Evaluation of variants in IL6R, TLR3, and DC-SIGN genes associated with dengue in a sampled Colombian population
Introduction: Host genetics is recognized as an influential factor for the development of dengue disease. Objective: This study evaluated the association of dengue with the polymorphisms rs8192284 for gene IL6R, rs3775290 for TLR3, and rs7248637 for DC-SIGN. Materials and methods: Of the 292 surveye...
- Autores:
-
Avendaño Tamayo, Efrén De Jesús
Rúa Cardona, Alex Fernando
Parra Marín, María Victoria
Rojas Montoya, Winston
Campo Nieto, Omer
Chacón Duque, Juan Camilo
Agudelo Flórez, Piedad Matilde
Narváez Rojas, Carlos Fernando
Salgado García, Doris Martha Cecilia
Restrepo Jaramillo, Berta Nelly
Bedoya Berrío, Gabriel de Jesús
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2019
- Institución:
- Tecnológico de Antioquia
- Repositorio:
- Repositorio Tdea
- Idioma:
- eng
- OAI Identifier:
- oai:dspace.tdea.edu.co:tdea/2798
- Acceso en línea:
- https://dspace.tdea.edu.co/handle/tdea/2798
- Palabra clave:
- Polymorphism
Polimorfismo
Polimorfism genetic
Genetic polymorphism
Polimorfismo genético
Toll-Like Receptor 3
Receptor Toll-Like 3
Receptor 3 Toll-Like
Colombia
Colômbia
Dengue/genetics
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by/4.0/
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| dc.title.none.fl_str_mv |
Evaluation of variants in IL6R, TLR3, and DC-SIGN genes associated with dengue in a sampled Colombian population |
| dc.title.translated.none.fl_str_mv |
Evaluación de las variantes en los genes IL6R, TLR3 y DC-SIGN asociadas con dengue en una muestra de población colombiana |
| title |
Evaluation of variants in IL6R, TLR3, and DC-SIGN genes associated with dengue in a sampled Colombian population |
| spellingShingle |
Evaluation of variants in IL6R, TLR3, and DC-SIGN genes associated with dengue in a sampled Colombian population Polymorphism Polimorfismo Polimorfism genetic Genetic polymorphism Polimorfismo genético Toll-Like Receptor 3 Receptor Toll-Like 3 Receptor 3 Toll-Like Colombia Colômbia Dengue/genetics |
| title_short |
Evaluation of variants in IL6R, TLR3, and DC-SIGN genes associated with dengue in a sampled Colombian population |
| title_full |
Evaluation of variants in IL6R, TLR3, and DC-SIGN genes associated with dengue in a sampled Colombian population |
| title_fullStr |
Evaluation of variants in IL6R, TLR3, and DC-SIGN genes associated with dengue in a sampled Colombian population |
| title_full_unstemmed |
Evaluation of variants in IL6R, TLR3, and DC-SIGN genes associated with dengue in a sampled Colombian population |
| title_sort |
Evaluation of variants in IL6R, TLR3, and DC-SIGN genes associated with dengue in a sampled Colombian population |
| dc.creator.fl_str_mv |
Avendaño Tamayo, Efrén De Jesús Rúa Cardona, Alex Fernando Parra Marín, María Victoria Rojas Montoya, Winston Campo Nieto, Omer Chacón Duque, Juan Camilo Agudelo Flórez, Piedad Matilde Narváez Rojas, Carlos Fernando Salgado García, Doris Martha Cecilia Restrepo Jaramillo, Berta Nelly Bedoya Berrío, Gabriel de Jesús |
| dc.contributor.author.none.fl_str_mv |
Avendaño Tamayo, Efrén De Jesús Rúa Cardona, Alex Fernando Parra Marín, María Victoria Rojas Montoya, Winston Campo Nieto, Omer Chacón Duque, Juan Camilo Agudelo Flórez, Piedad Matilde Narváez Rojas, Carlos Fernando Salgado García, Doris Martha Cecilia Restrepo Jaramillo, Berta Nelly Bedoya Berrío, Gabriel de Jesús |
| dc.subject.agrovoc.none.fl_str_mv |
Polymorphism Polimorfismo Polimorfism genetic Genetic polymorphism Polimorfismo genético |
| topic |
Polymorphism Polimorfismo Polimorfism genetic Genetic polymorphism Polimorfismo genético Toll-Like Receptor 3 Receptor Toll-Like 3 Receptor 3 Toll-Like Colombia Colômbia Dengue/genetics |
| dc.subject.decs.none.fl_str_mv |
Toll-Like Receptor 3 Receptor Toll-Like 3 Receptor 3 Toll-Like Colombia Colômbia |
| dc.subject.proposal.none.fl_str_mv |
Dengue/genetics |
| description |
