Factores asociados a la sobrevida en pacientescon tumor de Wilms
Introducción. El tumor de Wilms es el segundo tumor abdominal más frecuente en la edad pediátrica y responde por más del 90 % de los tumores renales en pediatría. A pesar de que la sobrevida descrita es mayor del 90 %, en nuestro medio encontramos que solo alcanza al 70 %, por lo que deseamos evalua...
- Autores:
-
Herrera Toro, Mirian Natalia
Peña Aguirre, Laura
Molina Castaño, Carlos Federico
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2020
- Institución:
- Tecnológico de Antioquia
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- Repositorio Tdea
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- spa
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- https://dspace.tdea.edu.co/handle/tdea/3836
- Palabra clave:
- Tumor de Wilms
Wilms Tumor
Tumeur de Wilms
Nefroblastoma
Nephroblastoma
Néphroblastome
Cirugía
Surgery
Chirurgie
Urología
Urology
Urologie
Oncología Quirúrgica
Surgical Oncology
Oncologia Cirúrgica
Oncologie chirurgicale
Supervivientes de Cáncer
Cancer Survivors
Sobreviventes de Câncer
Survivants du cancer
Pediatría
Pediatrics
Pédiatrie
Quimioterapia
Drug Therapy
Tratamento Farmacológico
Traitement médicamenteux
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| dc.title.none.fl_str_mv |
Factores asociados a la sobrevida en pacientescon tumor de Wilms |
| dc.title.translated.none.fl_str_mv |
Factors associated with survival in patient with Wilms tumor |
| title |
Factores asociados a la sobrevida en pacientescon tumor de Wilms |
| spellingShingle |
Factores asociados a la sobrevida en pacientescon tumor de Wilms Tumor de Wilms Wilms Tumor Tumeur de Wilms Nefroblastoma Nephroblastoma Néphroblastome Cirugía Surgery Chirurgie Urología Urology Urologie Oncología Quirúrgica Surgical Oncology Oncologia Cirúrgica Oncologie chirurgicale Supervivientes de Cáncer Cancer Survivors Sobreviventes de Câncer Survivants du cancer Pediatría Pediatrics Pédiatrie Quimioterapia Drug Therapy Tratamento Farmacológico Traitement médicamenteux |
| title_short |
Factores asociados a la sobrevida en pacientescon tumor de Wilms |
| title_full |
Factores asociados a la sobrevida en pacientescon tumor de Wilms |
| title_fullStr |
Factores asociados a la sobrevida en pacientescon tumor de Wilms |
| title_full_unstemmed |
Factores asociados a la sobrevida en pacientescon tumor de Wilms |
| title_sort |
Factores asociados a la sobrevida en pacientescon tumor de Wilms |
| dc.creator.fl_str_mv |
Herrera Toro, Mirian Natalia Peña Aguirre, Laura Molina Castaño, Carlos Federico |
| dc.contributor.author.none.fl_str_mv |
Herrera Toro, Mirian Natalia Peña Aguirre, Laura Molina Castaño, Carlos Federico |
| dc.subject.decs.none.fl_str_mv |
Tumor de Wilms Wilms Tumor Tumeur de Wilms Nefroblastoma Nephroblastoma Néphroblastome Cirugía Surgery Chirurgie Urología Urology Urologie Oncología Quirúrgica Surgical Oncology Oncologia Cirúrgica Oncologie chirurgicale Supervivientes de Cáncer Cancer Survivors Sobreviventes de Câncer Survivants du cancer Pediatría Pediatrics Pédiatrie Quimioterapia Drug Therapy Tratamento Farmacológico Traitement médicamenteux |
| topic |
Tumor de Wilms Wilms Tumor Tumeur de Wilms Nefroblastoma Nephroblastoma Néphroblastome Cirugía Surgery Chirurgie Urología Urology Urologie Oncología Quirúrgica Surgical Oncology Oncologia Cirúrgica Oncologie chirurgicale Supervivientes de Cáncer Cancer Survivors Sobreviventes de Câncer Survivants du cancer Pediatría Pediatrics Pédiatrie Quimioterapia Drug Therapy Tratamento Farmacológico Traitement médicamenteux |
