Genetic Characterization of Northwestern Colombian Chikungunya Virus Strains from the 2014–2015 Epidemic.
Artículo digital
- Autores:
-
Rodas, Juan D.
Kautz, Tiffany
Camacho, Erwin
Paternina, Luis
Díaz, Francisco J.
Tesh, Robert
Weaver, Scott C.
Blanco, Pedro
Guzmán, Hilda
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2019
- Institución:
- Universidad de Sucre
- Repositorio:
- Repositorio Unisucre
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unisucre.edu.co:001/802
- Acceso en línea:
- https://repositorio.unisucre.edu.co/handle/001/802
- Palabra clave:
- Chikungunya
CHIKV
Alphavirus
RNA
Epidemic
- Rights
- openAccess
- License
- Derechos Reservados - Universidad de Sucre, 2019
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Genetic Characterization of Northwestern Colombian Chikungunya Virus Strains from the 2014–2015 Epidemic. |
| title |
Genetic Characterization of Northwestern Colombian Chikungunya Virus Strains from the 2014–2015 Epidemic. |
| spellingShingle |
Genetic Characterization of Northwestern Colombian Chikungunya Virus Strains from the 2014–2015 Epidemic. Chikungunya CHIKV Alphavirus RNA Epidemic |
| title_short |
Genetic Characterization of Northwestern Colombian Chikungunya Virus Strains from the 2014–2015 Epidemic. |
| title_full |
Genetic Characterization of Northwestern Colombian Chikungunya Virus Strains from the 2014–2015 Epidemic. |
| title_fullStr |
Genetic Characterization of Northwestern Colombian Chikungunya Virus Strains from the 2014–2015 Epidemic. |
| title_full_unstemmed |
Genetic Characterization of Northwestern Colombian Chikungunya Virus Strains from the 2014–2015 Epidemic. |
| title_sort |
Genetic Characterization of Northwestern Colombian Chikungunya Virus Strains from the 2014–2015 Epidemic. |
| dc.creator.fl_str_mv |
Rodas, Juan D. Kautz, Tiffany Camacho, Erwin Paternina, Luis Díaz, Francisco J. Tesh, Robert Weaver, Scott C. Blanco, Pedro Guzmán, Hilda |
| dc.contributor.author.spa.fl_str_mv |
Rodas, Juan D. Kautz, Tiffany Camacho, Erwin Paternina, Luis Díaz, Francisco J. Tesh, Robert Weaver, Scott C. Blanco, Pedro Guzmán, Hilda |
| dc.contributor.corporatename.spa.fl_str_mv |
The American Society of Tropical Medicine and Hygiene. |
| dc.subject.proposal.spa.fl_str_mv |
Chikungunya CHIKV Alphavirus RNA Epidemic |
| topic |
Chikungunya CHIKV Alphavirus RNA Epidemic |
| description |
Artículo digital |
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2019 |
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2019-09-27T15:55:42Z |
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2019-09-27T15:55:42Z |
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2019-09-27 |
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Artículo de revista |
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Rodas, J.D., Kautz, T., Camacho, E., Paternina, L., Guzmán, H., Díaz, F.J., Blanco, P., Tesh, R. & Weaver S.C. ( 2016). Genetic Characterization of Northwestern Colombian Chikungunya Virus Strains from the 2014–2015 Epidemic. American Journal of Tropical Medicine and Hygiene . 95(3), 639–646. |
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0002-9637 |
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https://repositorio.unisucre.edu.co/handle/001/802 |
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10.4269/ajtmh.16-0091 |
| identifier_str_mv |
Rodas, J.D., Kautz, T., Camacho, E., Paternina, L., Guzmán, H., Díaz, F.J., Blanco, P., Tesh, R. & Weaver S.C. ( 2016). Genetic Characterization of Northwestern Colombian Chikungunya Virus Strains from the 2014–2015 Epidemic. American Journal of Tropical Medicine and Hygiene . 95(3), 639–646. 0002-9637 10.4269/ajtmh.16-0091 |
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https://repositorio.unisucre.edu.co/handle/001/802 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.spa.fl_str_mv |
