Resultados clinicos del uso de espaciadores de cemento con doble antibiótico (Gentamicina + Vancomicina) en infecciones periprotésicas en una institución prestadora de servicios de salud Barranquilla 2018-2022

El reemplazo articular es uno de los procedimientos programados más exitosos en ortopedia, por cuanto mejora la calidad de vida de los pacientes, al incrementar la función y reducir el dolor. No obstante, una de las complicaciones más temidas y de difícil manejo en los reemplazos articulares es la i...

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Autores:: Jiménez Romero, Andrés
Ordoñez Díaz, Rubén

Tipo de recurso:

Fecha de publicación:: 2023

Institución:: Universidad Libre

Repositorio:: RIU - Repositorio Institucional UniLibre

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dc.title.spa.fl_str_mv	Resultados clinicos del uso de espaciadores de cemento con doble antibiótico (Gentamicina + Vancomicina) en infecciones periprotésicas en una institución prestadora de servicios de salud Barranquilla 2018-2022
title	Resultados clinicos del uso de espaciadores de cemento con doble antibiótico (Gentamicina + Vancomicina) en infecciones periprotésicas en una institución prestadora de servicios de salud Barranquilla 2018-2022
spellingShingle	Resultados clinicos del uso de espaciadores de cemento con doble antibiótico (Gentamicina + Vancomicina) en infecciones periprotésicas en una institución prestadora de servicios de salud Barranquilla 2018-2022 Infección periprotésica Espaciadores de cemento con doble antibiótico (gentamicina + vancomicina) Periprosthetic infection Dual antibiotic (gentamicin + vancomycin) cement spacers Cirugía ortopédica - transplante Profilaxis antibiótica Vancomicina Gentamicinas
title_short	Resultados clinicos del uso de espaciadores de cemento con doble antibiótico (Gentamicina + Vancomicina) en infecciones periprotésicas en una institución prestadora de servicios de salud Barranquilla 2018-2022
title_full	Resultados clinicos del uso de espaciadores de cemento con doble antibiótico (Gentamicina + Vancomicina) en infecciones periprotésicas en una institución prestadora de servicios de salud Barranquilla 2018-2022
title_fullStr	Resultados clinicos del uso de espaciadores de cemento con doble antibiótico (Gentamicina + Vancomicina) en infecciones periprotésicas en una institución prestadora de servicios de salud Barranquilla 2018-2022
title_full_unstemmed	Resultados clinicos del uso de espaciadores de cemento con doble antibiótico (Gentamicina + Vancomicina) en infecciones periprotésicas en una institución prestadora de servicios de salud Barranquilla 2018-2022
title_sort	Resultados clinicos del uso de espaciadores de cemento con doble antibiótico (Gentamicina + Vancomicina) en infecciones periprotésicas en una institución prestadora de servicios de salud Barranquilla 2018-2022
dc.creator.fl_str_mv	Jiménez Romero, Andrés Ordoñez Díaz, Rubén
dc.contributor.advisor.none.fl_str_mv	Severini, Carlos Bilbao Ramírez, Jorge
dc.contributor.author.none.fl_str_mv	Jiménez Romero, Andrés Ordoñez Díaz, Rubén
dc.subject.spa.fl_str_mv	Infección periprotésica Espaciadores de cemento con doble antibiótico (gentamicina + vancomicina)
topic	Infección periprotésica Espaciadores de cemento con doble antibiótico (gentamicina + vancomicina) Periprosthetic infection Dual antibiotic (gentamicin + vancomycin) cement spacers Cirugía ortopédica - transplante Profilaxis antibiótica Vancomicina Gentamicinas
dc.subject.subjectenglish.spa.fl_str_mv	Periprosthetic infection Dual antibiotic (gentamicin + vancomycin) cement spacers
dc.subject.lemb.spa.fl_str_mv	Cirugía ortopédica - transplante Profilaxis antibiótica Vancomicina Gentamicinas
description	El reemplazo articular es uno de los procedimientos programados más exitosos en ortopedia, por cuanto mejora la calidad de vida de los pacientes, al incrementar la función y reducir el dolor. No obstante, una de las complicaciones más temidas y de difícil manejo en los reemplazos articulares es la infección periprotésica (ipp). Se planteó la realización de un estudio de corte trasversal, diseñado con el objetivo de describir los resultados clínicos del uso de espaciadores de cemento con doble antibiótico (gentamicina + vancomicina) en infecciones periprotésicas aplicadas en pacientes atendidos en una institución prestadora de servicios de salud en Barranquilla en el periodo enero de 2018 a diciembre de 2022. El 52.8% de los pacientes pertenecen al sexo masculino, la edad media 64.7 ± 7.9 años (rango 46 – 82 años); el 52.8% de las prótesis involucradas fueron de rodilla y el 47.8% restante prótesis de cadera, el dolor fue la principal manifestación clínica con el 81.1% seguida de la fiebre con el 60.4%. se concluyó que 2 de cada 3 pacientes con ipp de rodilla o cadera evolucionaron satisfactoriamente a nuevo reemplazo articular con manejo antimicrobiano y utilización de espaciadores de cemento con doble antibiótico (gentamicina + vancomicina).
