Hepatitis D virus and hepatitis B virus infection in Amerindian communities of the Amazonas state, Colombia

Background: In Colombia, cases of Hepatitis D virus (HDV) infection have been officially described since 1985 mainly in Amerindian population from Sierra Nevada de Santa Marta (North Caribbean Coast), Uraba (North West), and Amazon (South East). The last official report of a clinical case of HDV inf...

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Autores:
di Filipo Villa, Diana Carolina
Navas Navas, María Cristina
Cortés Mancera, Fabián Mauricio
Payares Mendoza, Edra Yajaida
Montes, Neyla
De La Hoz Restrepo, Fernando Pio
Arbeláez Montoya, María Patricia
Correa Arango, Gonzalo
Tipo de recurso:
Article of investigation
Fecha de publicación:
2015
Institución:
Tecnológico de Antioquia
Repositorio:
Repositorio Tdea
Idioma:
eng
OAI Identifier:
oai:dspace.tdea.edu.co:tdea/3771
Acceso en línea:
https://dspace.tdea.edu.co/handle/tdea/3771
Palabra clave:
Virus de la Hepatitis Delta
Hepatitis Delta Virus
Vírus Delta da Hepatite
Virus de l'hépatite delta
Virus de la Hepatitis B
Hepatitis B Virus
Vírus da Hepatite B
Virus de l'hépatite B
Sobreinfección
Superinfection
Superinfecção
Surinfection
Genotypes
Genotipo
Genótipo
Génotype
South America
América del Sur
América do Sul
Amérique du Sud
Amazonas state
Amerindian population
Estado Amazonas
Población amerindia
Rights
openAccess
License
https://creativecommons.org/licenses/by/4.0/
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network_acronym_str RepoTdea2
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repository_id_str
dc.title.none.fl_str_mv Hepatitis D virus and hepatitis B virus infection in Amerindian communities of the Amazonas state, Colombia
title Hepatitis D virus and hepatitis B virus infection in Amerindian communities of the Amazonas state, Colombia
spellingShingle Hepatitis D virus and hepatitis B virus infection in Amerindian communities of the Amazonas state, Colombia
Virus de la Hepatitis Delta
Hepatitis Delta Virus
Vírus Delta da Hepatite
Virus de l'hépatite delta
Virus de la Hepatitis B
Hepatitis B Virus
Vírus da Hepatite B
Virus de l'hépatite B
Sobreinfección
Superinfection
Superinfecção
Surinfection
Genotypes
Genotipo
Genótipo
Génotype
South America
América del Sur
América do Sul
Amérique du Sud
Amazonas state
Amerindian population
Estado Amazonas
Población amerindia
title_short Hepatitis D virus and hepatitis B virus infection in Amerindian communities of the Amazonas state, Colombia
title_full Hepatitis D virus and hepatitis B virus infection in Amerindian communities of the Amazonas state, Colombia
title_fullStr Hepatitis D virus and hepatitis B virus infection in Amerindian communities of the Amazonas state, Colombia
title_full_unstemmed Hepatitis D virus and hepatitis B virus infection in Amerindian communities of the Amazonas state, Colombia
title_sort Hepatitis D virus and hepatitis B virus infection in Amerindian communities of the Amazonas state, Colombia
dc.creator.fl_str_mv di Filipo Villa, Diana Carolina
Navas Navas, María Cristina
Cortés Mancera, Fabián Mauricio
Payares Mendoza, Edra Yajaida
Montes, Neyla
De La Hoz Restrepo, Fernando Pio
Arbeláez Montoya, María Patricia
Correa Arango, Gonzalo
dc.contributor.author.none.fl_str_mv di Filipo Villa, Diana Carolina
Navas Navas, María Cristina
Cortés Mancera, Fabián Mauricio
Payares Mendoza, Edra Yajaida
Montes, Neyla
De La Hoz Restrepo, Fernando Pio
Arbeláez Montoya, María Patricia
Correa Arango, Gonzalo
dc.subject.decs.none.fl_str_mv Virus de la Hepatitis Delta
Hepatitis Delta Virus
Vírus Delta da Hepatite
Virus de l'hépatite delta
Virus de la Hepatitis B
Hepatitis B Virus
Vírus da Hepatite B
Virus de l'hépatite B
Sobreinfección
Superinfection
Superinfecção
