Cáncer de endometrio: una actualización en el diagnóstico y tratamiento; revisión de la literatura

El cáncer endometrial es considerado según las estadísticas el tumor ginecológico más frecuente en los países desarrollados y se ha observado que su incidencia ha ido en aumento. Históricamente, el carcinoma endometrial se ha clasificado en dos tipos clínico-patológicos y moleculares: el tipo I (ade...

Full description

Autores:
Pérez Manzano, Gerardo
Restrepo Pulgarín, Juan Carlos
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2016
Institución:
Universidad Libre
Repositorio:
RIU - Repositorio Institucional UniLibre
Idioma:
spa
OAI Identifier:
oai:repository.unilibre.edu.co:10901/10256
Acceso en línea:
https://hdl.handle.net/10901/10256
Palabra clave:
Cáncer
Endometrio
Medicina
Endometrial Neoplasms
CANCER
ENDOMETRIO
DIAGNOSTICO Y TRATAMIENTO
Cáncer de endometrio
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-nd/2.5/co/
id RULIBRE2_4f35ad3ce8abb10e96271b293e087a5f
oai_identifier_str oai:repository.unilibre.edu.co:10901/10256
network_acronym_str RULIBRE2
network_name_str RIU - Repositorio Institucional UniLibre
repository_id_str
dc.title.spa.fl_str_mv Cáncer de endometrio: una actualización en el diagnóstico y tratamiento; revisión de la literatura
title Cáncer de endometrio: una actualización en el diagnóstico y tratamiento; revisión de la literatura
spellingShingle Cáncer de endometrio: una actualización en el diagnóstico y tratamiento; revisión de la literatura
Cáncer
Endometrio
Medicina
Endometrial Neoplasms
CANCER
ENDOMETRIO
DIAGNOSTICO Y TRATAMIENTO
Cáncer de endometrio
title_short Cáncer de endometrio: una actualización en el diagnóstico y tratamiento; revisión de la literatura
title_full Cáncer de endometrio: una actualización en el diagnóstico y tratamiento; revisión de la literatura
title_fullStr Cáncer de endometrio: una actualización en el diagnóstico y tratamiento; revisión de la literatura
title_full_unstemmed Cáncer de endometrio: una actualización en el diagnóstico y tratamiento; revisión de la literatura
title_sort Cáncer de endometrio: una actualización en el diagnóstico y tratamiento; revisión de la literatura
dc.creator.fl_str_mv Pérez Manzano, Gerardo
Restrepo Pulgarín, Juan Carlos
dc.contributor.advisor.none.fl_str_mv Fernandez Mercado, Robinson
Iglesias Acosta, Jesús
dc.contributor.author.none.fl_str_mv Pérez Manzano, Gerardo
Restrepo Pulgarín, Juan Carlos
dc.subject.spa.fl_str_mv Cáncer
Endometrio
Medicina
topic Cáncer
Endometrio
Medicina
Endometrial Neoplasms
CANCER
ENDOMETRIO
DIAGNOSTICO Y TRATAMIENTO
Cáncer de endometrio
dc.subject.subjectenglish.eng.fl_str_mv Endometrial Neoplasms
dc.subject.lemb.spa.fl_str_mv CANCER
ENDOMETRIO
DIAGNOSTICO Y TRATAMIENTO
dc.subject.proposal.spa.fl_str_mv Cáncer de endometrio
description El cáncer endometrial es considerado según las estadísticas el tumor ginecológico más frecuente en los países desarrollados y se ha observado que su incidencia ha ido en aumento. Históricamente, el carcinoma endometrial se ha clasificado en dos tipos clínico-patológicos y moleculares: el tipo I (adenocarcinoma endometrioide), es el más común y se presenta en el 80-90% de los casos, el tipo II comprende los subtipos no endometrioides tales como el de células serosas, claras y carcinomas indiferenciados. Un dato importante es, que las pacientes en su mayoría son diagnosticadas cuando la enfermedad se encuentra en etapas tempranas, es decir cuando la lesión todavía está confinada al útero. El tratamiento convencional radica en una histerectomía primaria más salpingooforectomía bilateral, ya sea por medio de una laparotomía abdominal o utilizando métodos mínimamente invasivos como la laparoscopia o la laparoscopia asistida por robot. La resección de los ganglios linfáticos va a depender de factores histológicos, estadio de la enfermedad, características de las pacientes y directrices nacionales e internacionales para la gestión de este tipo de enfermedad. Con relación al tratamiento adyuvante este debe adaptarse a la histología y estadio del tumor. Debido a la gran cantidad de literatura disponible que se ocupa de la gestión del cáncer endometrial, el objetivo de este trabajo era realizar una breve actualización sobre esta enfermedad en relación al diagnóstico y tratamiento, basada en una serie de preguntas que se consideraron clínicamente relevantes y que han generado controversia para tal fin. Mediante una estrategia de búsqueda en la base de datos de MEDLINE, EMBASE, PubMed, ClinicalKey, Ovid y la librería de Cochrane; utilizando las palabras clave cáncer, endometrio, diagnóstico y tratamiento hasta el año 2016. Además se formularon una serie de preguntas controversiales sobre el diagnóstico y tratamiento del cáncer de endometrio, en base a las cuales se utilizaron las diferentes palabras claves para resolver dichos interrogantes.
publishDate 2016
dc.date.created.none.fl_str_mv 2016
dc.date.accessioned.none.fl_str_mv 2017-07-27T14:23:40Z
dc.date.available.none.fl_str_mv 2017-07-27T14:23:40Z
dc.type.local.spa.fl_str_mv Tesis de Especialización
dc.type.hasversion.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/bachelorThesis
format http://purl.org/coar/resource_type/c_7a1f
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10901/10256
dc.identifier.instname.spa.fl_str_mv instname:Universidad Libre
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad Libre
url https://hdl.handle.net/10901/10256
identifier_str_mv instname:Universidad Libre
reponame:Repositorio Institucional Universidad Libre
dc.language.iso.none.fl_str_mv spa
language spa
dc.relation.references.SPA.fl_str_mv International Agency for Research on Cancer/World Health Organization. [Online].; Francia: IARC; 2012 [cited 5 Enero 2016].GLOBOCAN "ESTIMATED CANCER INCIDENCE, MORTALITY AND PREVALENCE WORLDWIDE IN 2012". Disponible en: http://www.globocan.iarc.fr/Pages/fact_sheets_population.aspx.
Pardo C, Cendales R. Incidencia, mortalidad y prevalencia de cáncer en Colombia, 2007-2011. ; Primera edición. Bogotá. D.C. Instituto Nacional de Cancerología, 2015, v.1.p. 148. Reporte No: ISBN 978-958-58832-5-3. Disponible en: http://www.cancer.gov.co/files/libros/archivos/incidencia1.pdf.
Felix AS, Weissfeld JL, Stone RA, Bowser R, Chivukula M, Edwards RP, et al. Factors associated with Type I and Type II endometrial cancer. Cancer Causes Control [Online]. 2010 [5 Enero 2016]; 21(11): p. 1851-1856. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962676/.
Amaya J, Beltran A, Chavarro D, Romero G, Matallana M, Puerto S, et al. Estudio de Distribucion de la oferta de medicos especialistas, en servicios de alta y mediana complejidad en Colombia. [Internet]. Bogotá-Colombia. Septiembre 2013. [7 Abril 2016]. Disponible en: https://www.minsalud.gov.co/salud/Documents/Observatorio%20Talento%20 Humano%20en%20Salud/DisponibilidadDistribuci%C3%B3nMdEspecialistas Cendex.pdf:; 2013.
Vargas I, Vasquez M, Mogollón A. Acceso a la atención en salud en Colombia. Rev. salud pública [Internet]. 2010. [7 Abril 2016]; 12(5): p. 701- 712. Disponible en: http://www.scielosp.org/pdf/rsap/v12n5/v12n5a01.pdf.
Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin [Internet].. 2015 [6 Abril 2016].; 65(2): p. 87-108. Disponible en: http://onlinelibrary.wiley.com/doi/10.3322/caac.21262/full
NIH: NATIONAL CANCER INSTITUTE. USA: NIH; 2016. [Online]. [cited 5 Enero 2016]. Endometrial Cancer Screening–Health Professional Version (PDQ®) [aprox. 1 pantalla]. Disponible en: http://www.cancer.gov/types/uterine/hp/endometrial-screening-pdq.
In Ries LAG, Krapcho M, Mariotto A. SEER Cancer Statistics Review, 1975- 2004, National Cancer Institute. 2012;: p. Disponible en: http://seer.cancer.gov/archive/csr/1975_2004/
González J, González E. Embriología y anatomía del aparato reproductor femenino. In González-Merlo J, González Bosquet E, González Bosquet J. Ginecología. 9a ed. España: Elsevier; 2014. p. 1-21.
Bulub SE. Physiology and Pathology of the Female Reproductive Axis. In Melmed Sh, Polonsky KS, Larsen R, et al, editores. Williams Textbook of 127 Endocrinology. 13a ed. Philadelphia: Elsevier, Inc; 2016. p. 589-663
Standring S. Female reproductive system. In Standring S, Anand N, Birch R, et al, editores. Gray's Anatomy. 41a ed. Londres: Elsevier; 2016. p. 1288- 1313
Gartner LP. Female Reproductive System. In Gartner LP. Textbook of Histology. 4a ed. Philadelphia: Elsevier, Inc; 2017. p. 529-558.
ACS: American Cancer Society. [Online].; Estados Unidos: ACS; 2015 [cited 17 Abril 2016]. Qué es el cáncer de endometrio? [aprox. 1 pantalla]. Disponible en: http://www.cancer.org/espanol/cancer/cancerdeendometrio/guiadetallada/can cer-de-endometrio-uterino-what-is-what-is-endometrial-cancer.
De la Fuente C. Encuesta Nacional de la Situación Nutricional en Colombia (ENSIN 2010). Bogota.D.C. Resumen Ejecutivo ENSIN 2010. Instituto Colombiano de Bienestar Familiar. p 26. Disponible en: http://www.icbf.gov.co/portal/page/portal/Descargas1/Resumenfi.pdf.
García E, Cárdenas L, Sandoval D, Mayorga H. HIPERPLASIA ENDOMETRIAL: ANÁLISIS DE SERIE DE CASOS DIAGNOSTICADOS EN BIOPSIA ENDOMETRIAL. Rev. chil. obstet. ginecol [Internet]. 2010 [citado 21 Abril 2016]; 75(3): p. 146-152. Disponible en: http://dx.doi.org/10.4067/S0717-75262010000300002.
Kyung Hee Han, Noh Hyun Park, Hee Seung Kim, Hyun Hoon Chung, Jae Weon Kim y Yong Sang Song. Peritoneal cytology: A risk factor of recurrence for non-endometrioid endometrial cancer. Gynecologic Oncology [Internet]. 2014 [Citado 11 Mayo 2016]; 134(2): p. 293-296. Disponible en: https://www- clinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0090825814009652?scrollTo=%23hl0000604.
dc.relation.references.eng.fl_str_mv Derogatis LR, Morrow GR, Fetting J, et al. The prevalence of psychiatric disorders among cancer patients. JAMA [Internet]. 1983 [7 Abril 2016]; 259(6): p. 751-757. Disponible en: https://www.researchgate.net/publication/16376048_The_Prevalence_of_Psy chiatric_Disorders_Among_Cancer_Patients.
Seebacher V, Schmid M, Polterauer S, Hefler-Frischmuth K, Leipold H, Concin N, et al. The presence of postmenopausal bleeding as prognostic parameter in patients with endometrial cancer: a retrospective multi-center study. BMC Cancer [Internet]. 2009 [7 Abril 2016];: p. Disponible en: http://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-9-460.
Guidos BJ, Selvaggi SM. Detection of endometrial adenocarcinoma with the ThinPrep Pap test. Diagn Cytopathol [Internet]. 2000 [6 Abril 2016]; 23(4): p. 260-265. Disponible en: http://onlinelibrary.wiley.com/doi/10.1002/1097- 0339(200010)23:4%3C260:AID-DC9%3E3.0.CO;2-Y/abstract.
Gu M, Shi W, Barakat RR, Thaler HT, Saigo PE. Pap smears in women with endometrial carcinoma. Acta Cytol.[Internet]. 2001 [6 Abril 2016].; 45(4): p. 555-560. Disponible en: http://www.karger.com/Article/Abstract/327864.
Karlsson B, Granberg S, Wikland M, Ylöstalo P, Torvid K, Marsal K, et al. Transvaginal ultrasonography of the endometrium in women with postmenopausal bleeding--a Nordic multicenter study. Am J Obstet Gynecol [Internet]. 1995 [6 Abril 2016]; 172(5): p. 1488-1494. Disponible en: http://www.sciencedirect.com/science/article/pii/0002937895904832.