publishDate	2023
dc.date.accessioned.none.fl_str_mv	2023-12-15T21:15:43Z
dc.date.available.none.fl_str_mv	2023-12-15T21:15:43Z
dc.date.created.none.fl_str_mv	2023
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_7a1f
dc.type.local.spa.fl_str_mv	Tesis de Especialización
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/bachelorThesis
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/10901/27901
url	https://hdl.handle.net/10901/27901
dc.relation.references.spa.fl_str_mv	Nequesha S. Mohamed, Wayne A. Wilkie, Ethan A. Remily, James Nace, Ronald E. Delanois, James A. Browne. Antibiotic Choice: The Synergistic Effect of Single vs Dual Antibiotics, The Journal of Arthroplasty. 2020; 35: S19-S23 Petra Izakovicova, Olivier Borens, Andrej Trampuz, Periprosthetic joint infection: current concepts and outlook. EFORT Open Reviews, General Orthopaedics. 2019; 4: 482-494 Gómez-García F, Espinoza-Mendoza RL. ¿Qué hay de nuevo para el diagnóstico de infecciones periprotésicas después del Consenso de Filadelfia?. Acta ortop. mex. 2019; 33(2):127-135 Sprowson, C. Jensen, S. Chambers, N. R. Parsons, N. M. Aradhyula, I. Carluke, D. Inman, M. R. Reed. The use of high-dose dual-impregnated antibiotic-laden cement with hemiarthroplasty for the treatment of a fracture of the hip: The Fractured Hip Infection Trial, The Bone and Joint Journal. 2016; 98-B: 1534–41 Shinsuke Ikeda, Katsufumi Uchiyama, Yojiro Minegishi, Keiko Ohno, Masaki Nakamura, Kazuhiro Yoshida, Kensuke Fukushima, Naonobu Takahira, and Masashi Takaso. Doublelayered antibiotic-loaded cement spacer as a novel alternative for managing periprosthetic joint infection: an in vitro study, Journal of Orthopaedic Surgery and Research. 2018;13:322 Tsaras G, Maduka-Ezeh A, Inwards CY, Mabry T, Erwin PJ, Murad MH, et al. Utility of intraoperative frozen section histopathology in the diagnosis of periprosthetic joint infection: a systematic review and meta-analysis. J Bone Joint Surg Am. 2012;94:1700-11 Deirmengian C, Kardos K, Kilmartin P, Cameron A, Schiller K, Parvizi J. Diagnosing periprosthetic joint infection: Has the Era of the biomarker arrived? Clin Orthop Relat Res 2014;472:3254-62 Lindeque B, Hartman Z, Noshchenko A, Cruse M. Infection after primary total hip arthroplasty. Orthopedics. 2014; 37:257–265. doi:10.3928/01477447-20140401-08 Gutiérrez D, Manrique J, Restrepo C, Parvizi J, Manrique J. Infecciones periprotésicas de cadera y rodilla: diagnóstico y manejo. Revisión de conceptos actuales. Rev Colomb Ortop Traumatol. 2017;31(2):87-92 Del Pozo J, Patel R. Infection associated with prosthetic joints. N Engl J Med. 2009;361:787---94 Manrique JGM. Management of infected orthopedic joint implants: Pertinent Information for family medicine physicians. Fam Med Med Sci Res. 2014;3:2-5 Ibrahim R, Bakhshi H. Incidence and burden of periprosthetic joint infections. En: Parvizi J, editor. Periprosthetic joint infection: Practical management guide. New Delhi: Jaypee Brothers Medical Publishers; 2013. p. 9-16 Parvizi J, Zmistowski B, Berbari EF, Bauer TW, Springer BD, Della Valle CJ, et al. New definition for periprosthetic joint infection: from the Workgroup of the Musculoskeletal Infection Society. Clin Orthop Relat Res. 2011;469:2992-4 Osmon DR, Berbari EF, Berendt AR, Lew D, Zimmerli W, Steckelberg JM, et al. Diagnosis and management of prosthetic joint infection: Clinical practice guidelines by the infectious diseases Society of America. Clin Infect Dis. 2013;56:e1-25 Ouyang Z, Li H, Liu X, Zhai Z, Li X. Prosthesis infection: diagnosis after total joint arthroplasty with three-phase bone scintigraphy. Ann Nucl Med. 2014;28:994-1003 Parvizi J, Gehrke T. Definition of periprosthetic joint infection. J Arthroplasty. 