Surinfection
Genotypes
Genotipo
Genótipo
Génotype
South America
América del Sur
América do Sul
Amérique du Sud
topic Virus de la Hepatitis Delta
Hepatitis Delta Virus
Vírus Delta da Hepatite
Virus de l'hépatite delta
Virus de la Hepatitis B
Hepatitis B Virus
Vírus da Hepatite B
Virus de l'hépatite B
Sobreinfección
Superinfection
Superinfecção
Surinfection
Genotypes
Genotipo
Genótipo
Génotype
South America
América del Sur
América do Sul
Amérique du Sud
Amazonas state
Amerindian population
Estado Amazonas
Población amerindia
dc.subject.proposal.none.fl_str_mv Amazonas state
Amerindian population
Estado Amazonas
Población amerindia
description Background: In Colombia, cases of Hepatitis D virus (HDV) infection have been officially described since 1985 mainly in Amerindian population from Sierra Nevada de Santa Marta (North Caribbean Coast), Uraba (North West), and Amazon (South East). The last official report of a clinical case of HDV infection in Colombia was registered in 2005. Objectives: The aims of this study were to identify cases of HDV and/or Hepatitis B virus (HBV) infection in asymptomatic Amerindians from Amazonas state, South East Colombia, and to describe the circulating viral genotypes in this population. Study design: The study population was recruited in 19 Amerindian communities in the Amazonas state. Individuals over 18 years old were screened by rapid test for Hepatitis B surface Antigen (HBsAg). Blood samples obtained from individuals positives for HBsAg in the rapid-test assay were analyzed for HBsAg, anti-HBc, anti-HDV IgM/IgG by ELISA. The detection of HBV DNA and HDV RNA was performed by PCR amplification. The viral genotype was determined by sequencing and phylogenetic analysis. Results: A total of 23/861 individuals were positive for HBsAg detection by rapid test. Serological and/or molecular markers of HDV infection were demonstrated in 43.5 % (10/23) of samples from Amerindians. The phylogenetic analysis demonstrated the exclusive circulation of HBV subgenotype F1b of and HDV 3 in this population. Conclusions: A high frequency of HBV/HDV infection was found in Amerindian population from Amazonas State, Colombia (43.5 %, 10/23). Nine cases were identified in a population of 861 asymptomatic Amerindian individuals; one symptomatic case (with diagnosis of end-stage hepatic disease) was also identified in the study. The circulation of HDV 3 and HBV subgenotype F1b suggests a constant flow of these viral genotypes as a result of the interaction of the Amerindian populations from Amazon basin. Further studies are necessary to confirm whether HBV subgenotype F1b is the prevalent in the population from South East region in Colombia. Keywords: Hepatitis D virus, Hepatitis B virus, Amazonas state, Amerindian population, Superinfection, Genotypes, South America
publishDate 2015
dc.date.issued.none.fl_str_mv 2015
dc.date.accessioned.none.fl_str_mv 2023-08-11T23:27:27Z
dc.date.available.none.fl_str_mv 2023-08-11T23:27:27Z
dc.type.spa.fl_str_mv Artículo de revista
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dc.type.content.spa.fl_str_mv Text
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dc.identifier.eissn.spa.fl_str_mv 1743-422X
url https://dspace.tdea.edu.co/handle/tdea/3771
identifier_str_mv 1743-422X
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationendpage.spa.fl_str_mv 10
dc.relation.citationissue.spa.fl_str_mv 172
dc.relation.citationstartpage.spa.fl_str_mv 1
dc.relation.citationvolume.spa.fl_str_mv 12
dc.relation.ispartofjournal.spa.fl_str_mv Virology Journal
dc.relation.references.spa.fl_str_mv Taylor JM. Virology of hepatitis D virus. Semin Liver Dis. 2012;32(3):195–200
Pascarella S, Negro F. Hepatitis D virus: an update. Liver Int. 2011;31(1):7–21