Revista |
| dc.relation.references.spa.fl_str_mv |
Cardona-Ospina JA, Vera-Polania F, Rodriguez-Morales AJ, 2015. Chikungunya or not, differential diagnosis and the importance of laboratory confirmation for clinical and epidemiological research: comment on the article by Rosario et al. Clin Rheumatol 35: 829–830. Tsetsarkin KA, Chen R, Sherman MB, Weaver SC, 2011. Chikungunya virus: evolution and genetic determinants of emergence. Curr Opin Virol 1: 310–317.Tsetsarkin KA, Chen R, Sherman MB, Weaver SC, 2011. Chikungunya virus: evolution and genetic determinants of emergence. Curr Opin Virol 1: 310–317. Voss JE, Vaney M-C, Duquerroy S, Vonrhein C, Girard-Blanc C, Crublet E, Thompson A, Bricogne G, Rey FA, 2010. Glycoprotein organization of chikungunya virus particles revealed by X-ray crystallography. Nature 468: 709–712. Weaver SC, Lecuit M, 2015. Chikungunya virus and the global spread of a mosquito-borne disease. N Engl J Med 372: 1231–1239. Porta J, Jose J, Roehrig JT, Blair CD, Kuhn RJ, Rossmann MG, 2014. Locking and blocking the viral landscape of an alphavirus with neutralizing antibodies. J Virol 88: 9616–9623. |
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Derechos Reservados - Universidad de Sucre, 2019 |
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https://creativecommons.org/licenses/by-nc/4.0/ |
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info:eu-repo/semantics/openAccess |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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Derechos Reservados - Universidad de Sucre, 2019 https://creativecommons.org/licenses/by-nc/4.0/ Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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Colombia |
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Estados Unidos: The American Journal of Tropical Medicine and Hygiene , 2016. |
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014272/pdf/ |
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Universidad de Sucre |
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Rodas, Juan D.7fd77d298f0779fd3cb1409f32ee3170-1Kautz, Tiffany6e9230e39587f6b19eedbc8785a9bff2-1Camacho, Erwin4ebd6b0fa590af42f93f6010be385a88-1Paternina, Luisd7791a1e1ec52aa651d0f213e2ced31b-1Díaz, Francisco J.123ec94b0128409db5d79f3e5e1ab114-1Tesh, Robertf27f7568c077a611c2304770eee5ae74-1Weaver, Scott C.0ba3ebbf2105166cc5e205e6395955c7-1Blanco, Pedro53fe6e7b5af988630794acf9982e0ed5-1Guzmán, Hilda712d48503c45251c14b0b98b97df32d7-1The American Society of Tropical Medicine and Hygiene.Colombia2019-09-27T15:55:42Z2019-09-27T15:55:42Z2019-09-27Rodas, J.D., Kautz, T., Camacho, E., Paternina, L., Guzmán, H., Díaz, F.J., Blanco, P., Tesh, R. & Weaver S.C. ( 2016). Genetic Characterization of Northwestern Colombian Chikungunya Virus Strains from the 2014–2015 Epidemic. American Journal of Tropical Medicine and Hygiene . 95(3), 639–646.0002-9637https://repositorio.unisucre.edu.co/handle/001/80210.4269/ajtmh.16-0091Artículo digitalChikungunya fever, an acute and often chronic arthralgic disease caused by the mosquito-borne alphavirus,chikungunya virus (CHIKV), spread into the Americas in late 2013. Since then it has caused epidemics in nearly all New World countries, the second largest being Colombia with over 450,000 suspected cases beginning in September, 2014, and focused in Bolivar Department in the north. We examined 32 human sera from suspected cases, including diverse age groups and both genders, and sequenced the CHIKV envelope glycoprotein genes, known determinants of vector host range. As expected for Asian lineage CHIKV strains, these isolates lacked known Aedes albopictus–adaptive mutations. All the Colombian strains were closely related to those from the Virgin Islands, Saint Lucia, Mexico, Puerto Rico, and Brazil, consistent with a single, point-source