Successful sporozoite challenge model in human volunteers with plasmodium vivax strain derived from human donors.
Artículo digital.
- Autores:
-
Herrera, Sócrates
Fernández, Olga
Manzano, María R.
Murrain, Bermans
Vergara, Juana
Blanco, Pedro
Palacios, Ricardo
Vélez, Juan D.
Epstein, Judith E.
Chen-Mok, Mario
Reed, ZarifahH
Arévalo Herrera, Myriam
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2019
- Institución:
- Universidad de Sucre
- Repositorio:
- Repositorio Unisucre
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unisucre.edu.co:001/859
- Acceso en línea:
- https://repositorio.unisucre.edu.co/handle/001/859
- Palabra clave:
- Plasmodium vivax
sporozoites
Anopheles
- Rights
- openAccess
- License
- Derechos Reservados - Universidad de Sucre, 2019
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| dc.title.spa.fl_str_mv |
Successful sporozoite challenge model in human volunteers with plasmodium vivax strain derived from human donors. |
| title |
Successful sporozoite challenge model in human volunteers with plasmodium vivax strain derived from human donors. |
| spellingShingle |
Successful sporozoite challenge model in human volunteers with plasmodium vivax strain derived from human donors. Plasmodium vivax sporozoites Anopheles |
| title_short |
Successful sporozoite challenge model in human volunteers with plasmodium vivax strain derived from human donors. |
| title_full |
Successful sporozoite challenge model in human volunteers with plasmodium vivax strain derived from human donors. |
| title_fullStr |
Successful sporozoite challenge model in human volunteers with plasmodium vivax strain derived from human donors. |
| title_full_unstemmed |
Successful sporozoite challenge model in human volunteers with plasmodium vivax strain derived from human donors. |
| title_sort |
Successful sporozoite challenge model in human volunteers with plasmodium vivax strain derived from human donors. |
| dc.creator.fl_str_mv |
Herrera, Sócrates Fernández, Olga Manzano, María R. Murrain, Bermans Vergara, Juana Blanco, Pedro Palacios, Ricardo Vélez, Juan D. Epstein, Judith E. Chen-Mok, Mario Reed, ZarifahH Arévalo Herrera, Myriam |
| dc.contributor.author.spa.fl_str_mv |
Herrera, Sócrates Fernández, Olga Manzano, María R. Murrain, Bermans Vergara, Juana Blanco, Pedro Palacios, Ricardo Vélez, Juan D. Epstein, Judith E. Chen-Mok, Mario Reed, ZarifahH Arévalo Herrera, Myriam |
| dc.contributor.corporatename.spa.fl_str_mv |
American Society of Tropical Medicine and Hygiene. |
| dc.subject.proposal.spa.fl_str_mv |
Plasmodium vivax sporozoites Anopheles |
| topic |
Plasmodium vivax sporozoites Anopheles |
| description |
Artículo digital. |
| publishDate |
2019 |
| dc.date.accessioned.spa.fl_str_mv |
2019-10-11T20:18:00Z |
| dc.date.available.spa.fl_str_mv |
2019-10-11T20:18:00Z |
| dc.date.issued.spa.fl_str_mv |
2019-10-11 |
| dc.type.spa.fl_str_mv |
Artículo de revista |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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Text |
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Herrera, S., Fernández, O., Manzano, M.R., Murrain, B., Vergara, J., Blanco, P., Palacios, R., Vélez, J.D., Epstein, J.E., Chen-Mok, M., Reed, Z.H. & Arévalo, M. (2009). Successful sporozoite challenge model in human volunteers with plasmodium vivax strain derived from human donors. American Journal of Tropical Medicine and Hygiene. 81(5): 740–746. |
| dc.identifier.issn.spa.fl_str_mv |
0002-9637 |
| dc.identifier.uri.spa.fl_str_mv |
https://repositorio.unisucre.edu.co/handle/001/859 |
| dc.identifier.doi.spa.fl_str_mv |
10.4269/ajtmh.2009.09-0194. |
| identifier_str_mv |
Herrera, S., Fernández, O., Manzano, M.R., Murrain, B., Vergara, J., Blanco, P., Palacios, R., Vélez, J.D., Epstein, J.E., Chen-Mok, M., Reed, Z.H. & Arévalo, M. (2009). Successful sporozoite challenge model in human volunteers with plasmodium vivax strain derived from human donors. American Journal of Tropical Medicine and Hygiene. 81(5): 740–746. 0002-9637 10.4269/ajtmh.2009.09-0194. |
| url |