2014;29:1331 Zmitowski B, Della Valle M. International Consensus Meeting: Workgroup 7 Diagnosis of Periprosthetic Joint Infection. Philadelphia:Thomas Jefferson University; 2013 Toossi N, Adeli B, Rasouli MR, Huang R, Parvizi J. Serum white blood cell count and differential do not have a role in the diagnosis of periprosthetic joint infection. J Arthroplasty. 2012;27 8 Suppl, 51-4.e1 Osmon DR, Berbari EF, Berendt AR, Lew D, Zimmerli W, Steckelberg JM, et al. Executive summary: diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis 2013;56:1-10 Berbari E, Mabry T, Tsaras G, Spangehl M, Erwin PJ, Murad MH, et al. Inflammatory blood laboratory levels as markers of prosthetic joint infection: a systematic review and metaanalysis. J Bone Joint Surg Am. 2010;92:2102-9 McArthur BA, Abdel MP, Taunton MJ, Osmon DR, Hanssen AD. Seronegative infections in hip and knee arthroplasty: Periprosthetic infections with normal erythrocyte sedimentation rate and C-reactive protein level. Bone Joint J. 2015;97-B:939-44 Morgan PM, Sharkey P, Ghanem E, Parvizi J, Clohisy JC, Burnett RS, et al. The value of intraoperative Gram stain in revision total knee arthroplasty. J Bone Joint Surg Am. 2009;91:2124-9 Parvizi J, Ghanem E, Sharkey P, Aggarwal A, Burnett RSJ, Barrack RL. Diagnosis of infected total knee: findings of a multicenter database. Clin Orthop Relat Res. 2008;466:2628- 33 Wetters NG, Berend KR, Lombardi AV, Morris MJ, Tucker TL, Della Valle CJ. Leukocyte esterase reagent strips for the rapid diagnosis of periprosthetic joint infection. J Arthroplasty. 2012;27 8 Suppl:8-11 Tsaras G, Maduka-Ezeh A, Inwards CY, Mabry T, Erwin PJ, Murad MH, et al. Utility of intraoperative frozen section histopathology in the diagnosis of periprosthetic joint infection: a systematic review and meta-analysis. J Bone Joint Surg Am. 2012;94:1700-11 Deirmengian C, Kardos K, Kilmartin P, Cameron A, Schiller K, Parvizi J. Diagnosing periprosthetic joint infection: Has the Era of the biomarker arrived? Clin Orthop Relat Res. 2014;472:3254-62 Deirmengian C, Greenbaum J, Lotke PA, Booth RE, Lonner JH. Limited Success with open debridement and retention of components in the treatment of acute Staphylococcus aureus infections after total knee arthroplasty. 2003;18:22-6 Deirmengian C, Kardos K, Kilmartin P, Gulati S, Citrano P, Booth RE. The alpha-defensin test for periprosthetic joint infection responds to a wide spectrum of organisms. Clin Orthop Relat Res. 2015;473:2229-35 Deirmengian C, Kardos K, Kilmartin P, Cameron A, Schiller K, Booth RE, et al. The alphadefensin test for periprosthetic joint infection outperforms the leukocyte esterase test strip. Clin Orthop Relat Res. 2014;473:198-203 Randau TM, Friedrich MJ, Wimmer MD, Reichert B, Kuberra D, Stoffel-Wagner B, et al. Interleukin-6 in serum and in synovial fluid enhances the differentiation between periprosthetic joint infection and aseptic loosening. PLoS One. 2014;9:e89045 Di Cesare PE, Chang E, Preston CF, Liu C. Serum interleukin-6 as a marker of periprosthetic infection following total hip and knee arthroplasty. J Bone Joint Surg Am. 2005;87:1921-7 Matsen L, Parvizi J. Diagnosis of periprosthetic joint infection: Novel developments. Orthop Clin North Am. 2016;47:1-9 Achermann Y, Vogt M, Leunig M, Wüst J, Trampuz A. Improved diagnosis of periprosthetic joint infection by multiplex PCR of sonication fluid from removed implants. J Clin Microbiol. 