American College of Obstetricians and Gynecologists, ACOG Committee Opinion No 440. The role of transvaginal ultrasonography in the evaluation of postmenopausal bleeding. Obstet Gynecol [Internet]. 2009 [6 Abril 2016];(440): p. 1-3. Disponible en: http://www.acog.org/-/media/CommitteeOpinions/Committee-on-GynecologicPractice/co440.pdf?dmc=1&ts=20151207T0121115375.
Benedet JL, Bender H, Jones H 3rd, Ngan HY, Pecorelli S. FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers. FIGO Committee on Gynecologic Oncology. Int J Gynaecol Obstet [Internet]. 2000 [6 Abril 2016]; 70(2): p. 209-262. Disponible en: http://www.ginecologia.unipd.it/AssistenzaDocumenti/Unita'%20operative/Ginecologia%20Oncologica/staging_booklet. pdf.
Zaino RJ, Kauderer J, Trimble CL, Silverberg SG, Curtin JP, Lim PC, et al. Reproducibility of the diagnosis of atypical endometrial hyperplasia: a Gynecologic Oncology Group study. Cancer[Internet]. 2006[6 Abril 2016]; 106(4): p. 804-811. Disponible en: http://onlinelibrary.wiley.com/doi/10.1002/cncr.21649/pdf.
Lewin SN, Herzog TJ, Barrena Medel NI, Deutsch I, Burke WM, Sun X, et al. Comparative performance of the 2009 international Federation of gynecology and obstetrics' staging system for uterine corpus cancer. Obstet Gynecol[Internet]. 2010 [6 Abril 2016]; 116(5): p. 1141-1149. Disponible en: http://journals.lww.com/greenjournal/Fulltext/2010/11000/Comparative_Perfor mance_of_the_2009_International.21.aspx.
Heitmann R. Anatomía del sistema reproductor femenino. In DeCherney A, Nathan L, Laufer N, et al, editores. CURRENT Diagnosis & Treatment: Obstetrics & Gynecology. 11a ed. United States of America: McGraw-Hill Companies, Inc; 2013. p. Disponible en: http://accessmedicine.mhmedical.com.ezproxy.unilibrebaq.edu.co:8084/cont ent.aspx?bookid=498&sectionid=41008589.
Hertzberg B, Middleton W. Pelvis and uterus. In Hertzberg B, Middleton W. Ultrasound: The requisites. 3a ed. Philadelphia: Elsevier; 2016. p. 527-564.
Ball J, Dains J, Flynn J, Solomon B, Stewart R. Female Genitalia. In Ball J, Dains J, Flynn J, et al, editores.Seidel's Guide to Physical Examination. 8a ed. St. Louis, Missouri: Mosby Inc; 2015. p. 416-465.
Baggish MS. Anatomy of the Uterus. In Baggish MS, Valle RF, Guedj H. Hysteroscopy Visual Perspectives of Uterine Anatomy Physiology and Pathology. 3a ed. Philadelphia: Lippincott Williams and Wilkins; 2007. p. 15- 26.
Lessey BA, Young SL. The Structure, Function and Evaluation of the Female Reproductive Tract. In Strauss JF, Barbieri RL.Yen & Jaffe's Reproductive Endocrinology. 7a ed. Philadelphia: Elsevier, Inc; 2014. p. 192-235.
. Ellenson LH, Pirog EC. The Female Genital Tract. In Kumar V, Abbas AK, Aster JC. Robbins and Cotran PATHOLOGIC BASIS OF DISEASE. 9a ed. Philadelphia: Elsevier Inc; 2015. p. 991-1042.
Colgan TJ, Weir MM. Endometrial Hyperplasia and Carcinoma, Extrauterine Cancer, and Unusual Tumors. In Bibbo M, Wilbur DC, Abdul-Karim FW, et al, editores. Comprehensive Cytopathology. 4a ed. Philadelphia: Elsevier, Inc; 2015. p. 198-219.
Kumar V, Abbas AK, Aster JC. Neoplasia. In Kumar V, Abbas AK, Aster JC. Robbins and Cotran PATHOLOGIC BASIS OF DISEASE. 9a ed. Philadelphia: Elsevier, Inc; 2015. p. 265-340.
McMeekin DS. Sarcoma of the Uterus. In Di Saia PhJ, Creasman WT, Mannel RS, et al, editores. Clinical Gynecologic Oncology. 8a ed. Philadelphia: Elsevier, Inc; 2012. p. 175-187.
Mutter GL, Prat J. Endometrial Adenocarcinoma. In Mutter GL, Prat J. Pathology of the Female Reproductive Tract. 3a ed. Philadelphia: Elsevier; 2014. p. 370-401.
Murali R, Soslow RA, Weigelt B. Classification of endometrial carcinoma: more than two types. THE LANCET Oncology [Internet]. 2014 [citado 6 Abril 2016]; 15(7): p. 268-278. Disponible en: http://www.thelancet.com/oncology.
Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA: A Cancer Journal for Clinicians [Internet]. 2014 [citado 14 Diciembre 2015]; 64(1): p. 9- 29. Disponible en: http://onlinelibrary.wiley.com/doi/10.3322/caac.21208/full.
Morice Ph, Leary A, Creutzberg C, Abu-Rustum N, Darai E. Endometrial cancer. The Lancet [Internet]. 2015 [citado 15 Diciembre 2015]; 387(10023): p. 1094-1108. Disponible en: https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/journal/1- s2.0-S0140673615001300.
Colombo N, Creutzberg C, Amant F, Bosse T, González-Martín A, Ledermann J, et al. ESMO–ESGO–ESTRO consensus conference on endometrial cancer: Diagnosis, treatment and follow-up. Radiotherapy and Oncology [Internet]. 2015 [citado 16 Abril 2016]; 117(3): p. 559-581. Disponible en: https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/journal/1- s2.0-S0167814015006180.
Elshaikh M, Munkarah A, Robbins J, Laser B, Bhatt N, Cogan Ch, et al. The impact of race on outcomes of patients with early stage uterine endometrioid 129 carcinoma. Gynecologic Oncology. 2013; 128(2): p. 171-174. Disponible en: https://www-clinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1- s2.0-S0090825812008426.
Burke WM, Gold MA. Practice Bulletin Endometrial Cancer. Obstetrics & Gynecology [Internet]. 2015 [citado 2 Marzo 2016]; 125(4): p. 1006-1026. Disponible en: http://ovidsp.tx.ovid.com.ezproxy.unilibrebaq.edu.co:8084/sp3.19.0a/ovidweb.cgi?&S=FHICFPKINODDNOFHNCIKLFOBCABPAA00&Bro wse=Toc+Children%7cYES%7cS.sh.3561_1460827607_44.3561_14608276 07_56.3561_1460827607_65.3561_1460827607_66.356.
WCRF: World Cancer Research Fund International. [Online].; Londres: WCRF; 2013 [cited 7 Marzo 2016]. Endometrial Cancer 2013 Report. Food, Nutrition, Physical Activity, and the Prevention of Endometrial Cancer [aprox. 1 pantalla]. Disponible en: http://www.wcrf.org/sites/default/files/EndometrialCancer-2013-Report.pdf.
Crosbie EJ, Zwahlen M, Kitchener HC, Egger M, Renehan AG. Body mass index, hormone replacement therapy, and endometrial cancer risk: a metaanalysis. Cancer Epidemiol Biomarkers Prev [Internet]. 2010 [citado 5 Marzo 2016]; 19(31): p. 19-30. Disponible en: http://cebp.aacrjournals.org/content/19/12/3119.full.pdf.
Garg K, Soslow RA. Endometrial Carcinoma in Women Aged 40 Years and Younger. Archives of Pathology & Laboratory Medicine [Internet]. 2014 [citado 5 Abril 2016]; 138(3): p. 335-342. Disponible 130 en:http://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2012-0654-RA.
Garg K, Soslow RA. Endometrial Carcinoma in Women Aged 40 Years and Younger. Archives of Pathology & Laboratory Medicine [Internet]. 2014 [citado 5 Abril 2016]; 138(3): p. 335-342. Disponible 130 en:http://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2012-0654-RA.
Esposito K, Chiodini P, Capuano A, Bellastella G, Maiorino MI, Giugliano D. Metabolic syndrome and endometrial cancer: a meta-analysis. Diabetes Care [Internet]. 2013 [citado 6 Abril 2016]; 45(1): p. 28-36. Disponible en: http://care.diabetesjournals.org/content/35/11/2402.full.
Zhang Y, Liu H, Yang S et al. Overweight, obesity and endometrial cancer risk: results from a systematic review and meta-analysis. Int J Biol Markers [Internet]. 2014 [citado 6 Abril 2016]; 29(1): p. 21-29. Disponible en: http://dx.doi.org/10.5301/jbm.5000047.
Rosato V, Zucchetto A, Bosetti C et al. Metabolic syndrome and endometrial cancer risk. Annals of Oncology [Internet]. 2011 [citado 6 Abril 2016]; 22(4): p. 884-889. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/20937645.1.
Luo J, Beresford S, Chen C, Chlebowski R, García L, Kuller L, et al. Association between diabetes, diabetes treatment and risk of developing endometrial cancer. British Journal of Cancer [Internet]. 2014 [citado 7 Abril 2016]; 111(7): p. 1432-1439. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/25051408.1.
Burke W, Orr J, Leitao M, Salom E, Gehrig P, Olawaiye A, et al. Endometrial cancer: A review and current management strategies: Part I. Gynecologic Oncology [Internet]. 2014 [citado 7 Abril 2016]; 134(2): p. 385-392. Disponible en: http://dx.doi.org/10.1016/j.ygyno.2014.05.018.
Barry J, Azizia M, Hardiman P. Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis. Human Reproduction Update [Internet]. 2014 [citado 8 Abril 2016]; 20(5): p. 748-758. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/24688118.
Lancaster J, Powell B, Chen L, Richardson D. Society of Gynecologic Oncology statement on risk assessment for inherited gynecologic cancer predispositions. Gynecologic Oncology [Internet]. 2014 [citado 8 Abril 2016]; 136(1): p. 3-7. Disponible en: http://dx.doi.org/10.1016/j.ygyno.2014.09.009.
Boggess JF, Kilgore JE. Uterine Cancer. In Niederhuber JE, Armitage JO, Doroshow JH, et al editores. Abeloff's Clinical Oncology. 5a ed. Philadelphia: Elsevier, Inc; 2014. p. 1575-1591.
Everett E, Tamimi H, Greer B, Swisher E, Paley P, Mandel L, et al. The effect of body mass index on clinical/pathologic features, surgical morbidity, and outcome in patients with endometrial cancer. GYNECOLOGIC ONCOLOGY [Internet]. 2003 [citado 17 Abril 2016]; 90(1): p. 150-157. Disponible en: http://dx.doi.org/10.1016/S0090-8258(03)00232-4.
Creutzberg CL, Fleming GF. Endometrial Cancer. In Bogart JA, Buchholz ThA, Foote RL, et al, editores. CLINICAL Radiation Oncology. 4a ed. Philadelphia: Elsevier, Inc; 2016. p. 1203 - 1229
Gerber B, Krause A , Müller H , Reimer T , Külz T , Makovitzky J, et al. Effects of Adjuvant Tamoxifen on the Endometrium in Postmenopausal Women With Breast Cancer: A Prospective Long-Term Study Using Transvaginal Ultrasound. JOURNAL OF CLINICAL ONCOLOGY [Internet]. 2000 [citado 8 Abril 2016]; 18(20): p. 3464-3470. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/11032586.
Lu K, Daniels M. Endometrial and Ovarian Cancer in Women with Lynch syndrome: Update in Screening and Prevention. Familial Cancer [Internet]. 2013 [citado 9 Abril 2016]; 12(2): p. 273-277. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/23765559
Creasman WT, Scott D. Adenocarcinoma of the Uterine Corpus. In Di Saia PhJ, Creasman WT. Clinical Gynecologic Oncology. 8a ed. Philadelphia: Elsevier, Inc; 2012. p. 141-174.
Christopherson WM, Alberhasky RC, Connelly PJ. Carcinoma of the endometrium: I. A clinicopathologic study of clear-cell carcinoma and secretory carcinoma. Cancer [Internet]. 1982 [citado 24 Abril 2016]; 49(8): p. 1511-1523. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed?term=7066860.