https://repositorio.unisucre.edu.co/handle/001/859 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.spa.fl_str_mv |
Revista. |
| dc.relation.references.spa.fl_str_mv |
Mendis K, Sina BJ, Marchesini P, Carter R. The neglected burden of Plasmodium vivax malaria.Am J Trop Med Hyg 2001;64:97–106. [PubMed: 11425182. Arévalo-Herrera M, Herrera S. Plasmodium vivax malaria vaccine development. Mol Immunol2001;38:443–455. [PubMed: 11741694. Valderrama-Aguirre A, Quintero G, Gomez A, Castellanos A, Perez Y, Méndez F, Arévalo-HerreraM, Herrera S. Antigenicity, immunogenicity, and protective efficacy of Plasmodium vivax MSP1PV200l: a potential malaria vaccine subunit. Am J Trop Med Hyg 2005;73:16–24. [PubMed:16291762. Arévalo-Herrera M, Castellanos A, Yazdani SS, Shakri AR, Chitnis CE, Dominik R, Herrera S.Immunogenicity and protective efficacy of recombinant vaccine based on the receptor-bindingdomain of the Plasmodium vivax Duffy binding protein in Aotus monkeys. Am J Trop Med Hyg2005;73:25–31. [PubMed: 16291763]. Herrera S, Bonelo A, Perlaza BL, Fernandez OL, Victoria L, Lenis AM, Soto L, Hurtado H, AcunaLM, Velez JD, Palacios R, Chen-Mok M, Corradin G, Arévalo-Herrera M. Safety and elicitation ofhumoral and cellular responses in colombian malaria-naive volunteers by a Plasmodium vivaxcircumsporozoite protein-derived synthetic vaccine. Am J Trop Med Hyg 2005;73:3–9. [PubMed:16291760. |
| dc.rights.spa.fl_str_mv |
Derechos Reservados - Universidad de Sucre, 2019 |
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http://purl.org/coar/access_right/c_abf2 |
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https://creativecommons.org/licenses/by-nc/4.0/ |
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info:eu-repo/semantics/openAccess |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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Derechos Reservados - Universidad de Sucre, 2019 https://creativecommons.org/licenses/by-nc/4.0/ Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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Colombia. |
| dc.publisher.spa.fl_str_mv |
Estados Unidos: American Journal of Tropical Medicine and Hygiene, 2009. |
| dc.source.spa.fl_str_mv |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826834/pdf/nihms-175980.pdf. |
| institution |
Universidad de Sucre |
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Herrera, Sócrates0ca68c912d2a9684e742fa3b93958c0d-1Fernández, Olgaf175646354431e2ec5416b86f30906d2-1Manzano, María R.30fcbafdd0b8737a49a3034d7aff6873-1Murrain, Bermansa8018f009092453dec8f8d4a2775c192-1Vergara, Juanafd55d5c985804772678a678cc91a7475-1Blanco, Pedro53fe6e7b5af988630794acf9982e0ed5-1Palacios, Ricardo08e0b0ad0f32ffed4f39c8c9bf5f13f0-1Vélez, Juan D.73c68474d8b881b4272cff8ebc425b70-1Epstein, Judith E.7dd78c738a14ec0e1c5c4a8aa80b704e-1Chen-Mok, Mariob1ff84334a074054e80d5ea770aa45d6-1Reed, ZarifahH9f2ea2bb18fbc5478de9a9b2e0cba401-1Arévalo Herrera, Myriam2e9fd3cb4ccf25f1bea0aa9de1a42a64-1American Society of Tropical Medicine and Hygiene.Colombia.2019-10-11T20:18:00Z2019-10-11T20:18:00Z2019-10-11Herrera, S., Fernández, O., Manzano, M.R., Murrain, B., Vergara, J., Blanco, P., Palacios, R., Vélez, J.D., Epstein, J.E., Chen-Mok, M., Reed, Z.H. & Arévalo, M. (2009). Successful sporozoite challenge model in human volunteers with plasmodium vivax strain derived from human donors. American Journal of Tropical Medicine and Hygiene. 81(5): 740–746.0002-9637https://repositorio.unisucre.edu.co/handle/001/85910.4269/ajtmh.2009.09-0194.Artículo digital.Successful establishment of a Plasmodium vivax sporozoite challenge model in humans isdescribed. Eighteen healthy adult, malaria-naïve volunteers were randomly allocated to Groups A–C and exposed to 3 ± 1, 6 ± 1, and 9 ± 1 bites of Anopheles albimanus mosquitoes infected with P.vivax, respectively. Seventeen volunteers developed signs and symptoms consistent with malaria,and geometric mean prepatent periods of 11.1 days (9.3–11) for Group A; 10.8 days (9.8–11.9) forGroup B; and 10.6 days (8.7–12.4) for Group C, with no statistically significant difference amonggroups (Kruskal-Wallis, P = 0.70). One volunteer exposed to eight mosquito bites did not developa parasitemia. No differences in parasite density were observed and all individuals successfullyrecovered after anti-malarial treatment. None of the volunteers developed parasite relapses withinan 18-month follow-up. In conclusion, malaria-naive volunteers can be safely and reproducibly infected with bites of 2–10 An. albimanus mosquitoes carrying P. vivax sporozoites. Thischallenge method is suitable for vaccine and anti-malarial drug testing.application/pdfengEstados Unidos: American Journal of Tropical Medicine and Hygiene, 2009.Revista.Mendis K, Sina BJ, Marchesini P, Carter R. The neglected burden of Plasmodium vivax malaria.Am J Trop Med Hyg 2001;64:97–106. [PubMed: 11425182.Arévalo-Herrera M, Herrera S. Plasmodium vivax malaria vaccine development. Mol Immunol2001;38:443–455. [PubMed: 11741694.Valderrama-Aguirre A, Quintero G, Gomez A, Castellanos A, Perez Y, Méndez F, Arévalo-HerreraM, Herrera S. Antigenicity, immunogenicity, and protective efficacy of Plasmodium vivax MSP1PV200l: a potential malaria vaccine subunit. Am J Trop Med Hyg 2005;73:16–24. [PubMed:16291762.Arévalo-Herrera M, Castellanos A, Yazdani SS, Shakri AR, Chitnis CE, Dominik R, Herrera S.Immunogenicity and protective efficacy of recombinant vaccine based on the receptor-bindingdomain of the Plasmodium vivax Duffy binding protein in Aotus monkeys. Am J Trop Med Hyg2005;73:25–31. [PubMed: 16291763].Herrera S, Bonelo A, Perlaza BL, Fernandez OL, Victoria L, Lenis AM, Soto L, Hurtado H, AcunaLM, Velez JD, Palacios R, Chen-Mok M, Corradin G, Arévalo-Herrera M. Safety and elicitation ofhumoral and cellular responses in colombian malaria-naive volunteers by a Plasmodium vivaxcircumsporozoite protein-derived synthetic vaccine. Am J Trop Med Hyg 2005;73:3–9. [PubMed:16291760.Derechos Reservados - Universidad de Sucre, 2019https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)http://purl.org/coar/access_right/c_abf2https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826834/pdf/nihms-175980.pdf.Successful sporozoite challenge model in human volunteers with plasmodium vivax strain derived from human donors.Artículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501Texthttp://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Plasmodium vivaxsporozoitesAnophelesPublicationTEXTSuccessful sporozoite challenge model in human volunteers with plasmodium vivax strain derived from human donors..pdf.txtSuccessful sporozoite challenge model in human volunteers with plasmodium vivax strain derived from human donors..pdf.txtExtracted texttext/plain44759https://repositorio.unisucre.edu.co/bitstreams/e9a42081-ee74-4de3-91c9-d1d75a271ba3/download855560dbad6739968b52c08cba798a39MD55THUMBNAILSuccessful sporozoite challenge model in human volunteers with plasmodium vivax strain derived from human donors..pdf.jpgSuccessful sporozoite challenge model in human volunteers with plasmodium vivax strain derived from human donors..pdf.jpgGenerated Thumbnailimage/jpeg15446https://repositorio.unisucre.edu.co/bitstreams/e85e4790-bcdf-4ed1-b17f-c9d6b2bb1656/downloadf6326964bb9ad531c285592dc4f95385MD56ORIGINALSuccessful sporozoite challenge model in human volunteers with plasmodium vivax strain derived from human donors..pdfSuccessful sporozoite challenge model in human volunteers with plasmodium vivax strain derived from human donors..pdfapplication/pdf336283https://repositorio.unisucre.edu.co/bitstreams/eff570de-6e23-41a9-b7a3-24cfc2eb8f3e/download8292d659369660374971a2ab96624a27MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81366https://repositorio.unisucre.edu.co/bitstreams/6367e3f0-71d1-46d8-8e71-3c94ef38cc8e/download5f839364c91422e4b2a78812717048fbMD52001/859oai:repositorio.unisucre.edu.co:001/8592024-04-17 16:30:47.504https://creativecommons.org/licenses/by-nc/4.0/Derechos Reservados - Universidad de Sucre, 2019open.accesshttps://repositorio.unisucre.edu.coRepositorio Institucional Universidad de Sucrebdigital@metabiblioteca.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 |