2010;48:1208-14 Anagnostakos K, Schmitt C. Can periprosthetic hip joint infections be successfully managed by debridement and prosthesis retention? World J Orthop. 2014;5:218-24 Quanjun C, Mihalko W, Shields J, Ries M, Saleh K. Espaciadores de cemento impregnado de antibiótico para el tratamiento de la infección asociada con artroplastia total de cadera o de rodilla. J Bone Joint Surg Am. 2007;89:871-82 Marculescu CE, Berbari EF, Hanssen AD, Steckelberg JM, Harmsen SW, Mandrekar JN, et al. Outcome of prosthetic joint infections treated with debridement and retention of components. Clin Infect Dis. 2006;42:471-8 Kuiper JWP, Vos SJC, Saouti R, Vergroesen DA, Graat HC, Debets-Ossenkopp YJ, et al. Prosthetic joint-associated infections treated with DAIR (debridement, antibiotics, irrigation, and retention): analysis of risk factors and local antibiotic carriers in 91 patients. Acta Orthop. 2013;84:380-6 Sebastian Corro, Matías Vicente, Dolores Rodríguez-Pardo, Carles Pigrau, Mayli Lung, Pablo S. Corona, Vancomycin-Gentamicin Prefabricated Spacers in 2-Stage Revision Arthroplasty for Chronic Hip and Knee Periprosthetic Joint Infection: Insights Into Reimplantation Microbiology and Outcomes The Journal of Arthroplasty. 2020; 35:247-254 Omid Shahpari, Alireza Mousavian, Nafise Elahpour, Michael-Alexander Malahias, Mohammad H. Ebrahimzadeh, Ali Moradi, The Use of Antibiotic Impregnated Cement Spacers in the Treatment of Infected Total Joint Replacement: Challenges and Achievements, Current Concepts Review. Archives of the Bone and Joint Surgery. 2020; 8(1): 11-20 Scott M. Sporer, Spacer Design Options and Consideration for Periprosthetic Joint Infection, The Journal of Arthroplasty. 2020;35:S31-S34 Elena Beam, Douglas Osmon, Prosthetic Joint Infection Update, Infectious Disease Clinics of North America. 2018;32:843–859 Marcel E. Roy, Michael P. Peppers, Leo A. Whiteside, Renée M. LaZear. Vancomycin Concentration in Synovial Fluid: Direct Injection into the Knee vs. Intravenous Infusion. The Journal of Arthroplasty. 2014;564–568 Pablo S. Corona, Laia Espinal, Dolors Rodríguez-Pardo, Carles Pigrau, Nieves Larrosa, Xavier Flores. Antibiotic Susceptibility in Gram-Positive Chronic Joint Arthroplasty Infections: Increased Aminoglycoside Resistance Rate in Patients with Prior AminoglycosideImpregnated Cement Spacer Use, Journal of Arthroplasty. 2014 Eli Ben‑Chetrit, Amit Zamir, Ayman Natsheh, Gideon Nesher, Yonit Wiener‑Well, Gabriel Simon Breuer. Trends in antimicrobial resistance among bacteria causing septic arthritis in adults in a single center: A 15‑years retrospective analysis, Società Italiana di Medicina Interna (SIMI) 2019 Villa, J. M., Pannu, T. S., Piuzzi, N., Riesgo, A. M., & Higuera, C. A. Temporary removal: Evolution of Diagnostic Definitions for Periprosthetic Joint Infection in Total Hip and Knee Arthroplasty. The Journal of Arthroplasty. 2019 Meek RM, Masri BA, Dunlop D, Garbuz DS, Greidanus NV, McGraw R, Duncan CP. Patient satisfaction and functional status after treatment of infection at the site of a total knee arthroplasty with use of the PROSTALAC articulating spacer. J Bone Joint Surg Am. 2003;85:1888-92
