Zika virus like particles elicit protective antibodies in mice.
Artículo digital.
- Autores:
-
Salvo, Mauricio A
Kingstad Bakke, Brock
Salas Quinchucua, Cristhian
Camacho, Erwin
Osorio, Jorge E.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2019
- Institución:
- Universidad de Sucre
- Repositorio:
- Repositorio Unisucre
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unisucre.edu.co:001/941
- Acceso en línea:
- https://repositorio.unisucre.edu.co/handle/001/941
https://doi.org/10.1371/journal.pntd.0006210.
- Palabra clave:
- Zika virus
Antibodies
Infection
Protective
- Rights
- openAccess
- License
- Derechos Reservados - Universidad de Sucre, 2019
| id |
RUNISUCRE2_ec4ff98bfe42477524b85057bd8b2165 |
|---|---|
| oai_identifier_str |
oai:repositorio.unisucre.edu.co:001/941 |
| network_acronym_str |
RUNISUCRE2 |
| network_name_str |
Repositorio Unisucre |
| repository_id_str |
|
| dc.title.spa.fl_str_mv |
Zika virus like particles elicit protective antibodies in mice. |
| title |
Zika virus like particles elicit protective antibodies in mice. |
| spellingShingle |
Zika virus like particles elicit protective antibodies in mice. Zika virus Antibodies Infection Protective |
| title_short |
Zika virus like particles elicit protective antibodies in mice. |
| title_full |
Zika virus like particles elicit protective antibodies in mice. |
| title_fullStr |
Zika virus like particles elicit protective antibodies in mice. |
| title_full_unstemmed |
Zika virus like particles elicit protective antibodies in mice. |
| title_sort |
Zika virus like particles elicit protective antibodies in mice. |
| dc.creator.fl_str_mv |
Salvo, Mauricio A Kingstad Bakke, Brock Salas Quinchucua, Cristhian Camacho, Erwin Osorio, Jorge E. |
| dc.contributor.author.spa.fl_str_mv |
Salvo, Mauricio A Kingstad Bakke, Brock Salas Quinchucua, Cristhian Camacho, Erwin Osorio, Jorge E. |
| dc.subject.proposal.spa.fl_str_mv |
Zika virus Antibodies Infection Protective |
| topic |
Zika virus Antibodies Infection Protective |
| description |
Artículo digital. |
| publishDate |
2019 |
| dc.date.accessioned.spa.fl_str_mv |
2019-10-29T19:05:44Z |
| dc.date.available.spa.fl_str_mv |
2019-10-29T19:05:44Z |
| dc.date.issued.spa.fl_str_mv |
2019-10-29 |
| dc.type.spa.fl_str_mv |
Artículo de revista |
| dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
| dc.type.content.spa.fl_str_mv |
Text |
| dc.type.redcol.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| format |
http://purl.org/coar/resource_type/c_6501 |
| status_str |
publishedVersion |
| dc.identifier.citation.spa.fl_str_mv |
Salvo, M.A., Kingstad, B., Salas, C., Camacho, E. & Osorio, J. E. (2018). Zika virus like particles elicit protective antibodies in mice. PLoS Neglected Tropical Diseases. 12(2), 1-18. |
| dc.identifier.issn.spa.fl_str_mv |
1935-2735. |
| dc.identifier.uri.spa.fl_str_mv |
https://repositorio.unisucre.edu.co/handle/001/941 |
| dc.identifier.doi.spa.fl_str_mv |
https://doi.org/10.1371/journal.pntd.0006210. |
| identifier_str_mv |
Salvo, M.A., Kingstad, B., Salas, C., Camacho, E. & Osorio, J. E. (2018). Zika virus like particles elicit protective antibodies in mice. PLoS Neglected Tropical Diseases. 12(2), 1-18. 1935-2735. |
| url |
https://repositorio.unisucre.edu.co/handle/001/941 https://doi.org/10.1371/journal.pntd.0006210. |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.spa.fl_str_mv |
Articulo de revista |
| dc.relation.references.spa.fl_str_mv |