Zaino RJ, Kurman RJ, Brunetto VL, Morrow CP, Bentley RC, Cappellari JO, et al. Villoglandular adenocarcinoma of the endometrium: a clinicopathologic study of 61 cases: a gynecologic oncology group study. Am J Surg Pathol [Internet]. 1998 [citado 24 Abril 2016]; 22(11): p. 1379-1385. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed?term=9808130
Boruta DM, Gehrig PA, Groben PA, Bae-Jump V, Boggess JF, Fowler WC, et al. Uterine serous and grade 3 endometrioid carcinomas: is there a survival 133 difference? Cancer [Internet]. 2004
Zaino R, Whitney C, Brady MF, DeGeest K, Burger RA, Buller RE. Simultaneously detected endometrial and ovarian carcinomas--a prospective clinicopathologic study of 74 cases: a gynecologic oncology group study. Gynecol Oncol [Internet]. 2001 [citado 24 Abril 2016]; 83(2): p. 355-362. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed?term=11606097
Mutter GL, Lin MCh, Fitzgerald JT, Kum JB, Baak E, Lees J, et al. Altered PTEN Expression as a Diagnostic Marker for the Earliest Endometrial Precancers. JNCI [Internet]. 2000 [citado 24 Abril 2016]; 92(11): p. 924-930. Disponible en: http://jnci.oxfordjournals.org/content/92/11/924
Basil JB, Goodfellow PJ, Rader JS, Mutch DG, Herzog ThJ. Clinical significance of microsatellite instability in endometrial carcinoma. Cancer [Internet]. 2000 [citado 24 Abril 2016]; 89(8): p. 1758-1764. Disponible en: http://onlinelibrary.wiley.com/doi/10.1002/1097- 0142(20001015)89:8%3C1758:AID-CNCR16%3E3.0.CO;2-A/full.
Lax SF, Kendall B, Tashiro H, Slebos R, Hedrick L. The frequency of p53, kras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma. Cancer [Internet]. 2000 [citado 24 Abril 2016]; 88(4): p. 814-824. Disponible en: http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1097- 0142(20000215)88:4%3C814:AID-CNCR12%3E3.0.CO;2-U/full.
KERNER H, SABO E, Friedman M, BECK D, Samare O, Lichtig C. An immunohistochemical study of estrogen and progesteronereceptors in adenocarcinoma of the endometrium and in the adjacent mucosa. Int J Gynecol Cancer [Internet]. 1995 [citado 24 Abril 2016]; 5(4): p. 275-281. Disponible en: http://ovidsp.tx.ovid.com.ezproxy.unilibrebaq.edu.co:8084/sp- 3.19.0a/ovidweb.cgi
Creasman WT. Prognostic Significance of Hormone. Cancer [Internet]. 1993 [citado 24 Abril 2016]; 71(4): p. 1467-1470. Disponible en: http://onlinelibrary.wiley.com/doi/10.1002/cncr.2820710411/pdf.
Sutton GP, Geisler HE, Stehman FB, Joven P, Kimes TM, Ehrlich CE. Features associated with survival and disease-free survival in early endometrial cancer. AJOG [Internet]. 1989 [citado 24 Abril 2016]; 160(6): p. 1385-1393. Disponible en: http://www.sciencedirect.com/science/article/pii/0002937889908594.
Greven KM, Lanciano XM, Corn B. Pathologic Stage III Endometrial. Cancer [Internet]. 1993 [citado 24 Abril 2016]; 71(11): p. 3697-3702. Disponible en: http://onlinelibrary.wiley.com.ezproxy.unilibrebaq.edu.co:8084/doi/10.1002/10 97-0142(19930601)71:11%3C3697:AID-CNCR2820711137%3E3.0.CO;2- U/pdf.
Li Z, Gilbert Ch, Yang H, Zhao Ch. Histologic Follow-up in Patients With Papanicolaou Test Findings of Endometrial Cells. AJCP [Internet]. 2012 [citado 25 Abril 2016]; 138(1): p. 79-84. Disponible en: http://dx.doi.org/10.1309/AJCP07DCKKZFKSDL.
González-Merlo E. Cáncer de cuerpo uterino. In González-Merlo J, González Bosquet E, González Bosquet J. Ginecología. 9a ed. España: Elsevier Masson; 2014. p. 495-530.
American College of Obstetricians and Gynecologists, ACOG practice bulletin No 65. Management of endometrial cancer. Obstet Gynecol [Internet]. 2005; 106(2): p. 413-425. Disponible en: http://journals.lww.com/greenjournal/Citation/2006/04000/ACOG_Practice_B 135 ulletin__65__Management_of.43.aspx
Han SS, Lee SH, Kim DH, Kim JW, Park NH, Kang SB, et al. Evaluation of preoperative criteria used to predict lymph node metastasis in endometrial cancer. Acta Obstet Gynecol Scand. 2010; 89(2): p. 168–174. Disponible en: http://onlinelibrary.wiley.com/doi/10.3109/00016340903370114/full.
Kilgore LC, Partridge EE, Alvarez RD, Austin JM, Shingleton HM, Noojin F 3rd, et al. Adenocarcinoma of the endometrium: survival comparisons of patients with and without pelvic node sampling. Gynecol Oncol [Internet]. 1995 [8 Abril 2016]; 56(1): p. 29–33.Disponible en: http://www.sciencedirect.com/science/article/pii/S0090825885710050.
Chan JK, Cheung MK, Huh WK, Osann K, Husain A, Teng NN, et al. Therapeutic role of lymph node resection in endometrioid corpus cancer: a study of 12,333 patients. Cancer[Internet]. 2006 [8 Abril 2016]; 107(8): p. 1823–1830. Disponible en: http://cat.inist.fr/?aModele=afficheN&cpsidt=18197112.
Creasman WT, Morrow CP, Bundy BN, Homesley HD, Graham JE, Heller PB. Surgical pathologic spread patterns of endometrial cancer. A Gynecologic Oncology Group Study.. Cancer [Internet]. 1987 [8 Abril 2016] ; 60(8 Supl): p. 2035–2041. Disponible en: http://incanmexico.org/wp_ginecologia/wp-content/uploads/GOG-33.pdf.
Mariani A, Dowdy SC, Cliby WA, Gostout BS, Jones MB, Wilson TO, et al. Prospective assessment of lymphatic dissemination in endometrial cancer: a paradigm shift in surgical staging. Gynecol Oncol. 2008; 109(1): p. 11-18. Disponible en:https://www.researchgate.net/publication/5547081_Mariani_A_Dowdy_SC _Cliby_WA_Gostout_BS_Jones_MB_Wilson_TO_Podratz_KCProspective_a ssessment_of_lymphatic_dissemination_in_endometrial_cancer_a_paradigm _shift_in_surgical_staging_Gynecol_.
Walker JL, Piedmonte MR, Spirtos NM, Eisenkop SM, Schlaerth JB, Mannel RS, et al. Laparoscopy compared with laparotomy for comprehensive surgical staging of uterine cancer: Gynecologic Oncology Group Study LAP2. J Clin Oncol [Internet]. 2009 [21 abril 2016]; 27: p. 5331–5336. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773219/.
Boggess JF, Gehrig PA, Cantrell L, Shafer A, Ridgway M, Skinner EN, et al. A comparative study of 3 surgical methods for hysterectomy with staging for endometrial cancer: robotic assistance, laparoscopy, laparotomy. Am J Obstet Gynecol [Internet]. 2008 [21 Abril 2016]; 199: p. 360 369. Disponible en: http://incan-mexico.org/wp_ginecologia/wp-content/uploads/comparacionde-estadificacion-quirurgica-en-endometrio.pdf.
Chan JK, Lin YG, Monk BJ, Tewari K, Bloss JD, Berman ML. Vaginal hysterectomy as primary treatment of endometrial cancer in medically compromised women. Obstet Gynecol [Internet]. 2001 [21 Abril 2016]; 97(5): p. 707–711. Disponible en: http://journals.lww.com/greenjournal/Fulltext/2001/05000/Vaginal_Hysterecto my_as_Primary_Treatment_of.12.aspx#.
Susini T, Massi G, Amunni G, Carriero C, Marchionni M, Taddei G, et al. Vaginal hysterectomy and abdominal hysterectomy for treatment of endometrial cancer in the elderly. Gynecol Oncol [Internet]. 2005 [21 Abril 2016]; 96(2): p. 362–367. Disponible en: http://www.sciencedirect.com/science/article/pii/S0090825804008182.
Keys HM, Roberts JA, Brunetto VL, Zaino RJ, Spirtos NM, Bloss JD, et al. A phase III trial of surgery with or without adjunctive external pelvic radiation 137 therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study. Gynecol Oncol[Internet]. 2004 [21 Abril 2016]; 92: p. 744–751. Disponible en: http://ovidsp.tx.ovid.com.ezproxy.unilibrebaq.edu.co:8084/sp3.19.0a/ovidweb.cgi?WebLinkFrameset=1&S=FGJCFPKAKGDDHOMANCIK JGJCGNNHAA00&returnUrl=ovidweb.cgi%3f%26Titles%3dS.sh.22%257c1% 257c10%26FORMAT%3dtitle%26FIELDS%3dTITLES%26S%3.
Wolfson AH, Sightler SE, Markoe AM, Schwade JG, Averette HE, Ganjei P, et al. The prognostic significance of surgical staging for carcinoma of the endometrium. Gynecol Oncol [Internet]. 1992 [21 Abril 2016]; 45: p. 142–146. Disponible en: http://www.sciencedirect.com/science/article/pii/009082589290276O
Shih KK, Yun E, Gardner GJ, Barakat RR, Chi DS, Leitao MM Jr. citorreducción quirúrgica en estadio IV carcinoma endometrioide de endometrio. Gynecol Oncol [Internet]. 2011 [21 Abril 2016]; 122(3): p. 608- 611. Disponible en: http://www.sciencedirect.com/science/article/pii/S0090825811004173.
Barlin JN, Puri I, Bristow RE. Cytoreductive surgery for advanced or recurrent endometrial cancer: a meta-analysis. Gynecol Oncol [Internet]. 2010 [21 Abril 2016]; 118: p. 14–18: Disponible en: https://www.researchgate.net/profile/Robert_Bristow/publication/43533231_C ytoreductive_surgery_for_advanced_or_recurrent_endometrial_cancer_A_m eta-analysis/links/54a449b50cf256bf8bb32532.pdf.
Fleming GF, Brunetto VL, Cella D, Look KY, Reid GC, Munkarah AR, et al. Phase III trial of doxorubicin plus cisplatin with or without paclitaxel plus filgrastim in advanced endometrial carcinoma: a Gynecologic Oncology Group Study. J Clin Oncol [Internet]. 2004[21 Abril 2016]; 22(11): p. 2159– 2166. Disponible en: http://www.kalbemed.com/Portals/6/komelib/oncology/Onkologi/Filgrastim/filg rastim%20ca%20endometrium.pdf.
Sovak MA, Hensley ML, Dupont J, Ishill N, Alektiar KM, Abu-Rustum N, et al. Paclitaxel and carboplatin in the adjuvant treatment of patients with high-risk stage III and IV endometrial cancer: a retrospective study. Gynecol Oncol [Internet]. 2006 [21 Abril 2016]; 103(2): p. 451–457. Disponible en: http://www.sciencedirect.com/science/article/pii/S0090825806002472.
Erkanli S, Ayhan A. Fertility-sparing therapy in young women with endometrial cancer: 2010 update. Int J Gynecol Cancer [Internet]. 2010 [21 Abril 2016]; 20(7): p. 1170–1187. Disponible en: http://journals.lww.com/ijgc/Abstract/2010/10000/Fertility_Sparing_Therapy_i n_Young_Women_With.14.aspx.
Barakat RR, Bundy BN, Spirtos NM, Bell J, Mannel RS. Randomized doubleblind trial of estrogen replacement therapy versus placebo in stage I or II endometrial cancer: a Gynecologic Oncology Group Study. J Clin Oncol [internet]. 2006 [21 Abril 2016]; 24(4): p. 587–592. Disponible en:http://journal.9med.net/html/qikan/zlx/lczlxyxqk/20062242/2008083113020 0777_252435.html.
Braun MM, Overbeek-Wager EA, Grumbo RJ. Diagnosis and Management of Endometrial Cancer. American Family Physician [Internet]. 2016 [citado 10 Mayo 2016]; 93(6): p. 468-474. Disponible en: https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/journal/1- s2.0-S0002838X16600114.
Aune D, Navarro Rosenblatt DA, Chan DSM, Vingeliene S, Abar L, Vieira AR, et al. Anthropometric factors and endometrial cancer risk: a systematic 139 review and dose–response meta-analysis of prospective studies. Annals of Oncology [Internet]. 2015 [citado 10 Mayo 2016]; 26(8): p. 1635-1648. Disponible en: http://annonc.oxfordjournals.org/content/26/8/1635.long.
Hernandez AV, Pasupuleti V, Benites-Zapata VA, Thota P, Deshpande A, Perez-Lopez FR. Insulin resistance and endometrial cancer risk: A systematic review and meta-analysis. European Journal of Cancer [Internet]. 2015 [citado 10 Mayo 2016]; 51(18): p. 2747-2758. Disponible en: https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/journal/1- s2.0-S0959804915008515
Yang TK, Jung Ch, Chung ChD, Muo ChH, Chang ChH, Huang ChY. Risk of Endometrial Cancer in Women With Pelvic Inflammatory Disease. Medicine [Internet]. 2015 [citado 10 Mayo 2016]; 94(34): p. 1278. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602931/.