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spelling	Severini, CarlosBilbao Ramírez, JorgeJiménez Romero, AndrésOrdoñez Díaz, RubénBarranquilla2023-12-15T21:15:43Z2023-12-15T21:15:43Z2023https://hdl.handle.net/10901/27901El reemplazo articular es uno de los procedimientos programados más exitosos en ortopedia, por cuanto mejora la calidad de vida de los pacientes, al incrementar la función y reducir el dolor. No obstante, una de las complicaciones más temidas y de difícil manejo en los reemplazos articulares es la infección periprotésica (ipp). Se planteó la realización de un estudio de corte trasversal, diseñado con el objetivo de describir los resultados clínicos del uso de espaciadores de cemento con doble antibiótico (gentamicina + vancomicina) en infecciones periprotésicas aplicadas en pacientes atendidos en una institución prestadora de servicios de salud en Barranquilla en el periodo enero de 2018 a diciembre de 2022. El 52.8% de los pacientes pertenecen al sexo masculino, la edad media 64.7 ± 7.9 años (rango 46 – 82 años); el 52.8% de las prótesis involucradas fueron de rodilla y el 47.8% restante prótesis de cadera, el dolor fue la principal manifestación clínica con el 81.1% seguida de la fiebre con el 60.4%. se concluyó que 2 de cada 3 pacientes con ipp de rodilla o cadera evolucionaron satisfactoriamente a nuevo reemplazo articular con manejo antimicrobiano y utilización de espaciadores de cemento con doble antibiótico (gentamicina + vancomicina).Universidad Libre Seccional Barranquilla -- Facultad de Ciencias de la Salud -- Especialización en Ortopedia y TraumatologíaJoint replacement is one of the most successful scheduled procedures in orthopedics, as it improves the quality of life of patients by increasing function and reducing pain. However, one of the most feared and difficult-to-manage complications in joint replacements is periprosthetic infection (PPI). A cross-sectional study was proposed, designed with the objective of describing the clinical results of the use of Cement Spacers with double antibiotic (Gentamicin + Vancomycin) in periprosthetic infections applied in patients treated in a Health Services Provider Institution in Barranquilla in the period January 2018 to December 2022. 52.8% of the patients belong to the male sex, the mean age 64.7 ± 7.9 years (range 46 – 82 years); 52.8% of the prostheses involved were knee and the remaining 47.8% hip prosthesis, pain was the main clinical manifestation with 81.1% followed by fever with 60.4%. It was concluded that 2 out of 3 patients with PPI of the knee or hip progressed satisfactorily to a new joint replacement with antimicrobial management and the use of dual antibiotic cement spacers (gentamicin + vancomycin).PDFInfección periprotésicaEspaciadores de cemento con doble antibiótico (gentamicina + vancomicina)Periprosthetic infectionDual antibiotic (gentamicin + vancomycin) cement spacersCirugía ortopédica - transplanteProfilaxis antibióticaVancomicinaGentamicinasResultados clinicos del uso de espaciadores de cemento con doble antibiótico (Gentamicina + Vancomicina) en infecciones periprotésicas en una institución prestadora de servicios de salud Barranquilla 2018-2022Tesis de Especializacióninfo:eu-repo/semantics/bachelorThesishttp://purl.org/coar/resource_type/c_7a1fNequesha S. Mohamed, Wayne A. Wilkie, Ethan A. Remily, James Nace, Ronald E. Delanois, James A. Browne. Antibiotic Choice: The Synergistic Effect of Single vs Dual Antibiotics, The Journal of Arthroplasty. 