Identificación de Helicobacter Pylori mediante prueba molecular no invasiva y factores de riesgo asociados a esta infeccion, en el Departamento del Atlántico 2017
Determinar los factores de riesgo asociados a infección por Helicobacter Pylori diagnosticada por prueba molecular no invasiva, en niños entre los 4 y 14 años con diagnóstico de gastritis en el Departamento del Atlántico periodo 2017. Materiales y Métodos: Estudio analítico prospectivo de casos y co...
- Autores:
-
Fragozo Mendoza, Enrique
Mosquera Palacios, Marycel
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2018
- Institución:
- Universidad Libre
- Repositorio:
- RIU - Repositorio Institucional UniLibre
- Idioma:
- spa
- OAI Identifier:
- oai:repository.unilibre.edu.co:10901/17741
- Acceso en línea:
- https://hdl.handle.net/10901/17741
- Palabra clave:
- Helicobacter Pylori
Hábitos alimenticios
Agua no potable
Helicobacter pylori
Non-invasive molecular test
Gastritis
Gastritis
Técnicas de diagnóstico molecular
Úlcera péptica -- Investigaciones -- Atlántico, Colombia, Dpto.
Helicobacter pylori
Prueba molecular no invasiva
Gastritis
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-nd/2.5/co/
id |
RULIBRE2_e5a4b61de00934522353547bfbbf384a |
---|---|
oai_identifier_str |
oai:repository.unilibre.edu.co:10901/17741 |
network_acronym_str |
RULIBRE2 |
network_name_str |
RIU - Repositorio Institucional UniLibre |
repository_id_str |
|
dc.title.spa.fl_str_mv |
Identificación de Helicobacter Pylori mediante prueba molecular no invasiva y factores de riesgo asociados a esta infeccion, en el Departamento del Atlántico 2017 |
title |
Identificación de Helicobacter Pylori mediante prueba molecular no invasiva y factores de riesgo asociados a esta infeccion, en el Departamento del Atlántico 2017 |
spellingShingle |
Identificación de Helicobacter Pylori mediante prueba molecular no invasiva y factores de riesgo asociados a esta infeccion, en el Departamento del Atlántico 2017 Helicobacter Pylori Hábitos alimenticios Agua no potable Helicobacter pylori Non-invasive molecular test Gastritis Gastritis Técnicas de diagnóstico molecular Úlcera péptica -- Investigaciones -- Atlántico, Colombia, Dpto. Helicobacter pylori Prueba molecular no invasiva Gastritis |
title_short |
Identificación de Helicobacter Pylori mediante prueba molecular no invasiva y factores de riesgo asociados a esta infeccion, en el Departamento del Atlántico 2017 |
title_full |
Identificación de Helicobacter Pylori mediante prueba molecular no invasiva y factores de riesgo asociados a esta infeccion, en el Departamento del Atlántico 2017 |
title_fullStr |
Identificación de Helicobacter Pylori mediante prueba molecular no invasiva y factores de riesgo asociados a esta infeccion, en el Departamento del Atlántico 2017 |
title_full_unstemmed |
Identificación de Helicobacter Pylori mediante prueba molecular no invasiva y factores de riesgo asociados a esta infeccion, en el Departamento del Atlántico 2017 |
title_sort |
Identificación de Helicobacter Pylori mediante prueba molecular no invasiva y factores de riesgo asociados a esta infeccion, en el Departamento del Atlántico 2017 |
dc.creator.fl_str_mv |
Fragozo Mendoza, Enrique Mosquera Palacios, Marycel |
dc.contributor.advisor.none.fl_str_mv |
Bolaños Cervantes, Marcos |
dc.contributor.author.none.fl_str_mv |
Fragozo Mendoza, Enrique Mosquera Palacios, Marycel |
dc.subject.spa.fl_str_mv |
Helicobacter Pylori Hábitos alimenticios Agua no potable |
topic |
Helicobacter Pylori Hábitos alimenticios Agua no potable Helicobacter pylori Non-invasive molecular test Gastritis Gastritis Técnicas de diagnóstico molecular Úlcera péptica -- Investigaciones -- Atlántico, Colombia, Dpto. Helicobacter pylori Prueba molecular no invasiva Gastritis |
dc.subject.subjectenglish.spa.fl_str_mv |
Helicobacter pylori Non-invasive molecular test Gastritis |
dc.subject.lemb.spa.fl_str_mv |
Gastritis Técnicas de diagnóstico molecular Úlcera péptica -- Investigaciones -- Atlántico, Colombia, Dpto. |
dc.subject.proposal.spa.fl_str_mv |
Helicobacter pylori Prueba molecular no invasiva Gastritis |
description |