Schonfeld SJ, Hartge P, Pfeiffer RM, Freedman M, Greenlee RT, Linet MS, et al. An Aggregated Analysis of Hormonal Factors and Endometrial Cancer Risk by Parity. Cancer [Internet]. 2013 [citado 10 Mayo 2016]; 119(7): p. 1393–1401. Disponible en: http://onlinelibrary.wiley.com/doi/10.1002/cncr.27909/full.
Dashti SG, Chau R, Ouakrim D, Buchanan D, Clendenning M, Young JP, et al. Female Hormonal Factors and the Risk of Endometrial Cancer in Lynch Syndrome. JAMA [Internet]. 2015 [citado 9 Mayo 2016]; 314(1): p. 61-71. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688894/.
Vasen HF, Blanco I, Aktan-Collan K, Gopie JP, Alonso A, Aretz S, et al. Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts. Gut [Internet]. 2013 [citado 12 Mayo 2016]; 62(6): p. 812-823. Disponible en: http://gut.bmj.com/content/62/6/812.full
Forbes JF, Sestak I, Howell A, Bonanni B, Bundred N, Levy Ch, et al. Anastrozole versus tamoxifen for the prevention of locoregional and contralateral breast cancer in postmenopausal women with locally excised ductal carcinoma in situ (IBIS-II DCIS). THE LANCET [Internet]. 2016 [citado 9 Mayo 2016]; 387(10021): p. 866-873. Disponible en:https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/journal/1- s2.0-S0140673615011290.
Rydén L, Arnlind MH, Vitols S, Höistad M, Ahlgren J. Aromatase inhibitors alone or sequentially combined with tamoxifen in postmenopausal early breast cancer compared with tamoxifen or placebo. THE BREAST [Internet]. 2016 [citado 10 Mayo 2016]; 26(1): p. 106-114. Disponible en: https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/journal/1- s2.0-S0960977616000114
Verdoodt F, Friis S, Dehlendorff Ch, Albieri V, Kjaer SK. Non-steroidal antiinflammatory drug use and risk of endometrial cancer: A systematic review and meta-analysis of observational studies. Gynecologic Oncology [Internet]. 2016 [citado 10 Mayo 2016]; 140(2): p. 352-358. Disponible en: https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/journal/1- s2.0-S0090825815302134.
Brasky ThM, Rodabough RJ, Liu J, Kurta ML, Wise LA, Orchard TS, et al. Long-chain ω-3 fatty acid intake and endometrial cancer risk in the Women's Health Initiative. Am J Clin Nutr [Internet]. 2015 [citado 11 Mayo 2016]; 101(4): p. 824-834. Disponible en: http://ajcn.nutrition.org/content/101/4/824
Sorosky JI. Endometrial Cancer. Obstetrics & Gynecology [Internet]. 2012 [citado 12 Mayo 2016]; 120(2): p. 383-397. Disponible en: http://DOI: 10.1097 / AOG.0b013e3182605bf1.
Khati NJ, Glanc P, Bhosale PR, Harisinghani MG, Harris RD, Kim YB, et al. ACR Appropriateness Criteria® abnormal vaginal bleeding. AHRQ [Internet]. 2014 [citado 12 Mayo 2016];: p. 13. Disponible en: http://www.guideline.gov/content.aspx?id=48294.
Committee Opinion No. 557: Management of Acute Abnormal Uterine Bleeding in Nonpregnant Reproductive-Aged Women. Obstetrics & Gynecology [Internet]. 2013 [citado 12 Mayo 2016]; 121(4): p. 891-896. Disponible en: http:/ /DOI: 10.1097 / 01.AOG.0000428646.67925.9a
Diagnosis of Abnormal Uterine Bleeding in Reproductive-Aged Women. P RACT IC E BULLETIN. Obstetrics & Gynecology [Internet]. 2012 [citado 12 Mayo 2016]; 120(1): p. 197-206. Disponible en: http://www.uptodate.com.ezproxy.unilibrebaq.edu.co:8084/contents/endometr ial-carcinoma-clinical-features-and-diagnosis/abstract/12?utdPopup=true
Su H, Huang L, Huang KG, Feng ChY, Han ChM, Lee ChL. Accuracy of hysteroscopic biopsy, compared to dilation and curettage, as a predictor of final pathology in patients with endometrial cancer. Taiwanese Journal of Obstetrics and Gynecology [Internet]. 2015 [citado 12 Mayo 2016]; 54(6): p. 757-760. Disponible en: https://www-clinicalkeyes.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S1028455915002454.
Bakkum-Gamez JN, Wentzensen N, Maurer MJ, Hawthorne KM, Voss JS, Kroneman TN, et al. Detection of endometrial cancer via molecular analysis of DNA collected with vaginal tampons. Gynecologic Oncology [Internet]. 2015 [citado 12 Mayo 2016]; 137(1): p. 14-22. Disponible en: https://wwwclinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1-s2.0-
Lai HCh, Wang YCh, Yu MH, Huang RL, Yuan ChCh, Chen KJ, et al. DNA methylation as a biomarker for the detection of hidden carcinoma in endometrial atypical hyperplasia. Gynecologic Oncology [Internet]. 2014 [citado 12 Mayo 2016]; 135(3): p. 552-559. Disponible en: https://wwwclinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0090825814014024.
Timmermans A, Opmeer BC, Khan KS, Bachmann LM, Epstein E, Clark TJ, et al. Endometrial Thickness Measurement for Detecting Endometrial Cancer in Women With Postmenopausal Bleeding: A Systematic Review and MetaAnalysis. Obstetrics & Gynecology [Internet]. 2010 [citado 13 Mayo 2016]; 116(1): p. 160-167: Disponible en: http://DOI: 10.1097 / AOG.0b013e3181e3e7e8.
Wolfman W, Leyland N, Wolfman W, Heywood M, Singh SS. Asymptomatic Endometrial Thickening. JOGC [Internet]. 2010 [citado 13 Mayo 2016]; 32(10): p. 990-999. Disponible en: http://www.sciencedirect.com/science/article/pii/S1701216316346904#.
Menzies R, Wallace S, Ennis M, Bennett A, Jacobson M, Yip G, et al. Significance of Abnormal Sonographic Findings in Postmenopausal Women With and Without Bleeding. JOGC [Internet]. 2011 [citado 13 Mayo 2016]; 33(9): p. 944-951. Disponible en: http://www.sciencedirect.com/science/article/pii/S1701216316350204
uie M, Canavan TP, Mansuria S. Threshold for endometrial sampling among postmenopausal patients without vaginal bleeding. International Journal of Gynecology & Obstetrics [Internet]. 2016 [citado 13 Mayo 2016]; 132(3): p. 314-317. Disponible en: https://www-clinicalkey- 143 es.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S002072921500661X
Petru E, Lück HJ, Stuart G, Gaffney D, Millán D, Vergote I. Gynecologic Cancer Intergroup (GCIG) proposals for changes of the current FIGO staging system. ejog [Internet]. 2009 [citado 14 Mayo 2016]; 143(2): p. 69-74. Disponible en: http://dx.doi.org/10.1016/j.ejogrb.2008.12.015.
Mannelqvist M, Stefansson IM, Bredholt G, Hellem T, Dyan AM, Jonassen I, et al. Gene Expression Patterns Related to Vascular Invasion and Aggressive Features in Endometrial Cancer. The American Journal of Pathology [Internet]. 2011 [citado 14 Mayo 2016]; 178(2): p. 861-871. Disponible en: http://dx.doi.org/10.1016/j.ajpath.2010.10.040.
Kondalsamy-Chennakesavan S, Yu Ch, Kattan MW, Yee L, Sykes P, Nascimento M, et al. Nomograms to predict isolated loco-regional or distant recurrence among women with uterine cancer. GYNECOLOGIC ONCOLOGY [Internet]. 2012 [citado 15 Mayo 2016]; 125(3): p. 520-525. Disponible en: http://dx.doi.org/10.1016/j.ygyno.2012.02.022.
Ayeni TA, Bakkum-Gamez JN, Mariani A, McGree ME, Weaver AL, Eglefino MG, et al. Comparative outcomes assessment of uterine grade 3 endometrioid, serous, and clear cell carcinomas. GYNECOLOGIC ONCOLOGY [Internet]. 2013 [citado 15 Mayo 2016]; 129(3): p. 478-485. Disponible en: http://dx.doi.org/10.1016/j.ygyno.2013.03.011.
Aristizabal P, Graesslin O, Barranger E, Clavel-Chapelon F, Haddad B, Luton D, et al. A suggested modification to FIGO stage I endometrial cancer. GYNECOLOGIC ONCOLOGY [Internet]. 2014 [citado 13 Mayo 2016]; 133(2): p. 192-196. Disponible en: https://www-clinicalkeyes.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0090825814002418.
Torralba AE, González E, Callejo J, Lailla JL. Utilidad de la resonancia magnética en la estadificación prequirúrgica del cáncer de endometrio. Clinica e Investigacion en Ginecologia y Obstetricia [Internet]. 2014 [citado 19 Mayo 2016]; 41(3): p. 104-106. Disponible en: https://www-clinicalkeyes.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0210573X13000282
Husby JA, Salvesen DO, Magnussen IJ, Trovik J, Bjørge L, Salvesen HB, et al. Tumour apparent diffusion coefficient is associated with depth of myometrial invasion and is negatively correlated to tumour volume in endometrial carcinomas. Clinical Radiology[Internet]. 2015 [citado 15 Mayo 2016]; 70(5): p. 487-494. Disponible en: https://www-clinicalkeyes.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0009926015000203?scrollTo=%23bib4.
Mainenti PP, Pizzuti LM, Segreto S, Comerci M, De Fronzo S, Romano F, et al. Diffusion volume (DV) measurement in endometrial and cervical cancer: A new MRI parameter in the evaluation of the tumor grading and the risk classification. European Journal of Radiology [Internet]. 2016 [citado 19Mayo 2016]; 85(1): p. 113-124. Disponible en: https://www-clinicalkeyes.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0720048X15301340
Tuomi T, Pasanen A, Luomaranta A, Leminen A, Bützow R, Loukovaara M. Risk-stratification of endometrial carcinomas revisited: A combined preoperative and intraoperative scoring system for a reliable prediction of an advanced disease. Gynecologic Oncology [Internet]. 2015 [citado 19 Mayo 2016]; 137(1): p. 23-27. Disponible en: https://www-clinicalkeyes.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- 145 S0090825815005880
Burgmann E, Yun-Yi H, Armstrong A. The Value of Additional Pathology Comments Indicating Suspicion of Adenocarcinoma Among Women Diagnosed Preoperatively With Complex Atypical Endometrial Hyperplasia. Gynecological Pathology [Internet]. 2012 [citado 18 Mayo 2016]; 31(3): p. 222-226. Disponible en: http://DOI: 10.1097 / PGP.0b013e31823ef8b0.
Zhou L, Meng Zh, Wu Y, Zhu H, Wang X. Prediction of endometrial carcinogenesis probability while diagnosed as atypical endometrial hyperplasia: a new risk model based on age, CA199 and CA125 assay. European Journal of Obstetrics & Gynecology and Reproductive Biology [Internet]. 2014 [citado 18 Mayo 2016]; 183(1): p. 5-9. Disponible en: https://www-clinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1- s2.0-S0301211514005302.
Kitchener H. To stage or not to stage? That is the question: (with apologies to Shakespeare). Int J Gynecol Cancer.[internet]. 2010 [citado 11 Mayo 2016]; 20(11): p. s55-s56. Disponible en: http://ovidsp.tx.ovid.com.ezproxy.unilibrebaq.edu.co:8084/sp3.20.0b/ovidweb.cgi?WebLinkFrameset=1&S=EOKLFPEJLCDDMMNANCIK OAMCFMGAAA00&returnUrl=ovidweb.cgi%3f%26Titles%3dS.sh.22%257c1 %257c10%26FORMAT%3dtitle%26FIELDS%3dTITLES%26S%3.
Frost JA, Webster KE, Bryant A, Morrison J. Lymphadenectomy for the management of endometrial cancer. Cochrane Database Syst Rev. 2015 [citado 11 Mayo 2016].;: p. Disponible en: Cochrane Database Syst Rev. 2015 Sep 21;9:CD007585.
Cuadra M, Ceberio N, Rodríguez M, Mendizabal J, Gorostiaga J y Lete I. Tratamiento quirúrgico del cáncer de endometrio: ¿qué pasaría si no 146 realizamos biopsia intraoperatoria? Progresos de obstetricia y ginecología [Internet]. 2015; 58(10): p. 446-451. Disponible en: https://www-clinicalkeyes.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0304501315001557?scrollTo=%23bib0200.