2020; 35: S19-S23Petra Izakovicova, Olivier Borens, Andrej Trampuz, Periprosthetic joint infection: current concepts and outlook. EFORT Open Reviews, General Orthopaedics. 2019; 4: 482-494Gómez-García F, Espinoza-Mendoza RL. ¿Qué hay de nuevo para el diagnóstico de infecciones periprotésicas después del Consenso de Filadelfia?. Acta ortop. mex. 2019; 33(2):127-135Sprowson, C. Jensen, S. Chambers, N. R. Parsons, N. M. Aradhyula, I. Carluke, D. Inman, M. R. Reed. The use of high-dose dual-impregnated antibiotic-laden cement with hemiarthroplasty for the treatment of a fracture of the hip: The Fractured Hip Infection Trial, The Bone and Joint Journal. 2016; 98-B: 1534–41Shinsuke Ikeda, Katsufumi Uchiyama, Yojiro Minegishi, Keiko Ohno, Masaki Nakamura, Kazuhiro Yoshida, Kensuke Fukushima, Naonobu Takahira, and Masashi Takaso. Doublelayered antibiotic-loaded cement spacer as a novel alternative for managing periprosthetic joint infection: an in vitro study, Journal of Orthopaedic Surgery and Research. 2018;13:322Tsaras G, Maduka-Ezeh A, Inwards CY, Mabry T, Erwin PJ, Murad MH, et al. Utility of intraoperative frozen section histopathology in the diagnosis of periprosthetic joint infection: a systematic review and meta-analysis. J Bone Joint Surg Am. 2012;94:1700-11Deirmengian C, Kardos K, Kilmartin P, Cameron A, Schiller K, Parvizi J. Diagnosing periprosthetic joint infection: Has the Era of the biomarker arrived? Clin Orthop Relat Res 2014;472:3254-62Lindeque B, Hartman Z, Noshchenko A, Cruse M. Infection after primary total hip arthroplasty. Orthopedics. 2014; 37:257–265. doi:10.3928/01477447-20140401-08Gutiérrez D, Manrique J, Restrepo C, Parvizi J, Manrique J. Infecciones periprotésicas de cadera y rodilla: diagnóstico y manejo. Revisión de conceptos actuales. Rev Colomb Ortop Traumatol. 2017;31(2):87-92Del Pozo J, Patel R. Infection associated with prosthetic joints. N Engl J Med. 2009;361:787---94Manrique JGM. Management of infected orthopedic joint implants: Pertinent Information for family medicine physicians. Fam Med Med Sci Res. 2014;3:2-5Ibrahim R, Bakhshi H. Incidence and burden of periprosthetic joint infections. En: Parvizi J, editor. Periprosthetic joint infection: Practical management guide. New Delhi: Jaypee Brothers Medical Publishers; 2013. p. 9-16Parvizi J, Zmistowski B, Berbari EF, Bauer TW, Springer BD, Della Valle CJ, et al. New definition for periprosthetic joint infection: from the Workgroup of the Musculoskeletal Infection Society. Clin Orthop Relat Res. 2011;469:2992-4Osmon DR, Berbari EF, Berendt AR, Lew D, Zimmerli W, Steckelberg JM, et al. Diagnosis and management of prosthetic joint infection: Clinical practice guidelines by the infectious diseases Society of America. Clin Infect Dis. 2013;56:e1-25Ouyang Z, Li H, Liu X, Zhai Z, Li X. Prosthesis infection: diagnosis after total joint arthroplasty with three-phase bone scintigraphy. Ann Nucl Med. 2014;28:994-1003Parvizi J, Gehrke T. Definition of periprosthetic joint infection. J Arthroplasty. 