Casey JL, Brown TL, Colan EJ, Wignall FS, Gerin JL. A genotype of hepatitis D virus that occurs in northern South America. Proc Natl Acad Sci U S A. 1993;90(19):9016–20.
Bensabath G, Dias LB. Labrea hepatitis (Labrea black fever) and other fulminant forms of hepatitis in Sena Madureira, Acre and Boca do Acre, Amazonas, Brazil. Rev Inst Med Trop Sao Paulo. 1983;25(4):182–94.
Casey JL, Niro GA, Engle RE, Vega A, Gomez H, McCarthy M, et al. Hepatitis B virus (HBV)/hepatitis D virus (HDV) coinfection in outbreaks of acute hepatitis in the Peruvian Amazon basin: the roles of HDV genotype III and HBV genotype F. J Infect Dis. 1996;174(5):920–6
Gomes-Gouvea MS, Soares MC, Bensabath G, de Carvalho-Mello IM, Brito EM, Souza OS, et al. Hepatitis B virus and hepatitis delta virus genotypes in outbreaks of fulminant hepatitis (Labrea black fever) in the western Brazilian Amazon region. J Gen Virol. 2009;90(Pt 11):2638–43.
Hadler SC, De Monzon M, Ponzetto A, Anzola E, Rivero D, Mondolfi A, et al. Delta virus infection and severe hepatitis. An epidemic in the Yucpa Indians of Venezuela. Ann Intern Med. 1984;100(3):339–44
Ljunggren KE, Patarroyo ME, Engle R, Purcell RH, Gerin JL. Viral hepatitis in Colombia: a study of the “hepatitis of the Sierra Nevada de Santa Marta”. Hepatology (Baltimore, Md). 1985;5 (2):299–304.
Manock SR, Kelley PM, Hyams KC, Douce R, Smalligan RD, Watts DM, et al. An outbreak of fulminant hepatitis delta in the Waorani, an indigenous people of the Amazon basin of Ecuador. AmJTrop Med Hyg. 2000;63(3–4):209–13.
Buitrago B, Hadler SC, Popper H, Thung SN, Gerber MA, Purcell RH, et al. Epidemiologic aspects of Santa Marta hepatitis over a 40-year period. Hepatology (Baltimore, Md). 1986;6(6):1292–6
Martinez M HS, Maynard JE, Pachón Rosas T, Erazi O, Buitrago B. Prevalencia de hepatitis A, B y D en Colombia. Encuesta en cuatro poblaciones de la Zona Bananera. Biomédica. 1987;S1:92
Arboleda M JC, Echeverry ML, Arbeláez P, Gutierrez F, Yaruro C, Muriel AJ, Ramírez R. Un nuevo foco de hepatitis fulminante aguda por virus delta: Urabá, Colombia, Suramérica. X Jornadas Latinoamericanas de Hepatología, Medellin, Colombia. 1987.
Espinal C. Perfil Epidemiologico de la Hepatitis B y D en Colombia. Biomedica. 1998;18:216–49.
Martínez Durán M, De La Hoz F, Socorro Jaramillo L, Rojas C, Buitrago B, Boshell Samper J, et al. Seroepidemiología de la infección por el virus de la hepatitis B en niños de la Amazonía colombiana. Biomedica. 1991;11(1–4):6
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Instituto Nacional de Salud. Informe del comportamiento evento hepatitis b a nivel Nacional periodo XIII (semana 52) del año 2010. http://www.ins. gov.co/lineas-de-accion/Subdireccion-Vigilancia/Informe%20de%20 Evento%20Epidemiolgico/Hepatitis%20B%202010.pdf. Accessed 2015 April.
Instituto Nacional de Salud. Informe final hepatitis b y c, Colombia, 2014. http:// www.ins.gov.co/lineas-de-accion/Subdireccion-Vigilancia/Informe%20de% 20Evento%20Epidemiolgico/Hepatitis%20B%202014.pdf. Accessed 2015 April
Alvarado-Mora MV, Romano CM, Gomes-Gouvea MS, Gutierrez MF, Carrilho FJ, Pinho JR. Dynamics of hepatitis D (delta) virus genotype 3 in the Amazon region of South America. Infect Genet Evol. 2011;11(6):1462–8.
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de la Hoz F, Perez L, de Neira M, Hall AJ. Eight years of hepatitis B vaccination in Colombia with a recombinant vaccine: factors influencing hepatitis B virus infection and effectiveness. Int J Infect Dis. 2008;12(2):183–9.
Mederacke I, Yurdaydin C, Dalekos GN, Bremer B, Erhardt A, Cakaloglu Y, et al. Anti-HDV immunoglobulin M testing in hepatitis delta revisited: correlations with disease activity and response to pegylated interferon-α2a treatment. Antivir Ther. 2012;17(2):305–12.