Siobhan K, Miller D. The Role of Lymphadenectomy in Endometrial Cancer. Clinical Obstetrics and Gynecology [Internet]. 2011 [citado 16 Mayo 2016]; 54(2): p. 235-244. Disponible en: http://ovidsp.tx.ovid.com.ezproxy.unilibrebaq.edu.co:8084/sp3.20.0b/ovidweb.cgi?WebLinkFrameset=1&S=OEBIFPBIDIDDMMKLNCIKN DMCBGAHAA00&returnUrl=ovidweb.cgi%3f%26Full%2bText%3dL%257cS.s h.22.43%257c0%257c00003081-201106000-00007%26S%
Lécuru F, Bats A, Ngô C, Bensaid C, Achouri A, Makke L, et al.Linfadenectomías en el cáncer de endometrio. Ginecología – Obstetricia [Internet]. 2015 [citado 11 Mayo 2016].; 51(4): p. 1-6. Disponible en: https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/emc/51- s2.0-S1283081X15747429?scrollTo=%23hl0000357.
Plante M, Touhami O, Trinh X, Renaud M, Sebastianelli A, Grondin , et al. Sentinel node mapping with indocyanine green and endoscopic near-infrared fluorescence imaging in endometrial cancer. A pilot study and review of the literature. Gynecologic Oncology [Internet]. 2015 [Citado 11 Mayo 2016]; 137(3): p. 443-447. Disponible en: https://www-clinicalkeyes.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0090825815006794.
Lu KH, Loose DS, Yates MS, Nogueras GM, Munsell MF, Chen LM, Lynch H, et al. Prospective multicenter randomized intermediate biomarker study of oral contraceptive versus depo-provera for prevention of endometrial cancer in women with Lynch syndrme. Cancer Prev Res (Phila). [Internet]. 2013 [Citado 11Mayo 2016]; 6(8): p. 774-781. Disponible en: http://cancerpreventionresearch.aacrjournals.org/content/6/8/774.full.pdf+htm l.
Morelli M, Di Cello A, Venturella R, Mocciaro R, D'Alessandro P, Zullo F. Efficacy of the levonorgestrel intrauterine system (LNG-IUS) in the prevention of the atypical endometrial hyperplasia and endometrial cancer: retrospective data from selected obese menopausal symptomatic women. Gynecol. Endocrinol.[Internet]. 2013; 29(2): p. 156-159. Disponible en: https://www.researchgate.net/profile/Annalisa_Di_Cello/publication/23332795 1_Efficacy_of_the_levonorgestrel_intrauterine_system_(LNGIUS)_in_the_prevention_of_the_atypical_endometrial_hyperplasia_and_endo metrial_cancer_retrospectiv.
Linkov F, Elishaev E, Gloyeske N, Edwards R, Althouse A, Geller M, et al.Bariatric surgery-induced weight loss changes immune markers in the endometrium of morbidly obese women. Surgery for Obesity and Related Diseases [Internet]. 2014; 10(5): p. 921-926. Disponible en: https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/journal/1- s2.0-S1550728914001464.
Nasir M, Khan G, Ariffin R, Abu J, Chapman C, Deen S, et al.Preventing endometrial cancer risk in polycystic ovarian syndrome (PCOS) women: Could metformin help?. ecologic Oncology. [Internet]. 2014; 132(1): p. 248- 253. Disponible en: https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/journal/1- s2.0-S0090825813012778.
Gressel G, Parkash V y Pal L. Management options and fertility-preserving therapy for premenopausal endometrial hyperplasia and early-stage endometrial cancer. International Journal of Gynecology & Obstetrics [Internet]. 2015 [citado 11 ayo 2016]; 131(3): p. 234-239. Disponible en: https://www-clinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1- s2.0-S002072921500572X.
Carlson MJ, Thiel KW, Yang S, Leslie KK. Catch it before it kills: progesterone, obesity, and the prevention of endometrial cancer. Discov Med [Internet]. 2012 [Citado 11 Mayo 2016]; 14(76): p. 215-222. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964851/.
Scalici J, Laughlin B, Finan M, Wang B y Rocconi R. The trend towards minimally invasive surgery (MIS) for endometrial cancer: An ACS–NSQIP evaluation of surgical outcomes. Gynecologic Oncology [internet]. 2015 [Citado 11 Mayo 2016]; 136(3): p. 512-515. Disponible en: https://wwwclinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0090825814014796
Chan J, Gardner A, Taylor K, Thompson C, Blansit K, Yu X, et al.Robotic versus laparoscopic versus open surgery in morbidly obese endometrial cancer patients — A comparative analysis of total charges and complication rates. Gynecologic Oncology. [Internet]. 2015 [Citado 11 Mayo 2016]; 139(2): p. 300-305. Disponible en: https://www-clinicalkeyes.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0090825815301232.
Herling S, Møller A, Palle C y Thomsen T. Health-related quality of life after robotic-assisted laparoscopic hysterectomy for women with endometrial cancer — A prospective cohort study. Gynecologic Oncology. [Internet]. 2016 [Citado 11 Mayo 2016]; 140(1): p. 107-113. Disponible en: https://wwwclinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0090825815301712.
Corrado G, Chiantera V, Fanfani F, Cutillo G, Lucidi A, Mancini E, et al. Robotic Hysterectomy in Severely Obese Patients With Endometrial Cancer: A Multicenter Stud. Journal of Minimally Invasive Gynecology. [Internet]. 2016 [citado 11 Mayo 2016].; 23(1): p. 94-100. Disponible en: https://wwwclinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S1553465015015101.
Favero G, Miglino G, Köhler Ch, Pfiffer T, Silva e Silva A, Ribeiro A, et al. Herramientas para compartir y guardar. Journal of Minimally Invasive Gynecology.[Internet]. 2015[Citado 11 Mayo 2016].; 22(6): p. 938-943. Disponible en: https://www-clinicalkeyes.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S1553465015003258.
Boggess J, Kilgore J. Uterine Cancer. In Abeloff's Clinical Oncology. 5th ed.: Saunders; 2014. p. 1575-1591.
Homesley H, Filiaci V, Gibbons S, Long H, Cella D, Spirtos N, et al: A randomized phase III trial in advanced endometrial carcinoma of surgery and volume directed radiation followed by cisplatin and doxorubicin with or without paclitaxel: A Gynecologic On. Gynecologic Oncology. [Internet]. 2009 [citado 16 Mayo 2016]; 112(3): p. 543-552. Disponible en: https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/journal/1- s2.0-S0090825808009384.
Nout R, van de Poll-Franse L, Lybeert M, Wárlám-Rodenhuis C, Jobsen J, Mens J, et al: Long-term outcome and quality of life of patients with endometrial carcinoma treated with or without pelvic radiotherapy in the post operative radiation therapy in. endometrial carcinoma 1 (PORTEC-1) trial.J Clin Oncol.[Internet]. 2011 [Citado 16 Mayo 2016]; 29(13): p. 1692-1700. Disponible en: https://pure.uvt.nl/portal/files/1379512/MedPst_Pollfranse_longterm__JCO_2011.pdf.
Ly D, Soisson P, Dodson M, Sause W y Gaffney D:Adjuvant radiation therapy is associated with improved pelvic control and overall survival in FIGO IB endometrial carcinoma with high grade histology. Gynecologic Oncology [Internet]. 2015. [citado 16 mayo 2016]; 138(3): p. 526-531. Disponible en: https://www-clinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1- s2.0-S0090825815300433
Nout R, Smit V, Putter H, Jürgenliemk-Schulz I, Jobsen J, Lutgens L, et al: Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2). an openlabel, non-inferiority, randomised trial. Lancet. [Internet]. 2010 [Citado 16 Mayo 2016].; 375(9717): p. 816-823. Disponible en: https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/journal/1- s2.0-S0140673609621632.
Thigpen J.T., Brady M.F., Homesley H.D., Malfetano J., DuBeshter B., Burger R.A., et al: Phase III trial of doxorubicin with or without cisplatin in advanced endometrial carcinoma: a gynecologic oncology group study. J. Clin. Oncol. [Internet]. 2004 [Citado 16 Mayo 2016].; 22(19): p. 3902-3908. Disponible en: http://jco.ascopubs.org/content/22/19/3902.full.
Hei-Yu Lau, Min-Yu Chen, Yu-Min Ke, Jen Chen-Ruei, El I-Hui Chen, WenLiou Shiung et al. Outcome of ovarian preservation during surgical treatment for endometrial cancer: A Taiwanese Gynecologic Oncology Group study. Taiwanese Journal of Obstetrics and Gynecology [Internet]. 2015 [citado, 11 Mayo 2016]; 54(5): p. 532-536. Disponible en: https://www-clinicalkeyes.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S102845591500162X.
Sun Ch, Chen G, Yang Z, Jiang J, Yang X, Li N, et al. Safety of ovarian preservation in young patients with early-stage endometrial cancer: a retrospective study and meta-analysis. Fertility and Sterility [Internet]. 2013 [Citado 11 Mayo 2016]; 100(3): p. 782-787. Disponible en: https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/journal/1- s2.0-S0015028213006420.
Simpson A, Feigenberg T, Clarke B, Gien L, Ismiil N, Laframboise S, et al.Fertility sparing treatment of complex atypical hyperplasia and low grade endometrial cancer using oral progestin. Gynecologic Oncology [Internet]. 2014 [citado 11 Mayo 2016]; 133(2): p. 229-233. Disponible en: https://wwwclinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0090825814001383
Chen M, Jin Y, Li Y, Bi Y, Shan Y y Pan L. Oncologic and reproductive outcomes after fertility-sparing management with oral progestin for women with complex endometrial hyperplasia and endometrial cance. International Journal of Gynecology & Obstetrics [Internet]. 2016 [citado 11 Mayo 2016]; 132(1): p. 34-38. Disponible en: https://www-clinicalkeyes.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0020729215005962.
Gao Ch, Wang Y, Tian W, Zhu Wy Xue F. The therapeutic significance of aromatase inhibitors in endometrial carcinoma. Gynecologic Oncology [Internet]. 2014 [citado 11 Mayo 2016].; 134(1): p. 190-195. Disponible en: https://www-clinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1- s2.0-S0090825814009214.
Schointuch M, Gilliam T, Stine J, Han X, Zhou Ch, Gehrig P, et al.Simvastatin, an HMG-CoA reductase inhibitor, exhibits anti-metastatic and anti-tumorigenic effects in endometrial cancer. Gynecologic Oncology. [Internet]. 2014 [citado 11 Mayo 2016].; 134(2): p. 346-355. Disponible en: https://www-clinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1- s2.0-S0090825814009755.
dc.relation.references.spa.fl_str_mv Crum ChP, Duska LR, Nucci MR. Adenocarcinoma, Carcinosarcoma, and Other Epithelial Tumors of the Endometrium. In Crum ChP, Nucci MR, Lee KR. Diagnostic Gynecologic and Obstetric Pathology. 2a ed. Philadelphia: Elsevier, Inc; 2011. p. 517-581.