2014;29:1331Zmitowski B, Della Valle M. International Consensus Meeting: Workgroup 7 Diagnosis of Periprosthetic Joint Infection. Philadelphia:Thomas Jefferson University; 2013Toossi N, Adeli B, Rasouli MR, Huang R, Parvizi J. Serum white blood cell count and differential do not have a role in the diagnosis of periprosthetic joint infection. J Arthroplasty. 2012;27 8 Suppl, 51-4.e1Osmon DR, Berbari EF, Berendt AR, Lew D, Zimmerli W, Steckelberg JM, et al. Executive summary: diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis 2013;56:1-10Berbari E, Mabry T, Tsaras G, Spangehl M, Erwin PJ, Murad MH, et al. Inflammatory blood laboratory levels as markers of prosthetic joint infection: a systematic review and metaanalysis. J Bone Joint Surg Am. 2010;92:2102-9McArthur BA, Abdel MP, Taunton MJ, Osmon DR, Hanssen AD. Seronegative infections in hip and knee arthroplasty: Periprosthetic infections with normal erythrocyte sedimentation rate and C-reactive protein level. Bone Joint J. 2015;97-B:939-44Morgan PM, Sharkey P, Ghanem E, Parvizi J, Clohisy JC, Burnett RS, et al. The value of intraoperative Gram stain in revision total knee arthroplasty. J Bone Joint Surg Am. 2009;91:2124-9Parvizi J, Ghanem E, Sharkey P, Aggarwal A, Burnett RSJ, Barrack RL. Diagnosis of infected total knee: findings of a multicenter database. Clin Orthop Relat Res. 2008;466:2628- 33Wetters NG, Berend KR, Lombardi AV, Morris MJ, Tucker TL, Della Valle CJ. Leukocyte esterase reagent strips for the rapid diagnosis of periprosthetic joint infection. J Arthroplasty. 2012;27 8 Suppl:8-11Tsaras G, Maduka-Ezeh A, Inwards CY, Mabry T, Erwin PJ, Murad MH, et al. Utility of intraoperative frozen section histopathology in the diagnosis of periprosthetic joint infection: a systematic review and meta-analysis. J Bone Joint Surg Am. 2012;94:1700-11Deirmengian C, Kardos K, Kilmartin P, Cameron A, Schiller K, Parvizi J. Diagnosing periprosthetic joint infection: Has the Era of the biomarker arrived? Clin Orthop Relat Res. 2014;472:3254-62Deirmengian C, Greenbaum J, Lotke PA, Booth RE, Lonner JH. Limited Success with open debridement and retention of components in the treatment of acute Staphylococcus aureus infections after total knee arthroplasty. 2003;18:22-6Deirmengian C, Kardos K, Kilmartin P, Gulati S, Citrano P, Booth RE. The alpha-defensin test for periprosthetic joint infection responds to a wide spectrum of organisms. Clin Orthop Relat Res. 2015;473:2229-35Deirmengian C, Kardos K, Kilmartin P, Cameron A, Schiller K, Booth RE, et al. The alphadefensin test for periprosthetic joint infection outperforms the leukocyte esterase test strip. Clin Orthop Relat Res. 2014;473:198-203Randau TM, Friedrich MJ, Wimmer MD, Reichert B, Kuberra D, Stoffel-Wagner B, et al. Interleukin-6 in serum and in synovial fluid enhances the differentiation between periprosthetic joint infection and aseptic loosening. PLoS One. 2014;9:e89045Di Cesare PE, Chang E, Preston CF, Liu C. Serum interleukin-6 as a marker of periprosthetic infection following total hip and knee arthroplasty. J Bone Joint Surg Am. 2005;87:1921-7Matsen L, Parvizi J. Diagnosis of periprosthetic joint infection: Novel developments. Orthop Clin North Am. 2016;47:1-9Achermann Y, Vogt M, Leunig M, Wüst J, Trampuz A. Improved diagnosis of periprosthetic joint infection by multiplex PCR of sonication fluid from removed implants. J Clin Microbiol. 