| description |
Introducción. El tumor de Wilms es el segundo tumor abdominal más frecuente en la edad pediátrica y responde por más del 90 % de los tumores renales en pediatría. A pesar de que la sobrevida descrita es mayor del 90 %, en nuestro medio encontramos que solo alcanza al 70 %, por lo que deseamos evaluar cuáles son los factores asociados con dichos resultados desfavorables, con el fin de implementar medidas para mejorar la sobrevida de nuestros pacientes.Métodos. Se realizó un estudio observacional, transversal, en dos centros de alto nivel de atención, que incluyó una muestra de 84 pacientes menores de 15 años, con diagnóstico de tumor de Wilms.Resultados. Los factores que se asociaron significativamente con un aumento en la probabilidad de morir fueron: no completar el protocolo de quimioterapia, (OR 34; IC95% 3,7-312; p 0,000) y presentar recidiva tumoral (OR 35,7; IC95% 6,9-184; p 0,000). Otros factores que aumentaron esta probabilidad sin alcanzar a ser significativos, pero mostrando una evidente tendencia fueron: presentación bilateral (OR 4,1; IC95% 0,6-5,5; p 0,147), complicaciones quirúrgicas (OR 3,2; IC95% 0,7-14,6; p 0,136), compromiso de ganglios linfáticos en tomografía (OR 2,4; IC95% 0,7-8,4; p 0,139) y las metástasis a distancia (OR 2,5; IC95% 0,7-9; p 0,143). Discusión. La sobrevida de nuestros niños con tumor de Wilms es menor que la reportada en la literatura mundial, siendo la falla en terminar la quimioterapia, la recidiva y la necesidad de cirugía bilateral, los factores asociados con este desenlace. Palabras clave: tumor de Wilms; nefroblastoma; cirugía; urología; oncología quirúrgica; supervivientes de cáncer. |
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2020 |
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2020 |
| dc.date.accessioned.none.fl_str_mv |
2023-09-02T23:10:25Z |
| dc.date.available.none.fl_str_mv |
2023-09-02T23:10:25Z |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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2619-6107 |
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Revista Colombiana de Cirugía |
| dc.relation.references.spa.fl_str_mv |
Mejía F. Tumor de Wilms (nefroblastoma). En: Arango-Rave ME, Herrera-Toro N, Uribe-Restrepo FL, editores. Cirugía Pediátrica. Segunda edición. Medellín: Editorial Universidad de Antioquia, 2017. p 365-371. Gurney JG, Severson RK, Davis S, Robison LL. Incidence of cancer in children in the UnitedStates. Sex-, race-, and 1-year age-specific rates by histologic type. Cancer. 1995;75:2186-95. https://doi.org/10.1002/1097-0142(19950415)75:8<2186::AID-CNCR2820750825>3.0.CO;2-F Stiller CA, Parkin DM. International variations in the incidence of childhood renal tumours. Br J Cancer. 1990;62:1026-30. https://doi.org/10.1038/bjc.1990.432 Instituto Nacional de Cancerología - ESE. Anuario Estadístico 2015. Bogotá, 2018. p. 120. Fecha de consulta: 20 de enero de 2020. Disponible en: http://www.cancer.gov.co/files/libros/archivos/2015 Herrera-Toro NH, Peña-Aguirre L, Arango-Rave ME. Tumor de Wilms: experiencia de 12 años en dos hospitales de alto nivel en Medellín, Colombia. Iatreia. 2019;32:82-91. https://doi.org/10.17533/udea.iatreia.13 D’Angelo P, Di Cataldo A, Terenziani M, Bisogno G, Collini P, Di Martino M, et al. Factors possibly affecting prognosis in children with Wilms’ tumor diagnosed before 24 months of age: A report from the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) Wilms Tumor WorkingGroup. Pediatr Blood Cancer. 