Determinar los factores de riesgo asociados a infección por Helicobacter Pylori diagnosticada por prueba molecular no invasiva, en niños entre los 4 y 14 años con diagnóstico de gastritis en el Departamento del Atlántico periodo 2017. Materiales y Métodos: Estudio analítico prospectivo de casos y controles, la población corresponde a un total de 78 menores entre los 4 a 14 años con diagnóstico endoscópico de gastritis, de estos se realizó prueba molecular no invasiva para detección de Helicobacter Pylori en 56 menores, de las cuales se excluyeron 2 por perdida de datos; la muestra corresponde a 54 pacientes de los cuales 36 ingresaron al grupo casos (prueba molecular positiva en saliva) y 18 controles (prueba molecular negativa). Resultados: Se evidenció mayor prevalencia en el sexo femenino con el 66.7%, en los controles la mayor prevalencia se observó en el sexo masculino con el 61.1% con edad media de 9.8 ± 4.5 años en los casos frente 9.0 ± 3.8 años en los controles. La sensibilidad de la prueba molecular no invasiva en saliva fue de fue del 72%, especificidad del 63%. Conclusiones: La prevalencia de infección por Helicobacter pylori identificada mediante prueba molecular no invasiva en saliva fue de 70.3%; la sensibilidad de esta prueba fue del 72%, especificidad del 63%, valor predictivo positivo del 92%, valor predictivo negativo del 28% con 5.5% de falsos positivos y falsos negativos del 24%. |
publishDate |
2018 |
dc.date.created.none.fl_str_mv |
2018 |
dc.date.accessioned.none.fl_str_mv |
2020-01-16T21:30:05Z |
dc.date.available.none.fl_str_mv |
2020-01-16T21:30:05Z |
dc.type.local.spa.fl_str_mv |
Tesis de Especialización |
dc.type.hasversion.spa.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_7a1f |
dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
format |
http://purl.org/coar/resource_type/c_7a1f |
status_str |
acceptedVersion |
dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/10901/17741 |
dc.identifier.instname.spa.fl_str_mv |
instname:Universidad Libre |
dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional Universidad Libre |
url |
https://hdl.handle.net/10901/17741 |
identifier_str_mv |
instname:Universidad Libre reponame:Repositorio Institucional Universidad Libre |
dc.language.iso.none.fl_str_mv |
spa |
language |
spa |
dc.relation.references.spa.fl_str_mv |
Center for Disease Control. Helicobacter pylori and ulcer peptic disease. Disponible en http://www.cdc.gov/ulcer/ history.htm [Consultado el 20 de febrero de 2018]. Jaime F, Villagra A, Serrano C, Cerda J, Harrios P. Prevalencia de la infección por Helicobacter pylori en niños: estimando la edad de adquisición. Rev Med Chile 2013; 141: 1249-1254 American Cancer Society. Global Cancer Facts & Figures. Disponible en http://www.americancancersociety.com. [Consultado el 21 de febrero de 2018]. Rollán A, Ferreccio C, Gederlini A, Serrano C, Torres J, Harris P. Non-invasive diagnosis of gastric mucosal atrophy in an asymptomatic population with high prevalence of gastric cancer. Word Journal of Gastroenterology 2006; 44 (12): 7172-8 Blanchard SS, Czinn SI. Enfermedad ulcerosa péptica en niños. En: Kliegan RM.Tratado de Pediatría. Estómago e Intestino.. Madrid: Elsevier; 2012;19(4): 1346-50 Varea V. Gastritis, úlcera péptica. En: Cruz M. Tratado de Pediatría. Ocean Jergon; 2007; 15(1): 1102-4 Schwarz S, Morelli G, Kusecek B, Manica A, Balloux F, Owen RJ, et al. Horizontal versus Familial Transmission of Helicobacter pylori. PLoSPathog. 2008;4(10):e1000180. Andrade M, Garcia W, Davas Y, Hernandez L. Importancia de Helicobacter pylori en Pediatría, estudio diagnóstico en un grupo de niños. Revista Cubana de Pediatría. 2017;89(3) Thiebaud L, Luque MT, Sabillón L, Millares H, Bustillo K. Eficacia del tratamiento convencional para Helicobacter pylori en niños. Rev Med Hondur. 2011;79(2):65-7. Carter F, Seaton T, Yuan Y, Armstrong D. Prevalence of Helicobacter pylori Infection in Children in The Bahamas. West IndianMed J. 2012;61(7):698 Prochazka Zárate R, Salazar Muente FA, Barriga Calle E, Salazar Cabrera F. Prevalencia de Helicobacter pylori en una Clínica Privada de Lima. Sensibilidad de las Biopsias del Antro y el Cuerpo, y la Prueba Rápida de la Ureasa. Rev Gastroenterol Perú. 2010;30(1):33-9. Muñoz Urribarri A, Cok García J, Bussalleu Rivera A, Cetraro Cardó D. Helicobacter pylori en niños atendidos en el Hospital Nacional Cayetano Heredia durante los años 2003 al 2006. Rev Gastroenterol Perú. 2008;28:109-18. Velasco C. Tratamiento de la infección por Helicobacter pylori asociada con gastritis en niños. Colomb Med 2005; 36 (1): 32-35 Castillo V, Ruiz E, Valencia M, Alvarez G, Sotelo N. Detection of Helicobacter pylori in children and adolescents using the monoclonal coproantigen immunoassay and its association with gastrointestinal diseases. Cirugía y Cirujanos. 