introduction from the southeast Asia/Pacific region. Two substitutions in the E2 and E1 envelope glycoprotein genes were found in the Colombian strains, especially E1-K211E involving a residue shown previously to affect epistatically the penetrance of the E1-A226V A. albopictus–adaptive substitution. We also identified two amino acid substitutions unique to all American CHIKV sequences: E2-V368A and 6K-L20M. Only one codon, 6K-47, had a high nonsynonymous substitution rate suggesting positive selection.application/pdfengEstados Unidos: The American Journal of Tropical Medicine and Hygiene , 2016.RevistaCardona-Ospina JA, Vera-Polania F, Rodriguez-Morales AJ, 2015. Chikungunya or not, differential diagnosis and the importance of laboratory confirmation for clinical and epidemiological research: comment on the article by Rosario et al. Clin Rheumatol 35: 829–830.Tsetsarkin KA, Chen R, Sherman MB, Weaver SC, 2011. Chikungunya virus: evolution and genetic determinants of emergence. Curr Opin Virol 1: 310–317.Tsetsarkin KA, Chen R, Sherman MB, Weaver SC, 2011. Chikungunya virus: evolution and genetic determinants of emergence. Curr Opin Virol 1: 310–317.Voss JE, Vaney M-C, Duquerroy S, Vonrhein C, Girard-Blanc C, Crublet E, Thompson A, Bricogne G, Rey FA, 2010. Glycoprotein organization of chikungunya virus particles revealed by X-ray crystallography. Nature 468: 709–712.Weaver SC, Lecuit M, 2015. Chikungunya virus and the global spread of a mosquito-borne disease. N Engl J Med 372: 1231–1239.Porta J, Jose J, Roehrig JT, Blair CD, Kuhn RJ, Rossmann MG, 2014. Locking and blocking the viral landscape of an alphavirus with neutralizing antibodies. J Virol 88: 9616–9623.Derechos Reservados - Universidad de Sucre, 2019https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)http://purl.org/coar/access_right/c_abf2https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014272/pdf/Genetic Characterization of Northwestern Colombian Chikungunya Virus Strains from the 2014–2015 Epidemic.Artículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501Texthttp://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85ChikungunyaCHIKVAlphavirusRNAEpidemicPublicationTEXTGenetic Characterization of Northwestern Colombian Chikungunya Virus Strains from the 2014-2015 Epidemic..pdf.txtGenetic Characterization of Northwestern Colombian Chikungunya Virus Strains from the 2014-2015 Epidemic..pdf.txtExtracted texttext/plain41695https://repositorio.unisucre.edu.co/bitstreams/b97af5f0-5d69-48f5-a9ae-bb4faaac5f21/downloadd1e6b61fcbfcef22c1bc364c03dbc8bbMD55THUMBNAILGenetic Characterization of Northwestern Colombian Chikungunya Virus Strains from the 2014-2015 Epidemic..pdf.jpgGenetic Characterization of Northwestern Colombian Chikungunya Virus Strains from the 2014-2015 Epidemic..pdf.jpgGenerated Thumbnailimage/jpeg16458https://repositorio.unisucre.edu.co/bitstreams/6d88e283-2f57-4b5f-9405-984f235f888d/download91af81808c8e995fb5420c3397e01e95MD56ORIGINALGenetic Characterization of Northwestern Colombian Chikungunya Virus Strains from the 2014-2015 Epidemic..pdfGenetic Characterization of Northwestern Colombian Chikungunya Virus Strains from the 2014-2015 Epidemic..pdfapplication/pdf768620https://repositorio.unisucre.edu.co/bitstreams/b424144f-53b1-40e6-9dfd-5f8cecb37157/download7b7ae3b0cee0bf48a7fb374bdb421323MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81366https://repositorio.unisucre.edu.co/bitstreams/7ba21f85-805b-479c-a60f-85769d0a843a/download5f839364c91422e4b2a78812717048fbMD52001/802oai:repositorio.unisucre.edu.co:001/8022024-12-05 09:51:50.065https://creativecommons.org/licenses/by-nc/4.0/Derechos Reservados - Universidad de Sucre, 2019open.accesshttps://repositorio.unisucre.edu.coRepositorio Institucional Universidad de Sucrebdigital@metabiblioteca.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 |