2017;64:12-64. https://doi.org/10.1002/pbc.26644 Aronson DC, Hadley GP. Age is not a prognostic factor in children with Wilms tumor beyond stage I in Africa. Pediatr Blood Cancer. 2014;61:987-9. https://doi.org/10.1002/pbc.24948 Reinhard H, Semler O, Bürger D, Bode U, Flentje M, Göbel U, et al. Results of the SIOP 93-01/GPOH trial and study for the treatment of patients with unilateral non metastatic Wilms tumor. Klin Padiatr. 2004;216:132-40. https://doi.org/10.1055/s-2004-822625 Dome JS, Perlman EJ, Graf N. Risk stratification for Wilms tumor: current approach and future directions. Am Soc Clin Oncol. 2014;34:215-23. https://doi.org/10.14694/EdBook_AM.2014.34.215 Uba AF, Chirdan LB. Childhood Wilms’ tumour: prognostic factors in North Central Nigeria. West Afr J Med. 2007;26:222-5. https://doi.org/10.4314/wajm.v26i3.28314 Ekenze SO, Agugua-Obianyo NEN, Odetunde OA. The challenge of nephroblastoma in a developing country. Ann Oncol. 2006;17:1598-1600. https://doi.org/10.1093/annonc/mdl167 Axt J, Abdallah F, Axt M, Githanga J, Hansen E, Lessan J, et al. Wilms tumor survival in Kenya. J Pediatr Surg. 2013;48:1254-62. https://doi.org/10.1016/j.jpedsurg.2013.03.021 Atanda AT, Anyanwu L-JC, Atanda OJ, Mohammad AM, Abdullahi LB, Farinyaro AU. Wilms’ tumour: Determinants of prognosis in an African setting. Afr J Paediatr Surg. 2015;12:171-6. https://doi.org/10.4103/0189-6725.170185 Abubakar AM, Bwala JK, Abdur-Rahman LO, Chinda JY, Adeniran JO. Outcome of treatment of nephroblastoma in Nigerian children. Afr J Paediatr Surg. 2010;7:45-52. Osuoji RI, Williams OM, Ajai OT, Idika OC, Abolarinwa AA, Bankole MA. Wilms’ tumour: Experience in a developing tertiary centre in Nigeria. East Cent Afr J Surg. 2011;16:123-8. Sangkhathat S, Chotsampancharaen T, Kayasut K, Patrapinyokul S, Chiengkriwate P, Kitichet R, et al. Outcomes of pediatric nephroblastoma in southern Thailand. Asian Pac J Cancer Prev. 2008;9:643-7. Saltzman AF, Carrasco A, Amini A, Aldrink JH, Dasgupta R, Gow KW, et al. Patterns of lymph node sampling and the impact of lymph node density in favorable histology Wilms tumor: An analysis of the national cancer database. J Pediatr Urol. 2018;14:161.e1–161.e8. https://doi.org/10.1016/j.jpurol.2017.09.025 Zhuge Y, Cheung MC, Yang R, Koniaris LG, Neville HL, Sola JE. Improved survival with lymph node sampling in Wilms tumor. J Surg Res. 2011;167:e199-203. https://doi.org/10.1016/j.jss.2010.12.026 Kutluk T, Varan A, Büyükpamukçu N, Atahan L, Cağlar M, Akyüz C, et al. Improved survival of children with Wilms tumor. J Pediatr Hematol Oncol. 2006;28:423-6. Breslow N, Sharples K, Beckwith JB, Takashima J, Kelalis PP, Green DM, et al. Prognostic factors in non metastatic, favorable histology Wilms’ tumor. Results of the Third National Wilms’ Tumor Study. Cancer. 1991;68:2345-53. https://doi.org/10.1002/1097-0142(19911201)68:11<2345::aid-cncr2820681103>3.0.co;2-t Fernandez CV, Mullen EA, Chi Y-Y, Ehrlich PF, Perlman EJ, Kalapurakal JA, et al. Outcome and prognostic factors in stage III favorable-histology Wilms tumor: A report from the Children’s Oncology Group Study AREN0532. J Clin Oncol. 