2017; 85(1):27-33 Mendoza E, Camorlinga-Ponce M, Pérez-Pérez G, Vilchis J, Moran S, Rivera O, et al. Present and past Helicobacter pylori infection in Mexican school children. Helicobacter. 2014;19:55-64 Azevedo NF, Huntington J, Goodman KJ. The epidemiology of Helicobacter pylori and public health implications. Helicobacter. 2009;14 Suppl. 1:1-7. Koletzco S, Jones NL, Goodman KJ, Gold B, Rowland M, Cadranel S, et al. Evidenced-based guidelines from ESPAGHAN and NASAPGHAN for Helicobacter pylori infection in children. JPGN. 2011;53:230-43 Sykora J, Siala K, Varvarovska J, Pazdiora P, Pomahacova R, Huml M. Epidemiology of Helicobacter pylori infection in asymptomatic children: a prospective population based study from the Czech Republic. Application of a monoclonalbased antigen in stool enzyme immunoassay. Helicobacter. 2009;14:286-97 Axon A. Helicobacter and public health. Helicobacter. 2014;19 Suppl. 1:68-73. Smith SL, Oyedeji KS, Goodluck HA, Fowora MA, Anomneze E, Lesi OA. The use of Helicobacter pylori stool antigen for the diagnosis Helicobacter pylori in Lagos, Nigeria. West Indian Med J. 2011;60:33-5. Pourakbari B, Mirsalehian A, Maleknjead P, Mamishi S, Azhdarkoshh H, Daryani NE, et al. Evaluation a new antigen for diagnosis Helicobacter pylori infection in stool of adult and children. Helicobacter. 2011;16:42-6. Selgrad M, Kandulski A, Malfertheiner. Helicobacter pylori: diagnosis and treatment. Curr Opin Gastroenterol. 2009;25: 549-56 McNulty CA, Lehours P, Megraud F. Diagnosis of Helicobacter pylori infection. Helicobacter. 2011;16 Suppl. 1: 10-8. Leal-Herrera Y, Cedillo-Rivera R, Simón A, Velázquez JR, Flores LL, Torres J. Utility of stool sampled-based test for the diagnosis of Helicobacter pylori infection in children. JPGN. 2011;52:718-28. Sykora J, Siala K, Varvarovska J, Pazdiora P, Pomahacova R, Huml M. Epidemiology of Helicobacter pylori infection in asymptomatic children: a prospective population based study from the Czech Republic. Application of a monoclonalbased antigen in stool enzyme immunoassay. Helicobacter. 2009;14:286-97 Ramírez N, Quintanilla P. Infección por Helicobacter pylori en niños, Rev. Soc Bol Ped 2006; 45 (2): 102-7 Bizzorero G. Ueber die schlauchfermigen drusen das megendarmkanals and die baziehungen ihres epithels zudem oberfachen epithel der schleimhaur. Arch F Mikr Anat 1893; 42: 82-152. Salomon H. Ueber das spirillum des saugetiermagens und sein veerhalten zu den belegzellen. Zentrbl Bakteriol Mikrobiol Hyg 1896; 19: 433-42. Palmer DE. Investigation of the gastric spirochaetes of the human. Gastroenterol 1954; 27: 218-20. Warren JR, Marshall B. Unidentifi ed curved bacilli on gastric epiteliium in active chronic gastritis. Lancet 1983;1273-5. Goodwin CS, Armstrong JA, Chilvers T, Peters M, Collins MD, Sly L, et al. Transfer of Campylobacter pylori and Campylobacter mustelae to Helicobacter gen. nov. as Helicobacter pylori comb.nov., respectively. Int Syst Bacteriol.1989; 39: 397. Israel DA, Salama N, Krishna U, et al. Helicobacter pylori genetic diversity within the gastric niche of a single human host. Proc Natl Acad Sci USA 2001; 98: 14625-30. Alm RA, Ling LS, Moir DT, King BL, Brown DE, Doig PC, et al. Genomicsequence Comparison of two Unrelated Isolated of the Human Gastric Pathogen Helicobacter pylori. Nature 1999; 397: 176-80. Fox JG. Non-human reservorious of Helicobacter pylori. Aliment Pharmacol Ther 1995; 9 Suppl 2: 93-103. Grübel P, Hoffman JS, Chong FK, Burstein NA, Mepani C, Cave DR. Vector potential of housefl ies (Musca domestica) for Helicobacter pylori. J Clin Microbiol 1997; 35: 1300-3 Goodman KJ, Correa P, Tengana Aux HJ. Helicobacter pylori infection in the Colombian Andes: a population –based study of transmission pathways. Am J Epidemiol 1996; 144: 290-9. Böhmler G, Gerwert J, Scupin E, Sirelli HJ. The epidemiology of helicobacteriosis in humans, studies of the survival capacity of the microbe in food. Dtsch