Ioos S, Mallet HP, Leparc Goffart I, Gauthier V, Cardoso T, Herida M. Current Zika virus epidemiology and recent epidemics. Med Mal Infect. 2014; 44(7):302–7. https://doi.org/10.1016/j.medmal.2014.04. 008 PMID: 25001879. Musso D. Zika Virus Transmission from French Polynesia to Brazil. Emerg Infect Dis. 2015; 21 (10):1887. https://doi.org/10.3201/eid2110.151125 PMID: 26403318; PubMed Central PMCID: PMCPMC4593458. Faye O, Freire CC, Iamarino A, Faye O, de Oliveira JV, Diallo M, et al. Molecular evolution of Zika virus during its emergence in the 20(th) century. PLoS Negl Trop Dis. 2014; 8(1):e2636. https://doi.org/10. 1371/journal.pntd.0002636 PMID: 24421913; PubMed Central PMCID: PMCPMC3888466. Duffy MR, Chen TH, Hancock WT, Powers AM, Kool JL, Lanciotti RS, et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med. 2009; 360(24):2536–43. https://doi.org/10.1056/ NEJMoa0805715 PMID: 19516034. Cao-Lormeau VM, Roche C, Teissier A, Robin E, Berry AL, Mallet HP, et al. Zika virus, French polynesia, South pacific, 2013. Emerg Infect Dis. 2014; 20(6):1085–6. https://doi.org/10.3201/eid2006.140138 PMID: 24856001; PubMed Central PMCID: PMCPMC4036769. |
| dc.rights.spa.fl_str_mv |
Derechos Reservados - Universidad de Sucre, 2019 |
| dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| dc.rights.uri.spa.fl_str_mv |
https://creativecommons.org/licenses/by-nc/4.0/ |
| dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.creativecommons.spa.fl_str_mv |
Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
| rights_invalid_str_mv |
Derechos Reservados - Universidad de Sucre, 2019 https://creativecommons.org/licenses/by-nc/4.0/ Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.mimetype.spa.fl_str_mv |
application/pdf |
| dc.coverage.spatial.spa.fl_str_mv |
Colombia |
| dc.publisher.spa.fl_str_mv |
California, Estados Unidos: PLoS Neglected Tropical Diseases , 2018. |
| dc.source.spa.fl_str_mv |
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006210. |
| institution |
Universidad de Sucre |
| bitstream.url.fl_str_mv |
https://repositorio.unisucre.edu.co/bitstreams/4d6883b7-7520-4e72-b131-9facbaaa4600/download https://repositorio.unisucre.edu.co/bitstreams/85236bf5-e6e9-44b3-bc8d-fca5c9de9351/download https://repositorio.unisucre.edu.co/bitstreams/11efef23-9955-4611-be12-5586c5acc93c/download https://repositorio.unisucre.edu.co/bitstreams/10bfc73b-274a-4fb9-a5e1-a9c6d2df7c87/download |
| bitstream.checksum.fl_str_mv |
3855828c5966853d6a75b6b2c5b2213f 5f839364c91422e4b2a78812717048fb 32454118a7ae82aaf7115669135cd6c2 51af0ac323799ae214b272befa633d4e |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositorio Institucional Universidad de Sucre |
| repository.mail.fl_str_mv |
bdigital@metabiblioteca.com |
| _version_ |
1818102614510796800 |
| spelling |
Salvo, Mauricio A0e630696ffb8115482e29e44511a5151-1Kingstad Bakke, Brock5db1cff9d5739cc92f86feebc5c1fc9e-1Salas Quinchucua, Cristhian26799a4bcefd752dcaefcda857c2d772-1Camacho, Erwin4ebd6b0fa590af42f93f6010be385a88-1Osorio, Jorge E.1324bcfc42480b2f1bdb89098db20259-1Colombia2019-10-29T19:05:44Z2019-10-29T19:05:44Z2019-10-29Salvo, M.A., Kingstad, B., Salas, C., Camacho, E. & Osorio, J. E. (2018). Zika virus like particles elicit protective antibodies in mice. PLoS Neglected Tropical Diseases. 12(2), 1-18.1935-2735.https://repositorio.unisucre.edu.co/handle/001/941https://doi.org/10.1371/journal.pntd.0006210.Artículo digital.Mosquito-borne Zika virus (ZIKV) typically causes a mild and self-limiting illness known as Zika fever. Since its recent emergence in 2014 in the American continent, ZIKV infection during pregnancy has been closely associated with a wide range of congenital abnormalities. To date, no vaccines or antivirals are publicly available. We developed Zika virus-like particles (VLPs) and evaluated their immunogenicity and protective efficacy in mouse models. ZIKV VLPs (ZIKVLPs) formulated with alum were injected into 6-8-week-old interferon deficient AG129 mice as well as wild type BALB/c mice. Control