2018;36:254-61. https://doi.org/10.1200/JCO.2017.73.7999 Kinoshita Y, Suminoe A, Inada H, Yagi M, Yanai F, Zaizen Y, et al. The prognostic significance of blastemal predominant histology in initially resected Wilms’ tumors: a report from the Study Group for Pediatric Solid Tumors in the Kyushu Area, Japan. J Pediatr Surg. 2012;47:2205-9. https://doi.org/10.1016/j.jpedsurg.2012.09.009 Aoba T, Urushihara N, Fukumoto K, Furuta S, Fukuzawa H, Mitsunaga M, et al. Relapse of unilateral favorable histology Wilms’ tumor: significant clinicopathological factors. J Pediatr Surg. 2012;47:2210-15. https://doi.org/10.1016/j.jpedsurg.2012.09.010 Vujanić GM, Gessler M, Ooms AHAG, Collini P, Coulomb-l’Hermine A, D’Hooghe E, et al. The UMBRELLA SIOP-RTSG 2016 Wilms tumour pathology and molecular biology protocol. Nat Rev Urol. 2018;15:693-701. https://doi.org/10.1038/s41585-018-0100-3 Zani A, Schiavetti A, Gambino M, Cozzi DA, Conforti A, Cozzi F. Long-term outcome of nephron sparing surgery and simple nephrectomy for unilateral localized Wilms tumor. J Urol. 2005;173:946-8. https://doi.org/10.1097/01.ju.0000152580.90861.d3 Sarhan OM, El-Baz M, Sarhan MM, Ghali AM, Ghoneim MA. Bilateral Wilms’ tumors: single-center experience with 22 cases and literature review. Urology. 2010;76:946-51. https://doi.org/10.1016/j.urology.2010.03.055 |
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Herrera Toro, Mirian Nataliad7295771-d228-4e0c-b68e-5532093afcd4Peña Aguirre, Laura20ce4f5b-fa3e-4f99-917e-8b15e9467708Molina Castaño, Carlos Federico0bc3477d-f51c-460a-8587-5015dbb715ec2023-09-02T23:10:25Z2023-09-02T23:10:25Z20202011-7582https://dspace.tdea.edu.co/handle/tdea/38362619-6107Introducción. El tumor de Wilms es el segundo tumor abdominal más frecuente en la edad pediátrica y responde por más del 90 % de los tumores renales en pediatría. A pesar de que la sobrevida descrita es mayor del 90 %, en nuestro medio encontramos que solo alcanza al 70 %, por lo que deseamos evaluar cuáles son los factores asociados con dichos resultados desfavorables, con el fin de implementar medidas para mejorar la sobrevida de nuestros pacientes.Métodos. Se realizó un estudio observacional, transversal, en dos centros de alto nivel de atención, que incluyó una muestra de 84 pacientes menores de 15 años, con diagnóstico de tumor de Wilms.Resultados. Los factores que se asociaron significativamente con un aumento en la probabilidad de morir fueron: no completar el protocolo de quimioterapia, (OR 34; IC95% 3,7-312; p 0,000) y presentar recidiva tumoral (OR 35,7; IC95% 6,9-184; p 0,000). Otros factores que aumentaron esta probabilidad sin alcanzar a ser significativos, pero mostrando una evidente tendencia fueron: presentación bilateral (OR 4,1; IC95% 0,6-5,5; p 0,147), complicaciones quirúrgicas (OR 3,2; IC95% 0,7-14,6; p 0,136), compromiso de ganglios linfáticos en tomografía (OR 2,4; IC95% 0,7-8,4; p 0,139) y las metástasis a distancia (OR 2,5; IC95% 0,7-9; p 0,143). Discusión. La sobrevida de nuestros niños con tumor de Wilms es menor que la reportada en la literatura mundial, siendo la falla en terminar la quimioterapia, la recidiva y la necesidad de cirugía bilateral, los factores asociados con este desenlace. Palabras clave: tumor de Wilms; nefroblastoma; cirugía; urología; oncología quirúrgica; supervivientes de cáncer.Introduction. Wilms tumor is the second most frequent abdominal tumor in pediatric age, and it accounts for more than 90% of kidney tumors in pediatrics. Although the described survival is greater than 90%, in our set-ting we find that it only reaches 70%. Our objective was to evaluate the factors associated with