Tierrarztl Wochenschr 1996; 103: 438-43. Goodman KJ, Correa P. Transmission of Helicobacter pylori among siblings. Lancet 2000; 355: 358-62 Weyermann M, Adler G, Brenner H, Rothenbacher D. The Mother as Source of Helicobacter pylori Infection. Epidemiology 2006; 17: 332-4. Glynn MK, Friedman CR, Gold BD, Khanna B, Hutwagner L, Lihoshi L, et al. Seroincidence of Helicobacter pylori infection in a Cohort of Rural Bolivian Children: Acquisition and Analisis of Possible Risk Factors. Clin Infect Dis 2002; 35: 1059-65. Raymond J, Nguyen VB, Vidal-Trecan G, Kalach N. Helicobacter pylori infection in children of developing countries. Med Trop (Mars) 2005; 65: 383-8. Clyne M, Labigne A, Drumm B. Helicobacter pylori requires an acidic enviroment to survive in the presence of urea. Infect Immun 1995; 63: 1669-73. Censini S, Lange C, Xiang Z, et al. CagA pathogenicity island of Helicobacter pylori, encodes type I-specific and disease- associated virulence factors. Proc Natl Acad Sci USA 1996; 93: 14648-53. Day AS, Jones NL, Lynett JT, et al. CagE is a virulence factor associated with Helicobacter pylori-induced duodenal ulceration in children. J Infect Dis 2000; 181: 1370-5. Ernst PB, Gold BD. The disease spectrum of Helicobacter pylori: the immunopathogenesis of gastroduodenal ulcer and gastric cancer. Ann Rev Microbiol 2000; 54: 615-40. Correa P Miller MJS. Carcinogenesis, apoptosis and cell proliferation. Br Med Bull 1998; 54: 151-62. Özen A, Ertem D, Pehlivanoglu E. Natural History and Symptomatology of Helicobacter pylori in Childhood and factors Determining the Epidemiology of Infection. J Pediatr Gastroenterol Nutr 2006; 42: 398-404. Stephensen CB. Burden of infection on growth failure. J Nutr 1999; 129:534S8S. Thomas JE, Dale A, Bunn JE, et al. Early Helicobacter pylori colonisation: the association with growth faltering in The Gambia. Arch Dis Child 2004; 149-54. Baysoy G, Ertem D, Ademoglu E, et al. Gastric histophatology, iron status and iron defi ciency anemia in children with Helicobacter pylori infections. J Pediatr Gastroenterol Nutr 2004; 38: 146-51. Tunca A, Turkay C, Tekin O, et al. Is Helicobacter pylori infection a risk factor for migraine? A case-control study. Acta Neurol Belg 2004; 104: 161-4. 52 Mukherjee P, Chacko B, Singh T, Pawar G, Kaur H. Prevalence of Helicobacter pylori infection in children with recurrent abdominal pain. Trop Gastroenterol 2005; 26: 102-4. Mégraud F. European Pediatric Task Force on Helicobacter pylori. Comparison Of Non-Invasive Tests To Detect Helicobacter Pylori Infection In Children And Adolescents:n Results Of A Multicenter European Study. J Pediatr 2005; 146: 198203 Nurgalieva ZZ, Opekun AR, Graham DY. Problem of Distinguishing FalsePositive test from Acute or Transient Helicobacter pylori infections. Helicobacter 2006; 11:69-74. Jones NL, Sherman P, Fallone CA, et al. Canadian Helicobacter Study Group consensus conference: Update on the approach to Helicobacter pylori infection in children and adolescents - an evidence-based evaluation. Can J Gastroenterol 2005; 19:399-408. Coelho LGV, Zaterka S. II Consenso Brasileiro Sobre Helicobacter pylori. Arq Gastroenterol 2005; 42: 128-32. Gold BD. New Approaches to Helicobacter pylori Infection in Children. Curr Gastroenterol Rep 2001; 3: 235-47. Gold BD, Colletti RB, Abbott M, et al. Helicobacter pylori infection in children: recommendations for diagnosis and treatment. J Pediatr Gastroenterol Nutr 2000; 31: 490-7. Francavilla R, Lionetti E, Castellaneta SP, Magista AM, Boscarelli G, Piscitelli D, et al. Improved Effi cacy of 10- Day Sequential Treatment for Helicobacter pylori Eradication in Children: A Randomizer Trial. Gastroenterology 2005; 129: 1414-19. Nijevitch AA, Shcherbakov PL, Sataev VU, Kashanov RSH, Alkhashash R, Tuygunov MM. Helicobacter pylori eradication in childhood after failure of initial treatment: advantage of quadruple therapy with nifuratel to furazolidone. Aliment Pharmacol Ther 2005; 22: 881-7 Gotteland M, Brunser O, Cruchet S. Systematic review: are probiotics useful in controlling gastric colonization by Helicobacter pylori. Aliment Pharmacol Ther 2006; 23: 1077-86. Koletzko S. Richy F. Bontems P, Crone J, Kalach N, Monteiro ML, et al. Prospective multicenter study on antibiotic resistance of Helicobacter pylori strains obtained from children linving in Europe. Gut 2006. Halitim F, Vincent P, Michaud L, Kalach N, Guimber D, Boman Françoise, et al. High Rate of Helicobacter pylori Reinfection in Children and Adolescents. Helicobacter 2006; 11: 168-72 Eslick GD. Helicobacter pylori infection causes gastric cancer? A review of the epidemiological, meta-analytic, and experimental Evidence. World J Gastroenterol 2006; 12: 2991-9. Velin D, Michetti P. Immunology of Helicobacter pylori Infection. Digestion 2006; 73; 116-23. |
dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/2.5/co/ |
dc.rights.license.*.fl_str_mv |
Atribución-NoComercial-SinDerivadas 2.5 Colombia |
dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.coar.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/2.5/co/ Atribución-NoComercial-SinDerivadas 2.5 Colombia http://purl.org/coar/access_right/c_abf2 |
eu_rights_str_mv |
openAccess |
dc.format.spa.fl_str_mv |
PDF |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.coverage.spatial.spa.fl_str_mv |
Barranquilla |
institution |
Universidad Libre |
bitstream.url.fl_str_mv |
http://repository.unilibre.edu.co/bitstream/10901/17741/3/5.165.360.pdf.jpg http://repository.unilibre.edu.co/bitstream/10901/17741/2/license.txt http://repository.unilibre.edu.co/bitstream/10901/17741/1/5.165.360.pdf |
bitstream.checksum.fl_str_mv |
2c37502cb62c6e8d0da1287762c44dca 8a4605be74aa9ea9d79846c1fba20a33 39f0b89b38daf8fd8a0f6d03ff946d63 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositorio Institucional Unilibre |
repository.mail.fl_str_mv |
repositorio@unilibrebog.edu.co |
_version_ |
1814090464727400448 |
spelling |
Bolaños Cervantes, MarcosFragozo Mendoza, EnriqueMosquera Palacios, MarycelBarranquilla2020-01-16T21:30:05Z2020-01-16T21:30:05Z2018https://hdl.handle.net/10901/17741instname:Universidad Librereponame:Repositorio Institucional Universidad LibreDeterminar los factores de riesgo asociados a infección por Helicobacter Pylori diagnosticada por prueba molecular no invasiva, en niños entre los 4 y 14 años con diagnóstico de gastritis en el Departamento del Atlántico periodo 2017. Materiales y Métodos: Estudio analítico prospectivo de casos y controles, la población corresponde a un total de 78 menores entre los 4 a 14 años con diagnóstico endoscópico de gastritis, de estos se realizó prueba molecular no invasiva para detección de Helicobacter Pylori en 56 menores, de las cuales se excluyeron 2 por perdida de datos; la muestra corresponde a 54 pacientes de los cuales 36 ingresaron al grupo casos (prueba molecular positiva en saliva) y 18 controles (prueba molecular negativa). Resultados: Se evidenció mayor prevalencia en el sexo femenino con el 66.7%, en los controles la mayor prevalencia se observó en el sexo masculino con el 61.1% con edad media de 9.8 ± 4.5 años en los casos frente 9.0 ± 3.8 años en los controles. La sensibilidad de la prueba molecular no invasiva en saliva fue de fue del 72%, especificidad del 63%. Conclusiones: La prevalencia de infección por Helicobacter pylori identificada mediante prueba molecular no invasiva en saliva fue de 70.3%; la sensibilidad de esta prueba fue del 72%, especificidad del 63%, valor predictivo positivo del 92%, valor predictivo negativo del 28% con 5.5% de falsos positivos y falsos negativos del 24%.To determine the risk factors associated with Helicobacter pylori infection diagnosed by non-invasive molecular test in children between 4 and 14 years diagnosed with gastritis in the Departamento of the Atlantico period 2017. Materials and methods: Prospective analytical study of cases and controls, the population corresponds to a total of 78 children between 4 to 14 years with endoscopic diagnosis of gastritis, of these non-invasive molecular tests were performed for the detection of Helicobacter pylori in 56 children, of which 2 were excluded due to loss of data; the sample corresponds to 54 patients of which 36 entered the case group (positive molecular test in saliva) and 18 controls (negative molecular test). Results: A higher prevalence was observed in females with 66.7%, in controls the highest prevalence was observed in males with 61.1% with a mean age of 9.8 ± 4.5 years in cases versus 9.0 ± 3.8 years in controls. The sensitivity of the noninvasive molecular test in saliva