Introduction: Host genetics is recognized as an influential factor for the development of dengue disease. Objective: This study evaluated the association of dengue with the polymorphisms rs8192284 for gene IL6R, rs3775290 for TLR3, and rs7248637 for DC-SIGN. Materials and methods: Of the 292 surveyed subjects, 191 were confirmed for dengue fever and the remaining 101 were included as controls. The genotypes were resolved using polymerase chain reaction and restriction fragment length polymorphism (PCRRFLP). In an attempt to determine the risk (Odds Ratio) of suffering dengue fever, data were analyzed using chi-square for alleles and logistic regression for both genotypes and allelic combinations. Confidence intervals were set to 95% for all tests regardless of the adjustment by either self-identification or ancestry |
| publishDate |
2019 |
| dc.date.issued.none.fl_str_mv |
2019 |
| dc.date.accessioned.none.fl_str_mv |
2023-04-18T03:04:33Z |
| dc.date.available.none.fl_str_mv |
2023-04-18T03:04:33Z |
| dc.type.spa.fl_str_mv |
Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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Text |
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https://dspace.tdea.edu.co/handle/tdea/2798 |
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2590-7379 |
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0120-4157 2590-7379 |
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https://dspace.tdea.edu.co/handle/tdea/2798 |
| dc.language.iso.spa.fl_str_mv |
eng |
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eng |
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101 |
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1 |
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88 |
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39 |
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Biomédica |
| dc.relation.references.spa.fl_str_mv |
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The battle between infection and host immune responses of dengue virus and its implication in dengue disease pathogenesis. Scientific World Journal. 2013;2013:1-11. https://doi.org/10.1155/2013/843469 World Health Organization. Dengue haemorrhagic fever. Diagnosis, treatment, prevention and control. Geneva: WHO; 1997. p. 12-23. Alagarasu K, Damle I, Bachal R, Mulay A, Shah P, Dayaraj C. Association of promoter region polymorphisms of CD209 gene with clinical outcomes of dengue virus infection in Western India. Infect Genet Evol. 2013;17:239-42. https://doi.org/10.1016/j. meegid.2013.04.024 Pabalan N, Chaisri S, Tabunhan S, Phumyen A, Jarjanazi H, Steiner TS. Associations of DC-SIGN (CD209) promoter -336G/A polymorphism (rs4804803) with dengue infection: A systematic review and meta-analysis. Acta Trop. 2018;177:186-93. https://doi.org/10.1016/j. actatropica.2017.10.017 Liu P, Ridilla M, Patel P, Betts L, Gallichotte E, Shahidi L, et al. Beyond attachment: Roles of DC-SIGN in dengue virus infection. Traffic. 2017;18:218-31. https://doi.org/10.1111/ tra.12469 Zapata JC, Cox D, Salvato MS.The role of platelets in the pathogenesis of viral hemorrhagic fevers. PLoS Negl Trop Dis. 2014;8:e2858. https://doi.org/10.1371/journal. pntd.0002858 Wan SW, Lin CF, Yeh TM, Liu CC, Liu HS, Wang S, et al. Autoimmunity in dengue pathogenesis. J Formos Med Assoc. 2013;112:3-11. https://doi.org/10.1016/j. jfma.2012.11.006 Nielsen DG. The relationship of interacting immunological components in dengue pathogenesis. Virol J. 2009;6:211. https://doi.org/10.1186/1743-422X-6-211 Juffrie M, van Der Meer GM, Hack CE, Haasnoot K, Sutaryo S, Veerman AJ, et al. Inflammatory mediators in dengue virus infection in children: Interleukin-8 and its relationship to neutrophil degranulation. Infect Immun. 2000;68:702-7. https://doi. org/10.1128/IAI.68.2.702-707.2000 Ferreira RC, Freitag DF, Cutler AJ, Howson JM, Rainbow DB, Smyth DJ, et al. Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases. PLoS Genet. 