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rights.license.*.fl_str_mv Atribución-NoComercial-SinDerivadas 2.5 Colombia
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.coar.spa.fl_str_mv http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/co/
Atribución-NoComercial-SinDerivadas 2.5 Colombia
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv PDF
dc.format.mimetype.none.fl_str_mv application/pdf
dc.coverage.spatial.spa.fl_str_mv Barranquilla
institution Universidad Libre
bitstream.url.fl_str_mv http://repository.unilibre.edu.co/bitstream/10901/10256/1/94326904.pdf
http://repository.unilibre.edu.co/bitstream/10901/10256/2/license.txt
http://repository.unilibre.edu.co/bitstream/10901/10256/3/94326904.pdf.jpg
bitstream.checksum.fl_str_mv 4216424b08edd408ec4af7fb53a610d7
8a4605be74aa9ea9d79846c1fba20a33
328e96c3696e7b69e2ded6b1dfe64112
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositorio Institucional Unilibre
repository.mail.fl_str_mv repositorio@unilibrebog.edu.co
_version_ 1814090399804817408
spelling Fernandez Mercado, RobinsonIglesias Acosta, JesúsPérez Manzano, GerardoRestrepo Pulgarín, Juan CarlosBarranquilla2017-07-27T14:23:40Z2017-07-27T14:23:40Z2016https://hdl.handle.net/10901/10256instname:Universidad Librereponame:Repositorio Institucional Universidad LibreEl cáncer endometrial es considerado según las estadísticas el tumor ginecológico más frecuente en los países desarrollados y se ha observado que su incidencia ha ido en aumento. Históricamente, el carcinoma endometrial se ha clasificado en dos tipos clínico-patológicos y moleculares: el tipo I (adenocarcinoma endometrioide), es el más común y se presenta en el 80-90% de los casos, el tipo II comprende los subtipos no endometrioides tales como el de células serosas, claras y carcinomas indiferenciados. Un dato importante es, que las pacientes en su mayoría son diagnosticadas cuando la enfermedad se encuentra en etapas tempranas, es decir cuando la lesión todavía está confinada al útero. El tratamiento convencional radica en una histerectomía primaria más salpingooforectomía bilateral, ya sea por medio de una laparotomía abdominal o utilizando métodos mínimamente invasivos como la laparoscopia o la laparoscopia asistida por robot. La resección de los ganglios linfáticos va a depender de factores histológicos, estadio de la enfermedad, características de las pacientes y directrices nacionales e internacionales para la gestión de este tipo de enfermedad. Con relación al tratamiento adyuvante este debe adaptarse a la histología y estadio del tumor. Debido a la gran cantidad de literatura disponible que se ocupa de la gestión del cáncer endometrial, el objetivo de este trabajo era realizar una breve actualización sobre esta enfermedad en relación al diagnóstico y tratamiento, basada en una serie de preguntas que se consideraron clínicamente relevantes y que han generado controversia para tal fin. Mediante una estrategia de búsqueda en la base de datos de MEDLINE, EMBASE, PubMed, ClinicalKey, Ovid y la librería de Cochrane; utilizando las palabras clave cáncer, endometrio, diagnóstico y tratamiento hasta el año 2016. Además se formularon una serie de preguntas controversiales sobre el diagnóstico y tratamiento del cáncer de endometrio, en base a las cuales se utilizaron las diferentes palabras claves para resolver dichos interrogantes.Endometrial cancer is considered according to statistics the most common gynecological tumor developed countries and observed that its incidence has been increasing. Historically, endometrial carcinoma is classified into two clinicopathological and molecular types: type I (endometrioid adenocarcinoma) is the most common and occurs in 80-90% of cases, type II comprises non-endometrioid subtypes such as serous, clear and undifferentiated carcinomas cells. An important fact is that most patients are diagnosed when the disease is in the early stages, ie when the lesion is still confined to the uterus. Conventional treatment lies in a bilateral salpingo-oophorectomy more primary hysterectomy, either through an abdominal laparotomy or using minimally invasive methods such as laparoscopy or robot-assisted laparoscopy. Resection of lymph nodes will depend on histological factors, stage of disease, patient characteristics and national and international guidelines for the management of this type of disease. With regard to this adjuvant treatment should be tailored to histology and tumor stage. Due to the large amount of literature available that deals with the management of endometrial cancer, the aim of this study was to perform a brief update on the disease in relation to diagnosis and treatment, based on a series of questions that were considered clinically relevant and that they have generated controversy for this purpose. By a search strategy in the database MEDLINE, EMBASE, PubMed, ClinicalKey, Ovid and Cochrane library; Using keywords, endometrial, diagnosis and treatment until 2016. In addition a number of controversial questions about diagnosis and treatment of endometrial cancer were formulated, based on which different keys to solving these questions words were used.PDFapplication/pdfspahttp://creativecommons.org/licenses/by-nc-nd/2.5/co/Atribución-NoComercial-SinDerivadas 2.5 Colombiainfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2CáncerEndometrioMedicinaEndometrial NeoplasmsCANCERENDOMETRIODIAGNOSTICO Y TRATAMIENTOCáncer de endometrioCáncer de endometrio: una actualización en el diagnóstico y tratamiento; revisión de la literaturaTesis de Especializacióninfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisInternational Agency for Research on Cancer/World Health Organization. [Online].; Francia: IARC; 2012 [cited 5 Enero 2016].GLOBOCAN "ESTIMATED CANCER INCIDENCE, MORTALITY AND PREVALENCE WORLDWIDE IN 2012". Disponible en: http://www.globocan.iarc.fr/Pages/fact_sheets_population.aspx.Pardo C, Cendales R. Incidencia, mortalidad y prevalencia de cáncer en Colombia, 2007-2011. ; Primera edición. Bogotá. D.C. Instituto Nacional de Cancerología, 2015, v.1.p. 148. Reporte No: ISBN 978-958-58832-5-3. Disponible en: http://www.cancer.gov.co/files/libros/archivos/incidencia1.pdf.Felix AS, Weissfeld JL, Stone RA, Bowser R, Chivukula M, Edwards RP, et al. Factors associated with Type I and Type II endometrial cancer. Cancer Causes Control [Online]. 2010 [5 Enero 2016]; 21(11): p. 1851-1856. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962676/.Amaya J, Beltran A, Chavarro D, Romero G, Matallana M, Puerto S, et al. Estudio de Distribucion de la oferta de medicos especialistas, en servicios de alta y mediana complejidad en Colombia. [Internet]. Bogotá-Colombia. Septiembre 2013. [7 Abril 2016]. Disponible en: https://www.minsalud.gov.co/salud/Documents/Observatorio%20Talento%20 Humano%20en%20Salud/DisponibilidadDistribuci%C3%B3nMdEspecialistas Cendex.pdf:; 2013.Vargas I, Vasquez M, Mogollón A. Acceso a la atención en salud en Colombia. Rev. salud pública [Internet]. 2010. [7 Abril 2016]; 12(5): p. 701- 712. Disponible en: http://www.scielosp.org/pdf/rsap/v12n5/v12n5a01.pdf.Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin [Internet].. 2015 [6 Abril 2016].; 65(2): p. 87-108. Disponible en: http://onlinelibrary.wiley.com/doi/10.3322/caac.21262/fullNIH: NATIONAL CANCER INSTITUTE. USA: NIH; 2016. [Online]. [cited 5 Enero 2016]. Endometrial Cancer Screening–Health Professional Version (PDQ®) [aprox. 1 pantalla]. Disponible en: http://www.cancer.gov/types/uterine/hp/endometrial-screening-pdq.In Ries LAG, Krapcho M, Mariotto A. SEER Cancer Statistics Review, 1975- 2004, National Cancer Institute. 2012;: p. Disponible en: http://seer.cancer.gov/archive/csr/1975_2004/González J, González E. Embriología y anatomía del aparato reproductor femenino. In González-Merlo J, González Bosquet E, González Bosquet J. Ginecología. 9a ed. España: Elsevier; 2014. p. 1-21.Bulub SE. Physiology and Pathology of the Female Reproductive Axis. In Melmed Sh, Polonsky KS, Larsen R, et al, editores. Williams Textbook of 127 Endocrinology. 13a ed. Philadelphia: Elsevier, Inc; 2016. p. 589-663Standring S. Female reproductive system. In Standring S, Anand N, Birch R, et al, editores. Gray's Anatomy. 41a ed. Londres: Elsevier; 2016. p. 1288- 1313Gartner LP. Female Reproductive System. In Gartner LP. Textbook of Histology. 4a ed. Philadelphia: Elsevier, Inc; 2017. p. 529-558.ACS: American Cancer Society. [Online].; Estados Unidos: ACS; 2015 [cited 17 Abril 2016]. Qué es el cáncer de endometrio? [aprox. 1 pantalla]. Disponible en: http://www.cancer.org/espanol/cancer/cancerdeendometrio/guiadetallada/can cer-de-endometrio-uterino-what-is-what-is-endometrial-cancer.De la Fuente C. Encuesta Nacional de la Situación Nutricional en Colombia (ENSIN 2010). Bogota.D.C. Resumen Ejecutivo ENSIN 2010. Instituto Colombiano de Bienestar Familiar. p 26. Disponible en: http://www.icbf.gov.co/portal/page/portal/Descargas1/Resumenfi.pdf.García E, Cárdenas L, Sandoval D, Mayorga H. HIPERPLASIA ENDOMETRIAL: ANÁLISIS DE SERIE DE CASOS DIAGNOSTICADOS EN BIOPSIA ENDOMETRIAL. Rev. chil. obstet. ginecol [Internet]. 2010 [citado 21 Abril 2016]; 75(3): p. 146-152. Disponible en: http://dx.doi.org/10.4067/S0717-75262010000300002.Kyung Hee Han, Noh Hyun Park, Hee Seung Kim, Hyun Hoon Chung, Jae Weon Kim y Yong Sang Song. Peritoneal cytology: A risk factor of recurrence for non-endometrioid endometrial cancer. Gynecologic Oncology [Internet]. 2014 [Citado 11 Mayo 2016]; 134(2): p. 293-296. Disponible en: https://www- clinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0090825814009652?scrollTo=%23hl0000604.Derogatis LR, Morrow GR, Fetting J, et al. The prevalence of psychiatric disorders among cancer patients. JAMA [Internet]. 1983 [7 Abril 2016]; 259(6): p. 751-757. Disponible en: https://www.researchgate.net/publication/16376048_The_Prevalence_of_Psy chiatric_Disorders_Among_Cancer_Patients.Seebacher V, Schmid M, Polterauer S, Hefler-Frischmuth K, Leipold H, Concin N, et al. The presence of postmenopausal bleeding as prognostic parameter in patients with endometrial cancer: a retrospective multi-center study. BMC Cancer [Internet]. 2009 [7 Abril 2016];: p. Disponible en: http://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-9-460.Guidos BJ, Selvaggi SM. Detection of endometrial adenocarcinoma with the ThinPrep Pap test. Diagn Cytopathol [Internet]. 2000 [6 Abril 2016]; 23(4): p. 260-265. Disponible en: http://onlinelibrary.wiley.com/doi/10.1002/1097- 0339(200010)23:4%3C260:AID-DC9%3E3.0.CO;2-Y/abstract.Gu M, Shi W, Barakat RR, Thaler HT, Saigo PE. Pap smears in women with endometrial carcinoma. Acta Cytol.[Internet]. 2001 [6 Abril 2016].; 45(4): p. 555-560. Disponible en: http://www.karger.com/Article/Abstract/327864.Karlsson B, Granberg S, Wikland M, Ylöstalo P, Torvid K, Marsal K, et al. Transvaginal ultrasonography of the endometrium in women with postmenopausal bleeding--a Nordic multicenter study. Am J Obstet Gynecol [Internet]. 1995 [6 Abril 2016]; 172(5): p. 1488-1494. Disponible en: http://www.sciencedirect.com/science/article/pii/0002937895904832.American College of Obstetricians and Gynecologists, ACOG Committee Opinion No 440. The role of transvaginal ultrasonography in the evaluation of postmenopausal bleeding. Obstet Gynecol [Internet]. 2009 [6 Abril 2016];(440): p. 1-3. Disponible en: http://www.acog.org/-/media/CommitteeOpinions/Committee-on-GynecologicPractice/co440.pdf?dmc=1&ts=20151207T0121115375.Benedet JL, Bender H, Jones H 3rd, Ngan HY, Pecorelli S. FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers. FIGO Committee on Gynecologic Oncology. Int J Gynaecol Obstet [Internet]. 