Mumtaz K, Ahmed US, Memon S, Khawaja A, Usmani MT, Moatter T, et al. Virological and clinical characteristics of hepatitis delta virus in South Asia. Virol J. 2011;8:312
Braga WS, Brasil LM, de Souza RA, Castilho Mda C, da Fonseca JC. The occurrence of hepatitis B and delta virus infection within seven Amerindian ethnic groups in the Brazilian western Amazon. Rev Soc Bras Med Trop. 2001;34(4):349–55.
Duarte MC, Cardona N, Poblete F, Gonzalez K, Garcia M, Pacheco M, et al. A comparative epidemiological study of hepatitis B and hepatitis D virus infections in Yanomami and Piaroa Amerindians of Amazonas State, Venezuela. Trop Med Int Health. 2010;15(8):924–33.
César Cabezas S MSJ, Giovana Romero C, Carlos Carrillo P, María P. García,, Juan Reátegui S FVG, Luis Torres T. Hiperendemicidad de hepatitis viral B y Delta en pueblos indígenas de la Amazonía Peruana. Revista Peruana de Medicina Experimental y Salud Publica. 2006;23 (2):114–22
Alvarado-Mora MV, Gutierrez Fernandez MF, Gomes-Gouvêa MS, de Azevedo Neto RS, Carrilho FJ, Pinho JRR. Hepatitis B (HBV), Hepatitis C (HCV) and Hepatitis Delta (HDV) Viruses in the Colombian Population—How Is the Epidemiological Situation? PLoS ONE. 2011;6(4), e18888.
Lin YH, Wang Y, Loua A, Day GJ, Qiu Y, Nadala Jr EC, et al. Evaluation of a new hepatitis B virus surface antigen rapid test with improved sensitivity. J Clin Microbiol. 2008;46(10):3319–24.
Crispim MA, Fraiji NA, Campello SC, Schriefer NA, Stefani MM, Kiesslich D. Molecular epidemiology of hepatitis B and hepatitis delta viruses circulating in the Western Amazon region, North Brazil. BMC Infect Dis. 2014;14:94
Nakano T, Lu L, Hu X, Mizokami M, Orito E, Shapiro C, et al. Characterization of hepatitis B virus genotypes among Yucpa Indians in Venezuela. J Gen Virol. 2001;82(Pt 2):359–65
Viana S, Parana R, Moreira RC, Compri AP, Macedo V. High prevalence of hepatitis B virus and hepatitis D virus in the western Brazilian Amazon. AmJTrop Med Hyg. 2005;73(4):808–14.
Quintero A, Uzcategui N, Loureiro CL, Villegas L, Illarramendi X, Guevara ME, et al. Hepatitis delta virus genotypes I and III circulate associated with hepatitis B virus genotype F In Venezuela. J Med Virol. 2001;64(3):356–9.
Parana R, Kay A, Molinet F, Viana S, Silva LK, Salcedo JM, et al. HDV genotypes in the Western Brazilian Amazon region: A preliminary report. AmJTrop Med Hyg. 2006;75(3):475–9.
Barros LM, Gomes-Gouvea MS, Pinho JR, Alvarado-Mora MV, Dos Santos A, Mendes-Correa MC, et al. Hepatitis Delta virus genotype 8 infection in Northeast Brazil: inheritance from African slaves? Virus Res. 2011;160(1–2):333–9.
Lopez CL. Ticunas brasileros, colombianos y peruanos. Etnicidad y nacionalidad en la región de fronteras del alto Amazonas/ Solimões. Tesis Doctoral- Antropología. 2000
Cortes-Mancera F, Loureiro CL, Hoyos S, Restrepo JC, Correa G, Jaramillo S, et al. Etiology and Viral Genotype in Patients with End-Stage Liver Diseases admitted to a Hepatology Unit in Colombia. Hepat Res Treat. 2011;2011:363205.
Devesa M, Loureiro CL, Rivas Y, Monsalve F, Cardona N, Duarte MC, et al. Subgenotype diversity of hepatitis B virus American genotype F in Amerindians from Venezuela and the general population of Colombia. J Med Virol. 2008;80(1):20–6.
Ríos D, di Filippo D, Insuasty M, Rendón J, Ríos WA, Medina CL, et al. Infección por el virus de la hepatitis B en individuos con factores de exposición en Quibdó y Apartadó, Colombia. Revista Colombiana de Gastroenterología. 2015;30 (1):11–8
Alvarado-Mora MV, Romano CM, Gomes-Gouvêa MS, Gutierrez MF, Carrilho FJ, Pinho JR R. Phylogenetic analysis of complete genome sequences of hepatitis B virus from an Afro-Colombian community: presence of HBV F3/A1 recombinant strain. Virol J. 2012;9:244.