these unfavorable results, in order to implement measures to improve the survival of our patients.Methods. An observational, cross-sectional study was conducted in two tertiary medical centers, which included a sample of 84 patients under 15 years of age with a diagnosis of Wilms tumor.Results. The factors that were significantly associated with an increase in the probability of dying were not com-pleting the chemotherapy protocol (OR 34; 95%CI 3.7-312; p 0.000) and presenting tumor recurrence (OR 35.7; 95%CI 6.9-184; p 0.000). Other factors that increased this probability without being significant, but showing an evident trend were: bilateral presentation (OR 4.1; 95%CI 0.6-5.5; p 0.147), surgical complications (OR 3.2; 95%CI 0.7-14.6; p 0.136), lymph node involvement in tomography (OR 2.4; 95%CI 0.7-8.4; p 0.139) and distant metastases (OR 2.5; 95%CI 0.7-9; p 0.143).Discussion. The survival of the children with Wilms tumor in our study was lower than that reported in the world literature, with failure to complete chemotherapy, recurrence and the need for bilateral surgery being the factors associated with this outcome.Keywords:Wilms tumor; nephroblastoma; surgery; urology; surgical oncology; cancer survivors.9 páginasapplication/pdfspaAsociación Colombiana de CirugíaColombiahttps://creativecommons.org/licenses/by-nc-nd/4.0/Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2https://www.revistacirugia.org/index.php/cirugia/article/view/556Factores asociados a la sobrevida en pacientescon tumor de WilmsFactors associated with survival in patient with Wilms tumorArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Medellín, Colombia629462135Revista Colombiana de CirugíaMejía F. Tumor de Wilms (nefroblastoma). En: Arango-Rave ME, Herrera-Toro N, Uribe-Restrepo FL, editores. Cirugía Pediátrica. Segunda edición. Medellín: Editorial Universidad de Antioquia, 2017. p 365-371.Gurney JG, Severson RK, Davis S, Robison LL. Incidence of cancer in children in the UnitedStates. Sex-, race-, and 1-year age-specific rates by histologic type. Cancer. 1995;75:2186-95. https://doi.org/10.1002/1097-0142(19950415)75:8<2186::AID-CNCR2820750825>3.0.CO;2-FStiller CA, Parkin DM. International variations in the incidence of childhood renal tumours. Br J Cancer. 1990;62:1026-30. https://doi.org/10.1038/bjc.1990.432Instituto Nacional de Cancerología - ESE. Anuario Estadístico 2015. Bogotá, 2018. p. 120. Fecha de consulta: 20 de enero de 2020. Disponible en: http://www.cancer.gov.co/files/libros/archivos/2015Herrera-Toro NH, Peña-Aguirre L, Arango-Rave ME. Tumor de Wilms: experiencia de 12 años en dos hospitales de alto nivel en Medellín, Colombia. Iatreia. 2019;32:82-91. https://doi.org/10.17533/udea.iatreia.13D’Angelo P, Di Cataldo A, Terenziani M, Bisogno G, Collini P, Di Martino M, et al. Factors possibly affecting prognosis in children with Wilms’ tumor diagnosed before 24 months of age: A report from the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) Wilms Tumor WorkingGroup. Pediatr Blood Cancer. 2017;64:12-64. https://doi.org/10.1002/pbc.26644Aronson DC, Hadley GP. Age is not a prognostic factor in children with Wilms tumor beyond stage I in Africa. Pediatr Blood Cancer. 2014;61:987-9. https://doi.org/10.1002/pbc.24948Reinhard H, Semler O, Bürger D, Bode U, Flentje M, Göbel U, et al. Results of the SIOP 93-01/GPOH trial and study for the treatment of patients with unilateral non metastatic Wilms tumor. Klin Padiatr. 