Insulin resistance and -cell function in Colombian mestizo and Embera-Chamí populations and their relation with adiposity degree
Background and objective: Insulin resistance (IR) is a condition favored by metabolic and endocrine changes experienced by adipose tissue in the context of obesity. The prevalence and the presentation of both IR and obesity vary among the populations, and may be affected by ancestral genetic composi...
- Autores:
-
Caro Gómez, María Antonieta
Naranjo González, Carlos Andrés
Parra Marín, María Victoria
Gallego Lopera, Berta Natalia
Valencia, Diana María
Rúa Molina, Diana Carolina
Rosique Gracia, Javier
García Pineda, Andrés Felipe
Gómez Isaza, Luis Felipe
Pizano Ramírez, Norman Diego
Arcos Palma, Edgar Gerardo
Villegas Perrasse, Alberto del Carmen
Duque Botero, Julieta
Bedoya Berrío, Gabriel de Jesús
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2017
- Institución:
- Tecnológico de Antioquia
- Repositorio:
- Repositorio Tdea
- Idioma:
- eng
- OAI Identifier:
- oai:dspace.tdea.edu.co:tdea/3783
- Acceso en línea:
- https://dspace.tdea.edu.co/handle/tdea/3783
- Palabra clave:
- Resistencia a la Insulina
Insulin Resistance
Resistência à Insulina
Insulinorésistance
Obesidad
Obesidade
Obesity
Obésité
Admixed population
Población mezclada
Amerindians
Amerindio
Amérindien
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/
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| dc.title.none.fl_str_mv |
Insulin resistance and -cell function in Colombian mestizo and Embera-Chamí populations and their relation with adiposity degree |
| title |
Insulin resistance and -cell function in Colombian mestizo and Embera-Chamí populations and their relation with adiposity degree |
| spellingShingle |
Insulin resistance and -cell function in Colombian mestizo and Embera-Chamí populations and their relation with adiposity degree Resistencia a la Insulina Insulin Resistance Resistência à Insulina Insulinorésistance Obesidad Obesidade Obesity Obésité Admixed population Población mezclada Amerindians Amerindio Amérindien |
| title_short |
Insulin resistance and -cell function in Colombian mestizo and Embera-Chamí populations and their relation with adiposity degree |
| title_full |
Insulin resistance and -cell function in Colombian mestizo and Embera-Chamí populations and their relation with adiposity degree |
| title_fullStr |
Insulin resistance and -cell function in Colombian mestizo and Embera-Chamí populations and their relation with adiposity degree |
| title_full_unstemmed |
Insulin resistance and -cell function in Colombian mestizo and Embera-Chamí populations and their relation with adiposity degree |
| title_sort |
Insulin resistance and -cell function in Colombian mestizo and Embera-Chamí populations and their relation with adiposity degree |
| dc.creator.fl_str_mv |
Caro Gómez, María Antonieta Naranjo González, Carlos Andrés Parra Marín, María Victoria Gallego Lopera, Berta Natalia Valencia, Diana María Rúa Molina, Diana Carolina Rosique Gracia, Javier García Pineda, Andrés Felipe Gómez Isaza, Luis Felipe Pizano Ramírez, Norman Diego Arcos Palma, Edgar Gerardo Villegas Perrasse, Alberto del Carmen Duque Botero, Julieta Bedoya Berrío, Gabriel de Jesús |
| dc.contributor.author.none.fl_str_mv |
Caro Gómez, María Antonieta Naranjo González, Carlos Andrés Parra Marín, María Victoria Gallego Lopera, Berta Natalia Valencia, Diana María Rúa Molina, Diana Carolina Rosique Gracia, Javier García Pineda, Andrés Felipe Gómez Isaza, Luis Felipe Pizano Ramírez, Norman Diego Arcos Palma, Edgar Gerardo Villegas Perrasse, Alberto del Carmen Duque Botero, Julieta Bedoya Berrío, Gabriel de Jesús |
| dc.subject.decs.none.fl_str_mv |
Resistencia a la Insulina Insulin Resistance Resistência à Insulina Insulinorésistance Obesidad Obesidade Obesity Obésité |
| topic |
Resistencia a la Insulina Insulin Resistance Resistência à Insulina Insulinorésistance Obesidad Obesidade Obesity Obésité Admixed population Población mezclada Amerindians Amerindio Amérindien |
| dc.subject.proposal.none.fl_str_mv |
Admixed population Población mezclada |
| dc.subject.unesco.none.fl_str_mv |
Amerindians Amerindio Amérindien |
| description |