2000 [6 Abril 2016]; 70(2): p. 209-262. Disponible en: http://www.ginecologia.unipd.it/AssistenzaDocumenti/Unita'%20operative/Ginecologia%20Oncologica/staging_booklet. pdf.Zaino RJ, Kauderer J, Trimble CL, Silverberg SG, Curtin JP, Lim PC, et al. Reproducibility of the diagnosis of atypical endometrial hyperplasia: a Gynecologic Oncology Group study. Cancer[Internet]. 2006[6 Abril 2016]; 106(4): p. 804-811. Disponible en: http://onlinelibrary.wiley.com/doi/10.1002/cncr.21649/pdf.Lewin SN, Herzog TJ, Barrena Medel NI, Deutsch I, Burke WM, Sun X, et al. Comparative performance of the 2009 international Federation of gynecology and obstetrics' staging system for uterine corpus cancer. Obstet Gynecol[Internet]. 2010 [6 Abril 2016]; 116(5): p. 1141-1149. Disponible en: http://journals.lww.com/greenjournal/Fulltext/2010/11000/Comparative_Perfor mance_of_the_2009_International.21.aspx.Heitmann R. Anatomía del sistema reproductor femenino. In DeCherney A, Nathan L, Laufer N, et al, editores. CURRENT Diagnosis & Treatment: Obstetrics & Gynecology. 11a ed. United States of America: McGraw-Hill Companies, Inc; 2013. p. Disponible en: http://accessmedicine.mhmedical.com.ezproxy.unilibrebaq.edu.co:8084/cont ent.aspx?bookid=498&sectionid=41008589.Hertzberg B, Middleton W. Pelvis and uterus. In Hertzberg B, Middleton W. Ultrasound: The requisites. 3a ed. Philadelphia: Elsevier; 2016. p. 527-564.Ball J, Dains J, Flynn J, Solomon B, Stewart R. Female Genitalia. In Ball J, Dains J, Flynn J, et al, editores.Seidel's Guide to Physical Examination. 8a ed. St. Louis, Missouri: Mosby Inc; 2015. p. 416-465.Baggish MS. Anatomy of the Uterus. In Baggish MS, Valle RF, Guedj H. Hysteroscopy Visual Perspectives of Uterine Anatomy Physiology and Pathology. 3a ed. Philadelphia: Lippincott Williams and Wilkins; 2007. p. 15- 26.Lessey BA, Young SL. The Structure, Function and Evaluation of the Female Reproductive Tract. In Strauss JF, Barbieri RL.Yen & Jaffe's Reproductive Endocrinology. 7a ed. Philadelphia: Elsevier, Inc; 2014. p. 192-235.. Ellenson LH, Pirog EC. The Female Genital Tract. In Kumar V, Abbas AK, Aster JC. Robbins and Cotran PATHOLOGIC BASIS OF DISEASE. 9a ed. Philadelphia: Elsevier Inc; 2015. p. 991-1042.Colgan TJ, Weir MM. Endometrial Hyperplasia and Carcinoma, Extrauterine Cancer, and Unusual Tumors. In Bibbo M, Wilbur DC, Abdul-Karim FW, et al, editores. Comprehensive Cytopathology. 4a ed. Philadelphia: Elsevier, Inc; 2015. p. 198-219.Kumar V, Abbas AK, Aster JC. Neoplasia. In Kumar V, Abbas AK, Aster JC. Robbins and Cotran PATHOLOGIC BASIS OF DISEASE. 9a ed. Philadelphia: Elsevier, Inc; 2015. p. 265-340.McMeekin DS. Sarcoma of the Uterus. In Di Saia PhJ, Creasman WT, Mannel RS, et al, editores. Clinical Gynecologic Oncology. 8a ed. Philadelphia: Elsevier, Inc; 2012. p. 175-187.Mutter GL, Prat J. Endometrial Adenocarcinoma. In Mutter GL, Prat J. Pathology of the Female Reproductive Tract. 3a ed. Philadelphia: Elsevier; 2014. p. 370-401.Murali R, Soslow RA, Weigelt B. Classification of endometrial carcinoma: more than two types. THE LANCET Oncology [Internet]. 2014 [citado 6 Abril 2016]; 15(7): p. 268-278. Disponible en: http://www.thelancet.com/oncology.Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA: A Cancer Journal for Clinicians [Internet]. 2014 [citado 14 Diciembre 2015]; 64(1): p. 9- 29. Disponible en: http://onlinelibrary.wiley.com/doi/10.3322/caac.21208/full.Morice Ph, Leary A, Creutzberg C, Abu-Rustum N, Darai E. Endometrial cancer. The Lancet [Internet]. 2015 [citado 15 Diciembre 2015]; 387(10023): p. 1094-1108. Disponible en: https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/journal/1- s2.0-S0140673615001300.Colombo N, Creutzberg C, Amant F, Bosse T, González-Martín A, Ledermann J, et al. ESMO–ESGO–ESTRO consensus conference on endometrial cancer: Diagnosis, treatment and follow-up. Radiotherapy and Oncology [Internet]. 2015 [citado 16 Abril 2016]; 117(3): p. 559-581. Disponible en: https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/journal/1- s2.0-S0167814015006180.Elshaikh M, Munkarah A, Robbins J, Laser B, Bhatt N, Cogan Ch, et al. The impact of race on outcomes of patients with early stage uterine endometrioid 129 carcinoma. Gynecologic Oncology. 2013; 128(2): p. 171-174. Disponible en: https://www-clinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1- s2.0-S0090825812008426.Burke WM, Gold MA. Practice Bulletin Endometrial Cancer. Obstetrics & Gynecology [Internet]. 2015 [citado 2 Marzo 2016]; 125(4): p. 1006-1026. Disponible en: http://ovidsp.tx.ovid.com.ezproxy.unilibrebaq.edu.co:8084/sp3.19.0a/ovidweb.cgi?&S=FHICFPKINODDNOFHNCIKLFOBCABPAA00&Bro wse=Toc+Children%7cYES%7cS.sh.3561_1460827607_44.3561_14608276 07_56.3561_1460827607_65.3561_1460827607_66.356.WCRF: World Cancer Research Fund International. [Online].; Londres: WCRF; 2013 [cited 7 Marzo 2016]. Endometrial Cancer 2013 Report. Food, Nutrition, Physical Activity, and the Prevention of Endometrial Cancer [aprox. 1 pantalla]. Disponible en: http://www.wcrf.org/sites/default/files/EndometrialCancer-2013-Report.pdf.Crosbie EJ, Zwahlen M, Kitchener HC, Egger M, Renehan AG. Body mass index, hormone replacement therapy, and endometrial cancer risk: a metaanalysis. Cancer Epidemiol Biomarkers Prev [Internet]. 2010 [citado 5 Marzo 2016]; 19(31): p. 19-30. Disponible en: http://cebp.aacrjournals.org/content/19/12/3119.full.pdf.Garg K, Soslow RA. Endometrial Carcinoma in Women Aged 40 Years and Younger. Archives of Pathology & Laboratory Medicine [Internet]. 2014 [citado 5 Abril 2016]; 138(3): p. 335-342. Disponible 130 en:http://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2012-0654-RA.Garg K, Soslow RA. Endometrial Carcinoma in Women Aged 40 Years and Younger. Archives of Pathology & Laboratory Medicine [Internet]. 2014 [citado 5 Abril 2016]; 138(3): p. 335-342. Disponible 130 en:http://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2012-0654-RA.Esposito K, Chiodini P, Capuano A, Bellastella G, Maiorino MI, Giugliano D. Metabolic syndrome and endometrial cancer: a meta-analysis. Diabetes Care [Internet]. 2013 [citado 6 Abril 2016]; 45(1): p. 28-36. Disponible en: http://care.diabetesjournals.org/content/35/11/2402.full.Zhang Y, Liu H, Yang S et al. Overweight, obesity and endometrial cancer risk: results from a systematic review and meta-analysis. Int J Biol Markers [Internet]. 2014 [citado 6 Abril 2016]; 29(1): p. 21-29. Disponible en: http://dx.doi.org/10.5301/jbm.5000047.Rosato V, Zucchetto A, Bosetti C et al. Metabolic syndrome and endometrial cancer risk. Annals of Oncology [Internet]. 2011 [citado 6 Abril 2016]; 22(4): p. 884-889. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/20937645.1.Luo J, Beresford S, Chen C, Chlebowski R, García L, Kuller L, et al. Association between diabetes, diabetes treatment and risk of developing endometrial cancer. British Journal of Cancer [Internet]. 2014 [citado 7 Abril 2016]; 111(7): p. 1432-1439. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/25051408.1.Burke W, Orr J, Leitao M, Salom E, Gehrig P, Olawaiye A, et al. Endometrial cancer: A review and current management strategies: Part I. Gynecologic Oncology [Internet]. 2014 [citado 7 Abril 2016]; 134(2): p. 385-392. Disponible en: http://dx.doi.org/10.1016/j.ygyno.2014.05.018.Barry J, Azizia M, Hardiman P. Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis. Human Reproduction Update [Internet]. 2014 [citado 8 Abril 2016]; 20(5): p. 748-758. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/24688118.Lancaster J, Powell B, Chen L, Richardson D. Society of Gynecologic Oncology statement on risk assessment for inherited gynecologic cancer predispositions. Gynecologic Oncology [Internet]. 2014 [citado 8 Abril 2016]; 136(1): p. 3-7. Disponible en: http://dx.doi.org/10.1016/j.ygyno.2014.09.009.Boggess JF, Kilgore JE. Uterine Cancer. In Niederhuber JE, Armitage JO, Doroshow JH, et al editores. Abeloff's Clinical Oncology. 5a ed. Philadelphia: Elsevier, Inc; 2014. p. 1575-1591.Everett E, Tamimi H, Greer B, Swisher E, Paley P, Mandel L, et al. The effect of body mass index on clinical/pathologic features, surgical morbidity, and outcome in patients with endometrial cancer. GYNECOLOGIC ONCOLOGY [Internet]. 2003 [citado 17 Abril 2016]; 90(1): p. 150-157. Disponible en: http://dx.doi.org/10.1016/S0090-8258(03)00232-4.Creutzberg CL, Fleming GF. Endometrial Cancer. In Bogart JA, Buchholz ThA, Foote RL, et al, editores. CLINICAL Radiation Oncology. 4a ed. Philadelphia: Elsevier, Inc; 2016. p. 1203 - 1229Gerber B, Krause A , Müller H , Reimer T , Külz T , Makovitzky J, et al. Effects of Adjuvant Tamoxifen on the Endometrium in Postmenopausal Women With Breast Cancer: A Prospective Long-Term Study Using Transvaginal Ultrasound. JOURNAL OF CLINICAL ONCOLOGY [Internet]. 2000 [citado 8 Abril 2016]; 18(20): p. 3464-3470. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/11032586.Lu K, Daniels M. Endometrial and Ovarian Cancer in Women with Lynch syndrome: Update in Screening and Prevention. Familial Cancer [Internet]. 2013 [citado 9 Abril 2016]; 12(2): p. 273-277. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/23765559Creasman WT, Scott D. Adenocarcinoma of the Uterine Corpus. In Di Saia PhJ, Creasman WT. Clinical Gynecologic Oncology. 8a ed. Philadelphia: Elsevier, Inc; 2012. p. 141-174.Christopherson WM, Alberhasky RC, Connelly PJ. Carcinoma of the endometrium: I. A clinicopathologic study of clear-cell carcinoma and secretory carcinoma. Cancer [Internet]. 1982 [citado 24 Abril 2016]; 49(8): p. 1511-1523. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed?term=7066860.Zaino RJ, Kurman RJ, Brunetto VL, Morrow CP, Bentley RC, Cappellari JO, et al. Villoglandular adenocarcinoma of the endometrium: a clinicopathologic study of 61 cases: a gynecologic oncology group study. Am J Surg Pathol [Internet]. 1998 [citado 24 Abril 2016]; 22(11): p. 1379-1385. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed?term=9808130Boruta DM, Gehrig PA, Groben PA, Bae-Jump V, Boggess JF, Fowler WC, et al. Uterine serous and grade 3 endometrioid carcinomas: is there a survival 133 difference? Cancer [Internet]. 2004Zaino R, Whitney C, Brady MF, DeGeest K, Burger RA, Buller RE. Simultaneously detected endometrial and ovarian carcinomas--a prospective clinicopathologic study of 74 cases: a gynecologic oncology group study. Gynecol Oncol [Internet]. 2001 [citado 24 Abril 2016]; 83(2): p. 355-362. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed?term=11606097Mutter GL, Lin MCh, Fitzgerald JT, Kum JB, Baak E, Lees J, et al. Altered PTEN Expression as a Diagnostic Marker for the Earliest Endometrial Precancers. JNCI [Internet]. 2000 [citado 24 Abril 2016]; 92(11): p. 924-930. Disponible en: http://jnci.oxfordjournals.org/content/92/11/924Basil JB, Goodfellow PJ, Rader JS, Mutch DG, Herzog ThJ. Clinical significance of microsatellite instability in endometrial carcinoma. Cancer [Internet]. 2000 [citado 24 Abril 2016]; 89(8): p. 1758-1764. Disponible en: http://onlinelibrary.wiley.com/doi/10.1002/1097- 0142(20001015)89:8%3C1758:AID-CNCR16%3E3.0.CO;2-A/full.Lax SF, Kendall B, Tashiro H, Slebos R, Hedrick L. The frequency of p53, kras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma. Cancer [Internet]. 2000 [citado 24 Abril 2016]; 88(4): p. 814-824. Disponible en: http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1097- 0142(20000215)88:4%3C814:AID-CNCR12%3E3.0.CO;2-U/full.KERNER H, SABO E, Friedman M, BECK D, Samare O, Lichtig C. An immunohistochemical study of estrogen and progesteronereceptors in adenocarcinoma of the endometrium and in the adjacent mucosa. Int J Gynecol Cancer [Internet]. 