relevance? Exercise Immunology review, 12, 6-33.Fonseca-Junior, S. J., Avelar de Bustamante, C. G., Ferreira Rodriguez, P., Oliveira, A. J., & Fernandes-Filho, J. (2013). Physical exercise and morbid obesity: a systematic review. ABCD, Arquivos Brasileiros de Cirugia Digestiva, 26(1).Fried, S., Bunkin, D., & Greenberg, A. (1998). Omental and subcutaneous adipose tissues of obese subjects release interleukin-6 depot difference and regulation by glucocorticoid. J Clin Endocrinol Metabol, 83(3), 847-850.Grasdalmoen, M., Eriksen, H. R., Lonning, K. J., & Silversten, B. (2019). Physical exercise and body-mass index in young adults: a national survey of Norwegian university students. BMC Public Health, 19(1354).Haskell, W., Lee, M., Pate, R., Powell, K., Blair, S., Franklin, B., . . . Bauman, A. (2007). Physical Activity and Public Health: Updated Recommendation for Adults From the American College of Sports Medicine and the American Heart Association. Circulation, 116(9), 1081-1093.He, Z., Tian, Y., Valenzuela, P., Huang, C., Zhao, J., Hong, P., . . . Lucia, A. (2018). Miokine Response to High-Intensity Interval vs. Resistance Exercise: A Individual Approach. Frontiers in Physiology, 9(1735).Hernández, R. (2014). Metodología de la Investigación . México: Mc Graw Hill Education.Keller, C., Steensberg, A., Pilegaard, H., Osada, T., Saltin, B., Pedersen, B. K., & Neufer, P. (2001). Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content. FASEB J, 15, 2748-2750.Laredo Aguilera, J. A., Cobo Cuenca, A. I., Santacruz, E., Martins, M. M., Rodríguez, M. A., López Soto, P. J., & Carmona, J. M. (2019). Levels of Physical activity, obesity and related factors in young adults aged 18-30 during 2009-2017. International Journal of environmental research and public health, 16(20), 4033.Leon, H., Melo Moreno, C., & Ramirez, J. (2012). Role of the miokynes production through the exercise . Journal of Sport and Health Research, 4(2), 157-166.López Chicharro, J., & Fernández Vaquero, A. (2006). Fisiología del ejercicio (Tercera ed.). Madrid: Panamericana.Marie, N., Fleming, T., Robinson, M., Thomson, B., Graetz, N., Margono, C., . . . Gakidou, E. (2014). Global, regional and national prevalence of overweight and obesity in children and adults 1980-2013: A systematic analysis. The Lancet, 384(9945), 766-781.Martinez Lopez, E., Zagalaz Sanchez, M., & Latorre, P. (2005). Respuestas a la demanda social de Actividad física. Madrid Gymnos.Mavi, N. K., Nikbakht, H., Gaieni, A. A., & Ghazalian, F. (2015). Effects of High Intensity Interval Training (HIIT) on Interleukin 6 (IL-6) in Young Inactive Women . Advances in Environmental Biology, 9(3), 806-810.Moreno, M. (2014). Definition and classification of obesity. Medicine clinical condes, 2(23), 124-128.National Institutes of Health, National Hearth, Lung and Blood Institute e North American Association for the study of Obesity. (2000). The practical Guide: identification, evaluation and treatment of overweight and obesity in adults. Retrieved novembro 4, 2019, from http://www.nhlbi.nih.gov/guidelines/obesity/practgde.htmOMS. (2019, 12 5). Worl Health Organization. Retrieved from Obesidad y sobrepeso: https://www.who.int/es/news-room/fact-sheets/detail/obesityand-overweightOMS. (2019, 12 5). World Health Organization. Retrieved from Actividad física: https://www.who.int/dietphysicalactivity/pa/en/OMS. (2019, 12 5). World Health Organization. Retrieved from Inactividad: https://www.who.int/dietphysicalactivity/factsheet_inactivity/es/Ostrowski, K., Rohde, T., Asp, S., Schjerling, P., & Pedersen, B. K. (1999). Pro- and anti-inflammatory cytokine balance in strenuous exercise in humans. Journal of Physiology, 515, 287-291.Ostrowski, K., Schjerling, P., & Pedersen, B. K. (2000). Physical activity and plasma interleukin-6 in humans-effect of intensity of exercise. European Journal of Applied Physiology, 83(6), 512-515.Pedersen, B. (2013). Muscle as a Secretory Organ. American physiological society, 3(3).Pedersen, B. K. (2009). Edward F. Adolph Distinguished Lecture: Muscle as an endocrine organ: IL-6 and other myokines. Journal of applied physiology, 107(4), 1006-1014.Pedersen, B. K. (2009). The diseasome of physical inactivity – and the role of myokines in muscle–fat cross talk. The Journal of physiology, 587(23), 5559- 5568.Pedersen, B. K. (2010). Muscles and their myokines. The Journal of Experimental Biology, 337-346.Pedersen, B. K. (2011). Exercise-induced myokines and their role in chronic diseases. Brain, behavior, and Inmunity, 25(5), 811-816.Pedersen, B. K., & Febbraio, M. A. (2008). Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6. Physiological reviews, 88, 1379-1406.Pedersen, B. K., & Toft, A. D. (2000). Effects of Exercise on lymphocytes and cytokines. Britsh Journal of Sports Medicine, 246-251.Pedersen, B., & Febbrairo, M. (2012). Muscles, excercise and obesity: skeletal muscle as a secretory organ. Nature Reviews Endocrinology, 8, 457-465.Pedersen, B., & Fischer, C. (2007). Beneficial health effects of exercise: the role of IL-6 as a myokine. Trends Pharmacol Sci, 28, 152-156.Plomagaard, P., Penkowa, M., & Pedersen, B. (2005). Fiber type specific expression of TNF-alpha, IL-6 and IL-18 in human skeletal muscles. Exerc Immunol Rev, 11, 53-63.Ramirez Alvarado, M., & Sánchez Roitz, C. (2012). Tumor necrosis factor-α, insulin resistance, the lipoprotein metabolism and obesity in humans. Nutrición hospitalaria, 27(6), 1752-1757.Raschke, S., & Eckel, J. (2013). Adipo-Myokines: Two Sides of the Same Coin— Mediators of Inflammation and mediators of the exercise. Hindawi Publishing Corporation, 1-16.Rexrode, K., Carey, V., Henmakens, C., Walters, E., Colditz, G., Stampfer, M., & Manson, J. (1998). Abdominal adiposity and coronary heart disease in woman. Journal of the American Medical Association, 280, 1843-1848.Rosenkilde, M., Auerbach, P., Reichkendler, M. H., Ploug, T., Stallknecht, B. M., & Sjodin, A. (2012). Body fat loss and compensatory mechanisms in response to different doses of aerobic exercise – a randomized controlled trial in overweight sedentary males. American Journal of physiology, regulatory, integrative and comparative physiology, 303, 571-579.Saavedra, P., Vásquez, G., & González, L. (2011). Interleucina-6 ¡amiga o enemiga? Bases para comprender su utilizan como objetivo terapéutico. IATREIA Revista Médica Universidad de Antioquia , 157-166.Sarelius, I., & Pohl, U. (2010). Control of muscle blood flow guring exercise: local factors and integrative mechanisms. Acta Physiologica, 349-365.Silva Forjan, C., Salvador Rodriguez, F. J., & Fruhbeck Martínez, G. (2004). Obesidad. Concepto. Clasificación. Implicaciones fisiopatológicas. Complicaciones asociadas. Valoración clínica. Medicine: Programa de formación Médica Continuada Acreditado, 9(19), 1167-1175. Retrieved from https://dialnet.unirioja.es/servlet/articulo?codigo=1283492Subbotina, E., Sierra, A., Zhu, Z., Gao, Z., Krishna, S., Reyes , S., . . . Zingman, L. (2005). Musclin is an activity-stimuled myokine that enhaces physical endurance . PNAS Early Edition, 1-6.Tencio , J., Alpizar, D., Camacho , S., Muñoz, J., & Morales, G. (2017). Miquinas: Mediadoras de los efectos del ejercicio fisico en la salud. Revista Medica de la Universidad de Costa Rica , 10(2), 32-43.Van Hall, G., Steensberg, A., Sachetti, M., Fischer, C., Keller, C., Shcjerling, P., . . . Pedersen, B. (2003). Interleukin-6 stimulates lipolysis and fat oxidation in humans. The Journal of clinical endocrinology and metabolism, 88(7), 3005- 3010.Weyer, C., Snitcker, S., Rising, R., Ravussin, E., & Bogardus, C. (1999). Determinants of energy expenditure and fuel utilization in man: effects on body composition, age, sex, ethnicity, and glucose tolerance in 916 subjects. International Journal of obesity, 203, 715-722.Zárate, A., Basurto, L., & Saucedo, R. (2001). La obesidad: Conceptos actuales sobre fisiopatologia y tratamiento. Unidad de Investigación Médica en Enfermedades Endocrinas, Hospital de especialiddade, Centro Médico Nacional, 44(2), 66-70.PublicationORIGINALTrabajo grado.pdfTrabajo grado.pdfapplication/pdf581627https://repository.udca.edu.co/bitstreams/77475e92-b446-4169-9dd6-194235335815/download7a2ead5e6b452aa04ffa1671fcaf5cf6MD51identificacion-trabajo-grado.pdfidentificacion-trabajo-grado.pdfapplication/pdf262893https://repository.udca.edu.co/bitstreams/add117de-ba6a-4cc0-9cc9-1dff900f74a2/download337d0bfaa7b52fcf70d3826941c786faMD52autorización.pdfautorización.pdfapplication/pdf1462353https://repository.udca.edu.co/bitstreams/a42a644f-4526-4509-bca8-0a843c477b19/downloadb5b115046d460a36d669a0d9d2b9b189MD53LICENSElicense.txtlicense.txttext/plain; charset=utf-814775https://repository.udca.edu.co/bitstreams/ccf98dc9-cbc4-448b-8235-325a74164a8d/downloadf661acf14bedbf9f5d13897a0387e751MD54TEXTTrabajo grado.pdf.txtTrabajo grado.pdf.txtExtracted texttext/plain78098https://repository.udca.edu.co/bitstreams/c8270706-53ba-4990-a54f-5ba62258d43c/downloade006dee5b06b994422f839dfec413b8cMD55identificacion-trabajo-grado.pdf.txtidentificacion-trabajo-grado.pdf.txtExtracted texttext/plain1836https://repository.udca.edu.co/bitstreams/85901c39-59f4-4f25-a546-1f2efa04c0a9/download4e7bb887d39932f5b138191b5cf237b3MD57autorización.pdf.txtautorización.pdf.txtExtracted texttext/plain2https://repository.udca.edu.co/bitstreams/c920f897-aca0-4d5c-bb5d-59d205486c57/downloade1c06d85ae7b8b032bef47e42e4c08f9MD59THUMBNAILTrabajo grado.pdf.jpgTrabajo grado.pdf.jpgGenerated Thumbnailimage/jpeg3495https://repository.udca.edu.co/bitstreams/7e89b0b4-816a-4e5f-90b7-6a90bc73a17a/downloaded3bb084401796b42ae6d4640d2eb8c4MD56identificacion-trabajo-grado.pdf.jpgidentificacion-trabajo-grado.pdf.jpgGenerated Thumbnailimage/jpeg5993https://repository.udca.edu.co/bitstreams/7ff936b2-d9f9-448c-84e2-bd0e22b6600c/download8d42f4b7a71fe93f1aebb34850491a58MD58autorización.pdf.jpgautorización.pdf.jpgGenerated Thumbnailimage/jpeg8776https://repository.udca.edu.co/bitstreams/e4d3a636-93eb-4ed4-9156-c452c3d03458/downloadf3d1daa66babb69819dccef7ca358de3MD51011158/3396oai:repository.udca.edu.co:11158/33962024-05-09 14:38:08.16https://creativecommons.org/licenses/by-nc-sa/4.0/Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientalesopen.accesshttps://repository.udca.edu.coRepositorio - Universidad de Ciencias Aplicadas y Ambientales UDCA.bdigital@metabiblioteca.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 |