Background and objective: Insulin resistance (IR) is a condition favored by metabolic and endocrine changes experienced by adipose tissue in the context of obesity. The prevalence and the presentation of both IR and obesity vary among the populations, and may be affected by ancestral genetic composition among other factors. The aim of this study was to compare the presence of IR and obesity in Amerindians of the Embera-Chamí ethnicity and Colombian mestizo population. Patients and methods: A sample of 630 individuals, 471 mestizos and 159 Amerindians of the Embera-Chamí ethnicity, from the general population of Colombia were studied. For each participant, anthropometric and biochemical measurements, as well as blood pressure and the Homeostatic Model Assessment (HOMA) of IR and -cell function (%B) were recorded. These values were compared between the two populations. Results: While prevalence of central obesity was similar in both populations (48.7% and 42.6% in the mestizo and Embera groups respectively; p = 0.148), body mass index (BMI) values suggested a higher prevalence of overweight in the Embera than in mestizo population (43.4% Embera, 31.8% mestizo; p = 0.027). Despite the similarities in the prevalence of HOMA-IR and HOMA-%B status between both populations, the Embera population had a significantly greater pancreatic ˇ-cell function, higher insulin levels, and better glucose control, across BMI and central obesity categories, than the mestizo population. Conclusion: There are differences in aspects related to energy metabolism between the samples of the mestizo and Amerindian populations analyzed |
| publishDate |
2017 |
| dc.date.issued.none.fl_str_mv |
2017 |
| dc.date.accessioned.none.fl_str_mv |
2023-08-16T21:37:44Z |
| dc.date.available.none.fl_str_mv |
2023-08-16T21:37:44Z |
| dc.type.spa.fl_str_mv |
Artículo de revista |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.content.spa.fl_str_mv |
Text |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/article |
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http://purl.org/redcol/resource_type/ART |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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publishedVersion |
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https://dspace.tdea.edu.co/handle/tdea/3783 |
| dc.identifier.eissn.spa.fl_str_mv |
2530-0164 |
| url |
https://dspace.tdea.edu.co/handle/tdea/3783 |
| identifier_str_mv |
2530-0164 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.citationendpage.spa.fl_str_mv |
220 |
| dc.relation.citationissue.spa.fl_str_mv |
4 |
| dc.relation.citationstartpage.spa.fl_str_mv |
211 |
| dc.relation.citationvolume.spa.fl_str_mv |
64 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Endocrinología, Diabetes y Nutrición |
| dc.relation.references.spa.fl_str_mv |
1.LassA,ZimmermannR,ObererM,ZechnerR.Lipolysis---ahighlyregulatedmulti-enzymecomplexmediatesthecatabolismofcellularfatstores.ProgLipidRes.2011;50:14---27. 2.RazakF,AnandSS,ShannonH,VurksanV,DavisB,JacobsR,etal.Definingobesitycutpointsinamultiethnicpopulation.Circulation.2007;115:2111-8 3.SongY,MansonJE,TinkerL,HowardBV,KullerLH,NathanL,etal.Insulinsensitivityandinsulinsecretiondeterminedbyhomeostasismodelassessmentandriskofdiabetesinamultiethniccohortofwom2en:theWomen’sHealthInitiativeObservationalStudy.DiabetesCare.2007;30:1747-52 4. Schulz LO, Bennet PH, Ravussin E, Kidd JR, Kidd KK, Esparza J, et al. Effects of traditional and western environments on prevalence of type 2 diabetes in Pima Indians in Mexico and the U.S. Diabetes Care. 2006;29:1866---71. 5. Campbell DD, Parra MV, Duque C, Gallego N, Franco L, Tandon A, et al. Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a colombian population. PLoS One. 2012;7:e33570 6. Catano-Bedoya ˜ JU, Duque-Botero J, Naranjo-Gonzalez CA, RúaMolina DC, Rosique-García J, García-Pineda F, et al. Prevalencia de factores de riesgo cardiovascular en indígenas emberachamí de Cristianía (Jardín), Antioquia. Iatreia. 2014;28(1): 5---16. 7. Wallace T, Levy J, Matthews D. Use and abuse of HOMA modeling. Diabetes Care. 2004;27:1487---95 8. Albert KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International. Circulation. 2009;120:1640---5. 9. Buccini G, Wolfthal D. Valores de corte para índices de insulinorresistencia, insulinosensibilidad e insulinosecreción derivados de la fórmula HOMA y del programa HOMA2: Interpretación. Rev Argent Endocrinol Metab. 2008;45:3---21 10. R Core Team. R A language and environment for statistical computing. Available at: http://www.r-project.org/. 