mice received PBS/alum. Animals were challenged with 200 PFU (>1000 AG129 LD50s) of ZIKV strain H/PF/2013. All vaccinated mice survived with no morbidity or weight loss while control animals either died at 9 days post challenge (AG129) or had increased viremia (BALB/c). Neutralizing antibodies were observed in all ZIKVLP vaccinated mice. The role of neutralizing antibodies in protecting mice was demonstrated by passive transfer. Our findings demonstrate the protective efficacy of the ZIKVLP vaccine and highlight the important role that neutralizing antibodies play in protection against ZIKV infection.application/pdfengCalifornia, Estados Unidos: PLoS Neglected Tropical Diseases , 2018.Articulo de revistaIoos S, Mallet HP, Leparc Goffart I, Gauthier V, Cardoso T, Herida M. Current Zika virus epidemiology and recent epidemics. Med Mal Infect. 2014; 44(7):302–7. https://doi.org/10.1016/j.medmal.2014.04. 008 PMID: 25001879.Musso D. Zika Virus Transmission from French Polynesia to Brazil. Emerg Infect Dis. 2015; 21 (10):1887. https://doi.org/10.3201/eid2110.151125 PMID: 26403318; PubMed Central PMCID: PMCPMC4593458.Faye O, Freire CC, Iamarino A, Faye O, de Oliveira JV, Diallo M, et al. Molecular evolution of Zika virus during its emergence in the 20(th) century. PLoS Negl Trop Dis. 2014; 8(1):e2636. https://doi.org/10. 1371/journal.pntd.0002636 PMID: 24421913; PubMed Central PMCID: PMCPMC3888466.Duffy MR, Chen TH, Hancock WT, Powers AM, Kool JL, Lanciotti RS, et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med. 2009; 360(24):2536–43. https://doi.org/10.1056/ NEJMoa0805715 PMID: 19516034.Cao-Lormeau VM, Roche C, Teissier A, Robin E, Berry AL, Mallet HP, et al. Zika virus, French polynesia, South pacific, 2013. Emerg Infect Dis. 2014; 20(6):1085–6. https://doi.org/10.3201/eid2006.140138 PMID: 24856001; PubMed Central PMCID: PMCPMC4036769.Derechos Reservados - Universidad de Sucre, 2019https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)http://purl.org/coar/access_right/c_abf2https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006210.Zika virus like particles elicit protective antibodies in mice.Artículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501Texthttp://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Zika virusAntibodiesInfectionProtectivePublicationORIGINALZika virus like particles elicit protective antibodies in mice..pdfZika virus like particles elicit protective antibodies in mice..pdfapplication/pdf5387989https://repositorio.unisucre.edu.co/bitstreams/4d6883b7-7520-4e72-b131-9facbaaa4600/download3855828c5966853d6a75b6b2c5b2213fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81366https://repositorio.unisucre.edu.co/bitstreams/85236bf5-e6e9-44b3-bc8d-fca5c9de9351/download5f839364c91422e4b2a78812717048fbMD52TEXTZika virus like particles elicit protective antibodies in mice..pdf.txtZika virus like particles elicit protective antibodies in mice..pdf.txtExtracted texttext/plain57624https://repositorio.unisucre.edu.co/bitstreams/11efef23-9955-4611-be12-5586c5acc93c/download32454118a7ae82aaf7115669135cd6c2MD55THUMBNAILZika virus like particles elicit protective antibodies in mice..pdf.jpgZika virus like particles elicit protective antibodies in mice..pdf.jpgGenerated Thumbnailimage/jpeg14641https://repositorio.unisucre.edu.co/bitstreams/10bfc73b-274a-4fb9-a5e1-a9c6d2df7c87/download51af0ac323799ae214b272befa633d4eMD56001/941oai:repositorio.unisucre.edu.co:001/9412024-12-05 09:51:50.789https://creativecommons.org/licenses/by-nc/4.0/Derechos Reservados - Universidad de Sucre, 2019open.accesshttps://repositorio.unisucre.edu.coRepositorio Institucional Universidad de Sucrebdigital@metabiblioteca.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 |