Trafficking through the late endosome significantly impacts candida albicans tolerance of the azole antifungals.
Artículo digital.
- Autores:
-
Luna Tapia, Arturo
Kerns, Morgan E.
Jursic, Branko S.
Eberle, Karen E.
Palmer, Glen E.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2019
- Institución:
- Universidad de Sucre
- Repositorio:
- Repositorio Unisucre
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unisucre.edu.co:001/817
- Acceso en línea:
- https://repositorio.unisucre.edu.co/handle/001/817
- Palabra clave:
- Candida albicans
Antifungals
Azole
- Rights
- openAccess
- License
- Derechos Reservados - Universidad de Sucre, 2019
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| dc.title.spa.fl_str_mv |
Trafficking through the late endosome significantly impacts candida albicans tolerance of the azole antifungals. |
| title |
Trafficking through the late endosome significantly impacts candida albicans tolerance of the azole antifungals. |
| spellingShingle |
Trafficking through the late endosome significantly impacts candida albicans tolerance of the azole antifungals. Candida albicans Antifungals Azole |
| title_short |
Trafficking through the late endosome significantly impacts candida albicans tolerance of the azole antifungals. |
| title_full |
Trafficking through the late endosome significantly impacts candida albicans tolerance of the azole antifungals. |
| title_fullStr |
Trafficking through the late endosome significantly impacts candida albicans tolerance of the azole antifungals. |
| title_full_unstemmed |
Trafficking through the late endosome significantly impacts candida albicans tolerance of the azole antifungals. |
| title_sort |
Trafficking through the late endosome significantly impacts candida albicans tolerance of the azole antifungals. |
| dc.creator.fl_str_mv |
Luna Tapia, Arturo Kerns, Morgan E. Jursic, Branko S. Eberle, Karen E. Palmer, Glen E. |
| dc.contributor.author.spa.fl_str_mv |
Luna Tapia, Arturo Kerns, Morgan E. Jursic, Branko S. Eberle, Karen E. Palmer, Glen E. |
| dc.contributor.corporatename.spa.fl_str_mv |
American Society for Microbiology. |
| dc.subject.proposal.spa.fl_str_mv |
Candida albicans Antifungals Azole |
| topic |
Candida albicans Antifungals Azole |
| description |
Artículo digital. |
| publishDate |
2019 |
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2019-10-02T16:38:52Z |
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2019-10-02T16:38:52Z |
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2019-10-02 |
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Artículo de revista |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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Luna, A., Kerns, M.E., Eberle, K.E., Jursic, B.S. & Palmer, G.E. (2015). Trafficking through the late endosome significantly impacts candida albicans tolerance of the azole antifungals. Antimicrobial Agents and Chemotherapy . 59(4), 2410 – 2420. |
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1535-9786 |
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https://repositorio.unisucre.edu.co/handle/001/817 |
| dc.identifier.doi.spa.fl_str_mv |
10.1128/AAC.04239-14 |
| identifier_str_mv |
Luna, A., Kerns, M.E., Eberle, K.E., Jursic, B.S. & Palmer, G.E. (2015). Trafficking through the late endosome significantly impacts candida albicans tolerance of the azole antifungals. Antimicrobial Agents and Chemotherapy . 59(4), 2410 – 2420. 1535-9786 10.1128/AAC.04239-14 |
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https://repositorio.unisucre.edu.co/handle/001/817 |
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eng |
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eng |
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Revista |
| dc.relation.references.spa.fl_str_mv |
Vandeputte P, Ferrari S, Coste AT. 2012. Antifungal resistance and new strategies to control fungal infections. Int J Microbiol 2012:713687. http: //dx.doi.org/10.1155/2012/713687. Marichal P, Koymans L, Willemsens S, Bellens D, Verhasselt P, Luyten WH, Borgers M, Ramaekers F, Odds FC, Bossche HV. 1999. Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans. Microbiology 145:2701– 2713. Perea S, Lopez-Ribot JL, Kirkpatrick WR, McAtee RK, Santillan RA, Martinez M, Calabrese D, Sanglard D, Patterson TF. 2001. Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients. Antimicrob Agents Chemother 45:2676 –2684. http://dx.doi.org/10.1128/AAC.45.10.2676 -2684.2001. White TC. 1997. Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus. Antimicrob Agents Chemother 41:1482–1487. Sanglard D, Ischer F, Monod M, Bille J. 1997. Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 143:405–416. http://dx.doi.org/10.1099/00221287-143-2-405. |
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Derechos Reservados - Universidad de Sucre, 2019 |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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Derechos Reservados - Universidad de Sucre, 2019 https://creativecommons.org/licenses/by-nc/4.0/ Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) http://purl.org/coar/access_right/c_abf2 |