11. Webber L, Kilpi F, Marsh T, Rtveladze K, Brown M, McPherson K. High rates of obesity and non-communicable diseases predicted across Latin America. PLoS One. 2012;7:e39589. . Instituto Colombiano de Bienestar Familiar. Encuesta Nacional de la Situación Nutricional en Colombia; 2010. Availableat: http://www.icbf.gov.co/portal/page/portal/PortalICBF/ bienestar/nutricion/ensin/LibroENSIN2010.pdf. . Ruiz ÁJ, Aschner PJ, Puerta MF, Alfonso-Cristancho R. Estudio IDEA (International Day for Evaluation of Abdominal Obesity): prevalencia de obesidad abdominal y factores de riesgo asociados en atención primaria en Colombia. Biomédica. 2012;32:610---6. 14. Miranda JJ, Herrera VM, Chirinos JA, Gómez LF, Perel P, Pichardo R, et al. Major cardiovascular risk factors in Latin America: a comparison with the United States. The Latin American Consortium of Studies in Obesity (LASO). PLoS One. 2013;8:e54056. 15. Rosique J, Restrepo MT, Manjarrés LM, Gálvez A, Santa J. Estado nutricional y hábitos alimentarios en indígenas embará en Colombia. Rev Chil Nutr. 2010;37:270---80. . Arias Cardona JA, Rivera Palomin Y, Llanes Agudelo OM. Prevalencia de Diabetes Mellitus y dislipidemias en indigenas del resguardo Canamomo-Lomaprieta. ˜ Colombia Investig Andin. 2012;14:414---26. 17. Oliveira GF, de Oliveira TRR, de Rodrigues FF, Corrêa LF, Ikejiri AT, Casulari LA. Prevalence of diabetes mellitus and impaired glucose tolerance in indigenous people from Aldeia Jaguapiru, Brazil. Rev Panam Salud Públ. 2011;29:315---21. 18. Carmona-Fonseca J, Correa A, Alcaraz G. Población, alimentación y estado nutricional entre los tules (kunas) del resguardo Caimán Nuevo (Turbo y Necoclí; Antioquia, Colombia), 2003---2004. Iatreia. 2005;18:259---78. 19. Aschner P, Buendía R, Brajkovich I, Gonzalez A, Figueredo R, Juarez XE, et al. Determination of the cutoff point for waist circumference that establishes the presence of abdominal obesity in Latin American men and women. Diabetes Res Clin Pract. 2011;93:243---7. 20. Lara M, Bustos P, Amigo H, Silva C, Rona RJ. Is waist circumference a better predictor of blood pressure, insulin resistance and blood lipids than body mass index in young Chilean adults? BMC Public Health. 2012;12:638. 21. Hosseinpanah F, Borzooei S, Barzin M, Farshadi M, Sarvghadi F, Azizi F. Diagnostic values of metabolic syndrome definitions for detection of insulin resistance: Tehran Lipid and Glucose Study (TLGS). Arch Iran Med. 2012;15:606---10. 22. Torréns JI, Skurnik J, Davidow AL, Korenman SG, Santoro N, Soto-Greene M, et al. Ethnic differences in insulin sensitivity and beta-cell function in premenopausal or early perimenopausal women without diabetes: the Study of Women’s Health Across the Nation (SWAN). Diabetes Care. 2004;27:354---61. 23. Lee ET, Howard BV, Go O, et al. Prevalence of undiagnosed diabetes in three American Indian populations. A comparison of the 1997 American Diabetes Association diagnostic criteria and the 1985 World Health Organization diagnostic criteria: the Strong Heart Study. Diabetes Care. 2000;23: 181---6. 24. Rasmussen-Torvik LJ, Wassel CL, Ding J, Carr J, Cushman Jenny N, et al. Associations of body mass index and insulin resistance with leptin, adiponectin, and the leptin-to-adiponectin ratio across ethnic groups: the Multi-Ethnic Study of Atherosclerosis (MESA). Ann Epidemiol. 2012;22:705---9 25. Karelis AD. Metabolically healthy but obese individuals. Lancet. 2008;372:1281---3. 26. Vazquez G, Duval S, Jacobs DR, Silventoinen K. Comparison of body mass index, waist circumference, and waist/hip ratio in predicting incident diabetes: a meta-analysis. Epidemiol Rev. 2007;29:115---28. 27. Choukem S-P, Gautier J-F. How to measure hepatic insulin resistance? Diabetes Metab. 2008;34:664---73. 28. Martínez-Hervas S, Argente C, García-Jodar J, Priego A, Real JT, Carratala A, et al. Misclassification of subjects with insulin resistance and associated cardiovascular risk factors by homeostasis model assessment index. Utility of a postprandial method based on oral glucose tolerance test. metabolism. 2011; 60:740-6 29. Schargrodosky H, Hernández-Hernández R, Champagne BM, Silva H, Vinueza R, Silva Ayc¸aguer LC, et al. CARMELA: assessment of cardiovascular risk in seven Latin American cities. Am J Med. 2008;121:58---65. 30. Ramos-Clason E. Transición epidemiológica en Colombia: de las enfermedades infecciosas a las no transmisibles. Ciencias Bioméd. 2012;3:282---90. 31. Lamus-Lemus F, Díaz-Quijano DM, Rincón-Rodríguez CJ, Huertas-Moreno ML. Avances en la comprensión de la transición nutricional colombiana. Rev Gerenc Polit Salud. 2012;11:121---33. |
