An azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis.
Artículo digital.
- Autores:
-
Peters, Brian M.
Luna Tapia, Arturo
Tournu, Héléne
Rybak, Jeffrey M.
Rogers, David P.
Palmer, Glen E.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2019
- Institución:
- Universidad de Sucre
- Repositorio:
- Repositorio Unisucre
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unisucre.edu.co:001/792
- Acceso en línea:
- https://repositorio.unisucre.edu.co/handle/001/792
- Palabra clave:
- Azoles
Candida albicans
Resistance
Tolerance
Vaginal candidiasis
Vps21p
- Rights
- openAccess
- License
- Derechos Reservados - Universidad de Sucre, 2019
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| dc.title.spa.fl_str_mv |
An azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis. |
| title |
An azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis. |
| spellingShingle |
An azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis. Azoles Candida albicans Resistance Tolerance Vaginal candidiasis Vps21p |
| title_short |
An azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis. |
| title_full |
An azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis. |
| title_fullStr |
An azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis. |
| title_full_unstemmed |
An azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis. |
| title_sort |
An azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis. |
| dc.creator.fl_str_mv |
Peters, Brian M. Luna Tapia, Arturo Tournu, Héléne Rybak, Jeffrey M. Rogers, David P. Palmer, Glen E. |
| dc.contributor.author.spa.fl_str_mv |
Peters, Brian M. Luna Tapia, Arturo Tournu, Héléne Rybak, Jeffrey M. Rogers, David P. Palmer, Glen E. |
| dc.contributor.corporatename.spa.fl_str_mv |
American Society for Microbiology. |
| dc.subject.proposal.spa.fl_str_mv |
Azoles Candida albicans Resistance Tolerance Vaginal candidiasis Vps21p |
| topic |
Azoles Candida albicans Resistance Tolerance Vaginal candidiasis Vps21p |
| description |
Artículo digital. |
| publishDate |
2019 |
| dc.date.accessioned.spa.fl_str_mv |
2019-09-24T22:14:35Z |
| dc.date.available.spa.fl_str_mv |
2019-09-24T22:14:35Z |
| dc.date.issued.spa.fl_str_mv |
2019-09-24 |
| dc.type.spa.fl_str_mv |
Artículo de revista |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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Peters, B.M., Luna, A., Tournu, H., Rybak, J.M., Rogers, P.D. & Palmer, G.E. (2017). An azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis. Antimicrobial Agents and Chemotherapy . 61(6). |
| dc.identifier.issn.spa.fl_str_mv |
1098-6596 |
| dc.identifier.uri.spa.fl_str_mv |
https://repositorio.unisucre.edu.co/handle/001/792 |
| dc.identifier.doi.spa.fl_str_mv |
10.1128/AAC.00084-17 |
| identifier_str_mv |
Peters, B.M., Luna, A., Tournu, H., Rybak, J.M., Rogers, P.D. & Palmer, G.E. (2017). An azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis. Antimicrobial Agents and Chemotherapy . 61(6). 1098-6596 10.1128/AAC.00084-17 |
| url |
https://repositorio.unisucre.edu.co/handle/001/792 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.spa.fl_str_mv |
Articulo de revista |
| dc.relation.references.spa.fl_str_mv |
White TC. 1997. Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus. Antimicrob Agents Chemother 41:1482–1487. Sanglard D, Ischer F, Monod M, Bille J. 1997. Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 143: 405–416. https://doi.org/10.1099/00221287-143-2-405. Goldway M, Teff D, Schmidt R, Oppenheim AB, Koltin Y. 1995. Multidrug resistance in Candida albicans: disruption of the BENr gene. Antimicrob Agents Chemother 39:422– 426. https://doi.org/10.1128/ AAC.39.2.422. Perea S, Lopez-Ribot JL, Kirkpatrick WR, McAtee RK, Santillan RA, Martinez M, Calabrese D, Sanglard D, Patterson TF. 2001. Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients. Antimicrob Agents Chemother 45:2676 –2684. https://doi.org/10.1128/AAC.45.10.2676-2684.2001. White TC, Holleman S, Dy F, Mirels LF, Stevens DA. 2002. Resistance mechanisms in clinical isolates of Candida albicans. Antimicrob Agents Chemother 46:1704 –1713. https://doi.org/10.1128/AAC.46.6.1704-1713.2002. |
| dc.rights.spa.fl_str_mv |
Derechos Reservados - Universidad de Sucre, 2019 |
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info:eu-repo/semantics/openAccess |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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Derechos Reservados - Universidad de Sucre, 2019 https://creativecommons.org/licenses/by-nc/4.0/ Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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Colombia |