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Schaefer S. Hepatitis B, virus taxonomy and hepatitis B virus genotypes. World J Gastroenterol. 2007;13(1):14–21.
Zeng GB, Wen SJ, Wang ZH, Yan L, Sun J, Hou JL. A novel hepatitis B virus genotyping system by using restriction fragment length polymorphism patterns of S gene amplicons. World J Gastroenterol. 2004;10(21):3132–6
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spelling di Filipo Villa, Diana Carolina4e7e0ddd-a8c8-4e4c-bfe8-1963f7d16b46Navas Navas, María Cristina9855c86d-219d-4379-be27-b75f17d3ee7cCortés Mancera, Fabián Mauricio2c70ddd3-c8df-4ae0-a4e3-bd8a4942c590Payares Mendoza, Edra Yajaida68addfd6-07be-4421-a195-8daec0d79051Montes, Neylacb054e3c-d641-436c-b5fe-c1a5aa07790bDe La Hoz Restrepo, Fernando Pioe3707577-9f62-4a38-ba95-a2e628d077a6Arbeláez Montoya, María Patricia8cc1487b-9429-4d0f-93c2-3295b34b9c7bCorrea Arango, Gonzalobf475a3d-a4aa-4b14-82de-f754590080592023-08-11T23:27:27Z2023-08-11T23:27:27Z2015https://dspace.tdea.edu.co/handle/tdea/37711743-422XBackground: In Colombia, cases of Hepatitis D virus (HDV) infection have been officially described since 1985 mainly in Amerindian population from Sierra Nevada de Santa Marta (North Caribbean Coast), Uraba (North West), and Amazon (South East). The last official report of a clinical case of HDV infection in Colombia was registered in 2005. Objectives: The aims of this study were to identify cases of HDV and/or Hepatitis B virus (HBV) infection in asymptomatic Amerindians from Amazonas state, South East Colombia, and to describe the circulating viral genotypes in this population. Study design: The study population was recruited in 19 Amerindian communities in the Amazonas state. Individuals over 18 years old were screened by rapid test for Hepatitis B surface Antigen (HBsAg). Blood samples obtained from individuals positives for HBsAg in the rapid-test assay were analyzed for HBsAg, anti-HBc, anti-HDV IgM/IgG by ELISA. The detection of HBV DNA and HDV RNA was performed by PCR amplification. The viral genotype was determined by sequencing and phylogenetic analysis. Results: A total of 23/861 individuals were positive for HBsAg detection by rapid test. Serological and/or molecular markers of HDV infection were demonstrated in 43.5 % (10/23) of samples from Amerindians. The phylogenetic analysis demonstrated the exclusive circulation of HBV subgenotype F1b of and HDV 3 in this population. Conclusions: A high frequency of HBV/HDV infection was found in Amerindian population from Amazonas State, Colombia (43.5 %, 10/23). Nine cases were identified in a population of 861 asymptomatic Amerindian individuals; one symptomatic case (with diagnosis of end-stage hepatic disease) was also identified in the study. The circulation of HDV 3 and HBV subgenotype F1b suggests a constant flow of these viral genotypes as a result of the interaction of the Amerindian populations from Amazon basin. Further studies are necessary to confirm whether HBV subgenotype F1b is the prevalent in the population from South East region in Colombia. Keywords: Hepatitis D virus, Hepatitis B virus, Amazonas state, Amerindian population, Superinfection, Genotypes, South America10 páginasapplication/pdfengBioMed CentralInglaterrahttps://creativecommons.org/licenses/by/4.0/Atribución 4.0 Internacional (CC BY 4.0)info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2https://virologyj.biomedcentral.com/counter/pdf/10.1186/s12985-015-0402-5.pdf?pdf=button%20stickyHepatitis D virus and hepatitis B virus infection in Amerindian communities of the Amazonas state, ColombiaArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Amazonas, Colombia10172112Virology JournalTaylor JM. Virology of hepatitis D virus. Semin Liver Dis. 2012;32(3):195–200Pascarella S, Negro F. Hepatitis D virus: an update. Liver Int. 2011;31(1):7–21Casey JL, Brown TL, Colan EJ, Wignall FS, Gerin JL. A genotype of hepatitis D virus that occurs in northern South America. Proc Natl Acad Sci U S A. 1993;90(19):9016–20.Bensabath G, Dias LB. Labrea hepatitis (Labrea black fever) and other fulminant forms of hepatitis in Sena Madureira, Acre and Boca do Acre, Amazonas, Brazil. Rev Inst Med Trop Sao Paulo. 