was 72%, specificity 63%. Conclusions: The prevalence of Helicobacter pylori infection identified by non-invasive molecular test in saliva was 70.3%; the sensitivity of this test was 72%, specificity 63%, positive predictive value 92%, negative predictive value 28% with 5.5% false positives and false negatives 24%.PDFapplication/pdfspahttp://creativecommons.org/licenses/by-nc-nd/2.5/co/Atribución-NoComercial-SinDerivadas 2.5 Colombiainfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Helicobacter PyloriHábitos alimenticiosAgua no potableHelicobacter pyloriNon-invasive molecular testGastritisGastritisTécnicas de diagnóstico molecularÚlcera péptica -- Investigaciones -- Atlántico, Colombia, Dpto.Helicobacter pyloriPrueba molecular no invasivaGastritisIdentificación de Helicobacter Pylori mediante prueba molecular no invasiva y factores de riesgo asociados a esta infeccion, en el Departamento del Atlántico 2017Tesis de Especializacióninfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisCenter for Disease Control. Helicobacter pylori and ulcer peptic disease. Disponible en http://www.cdc.gov/ulcer/ history.htm [Consultado el 20 de febrero de 2018].Jaime F, Villagra A, Serrano C, Cerda J, Harrios P. Prevalencia de la infección por Helicobacter pylori en niños: estimando la edad de adquisición. Rev Med Chile 2013; 141: 1249-1254American Cancer Society. Global Cancer Facts & Figures. Disponible en http://www.americancancersociety.com. [Consultado el 21 de febrero de 2018].Rollán A, Ferreccio C, Gederlini A, Serrano C, Torres J, Harris P. Non-invasive diagnosis of gastric mucosal atrophy in an asymptomatic population with high prevalence of gastric cancer. Word Journal of Gastroenterology 2006; 44 (12): 7172-8Blanchard SS, Czinn SI. Enfermedad ulcerosa péptica en niños. En: Kliegan RM.Tratado de Pediatría. Estómago e Intestino.. Madrid: Elsevier; 2012;19(4): 1346-50Varea V. Gastritis, úlcera péptica. En: Cruz M. Tratado de Pediatría. Ocean Jergon; 2007; 15(1): 1102-4Schwarz S, Morelli G, Kusecek B, Manica A, Balloux F, Owen RJ, et al. Horizontal versus Familial Transmission of Helicobacter pylori. PLoSPathog. 2008;4(10):e1000180.Andrade M, Garcia W, Davas Y, Hernandez L. Importancia de Helicobacter pylori en Pediatría, estudio diagnóstico en un grupo de niños. Revista Cubana de Pediatría. 2017;89(3)Thiebaud L, Luque MT, Sabillón L, Millares H, Bustillo K. Eficacia del tratamiento convencional para Helicobacter pylori en niños. Rev Med Hondur. 2011;79(2):65-7.Carter F, Seaton T, Yuan Y, Armstrong D. Prevalence of Helicobacter pylori Infection in Children in The Bahamas. West IndianMed J. 2012;61(7):698Prochazka Zárate R, Salazar Muente FA, Barriga Calle E, Salazar Cabrera F. Prevalencia de Helicobacter pylori en una Clínica Privada de Lima. Sensibilidad de las Biopsias del Antro y el Cuerpo, y la Prueba Rápida de la Ureasa. Rev Gastroenterol Perú. 2010;30(1):33-9.Muñoz Urribarri A, Cok García J, Bussalleu Rivera A, Cetraro Cardó D. Helicobacter pylori en niños atendidos en el Hospital Nacional Cayetano Heredia durante los años 2003 al 2006. Rev Gastroenterol Perú. 2008;28:109-18.Velasco C. Tratamiento de la infección por Helicobacter pylori asociada con gastritis en niños. Colomb Med 2005; 36 (1): 32-35Castillo V, Ruiz E, Valencia M, Alvarez G, Sotelo N. Detection of Helicobacter pylori in children and adolescents using the monoclonal coproantigen immunoassay and its association with gastrointestinal diseases. Cirugía y Cirujanos. 2017; 85(1):27-33Mendoza E, Camorlinga-Ponce M, Pérez-Pérez G, Vilchis J, Moran S, Rivera O, et al. Present and past Helicobacter pylori infection in Mexican school children. Helicobacter. 2014;19:55-64Azevedo NF, Huntington J, Goodman KJ. The epidemiology of Helicobacter pylori and public health implications. Helicobacter. 2009;14 Suppl. 1:1-7.Koletzco S, Jones NL, Goodman KJ, Gold B, Rowland M, Cadranel S, et al. Evidenced-based guidelines from ESPAGHAN and NASAPGHAN for Helicobacter pylori infection in children. JPGN. 2011;53:230-43Sykora J, Siala K, Varvarovska J, Pazdiora P, Pomahacova R, Huml M. Epidemiology of Helicobacter pylori infection in asymptomatic children: a prospective population based study from the Czech Republic. Application of a monoclonalbased antigen in stool enzyme immunoassay. Helicobacter. 