Análisis del papel del microbioma en el desarrollo de enfermedades alérgicas respiratorias

Las alergias son un grupo de enfermedades muy comunes que impactan las vías respiratorias, la piel, el sistema gastrointestinal o múltiples sistemas al mismo tiempo. En ciertos casos, pueden representar un riesgo mortal para los pacientes, como ocurre con el asma severa y la anafilaxia provocada por...

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Autores:: Boom Aguirre, Valeria Valentina

Tipo de recurso:: Trabajo de grado de pregrado

Fecha de publicación:: 2025

Institución:: Universidad Libre

Repositorio:: RIU - Repositorio Institucional UniLibre

Idioma:

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network_acronym_str	RULIBRE2
network_name_str	RIU - Repositorio Institucional UniLibre
repository_id_str
dc.title.spa.fl_str_mv	Análisis del papel del microbioma en el desarrollo de enfermedades alérgicas respiratorias
dc.title.alternative.spa.fl_str_mv	Analysis of the role of the microbiome in the development of respiratory allergic diseases
title	Análisis del papel del microbioma en el desarrollo de enfermedades alérgicas respiratorias
spellingShingle	Análisis del papel del microbioma en el desarrollo de enfermedades alérgicas respiratorias Enfermedades alérgicas Asma infantil Rinitis alérgica Microbioma humano Disbiosis Sistema inmune Tracto respiratorio Desarrollo temprano Homeostasis inmunológica Patogénesis alérgica Comunidades microbianas Epidemiología alérgica Allergic diseases Childhood asthma Allergic rhinitis Human microbiome Dysbiosis Immune system Respiratory tract Early development Immune homeostasis Allergic pathogenesis Microbial communities Allergic epidemiology Microbiomas Alergia en niños Alergia respiratoria Microbioma gastrointestinal
title_short	Análisis del papel del microbioma en el desarrollo de enfermedades alérgicas respiratorias
title_full	Análisis del papel del microbioma en el desarrollo de enfermedades alérgicas respiratorias
title_fullStr	Análisis del papel del microbioma en el desarrollo de enfermedades alérgicas respiratorias
title_full_unstemmed	Análisis del papel del microbioma en el desarrollo de enfermedades alérgicas respiratorias
title_sort	Análisis del papel del microbioma en el desarrollo de enfermedades alérgicas respiratorias
dc.creator.fl_str_mv	Boom Aguirre, Valeria Valentina
dc.contributor.advisor.none.fl_str_mv	Anaya Chavez, Yosed
dc.contributor.author.none.fl_str_mv	Boom Aguirre, Valeria Valentina
dc.subject.spa.fl_str_mv	Enfermedades alérgicas Asma infantil Rinitis alérgica Microbioma humano Disbiosis Sistema inmune Tracto respiratorio Desarrollo temprano Homeostasis inmunológica Patogénesis alérgica Comunidades microbianas Epidemiología alérgica
topic	Enfermedades alérgicas Asma infantil Rinitis alérgica Microbioma humano Disbiosis Sistema inmune Tracto respiratorio Desarrollo temprano Homeostasis inmunológica Patogénesis alérgica Comunidades microbianas Epidemiología alérgica Allergic diseases Childhood asthma Allergic rhinitis Human microbiome Dysbiosis Immune system Respiratory tract Early development Immune homeostasis Allergic pathogenesis Microbial communities Allergic epidemiology Microbiomas Alergia en niños Alergia respiratoria Microbioma gastrointestinal
dc.subject.subjectenglish.spa.fl_str_mv	Allergic diseases Childhood asthma Allergic rhinitis Human microbiome Dysbiosis Immune system Respiratory tract Early development Immune homeostasis Allergic pathogenesis Microbial communities Allergic epidemiology
dc.subject.lemb.spa.fl_str_mv	Microbiomas Alergia en niños Alergia respiratoria Microbioma gastrointestinal
description	Las alergias son un grupo de enfermedades muy comunes que impactan las vías respiratorias, la piel, el sistema gastrointestinal o múltiples sistemas al mismo tiempo. En ciertos casos, pueden representar un riesgo mortal para los pacientes, como ocurre con el asma severa y la anafilaxia provocada por picaduras de insectos. Estas condiciones implican un considerable costo para la salud de quienes las padecen, así como un impacto económico y social relevante para sus familias y el sistema de salud. El objetivo de estudio fue analizar el rol del microbioma en el continuo desarrollo de enfermedades alérgicas respiratorias en la población infantil, donde se encontró que, los complejos microbiomas intestinal y respiratorio están implicados de forma central en la ontogenia del sistema inmune, especialmente durante etapas críticas del desarrollo neonatal y la primera infancia. La disbiosis temprana de estas comunidades microbianas endógenas se ha correlacionado consistentemente con un aumento en la susceptibilidad a desarrollar trastornos alérgicos y asma más adelante en la vida. La evidencia actual propone un papel central del microbioma en la patogénesis de las enfermedades alérgicas respiratorias, que podría ser manipulado para desarrollar aproximaciones terapéuticas novedosas para estas condiciones. No obstante, aún faltan estudios definitivos que esclarezcan los mecanismos subyacentes con mayor precisión.