2004;216:132-40. https://doi.org/10.1055/s-2004-822625Dome JS, Perlman EJ, Graf N. Risk stratification for Wilms tumor: current approach and future directions. Am Soc Clin Oncol. 2014;34:215-23. https://doi.org/10.14694/EdBook_AM.2014.34.215Uba AF, Chirdan LB. Childhood Wilms’ tumour: prognostic factors in North Central Nigeria. West Afr J Med. 2007;26:222-5. https://doi.org/10.4314/wajm.v26i3.28314Ekenze SO, Agugua-Obianyo NEN, Odetunde OA. The challenge of nephroblastoma in a developing country. Ann Oncol. 2006;17:1598-1600. https://doi.org/10.1093/annonc/mdl167Axt J, Abdallah F, Axt M, Githanga J, Hansen E, Lessan J, et al. Wilms tumor survival in Kenya. J Pediatr Surg. 2013;48:1254-62. https://doi.org/10.1016/j.jpedsurg.2013.03.021Atanda AT, Anyanwu L-JC, Atanda OJ, Mohammad AM, Abdullahi LB, Farinyaro AU. Wilms’ tumour: Determinants of prognosis in an African setting. Afr J Paediatr Surg. 2015;12:171-6. https://doi.org/10.4103/0189-6725.170185Abubakar AM, Bwala JK, Abdur-Rahman LO, Chinda JY, Adeniran JO. Outcome of treatment of nephroblastoma in Nigerian children. 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Urology. 2010;76:946-51. https://doi.org/10.1016/j.urology.2010.03.055Tumor de WilmsWilms TumorTumeur de WilmsNefroblastomaNephroblastomaNéphroblastomeCirugíaSurgeryChirurgieUrologíaUrologyUrologieOncología QuirúrgicaSurgical OncologyOncologia CirúrgicaOncologie chirurgicaleSupervivientes de CáncerCancer SurvivorsSobreviventes de CâncerSurvivants du cancerPediatríaPediatricsPédiatrieQuimioterapiaDrug TherapyTratamento FarmacológicoTraitement médicamenteuxTHUMBNAILFactores asociados a la sobrevida en pacientes con tumor de Wilms.pdf.jpgFactores asociados a la sobrevida en pacientes con tumor de Wilms.pdf.jpgGenerated Thumbnailimage/jpeg12363https://dspace.tdea.edu.co/bitstream/tdea/3836/4/Factores%20asociados%20a%20la%20sobrevida%20en%20pacientes%20con%20tumor%20de%20Wilms.pdf.jpga2e7ebcefa0d26a92431249031e99d3fMD54open accessTEXTFactores asociados a la sobrevida en pacientes con tumor de Wilms.pdf.txtFactores asociados a la sobrevida en pacientes con tumor de Wilms.pdf.txtExtracted 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 incorporada en las Obras Colectivas.

b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda.

c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas. Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).

4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:

a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).

b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.

c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.

d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:

i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.

ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, los consagrados por la SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.

e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, ACINPRO), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.

5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

7. Término.

a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.

b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.

8. Varios.

a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.

b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.

c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.

d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.
 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