2009;14:286-97Axon A. Helicobacter and public health. Helicobacter. 2014;19 Suppl. 1:68-73.Smith SL, Oyedeji KS, Goodluck HA, Fowora MA, Anomneze E, Lesi OA. The use of Helicobacter pylori stool antigen for the diagnosis Helicobacter pylori in Lagos, Nigeria. West Indian Med J. 2011;60:33-5.Pourakbari B, Mirsalehian A, Maleknjead P, Mamishi S, Azhdarkoshh H, Daryani NE, et al. Evaluation a new antigen for diagnosis Helicobacter pylori infection in stool of adult and children. Helicobacter. 2011;16:42-6.Selgrad M, Kandulski A, Malfertheiner. Helicobacter pylori: diagnosis and treatment. Curr Opin Gastroenterol. 2009;25: 549-56McNulty CA, Lehours P, Megraud F. Diagnosis of Helicobacter pylori infection. Helicobacter. 2011;16 Suppl. 1: 10-8.Leal-Herrera Y, Cedillo-Rivera R, Simón A, Velázquez JR, Flores LL, Torres J. Utility of stool sampled-based test for the diagnosis of Helicobacter pylori infection in children. JPGN. 2011;52:718-28.Sykora J, Siala K, Varvarovska J, Pazdiora P, Pomahacova R, Huml M. Epidemiology of Helicobacter pylori infection in asymptomatic children: a prospective population based study from the Czech Republic. Application of a monoclonalbased antigen in stool enzyme immunoassay. Helicobacter. 2009;14:286-97Ramírez N, Quintanilla P. Infección por Helicobacter pylori en niños, Rev. Soc Bol Ped 2006; 45 (2): 102-7Bizzorero G. Ueber die schlauchfermigen drusen das megendarmkanals and die baziehungen ihres epithels zudem oberfachen epithel der schleimhaur. Arch F Mikr Anat 1893; 42: 82-152.Salomon H. Ueber das spirillum des saugetiermagens und sein veerhalten zu den belegzellen. Zentrbl Bakteriol Mikrobiol Hyg 1896; 19: 433-42.Palmer DE. Investigation of the gastric spirochaetes of the human. Gastroenterol 1954; 27: 218-20.Warren JR, Marshall B. Unidentifi ed curved bacilli on gastric epiteliium in active chronic gastritis. Lancet 1983;1273-5.Goodwin CS, Armstrong JA, Chilvers T, Peters M, Collins MD, Sly L, et al. Transfer of Campylobacter pylori and Campylobacter mustelae to Helicobacter gen. nov. as Helicobacter pylori comb.nov., respectively. Int Syst Bacteriol.1989; 39: 397.Israel DA, Salama N, Krishna U, et al. Helicobacter pylori genetic diversity within the gastric niche of a single human host. Proc Natl Acad Sci USA 2001; 98: 14625-30.Alm RA, Ling LS, Moir DT, King BL, Brown DE, Doig PC, et al. Genomicsequence Comparison of two Unrelated Isolated of the Human Gastric Pathogen Helicobacter pylori. Nature 1999; 397: 176-80.Fox JG. Non-human reservorious of Helicobacter pylori. Aliment Pharmacol Ther 1995; 9 Suppl 2: 93-103.Grübel P, Hoffman JS, Chong FK, Burstein NA, Mepani C, Cave DR. Vector potential of housefl ies (Musca domestica) for Helicobacter pylori. J Clin Microbiol 1997; 35: 1300-3Goodman KJ, Correa P, Tengana Aux HJ. Helicobacter pylori infection in the Colombian Andes: a population –based study of transmission pathways. Am J Epidemiol 1996; 144: 290-9.Böhmler G, Gerwert J, Scupin E, Sirelli HJ. The epidemiology of helicobacteriosis in humans, studies of the survival capacity of the microbe in food. Dtsch Tierrarztl Wochenschr 1996; 103: 438-43.Goodman KJ, Correa P. Transmission of Helicobacter pylori among siblings. Lancet 2000; 355: 358-62Weyermann M, Adler G, Brenner H, Rothenbacher D. The Mother as Source of Helicobacter pylori Infection. Epidemiology 2006; 17: 332-4.Glynn MK, Friedman CR, Gold BD, Khanna B, Hutwagner L, Lihoshi L, et al. Seroincidence of Helicobacter pylori infection in a Cohort of Rural Bolivian Children: Acquisition and Analisis of Possible Risk Factors. Clin Infect Dis 2002; 35: 1059-65.Raymond J, Nguyen VB, Vidal-Trecan G, Kalach N. Helicobacter pylori infection in children of developing countries. Med Trop (Mars) 2005; 65: 383-8.Clyne M, Labigne A, Drumm B. Helicobacter pylori requires an acidic enviroment to survive in the presence of urea. Infect Immun 1995; 63: 1669-73.Censini S, Lange C, Xiang Z, et al. CagA pathogenicity island of Helicobacter pylori, encodes type I-specific and disease- associated virulence factors. Proc Natl Acad Sci USA 1996; 93: 14648-53.Day AS, Jones NL, Lynett JT, et al. CagE is a virulence factor associated with Helicobacter pylori-induced duodenal ulceration in children. J Infect Dis 2000; 181: 1370-5.Ernst PB, Gold BD. The disease spectrum of Helicobacter pylori: the immunopathogenesis of gastroduodenal ulcer and gastric cancer. Ann Rev Microbiol 2000; 54: 615-40.Correa P Miller MJS. Carcinogenesis, apoptosis and cell proliferation. Br Med Bull 1998; 54: 151-62.