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application/pdf |
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Colombia |
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Estados Unidos: Antimicrobial Agents and Chemotherapy , 2015. |
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356793/pdf/zac2410.pdf. |
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Universidad de Sucre |
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Luna Tapia, Arturo37137097b30746a987e4adcda146f579-1Kerns, Morgan E.f0f22b99ef79a8e4c884a6bf345626e8-1Jursic, Branko S.5ac892b620130859b26e10b024ad0d3d-1Eberle, Karen E.81a867ef93ce49f01c8b04446c8a8a05-1Palmer, Glen E.5f5dd8dc79907c8395ffb4851dee7394-1American Society for Microbiology.Colombia2019-10-02T16:38:52Z2019-10-02T16:38:52Z2019-10-02Luna, A., Kerns, M.E., Eberle, K.E., Jursic, B.S. & Palmer, G.E. (2015). Trafficking through the late endosome significantly impacts candida albicans tolerance of the azole antifungals. Antimicrobial Agents and Chemotherapy . 59(4), 2410 – 2420.1535-9786https://repositorio.unisucre.edu.co/handle/001/81710.1128/AAC.04239-14Artículo digital.The purpose of this study was to characterize the effects of azole treatment upon the integrity of the Candida albicans vacuole and to determine whether, in turn, vacuolar trafficking influences azole susceptibility. Profound fragmentation of the C. albicans vacuole can be observed as an early consequence of azole treatment, and it precedes significant growth inhibition. In addition, a C. albicans vps21/ mutant, blocked in membrane trafficking through the late endosomal prevacuolar compartment (PVC), is able to grow significantly more than the wild type in the presence of several azole antifungals under standard susceptibility testing conditions. F.application/pdfengEstados Unidos: Antimicrobial Agents and Chemotherapy , 2015.RevistaVandeputte P, Ferrari S, Coste AT. 2012. Antifungal resistance and new strategies to control fungal infections. Int J Microbiol 2012:713687. http: //dx.doi.org/10.1155/2012/713687.Marichal P, Koymans L, Willemsens S, Bellens D, Verhasselt P, Luyten WH, Borgers M, Ramaekers F, Odds FC, Bossche HV. 1999. Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans. Microbiology 145:2701– 2713.Perea S, Lopez-Ribot JL, Kirkpatrick WR, McAtee RK, Santillan RA, Martinez M, Calabrese D, Sanglard D, Patterson TF. 2001. Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients. Antimicrob Agents Chemother 45:2676 –2684. http://dx.doi.org/10.1128/AAC.45.10.2676 -2684.2001.White TC. 1997. Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus. Antimicrob Agents Chemother 41:1482–1487.Sanglard D, Ischer F, Monod M, Bille J. 1997. Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 143:405–416. http://dx.doi.org/10.1099/00221287-143-2-405.Derechos Reservados - Universidad de Sucre, 2019https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)http://purl.org/coar/access_right/c_abf2https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356793/pdf/zac2410.pdf.Trafficking through the late endosome significantly impacts candida albicans tolerance of the azole antifungals.Artículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501Texthttp://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Candida albicansAntifungalsAzolePublicationLICENSElicense.txtlicense.txttext/plain; charset=utf-81366https://repositorio.unisucre.edu.co/bitstreams/2abd2764-38ea-4afb-8c1b-f9052e404e6c/download5f839364c91422e4b2a78812717048fbMD52TEXTTrafficking through the Late Endosome Significantly Impacts Candida albicans Tolerance of the Azole Antifungals..pdf.txtTrafficking through the Late Endosome Significantly Impacts Candida albicans Tolerance of the Azole Antifungals..pdf.txtExtracted texttext/plain53496https://repositorio.unisucre.edu.co/bitstreams/770dd703-8bb9-4071-85ed-f4807826c6fc/download1e838e1cd3714cc5632051cb48abc1d2MD55THUMBNAILTrafficking through the Late Endosome Significantly Impacts Candida albicans Tolerance of the Azole Antifungals..pdf.jpgTrafficking through the Late Endosome Significantly Impacts Candida albicans Tolerance of the Azole Antifungals..pdf.jpgGenerated Thumbnailimage/jpeg16839https://repositorio.unisucre.edu.co/bitstreams/9e4e2c35-cc6d-424b-9540-aa910228d705/downloadc4c3b2da5fa7edee7ea8e4be73487950MD56ORIGINALTrafficking through the Late Endosome Significantly Impacts Candida albicans Tolerance of the Azole Antifungals..pdfTrafficking through the Late Endosome Significantly Impacts Candida albicans Tolerance of the Azole Antifungals..pdfapplication/pdf2170521https://repositorio.unisucre.edu.co/bitstreams/5c853da3-b250-4238-837c-33d19f74a3e5/downloadedbaf1b08e49f821946c371696e64fe7MD51001/817oai:repositorio.unisucre.edu.co:001/8172024-12-05 09:51:50.083https://creativecommons.org/licenses/by-nc/4.0/Derechos Reservados - Universidad de Sucre, 2019open.accesshttps://repositorio.unisucre.edu.coRepositorio Institucional Universidad de Sucrebdigital@metabiblioteca.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 |