publishDate	2025
dc.date.accessioned.none.fl_str_mv	2025-03-28T21:05:27Z
dc.date.available.none.fl_str_mv	2025-03-28T21:05:27Z
dc.date.created.none.fl_str_mv	2025-02-06
dc.type.local.spa.fl_str_mv	Tesis de Pregrado
dc.type.coar.spa.fl_str_mv	http://purl.org/coar/resource_type/c_7a1f
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/bachelorThesis
format	http://purl.org/coar/resource_type/c_7a1f
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/10901/30888
url	https://hdl.handle.net/10901/30888
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spelling	Anaya Chavez, YosedBoom Aguirre, Valeria ValentinaBarranquilla2025-03-28T21:05:27Z2025-03-28T21:05:27Z2025-02-06https://hdl.handle.net/10901/30888Las alergias son un grupo de enfermedades muy comunes que impactan las vías respiratorias, la piel, el sistema gastrointestinal o múltiples sistemas al mismo tiempo. En ciertos casos, pueden representar un riesgo mortal para los pacientes, como ocurre con el asma severa y la anafilaxia provocada por picaduras de insectos. Estas condiciones implican un considerable costo para la salud de quienes las padecen, así como un impacto económico y social relevante para sus familias y el sistema de salud. El objetivo de estudio fue analizar el rol del microbioma en el continuo desarrollo de enfermedades alérgicas respiratorias en la población infantil, donde se encontró que, los complejos microbiomas intestinal y respiratorio están implicados de forma central en la ontogenia del sistema inmune, especialmente durante etapas críticas del desarrollo neonatal y la primera infancia. La disbiosis temprana de estas comunidades microbianas endógenas se ha correlacionado consistentemente con un aumento en la susceptibilidad a desarrollar trastornos alérgicos y asma más adelante en la vida. La evidencia actual propone un papel central del microbioma en la patogénesis de las enfermedades alérgicas respiratorias, que podría ser manipulado para desarrollar aproximaciones terapéuticas novedosas para estas condiciones. No obstante, aún faltan estudios definitivos que esclarezcan los mecanismos subyacentes con mayor precisión.Universidad Libre Seccional Barranquilla -- Facultad de Ciencias de la Salud, Exactas y Naturales -- Programa de MicrobiologíaAllergies are a group of very common diseases that impact the respiratory tract, skin, gastrointestinal system or multiple systems at the same time. In certain cases, they can be life-threatening for patients, as is the case with severe asthma and anaphylaxis caused by insect stings. These conditions imply a considerable cost for the health of those who suffer from them, as well as a relevant economic and social impact for their families and the health system. The aim of the study was to analyze the role of the microbiome in the continuous development of respiratory allergic diseases in the pediatric population, where it was found that the complex intestinal and respiratory microbiome complexes are centrally involved in the ontogeny of the immune system, especially during critical stages of neonatal development and early childhood. Early dysbiosis of these endogenous microbial communities has been consistently correlated with increased susceptibility to develop allergic disorders and asthma later in life. Current evidence proposes a central role of the microbiome in the pathogenesis of respiratory allergic diseases, which could be manipulated to develop novel therapeutic approaches for these conditions. However, definitive studies that elucidate the underlying mechanisms with greater precision are still lacking.PDFhttp://creativecommons.org/licenses/by-nc-nd/2.5/co/Atribución-NoComercial-SinDerivadas 2.5 Colombiainfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Enfermedades alérgicasAsma infantilRinitis alérgicaMicrobioma humanoDisbiosisSistema inmuneTracto respiratorioDesarrollo tempranoHomeostasis inmunológicaPatogénesis alérgicaComunidades microbianasEpidemiología alérgicaAllergic diseasesChildhood asthmaAllergic rhinitisHuman microbiomeDysbiosisImmune systemRespiratory tractEarly developmentImmune homeostasisAllergic pathogenesisMicrobial communitiesAllergic epidemiologyMicrobiomasAlergia en niñosAlergia respiratoriaMicrobioma gastrointestinalAnálisis del papel del microbioma en el desarrollo de enfermedades alérgicas respiratoriasAnalysis of the role of the microbiome in the development of respiratory allergic diseasesTesis de Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisDodi G, Atanasi M, Di Filippo P, Di Pillo S, Chiarelli F. 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Análisis del papel del microbioma en el desarrollo de enfermedades alérgicas respiratorias

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