2013;9:e1003444. https://doi.org/10.1371/ journal.pgen.1003444 Marín V, Montero-Julián FA, Gres S, Boulay V, Bongrand P, Farnarier C, et al. The IL-6-soluble IL-6Ralpha autocrine loop of endothelial activation as an intermediate between acute and chronic inflammation: An experimental model involving thrombin. J Immunol. 2001;167:3435-42. https://doi.org/10.4049/jimmunol.167.6.3435 Torres S, Hernández JC, Giraldo D, Arboleda M, Rojas M, Smit JM, et al. Differential expression of Toll-like receptors in dendritic cells of patients with dengue during early and late acute phases of the disease. PLoS Negl Trop Dis. 2013;7:e2060. https://doi. org/10.1371/journal.pntd.0002060 Sessions OM, Tan Y, Goh KC, Liu Y, Tan P, Rozen S, et al. Host cell transcriptome profile during wild-type and attenuated dengue virus infection. 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Nat Immunol. 2010;11:373-84. https://doi.org/10.1038/ni.1863 Alagarasu K, Bachal RV, Memane RS, Shah PS, Cecilia D. Polymorphisms in RNA sensing toll like receptor genes and its association with clinical outcomes of dengue virus infection. Immunobiology. 2015;220:164-8. https://doi.org/10.1016/j.imbio.2014.09.020 Sironi M, Biasin M, Cagliani R, Forni D, De Luca M, Saulle I, et al. A common polymorphism in TLR3 confers natural resistance to HIV-1 infection. J Immunol. 2012;188:818-23. https://doi.org/10.4049/jimmunol.1102179 Lamas JR, Rodríguez-Rodríguez L, Tornero-Esteban P, Villafuertes E, Hoyas J, Abasolo L, et al. Alternative splicing and proteolytic rupture contribute to the generation of soluble IL-6 receptors (sIL-6R) in rheumatoid arthritis. Cytokine. 2013;61:720-3. https://doi. org/10.1016/j.cyto.2012.12.025 Reich D, Patterson N, Ramesh V, De Jager PL, McDonald GJ, Tandon A, et al. Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels. Am J Hum Genet. 2007;80:716-26. https://doi.org/10.1086/513206 Rose-John S. IL-6 trans-signaling via the soluble IL-6 receptor: Importance for the proinflammatory activities of IL-6. Int J Biol Sci. 2012;8:1237-47. https://doi.org/10.7150/ ijbs.4989 Barcellini W, Rizzardi GP, Poli G, Tambussi G, Velati C, Meroni PL, et al. Cytokines and soluble receptor changes in the transition from primary to early chronic HIV type 1 infection. AIDS Res Hum Retroviruses. 1996;12:325-31. https://doi.org/10.1089/aid.1996.12.325 Yang HY, Lee HS, Lee CH, Fang WH, Chen HC, Salter DM, et al. Association of a functional polymorphism in the promoter region of TLR-3 with osteoarthritis: A two-stage case-control study. J Orthop Res. 2013;31:680-5. https://doi.org/10.1002/jor.22291 Chacón-Duque JC, Adhikari K, Avendaño E, Campo O, Ramírez R, Rojas W, et al. African genetic ancestry is associated with a protective effect on dengue severity in Colombian populations. Infect Genet Evol. 2014;27C:89-95. https://doi.org/10.1016/j. meegid.2014.07.003 Galanter JM, Fernández-López JC, Gignoux CR, Barnholtz-Sloan J, Fernández- Rozadilla C, Via M, et al. Development of a panel of genome-wide ancestry informative markers to study admixture throughout the Americas. PLoS Genet. 2012;8:1-16. https://doi. org/10.1371/journal.pgen.1002554 Restrepo BN, Piedrahita LD, Agudelo IY, Parra-Henao G, Osorio JE. Frequency and clinical features of dengue infection in a schoolchildren cohort from Medellín, Colombia. J Trop Med. 2012;2012:120496. https://doi.org/10.1155/2012/120496 Lanciotti RS, Calisher CH, Gubler DJ, Chang GJ, Vorndam AV. Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction. J Clin Microbiol. 1992;30:545-51. Harris E, Roberts TG, Smith L, Selle J, Kramer LD, Valle S, et al. 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Ann Hum Genet. 2000;64:171-86. https://doi.org/10.1017/ S0003480000008022 Chua KB, Mustafa B, Abdul-Wahab AH, Chem YK, Khairul AH, Kumarasamy V, et al. A comparative evaluation of dengue diagnostic tests based on single-acute serum samples for laboratory confirmation of acute dengue. Malays J Pathol. 