Özen A, Ertem D, Pehlivanoglu E. Natural History and Symptomatology of Helicobacter pylori in Childhood and factors Determining the Epidemiology of Infection. J Pediatr Gastroenterol Nutr 2006; 42: 398-404.Stephensen CB. Burden of infection on growth failure. J Nutr 1999; 129:534S8S.Thomas JE, Dale A, Bunn JE, et al. Early Helicobacter pylori colonisation: the association with growth faltering in The Gambia. Arch Dis Child 2004; 149-54.Baysoy G, Ertem D, Ademoglu E, et al. Gastric histophatology, iron status and iron defi ciency anemia in children with Helicobacter pylori infections. J Pediatr Gastroenterol Nutr 2004; 38: 146-51.Tunca A, Turkay C, Tekin O, et al. Is Helicobacter pylori infection a risk factor for migraine? A case-control study. Acta Neurol Belg 2004; 104: 161-4. 52Mukherjee P, Chacko B, Singh T, Pawar G, Kaur H. Prevalence of Helicobacter pylori infection in children with recurrent abdominal pain. Trop Gastroenterol 2005; 26: 102-4.Mégraud F. European Pediatric Task Force on Helicobacter pylori. Comparison Of Non-Invasive Tests To Detect Helicobacter Pylori Infection In Children And Adolescents:n Results Of A Multicenter European Study. J Pediatr 2005; 146: 198203Nurgalieva ZZ, Opekun AR, Graham DY. Problem of Distinguishing FalsePositive test from Acute or Transient Helicobacter pylori infections. Helicobacter 2006; 11:69-74.Jones NL, Sherman P, Fallone CA, et al. Canadian Helicobacter Study Group consensus conference: Update on the approach to Helicobacter pylori infection in children and adolescents - an evidence-based evaluation. Can J Gastroenterol 2005; 19:399-408.Coelho LGV, Zaterka S. II Consenso Brasileiro Sobre Helicobacter pylori. Arq Gastroenterol 2005; 42: 128-32.Gold BD. New Approaches to Helicobacter pylori Infection in Children. Curr Gastroenterol Rep 2001; 3: 235-47.Gold BD, Colletti RB, Abbott M, et al. Helicobacter pylori infection in children: recommendations for diagnosis and treatment. J Pediatr Gastroenterol Nutr 2000; 31: 490-7.Francavilla R, Lionetti E, Castellaneta SP, Magista AM, Boscarelli G, Piscitelli D, et al. Improved Effi cacy of 10- Day Sequential Treatment for Helicobacter pylori Eradication in Children: A Randomizer Trial. Gastroenterology 2005; 129: 1414-19.Nijevitch AA, Shcherbakov PL, Sataev VU, Kashanov RSH, Alkhashash R, Tuygunov MM. Helicobacter pylori eradication in childhood after failure of initial treatment: advantage of quadruple therapy with nifuratel to furazolidone. Aliment Pharmacol Ther 2005; 22: 881-7Gotteland M, Brunser O, Cruchet S. Systematic review: are probiotics useful in controlling gastric colonization by Helicobacter pylori. Aliment Pharmacol Ther 2006; 23: 1077-86.Koletzko S. Richy F. Bontems P, Crone J, Kalach N, Monteiro ML, et al. Prospective multicenter study on antibiotic resistance of Helicobacter pylori strains obtained from children linving in Europe. Gut 2006.Halitim F, Vincent P, Michaud L, Kalach N, Guimber D, Boman Françoise, et al. High Rate of Helicobacter pylori Reinfection in Children and Adolescents. Helicobacter 2006; 11: 168-72Eslick GD. Helicobacter pylori infection causes gastric cancer? A review of the epidemiological, meta-analytic, and experimental Evidence. World J Gastroenterol 2006; 12: 2991-9.Velin D, Michetti P. Immunology of Helicobacter pylori Infection. Digestion 2006; 73; 116-23.THUMBNAIL5.165.360.pdf.jpg5.165.360.pdf.jpgIM Thumbnailimage/jpeg10720http://repository.unilibre.edu.co/bitstream/10901/17741/3/5.165.360.pdf.jpg2c37502cb62c6e8d0da1287762c44dcaMD53LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repository.unilibre.edu.co/bitstream/10901/17741/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52ORIGINAL5.165.360.pdf5.165.360.pdfTrabajo de gradoapplication/pdf330668http://repository.unilibre.edu.co/bitstream/10901/17741/1/5.165.360.pdf39f0b89b38daf8fd8a0f6d03ff946d63MD5110901/17741oai:repository.unilibre.edu.co:10901/177412022-10-11 12:08:26.893Repositorio Institucional Unilibrerepositorio@unilibrebog.edu.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 |