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Caro Gómez, María Antonietaf6ae0204-fae2-49bb-89aa-fe356063d0a2Naranjo González, Carlos Andrés58860a1a-f878-41dc-b7d9-0ae856a713bbParra Marín, María Victoriacf2c90a2-f2a0-444f-bde5-5c5db89110eeGallego Lopera, Berta Nataliaac709b9b-beef-4ce8-8754-a5dc4fa5c419Valencia, Diana María30344eb1-dfee-452a-b803-99276b01e381Rúa Molina, Diana Carolinae5b06a52-9683-4711-bb48-5df5bdb4c2b7Rosique Gracia, Javier52ab66c8-6714-406d-b1f0-b133f8044181García Pineda, Andrés Felipe0bdd3fac-0af6-45e8-8a54-98d20b800276Gómez Isaza, Luis Felipe600be77b-8b05-4a5e-a271-aff1a811726bPizano Ramírez, Norman Diego0b757632-eda0-4e54-ae08-fd3fca0f8cf8Arcos Palma, Edgar Gerardo97d2d32a-e639-4b27-b402-256333d64b6fVillegas Perrasse, Alberto del Carmena8789883-5295-409c-957d-3015a7f4b952Duque Botero, Julieta33cc5238-f5ce-4fc7-b9c7-85694ca65ceaBedoya Berrío, Gabriel de Jesús18c5ce6d-baa3-4b8e-948d-f5ca61601ba02023-08-16T21:37:44Z2023-08-16T21:37:44Z2017https://dspace.tdea.edu.co/handle/tdea/37832530-0164Background and objective: Insulin resistance (IR) is a condition favored by metabolic and endocrine changes experienced by adipose tissue in the context of obesity. The prevalence and the presentation of both IR and obesity vary among the populations, and may be affected by ancestral genetic composition among other factors. The aim of this study was to compare the presence of IR and obesity in Amerindians of the Embera-Chamí ethnicity and Colombian mestizo population. Patients and methods: A sample of 630 individuals, 471 mestizos and 159 Amerindians of the Embera-Chamí ethnicity, from the general population of Colombia were studied. For each participant, anthropometric and biochemical measurements, as well as blood pressure and the Homeostatic Model Assessment (HOMA) of IR and -cell function (%B) were recorded. These values were compared between the two populations. Results: While prevalence of central obesity was similar in both populations (48.7% and 42.6% in the mestizo and Embera groups respectively; p = 0.148), body mass index (BMI) values suggested a higher prevalence of overweight in the Embera than in mestizo population (43.4% Embera, 31.8% mestizo; p = 0.027). Despite the similarities in the prevalence of HOMA-IR and HOMA-%B status between both populations, the Embera population had a significantly greater pancreatic ˇ-cell function, higher insulin levels, and better glucose control, across BMI and central obesity categories, than the mestizo population. Conclusion: There are differences in aspects related to energy metabolism between the samples of the mestizo and Amerindian populations analyzedAntecedentes y objetivo: La resistencia a la insulina (RI) es una condición favorecida por las alteraciones metabólicas y endocrinológicas experimentadas por el tejido adiposo en el contexto de obesidad. Tanto la prevalencia como la presentación de RI y obesidad varían entre las poblaciones y puede ser afectada, entre otros factores, por la composición genética ancestral. El objetivo de este estudio fue comparar la presentación tanto de RI como de obesidad entre amerindios de la etnia embera-chamí y población mestiza colombiana. Pacientes y métodos: Se estudió una muestra de 630 individuos de la población general mestiza colombiana (471 individuos) y de amerindios de la etnia embera-chamí (159 individuos). Para todos los participantes se registraron tanto medidas antropométricas, bioquímicas así como de presión arterial y el índice homeostatic model assessment (HOMA) para la RI y función de la célula ˇ, valores que fueron comparados entre las poblaciones. Resultados: Mientras que ambas poblaciones mostraron una prevalencia de obesidad central similar (48,7% en mestizos, 42,6% en embera; p = 0,148), los embera presentaron mayor exceso de peso de acuerdo al índice de masa corporal que los mestizos (43,4% en embera, 31,8% en mestizos; p = 0,027). A pesar de las similitudes en la prevalencia de HOMA2-RI y HOMA2- %B entre ambas poblaciones, los embera presentan una función significativamente mayor de las células ˇ del páncreas, niveles de insulina comparativamente mayores y un mejor control glucémico que los mestizos. Conclusión: Existen diferencias en aspectos del metabolismo energético entre las muestras de