2011;33:13-20. Silva LK, Blanton RE, Parrado AR, Melo PS, Morato VG, Reis EA, et al. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. Eur J Hum Genet. 2010;18:1221-7. https://doi.org/10.1038/ejhg.2010.98 Blanton RE, Silva LK, Morato VG, Parrado AR, Dias JP, Melo PR, et al. Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population. Eur J Hum Genet. 2008;16:762-5. https://doi.org/10.1038/ejhg.2008.4 Harapan H, Fajar JK, Wahyuniati N, Anand JR, Nambaru L, Jamil KF. Non-HLA gene polymorphisms and their implications on dengue virus infection. 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Interleukin-6 receptor polymorphism is prevalent in HIV-negative Castleman disease and is associated with increased soluble interleukin-6 receptor levels. PLoS One. 2013;8:e54610. https://doi. org/10.1371/journal.pone.0054610 Wang XJ, Taga T, Yoshida K, Saito M, Kishimoto T, Kikutani H. gp130, the cytokine common signal-transducer of interleukin-6 cytokine family, is downregulated in T cells in vivo by interleukin-6. Blood. 1998;91:3308-14. Yamasaki K, Taga T, Hirata Y, Yawata H, Kawanishi Y, Seed B, et al. Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor. Science. 1988;241:825- 8. https://doi.org/10.1126/science.3136546 Zayed RA, Omran D, Mokhtar DA, Zakaria Z, Ezzat S, Soliman MA, et al. Association of toll-like receptor 3 and toll-like receptor 9 single nucleotide polymorphisms with hepatitis c virus infection and hepatic fibrosis in Egyptian patients. Am J Trop Med Hyg. 2017;96:720-6. https://doi.org/10.4269/ajtmh.16-0644 Studzinska M, Jablonska A, Wisniewska-Ligier M, Nowakowska D, Gaj Z, Lesnikowski ZJ, et al. Association of TLR3 L412F polymorphism with cytomegalovirus infection in children. PLoS One. 2017;12:e0169420. https://doi.org/10.1371/journal.pone.0169420 Goktas EF, Bulut C, Goktas MT, Ozer EK, Karaca RO, Kinikli S, et al. Investigation of 1377C/T polymorphism of the Toll-like receptor 3 among patients with chronic hepatitis B. Can J Microbiol. 2016;62:617-22. https://doi.org/10.1139/cjm-2016-0129 Lu S, Bevier M, Huhn S, Sainz J, Lascorz J, Pardini B, et al. Genetic variants in C-type lectin genes are associated with colorectal cancer susceptibility and clinical outcome. Int J Cancer. 2013;133:2325-33. https://doi.org/10.1002/ijc.28251 |
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Atribución 4.0 Internacional (CC BY 4.0) |
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Avendaño Tamayo, Efrén De Jesúse1190af9-a1d6-4dfe-bd61-9f8d5cc94c86Rúa Cardona, Alex Fernando191d78ce-69bd-4fa9-89a1-2e5f9b795e9bParra Marín, María Victoriacf2c90a2-f2a0-444f-bde5-5c5db89110eeRojas Montoya, Winston77d5cf91-243d-41bd-a459-bef5c0f7ac37Campo Nieto, Omere7c9f7fa-54e5-4747-ad0c-4656bfef7729Chacón Duque, Juan Camilo29cd8392-4f2c-449e-9d90-3e8291771c8bAgudelo Flórez, Piedad Matilde1d54cb11-7096-41f4-b0be-52ae542d6aabNarváez Rojas, Carlos Fernando019eafd1-44f8-4518-82c3-b46cf4384be7Salgado García, Doris Martha Cecilia0ca6453e-7439-4e5c-aca3-83ea6734fc9aRestrepo Jaramillo, Berta Nellycd069e47-e80f-48f8-a626-b24295b6e0ceBedoya Berrío, Gabriel de Jesúsfa9f9fbd-c5db-4ffe-86bd-13f5fd0ea4c72023-04-18T03:04:33Z2023-04-18T03:04:33Z20190120-4157https://dspace.tdea.edu.co/handle/tdea/27982590-7379Introduction: Host genetics is recognized as an influential factor for the development of dengue disease. Objective: This study evaluated the association of dengue with the polymorphisms rs8192284 for gene IL6R, rs3775290 for TLR3, and rs7248637 for DC-SIGN. Materials and methods: Of the 292 surveyed subjects, 191 were confirmed for dengue fever and the remaining 101 were included as controls. The genotypes were resolved using polymerase chain reaction and restriction fragment length polymorphism (PCRRFLP). In an attempt to determine the risk (Odds Ratio) of suffering dengue fever, data were analyzed using chi-square for alleles and logistic regression for both genotypes and allelic combinations. Confidence