| dc.publisher.spa.fl_str_mv |
Estados Unidos Antimicrobial Agents and Chemotherapy, 2017. |
| dc.source.spa.fl_str_mv |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444139/ |
| institution |
Universidad de Sucre |
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Peters, Brian M.6950b411f4c62c3a9b335f472f53acab-1Luna Tapia, Arturo37137097b30746a987e4adcda146f579-1Tournu, Héléne1e6baf5d7fd2c313312b39ad139ae9d3-1Rybak, Jeffrey M.1271a4cea93c67dc07ac3a9096e56632-1Rogers, David P.767c451a1ba8c926209a68992155748a-1Palmer, Glen E.5f5dd8dc79907c8395ffb4851dee7394-1American Society for Microbiology.Colombia2019-09-24T22:14:35Z2019-09-24T22:14:35Z2019-09-24Peters, B.M., Luna, A., Tournu, H., Rybak, J.M., Rogers, P.D. & Palmer, G.E. (2017). An azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis. Antimicrobial Agents and Chemotherapy . 61(6).1098-6596https://repositorio.unisucre.edu.co/handle/001/79210.1128/AAC.00084-17Artículo digital.We recently reported that a Candida albicans endosomal trafficking mutant continues to grow after treatment with the azole antifungals. Herein, we report that the vps21Δ/Δ mutant does not have a survival advantage over wild-type isolates after fluconazole treatment in a mouse model of vaginal candidiasis. Furthermore, loss of VPS21 does not synergize with established mechanisms of azole resistance, such as overexpression of efflux pumps or of Erg11p, the target enzyme of the azoles. In summary, although loss of VPS21 function enhances C. albicans survival after azole treatment in vitro, it does not seem to affect azole susceptibility in vivo.application/pdfengEstados Unidos Antimicrobial Agents and Chemotherapy, 2017.Articulo de revistaWhite TC. 1997. Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus. Antimicrob Agents Chemother 41:1482–1487.Sanglard D, Ischer F, Monod M, Bille J. 1997. Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 143: 405–416. https://doi.org/10.1099/00221287-143-2-405.Goldway M, Teff D, Schmidt R, Oppenheim AB, Koltin Y. 1995. Multidrug resistance in Candida albicans: disruption of the BENr gene. Antimicrob Agents Chemother 39:422– 426. https://doi.org/10.1128/ AAC.39.2.422.Perea S, Lopez-Ribot JL, Kirkpatrick WR, McAtee RK, Santillan RA, Martinez M, Calabrese D, Sanglard D, Patterson TF. 2001. Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients. Antimicrob Agents Chemother 45:2676 –2684. https://doi.org/10.1128/AAC.45.10.2676-2684.2001.White TC, Holleman S, Dy F, Mirels LF, Stevens DA. 2002. Resistance mechanisms in clinical isolates of Candida albicans. Antimicrob Agents Chemother 46:1704 –1713. https://doi.org/10.1128/AAC.46.6.1704-1713.2002.Derechos Reservados - Universidad de Sucre, 2019https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)http://purl.org/coar/access_right/c_abf2https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444139/An azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis.Artículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501Texthttp://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85AzolesCandida albicansResistanceToleranceVaginal candidiasisVps21pPublicationORIGINALAn azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis..pdfAn azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis..pdfapplication/pdf620585https://repositorio.unisucre.edu.co/bitstreams/1298e031-9b93-4aff-bc1e-13dbd34b47dc/download4ae89e2b57ad3784120466730b5a7c92MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81366https://repositorio.unisucre.edu.co/bitstreams/a8ee262b-1132-439b-9564-b4be3a1c710b/download5f839364c91422e4b2a78812717048fbMD52TEXTAn azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis..pdf.txtAn azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis..pdf.txtExtracted texttext/plain16112https://repositorio.unisucre.edu.co/bitstreams/224c39a2-905b-48ad-9536-2be08127bc2d/downloadb36823b1d3ea5930cc39b7920737d8faMD55THUMBNAILAn azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis..pdf.jpgAn azole tolerant endosomal trafficking mutant of Candida albicans is susceptible to azole treatment in a mouse model of vaginal candidiasis..pdf.jpgGenerated Thumbnailimage/jpeg14173https://repositorio.unisucre.edu.co/bitstreams/4276a6eb-0e1b-44bc-a16b-3f815e5a0c5b/download6570a2a3b51d5e696849e5f7ddef742fMD56001/792oai:repositorio.unisucre.edu.co:001/7922024-12-05 09:51:51.534https://creativecommons.org/licenses/by-nc/4.0/Derechos Reservados - Universidad de Sucre, 2019open.accesshttps://repositorio.unisucre.edu.coRepositorio Institucional Universidad de Sucrebdigital@metabiblioteca.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 |