2010;48:1208-14Anagnostakos K, Schmitt C. Can periprosthetic hip joint infections be successfully managed by debridement and prosthesis retention? World J Orthop. 2014;5:218-24Quanjun C, Mihalko W, Shields J, Ries M, Saleh K. Espaciadores de cemento impregnado de antibiótico para el tratamiento de la infección asociada con artroplastia total de cadera o de rodilla. J Bone Joint Surg Am. 2007;89:871-82Marculescu CE, Berbari EF, Hanssen AD, Steckelberg JM, Harmsen SW, Mandrekar JN, et al. Outcome of prosthetic joint infections treated with debridement and retention of components. Clin Infect Dis. 2006;42:471-8Kuiper JWP, Vos SJC, Saouti R, Vergroesen DA, Graat HC, Debets-Ossenkopp YJ, et al. Prosthetic joint-associated infections treated with DAIR (debridement, antibiotics, irrigation, and retention): analysis of risk factors and local antibiotic carriers in 91 patients. Acta Orthop. 2013;84:380-6Sebastian Corro, Matías Vicente, Dolores Rodríguez-Pardo, Carles Pigrau, Mayli Lung, Pablo S. Corona, Vancomycin-Gentamicin Prefabricated Spacers in 2-Stage Revision Arthroplasty for Chronic Hip and Knee Periprosthetic Joint Infection: Insights Into Reimplantation Microbiology and Outcomes The Journal of Arthroplasty. 2020; 35:247-254Omid Shahpari, Alireza Mousavian, Nafise Elahpour, Michael-Alexander Malahias, Mohammad H. Ebrahimzadeh, Ali Moradi, The Use of Antibiotic Impregnated Cement Spacers in the Treatment of Infected Total Joint Replacement: Challenges and Achievements, Current Concepts Review. Archives of the Bone and Joint Surgery. 2020; 8(1): 11-20Scott M. Sporer, Spacer Design Options and Consideration for Periprosthetic Joint Infection, The Journal of Arthroplasty. 2020;35:S31-S34Elena Beam, Douglas Osmon, Prosthetic Joint Infection Update, Infectious Disease Clinics of North America. 2018;32:843–859Marcel E. Roy, Michael P. Peppers, Leo A. Whiteside, Renée M. LaZear. Vancomycin Concentration in Synovial Fluid: Direct Injection into the Knee vs. Intravenous Infusion. The Journal of Arthroplasty. 2014;564–568Pablo S. Corona, Laia Espinal, Dolors Rodríguez-Pardo, Carles Pigrau, Nieves Larrosa, Xavier Flores. Antibiotic Susceptibility in Gram-Positive Chronic Joint Arthroplasty Infections: Increased Aminoglycoside Resistance Rate in Patients with Prior AminoglycosideImpregnated Cement Spacer Use, Journal of Arthroplasty. 2014Eli Ben‑Chetrit, Amit Zamir, Ayman Natsheh, Gideon Nesher, Yonit Wiener‑Well, Gabriel Simon Breuer. Trends in antimicrobial resistance among bacteria causing septic arthritis in adults in a single center: A 15‑years retrospective analysis, Società Italiana di Medicina Interna (SIMI) 2019Villa, J. M., Pannu, T. S., Piuzzi, N., Riesgo, A. M., & Higuera, C. A. Temporary removal: Evolution of Diagnostic Definitions for Periprosthetic Joint Infection in Total Hip and Knee Arthroplasty. The Journal of Arthroplasty. 2019Meek RM, Masri BA, Dunlop D, Garbuz DS, Greidanus NV, McGraw R, Duncan CP. Patient satisfaction and functional status after treatment of infection at the site of a total knee arthroplasty with use of the PROSTALAC articulating spacer. 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Resultados clinicos del uso de espaciadores de cemento con doble antibiótico (Gentamicina + Vancomicina) en infecciones periprotésicas en una institución prestadora de servicios de salud Barranquilla 2018-2022

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