1983;25(4):182–94.Casey JL, Niro GA, Engle RE, Vega A, Gomez H, McCarthy M, et al. Hepatitis B virus (HBV)/hepatitis D virus (HDV) coinfection in outbreaks of acute hepatitis in the Peruvian Amazon basin: the roles of HDV genotype III and HBV genotype F. J Infect Dis. 1996;174(5):920–6Gomes-Gouvea MS, Soares MC, Bensabath G, de Carvalho-Mello IM, Brito EM, Souza OS, et al. Hepatitis B virus and hepatitis delta virus genotypes in outbreaks of fulminant hepatitis (Labrea black fever) in the western Brazilian Amazon region. J Gen Virol. 2009;90(Pt 11):2638–43.Hadler SC, De Monzon M, Ponzetto A, Anzola E, Rivero D, Mondolfi A, et al. Delta virus infection and severe hepatitis. An epidemic in the Yucpa Indians of Venezuela. Ann Intern Med. 1984;100(3):339–44Ljunggren KE, Patarroyo ME, Engle R, Purcell RH, Gerin JL. Viral hepatitis in Colombia: a study of the “hepatitis of the Sierra Nevada de Santa Marta”. Hepatology (Baltimore, Md). 1985;5 (2):299–304.Manock SR, Kelley PM, Hyams KC, Douce R, Smalligan RD, Watts DM, et al. An outbreak of fulminant hepatitis delta in the Waorani, an indigenous people of the Amazon basin of Ecuador. AmJTrop Med Hyg. 2000;63(3–4):209–13.Buitrago B, Hadler SC, Popper H, Thung SN, Gerber MA, Purcell RH, et al. Epidemiologic aspects of Santa Marta hepatitis over a 40-year period. Hepatology (Baltimore, Md). 1986;6(6):1292–6Martinez M HS, Maynard JE, Pachón Rosas T, Erazi O, Buitrago B. Prevalencia de hepatitis A, B y D en Colombia. 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Colombia.pdfapplication/pdf1659693https://dspace.tdea.edu.co/bitstream/tdea/3771/1/Hepatitis%20D%20virus%20and%20hepatitis%20B%20virus%20infection%20in%20Amerindian%20communities%20of%20the%20Amazonas%20state%2c%20Colombia.pdff2c55ff68e65be23762f43feff9e0cc3MD51open accesstdea/3771oai:dspace.tdea.edu.co:tdea/37712023-08-12 03:03:33.431An error occurred on the license name.|||https://creativecommons.org/licenses/by/4.0/open accessRepositorio Institucional Tecnologico de 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 incorporada en las Obras Colectivas.

b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda.

c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas. Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).

4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:

a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).

b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.

c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.

d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:

i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.

ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, los consagrados por la SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.

e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, ACINPRO), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.

5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

7. Término.

a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.

b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.

8. Varios.

a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.

b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.

c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.

d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.


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