población mestiza y amerindia analizadas10 páginasapplication/pdfengElsevierEspañahttps://creativecommons.org/licenses/by-nc-nd/4.0/Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2https://www.elsevier.es/es-revista-endocrinologia-diabetes-nutricion-13-pdf-S2530016417300800Insulin resistance and -cell function in Colombian mestizo and Embera-Chamí populations and their relation with adiposity degreeArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Colombia220421164Endocrinología, Diabetes y Nutrición1.LassA,ZimmermannR,ObererM,ZechnerR.Lipolysis---ahighlyregulatedmulti-enzymecomplexmediatesthecatabolismofcellularfatstores.ProgLipidRes.2011;50:14---27.2.RazakF,AnandSS,ShannonH,VurksanV,DavisB,JacobsR,etal.Definingobesitycutpointsinamultiethnicpopulation.Circulation.2007;115:2111-83.SongY,MansonJE,TinkerL,HowardBV,KullerLH,NathanL,etal.Insulinsensitivityandinsulinsecretiondeterminedbyhomeostasismodelassessmentandriskofdiabetesinamultiethniccohortofwom2en:theWomen’sHealthInitiativeObservationalStudy.DiabetesCare.2007;30:1747-524. Schulz LO, Bennet PH, Ravussin E, Kidd JR, Kidd KK, Esparza J, et al. Effects of traditional and western environments on prevalence of type 2 diabetes in Pima Indians in Mexico and the U.S. Diabetes Care. 2006;29:1866---71.5. Campbell DD, Parra MV, Duque C, Gallego N, Franco L, Tandon A, et al. Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a colombian population. PLoS One. 2012;7:e335706. Catano-Bedoya ˜ JU, Duque-Botero J, Naranjo-Gonzalez CA, RúaMolina DC, Rosique-García J, García-Pineda F, et al. Prevalencia de factores de riesgo cardiovascular en indígenas emberachamí de Cristianía (Jardín), Antioquia. Iatreia. 2014;28(1): 5---16.7. Wallace T, Levy J, Matthews D. Use and abuse of HOMA modeling. Diabetes Care. 2004;27:1487---958. Albert KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International. Circulation. 2009;120:1640---5.9. Buccini G, Wolfthal D. Valores de corte para índices de insulinorresistencia, insulinosensibilidad e insulinosecreción derivados de la fórmula HOMA y del programa HOMA2: Interpretación. Rev Argent Endocrinol Metab. 2008;45:3---2110. R Core Team. R A language and environment for statistical computing. Available at: http://www.r-project.org/.11. Webber L, Kilpi F, Marsh T, Rtveladze K, Brown M, McPherson K. High rates of obesity and non-communicable diseases predicted across Latin America. PLoS One. 2012;7:e39589.. Instituto Colombiano de Bienestar Familiar. Encuesta Nacional de la Situación Nutricional en Colombia; 2010. 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degree.pdfapplication/pdf580688https://dspace.tdea.edu.co/bitstream/tdea/3783/1/Insulin%20resistance%20and%20B-cell%20function%20in%20Colombian%20mestizo%20and%20EmberaCham%c3%ad%20populations%20and%20their%20relation%20with%20adiposity%20degree.pdf2204ab7e25175ef3ae0b821ecb5f299aMD51open accesstdea/3783oai:dspace.tdea.edu.co:tdea/37832023-08-17 03:00:15.664An error occurred on the license name.|||https://creativecommons.org/licenses/by-nc-nd/4.0/open accessRepositorio Institucional Tecnologico de 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 incorporada en las Obras Colectivas.

b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda.

c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas. Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).

4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:

a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).

b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.

c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.

d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:

i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.

ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, los consagrados por la SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.

e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, ACINPRO), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.

5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

7. Término.

a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.

b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.

8. Varios.

a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.

b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.

c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.

d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.
 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