intervals were set to 95% for all tests regardless of the adjustment by either self-identification or ancestryIntroducción. La genética del huésped se reconoce como un factor que influye en el desarrollo del dengue. Objetivo. Este estudio evaluó la asociación del dengue con los polimorfismos rs8192284 del gen IL6R, rs3775290 del TLR3 y rs7248637 del DC-SIGN. Materiales y métodos. De los 292 sujetos encuestados, en 191 se confirmó la presencia de fiebre por dengue y los restantes 101 se incluyeron como controles. Los genotipos se resolvieron mediante reacción en cadena de la polimerasa y polimorfismos en la longitud de los fragmentos de restricción (PCR-RFLP). En un intento por determinar el riesgo de sufrir dengue, los datos se analizaron mediante la prueba de ji al cuadrado para los alelos y la regresión logística para los genotipos y las combinaciones alélicas. Los intervalos de confianza se calcularon a 95 % para todas las pruebas independientemente ajustadas por autoidentificación o componente genético ancestral.14 páginasapplication/pdfengInstituto Nacional de SaludColombiahttps://creativecommons.org/licenses/by/4.0/Atribución 4.0 Internacional (CC BY 4.0)info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2http://www.scielo.org.co/pdf/bio/v39n1/0120-4157-bio-39-01-00088.pdfEvaluation of variants in IL6R, TLR3, and DC-SIGN genes associated with dengue in a sampled Colombian populationEvaluación de las variantes en los genes IL6R, TLR3 y DC-SIGN asociadas con dengue en una muestra de población colombianaArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Colombia10118839BiomédicaSalles TS, da Encarnacao Sa-Guimaraes T, de Alvarenga ES, Guimaraes-Ribeiro V, de Meneses MD, de Castro-Salles PF, et al. 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Int J Cancer. 2013;133:2325-33. https://doi.org/10.1002/ijc.28251PolymorphismPolimorfismoPolimorfism geneticGenetic polymorphismPolimorfismo genéticoToll-Like Receptor 3Receptor Toll-Like 3Receptor 3 Toll-LikeColombiaColômbiaDengue/geneticsLICENSElicense.txtlicense.txttext/plain; charset=utf-814828https://dspace.tdea.edu.co/bitstream/tdea/2798/2/license.txt2f9959eaf5b71fae44bbf9ec84150c7aMD52open accessORIGINALEvaluation of variants in IL6R, TLR3, and DC-SIGN.pdfEvaluation of variants in IL6R, TLR3, and DC-SIGN.pdfapplication/pdf836073https://dspace.tdea.edu.co/bitstream/tdea/2798/1/Evaluation%20of%20variants%20in%20IL6R%2c%20TLR3%2c%20and%20DC-SIGN.pdfb6a6faf6dc689440af9a3b172c88c9abMD51open accessTEXTEvaluation of variants in IL6R, TLR3, and DC-SIGN.pdf.txtEvaluation of variants in IL6R, TLR3, and DC-SIGN.pdf.txtExtracted 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 incorporada en las Obras Colectivas.

b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda.

c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas. Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).

4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:

a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).

b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.

c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.

d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:

i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.

ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, los consagrados por la SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.

e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, ACINPRO), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.

5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

7. Término.

a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.

b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.

8. Varios.

a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.

b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.

c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.

d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.
 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