1995 [citado 24 Abril 2016]; 5(4): p. 275-281. Disponible en: http://ovidsp.tx.ovid.com.ezproxy.unilibrebaq.edu.co:8084/sp- 3.19.0a/ovidweb.cgiCreasman WT. Prognostic Significance of Hormone. Cancer [Internet]. 1993 [citado 24 Abril 2016]; 71(4): p. 1467-1470. Disponible en: http://onlinelibrary.wiley.com/doi/10.1002/cncr.2820710411/pdf.Sutton GP, Geisler HE, Stehman FB, Joven P, Kimes TM, Ehrlich CE. Features associated with survival and disease-free survival in early endometrial cancer. AJOG [Internet]. 1989 [citado 24 Abril 2016]; 160(6): p. 1385-1393. Disponible en: http://www.sciencedirect.com/science/article/pii/0002937889908594.Greven KM, Lanciano XM, Corn B. Pathologic Stage III Endometrial. Cancer [Internet]. 1993 [citado 24 Abril 2016]; 71(11): p. 3697-3702. Disponible en: http://onlinelibrary.wiley.com.ezproxy.unilibrebaq.edu.co:8084/doi/10.1002/10 97-0142(19930601)71:11%3C3697:AID-CNCR2820711137%3E3.0.CO;2- U/pdf.Li Z, Gilbert Ch, Yang H, Zhao Ch. Histologic Follow-up in Patients With Papanicolaou Test Findings of Endometrial Cells. AJCP [Internet]. 2012 [citado 25 Abril 2016]; 138(1): p. 79-84. Disponible en: http://dx.doi.org/10.1309/AJCP07DCKKZFKSDL.González-Merlo E. Cáncer de cuerpo uterino. In González-Merlo J, González Bosquet E, González Bosquet J. Ginecología. 9a ed. España: Elsevier Masson; 2014. p. 495-530.American College of Obstetricians and Gynecologists, ACOG practice bulletin No 65. Management of endometrial cancer. Obstet Gynecol [Internet]. 2005; 106(2): p. 413-425. Disponible en: http://journals.lww.com/greenjournal/Citation/2006/04000/ACOG_Practice_B 135 ulletin__65__Management_of.43.aspxHan SS, Lee SH, Kim DH, Kim JW, Park NH, Kang SB, et al. Evaluation of preoperative criteria used to predict lymph node metastasis in endometrial cancer. Acta Obstet Gynecol Scand. 2010; 89(2): p. 168–174. Disponible en: http://onlinelibrary.wiley.com/doi/10.3109/00016340903370114/full.Kilgore LC, Partridge EE, Alvarez RD, Austin JM, Shingleton HM, Noojin F 3rd, et al. Adenocarcinoma of the endometrium: survival comparisons of patients with and without pelvic node sampling. Gynecol Oncol [Internet]. 1995 [8 Abril 2016]; 56(1): p. 29–33.Disponible en: http://www.sciencedirect.com/science/article/pii/S0090825885710050.Chan JK, Cheung MK, Huh WK, Osann K, Husain A, Teng NN, et al. Therapeutic role of lymph node resection in endometrioid corpus cancer: a study of 12,333 patients. Cancer[Internet]. 2006 [8 Abril 2016]; 107(8): p. 1823–1830. Disponible en: http://cat.inist.fr/?aModele=afficheN&cpsidt=18197112.Creasman WT, Morrow CP, Bundy BN, Homesley HD, Graham JE, Heller PB. Surgical pathologic spread patterns of endometrial cancer. A Gynecologic Oncology Group Study.. Cancer [Internet]. 1987 [8 Abril 2016] ; 60(8 Supl): p. 2035–2041. Disponible en: http://incanmexico.org/wp_ginecologia/wp-content/uploads/GOG-33.pdf.Mariani A, Dowdy SC, Cliby WA, Gostout BS, Jones MB, Wilson TO, et al. Prospective assessment of lymphatic dissemination in endometrial cancer: a paradigm shift in surgical staging. Gynecol Oncol. 2008; 109(1): p. 11-18. Disponible en:https://www.researchgate.net/publication/5547081_Mariani_A_Dowdy_SC _Cliby_WA_Gostout_BS_Jones_MB_Wilson_TO_Podratz_KCProspective_a ssessment_of_lymphatic_dissemination_in_endometrial_cancer_a_paradigm _shift_in_surgical_staging_Gynecol_.Walker JL, Piedmonte MR, Spirtos NM, Eisenkop SM, Schlaerth JB, Mannel RS, et al. Laparoscopy compared with laparotomy for comprehensive surgical staging of uterine cancer: Gynecologic Oncology Group Study LAP2. J Clin Oncol [Internet]. 2009 [21 abril 2016]; 27: p. 5331–5336. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773219/.Boggess JF, Gehrig PA, Cantrell L, Shafer A, Ridgway M, Skinner EN, et al. A comparative study of 3 surgical methods for hysterectomy with staging for endometrial cancer: robotic assistance, laparoscopy, laparotomy. Am J Obstet Gynecol [Internet]. 2008 [21 Abril 2016]; 199: p. 360 369. Disponible en: http://incan-mexico.org/wp_ginecologia/wp-content/uploads/comparacionde-estadificacion-quirurgica-en-endometrio.pdf.Chan JK, Lin YG, Monk BJ, Tewari K, Bloss JD, Berman ML. Vaginal hysterectomy as primary treatment of endometrial cancer in medically compromised women. Obstet Gynecol [Internet]. 2001 [21 Abril 2016]; 97(5): p. 707–711. Disponible en: http://journals.lww.com/greenjournal/Fulltext/2001/05000/Vaginal_Hysterecto my_as_Primary_Treatment_of.12.aspx#.Susini T, Massi G, Amunni G, Carriero C, Marchionni M, Taddei G, et al. Vaginal hysterectomy and abdominal hysterectomy for treatment of endometrial cancer in the elderly. Gynecol Oncol [Internet]. 2005 [21 Abril 2016]; 96(2): p. 362–367. Disponible en: http://www.sciencedirect.com/science/article/pii/S0090825804008182.Keys HM, Roberts JA, Brunetto VL, Zaino RJ, Spirtos NM, Bloss JD, et al. A phase III trial of surgery with or without adjunctive external pelvic radiation 137 therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study. Gynecol Oncol[Internet]. 2004 [21 Abril 2016]; 92: p. 744–751. Disponible en: http://ovidsp.tx.ovid.com.ezproxy.unilibrebaq.edu.co:8084/sp3.19.0a/ovidweb.cgi?WebLinkFrameset=1&S=FGJCFPKAKGDDHOMANCIK JGJCGNNHAA00&returnUrl=ovidweb.cgi%3f%26Titles%3dS.sh.22%257c1% 257c10%26FORMAT%3dtitle%26FIELDS%3dTITLES%26S%3.Wolfson AH, Sightler SE, Markoe AM, Schwade JG, Averette HE, Ganjei P, et al. The prognostic significance of surgical staging for carcinoma of the endometrium. Gynecol Oncol [Internet]. 1992 [21 Abril 2016]; 45: p. 142–146. Disponible en: http://www.sciencedirect.com/science/article/pii/009082589290276OShih KK, Yun E, Gardner GJ, Barakat RR, Chi DS, Leitao MM Jr. citorreducción quirúrgica en estadio IV carcinoma endometrioide de endometrio. Gynecol Oncol [Internet]. 2011 [21 Abril 2016]; 122(3): p. 608- 611. Disponible en: http://www.sciencedirect.com/science/article/pii/S0090825811004173.Barlin JN, Puri I, Bristow RE. Cytoreductive surgery for advanced or recurrent endometrial cancer: a meta-analysis. Gynecol Oncol [Internet]. 2010 [21 Abril 2016]; 118: p. 14–18: Disponible en: https://www.researchgate.net/profile/Robert_Bristow/publication/43533231_C ytoreductive_surgery_for_advanced_or_recurrent_endometrial_cancer_A_m eta-analysis/links/54a449b50cf256bf8bb32532.pdf.Fleming GF, Brunetto VL, Cella D, Look KY, Reid GC, Munkarah AR, et al. Phase III trial of doxorubicin plus cisplatin with or without paclitaxel plus filgrastim in advanced endometrial carcinoma: a Gynecologic Oncology Group Study. J Clin Oncol [Internet]. 2004[21 Abril 2016]; 22(11): p. 2159– 2166. Disponible en: http://www.kalbemed.com/Portals/6/komelib/oncology/Onkologi/Filgrastim/filg rastim%20ca%20endometrium.pdf.Sovak MA, Hensley ML, Dupont J, Ishill N, Alektiar KM, Abu-Rustum N, et al. Paclitaxel and carboplatin in the adjuvant treatment of patients with high-risk stage III and IV endometrial cancer: a retrospective study. Gynecol Oncol [Internet]. 2006 [21 Abril 2016]; 103(2): p. 451–457. Disponible en: http://www.sciencedirect.com/science/article/pii/S0090825806002472.Erkanli S, Ayhan A. Fertility-sparing therapy in young women with endometrial cancer: 2010 update. Int J Gynecol Cancer [Internet]. 2010 [21 Abril 2016]; 20(7): p. 1170–1187. Disponible en: http://journals.lww.com/ijgc/Abstract/2010/10000/Fertility_Sparing_Therapy_i n_Young_Women_With.14.aspx.Barakat RR, Bundy BN, Spirtos NM, Bell J, Mannel RS. Randomized doubleblind trial of estrogen replacement therapy versus placebo in stage I or II endometrial cancer: a Gynecologic Oncology Group Study. J Clin Oncol [internet]. 2006 [21 Abril 2016]; 24(4): p. 587–592. Disponible en:http://journal.9med.net/html/qikan/zlx/lczlxyxqk/20062242/2008083113020 0777_252435.html.Braun MM, Overbeek-Wager EA, Grumbo RJ. Diagnosis and Management of Endometrial Cancer. American Family Physician [Internet]. 2016 [citado 10 Mayo 2016]; 93(6): p. 468-474. Disponible en: https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/journal/1- s2.0-S0002838X16600114.Aune D, Navarro Rosenblatt DA, Chan DSM, Vingeliene S, Abar L, Vieira AR, et al. Anthropometric factors and endometrial cancer risk: a systematic 139 review and dose–response meta-analysis of prospective studies. Annals of Oncology [Internet]. 2015 [citado 10 Mayo 2016]; 26(8): p. 1635-1648. Disponible en: http://annonc.oxfordjournals.org/content/26/8/1635.long.Hernandez AV, Pasupuleti V, Benites-Zapata VA, Thota P, Deshpande A, Perez-Lopez FR. Insulin resistance and endometrial cancer risk: A systematic review and meta-analysis. European Journal of Cancer [Internet]. 2015 [citado 10 Mayo 2016]; 51(18): p. 2747-2758. Disponible en: https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/journal/1- s2.0-S0959804915008515Yang TK, Jung Ch, Chung ChD, Muo ChH, Chang ChH, Huang ChY. Risk of Endometrial Cancer in Women With Pelvic Inflammatory Disease. Medicine [Internet]. 2015 [citado 10 Mayo 2016]; 94(34): p. 1278. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602931/.Schonfeld SJ, Hartge P, Pfeiffer RM, Freedman M, Greenlee RT, Linet MS, et al. An Aggregated Analysis of Hormonal Factors and Endometrial Cancer Risk by Parity. Cancer [Internet]. 2013 [citado 10 Mayo 2016]; 119(7): p. 1393–1401. Disponible en: http://onlinelibrary.wiley.com/doi/10.1002/cncr.27909/full.Dashti SG, Chau R, Ouakrim D, Buchanan D, Clendenning M, Young JP, et al. Female Hormonal Factors and the Risk of Endometrial Cancer in Lynch Syndrome. JAMA [Internet]. 2015 [citado 9 Mayo 2016]; 314(1): p. 61-71. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688894/.Vasen HF, Blanco I, Aktan-Collan K, Gopie JP, Alonso A, Aretz S, et al. Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts. Gut [Internet]. 2013 [citado 12 Mayo 2016]; 62(6): p. 812-823. Disponible en: http://gut.bmj.com/content/62/6/812.fullForbes JF, Sestak I, Howell A, Bonanni B, Bundred N, Levy Ch, et al. Anastrozole versus tamoxifen for the prevention of locoregional and contralateral breast cancer in postmenopausal women with locally excised ductal carcinoma in situ (IBIS-II DCIS). THE LANCET [Internet]. 2016 [citado 9 Mayo 2016]; 387(10021): p. 866-873. Disponible en:https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/journal/1- s2.0-S0140673615011290.Rydén L, Arnlind MH, Vitols S, Höistad M, Ahlgren J. Aromatase inhibitors alone or sequentially combined with tamoxifen in postmenopausal early breast cancer compared with tamoxifen or placebo. THE BREAST [Internet]. 2016 [citado 10 Mayo 2016]; 26(1): p. 106-114. Disponible en: https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/journal/1- s2.0-S0960977616000114Verdoodt F, Friis S, Dehlendorff Ch, Albieri V, Kjaer SK. Non-steroidal antiinflammatory drug use and risk of endometrial cancer: A systematic review and meta-analysis of observational studies. Gynecologic Oncology [Internet]. 2016 [citado 10 Mayo 2016]; 140(2): p. 352-358. Disponible en: https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/journal/1- s2.0-S0090825815302134.Brasky ThM, Rodabough RJ, Liu J, Kurta ML, Wise LA, Orchard TS, et al. Long-chain ω-3 fatty acid intake and endometrial cancer risk in the Women's Health Initiative. Am J Clin Nutr [Internet]. 2015 [citado 11 Mayo 2016]; 101(4): p. 824-834. Disponible en: http://ajcn.nutrition.org/content/101/4/824Sorosky JI. Endometrial Cancer. Obstetrics & Gynecology [Internet]. 2012 [citado 12 Mayo 2016]; 120(2): p. 383-397. Disponible en: http://DOI: 10.1097 / AOG.0b013e3182605bf1.Khati NJ, Glanc P, Bhosale PR, Harisinghani MG, Harris RD, Kim YB, et al. ACR Appropriateness Criteria® abnormal vaginal bleeding. AHRQ [Internet]. 2014 [citado 12 Mayo 2016];: p. 13. Disponible en: http://www.guideline.gov/content.aspx?id=48294.Committee Opinion No. 557: Management of Acute Abnormal Uterine Bleeding in Nonpregnant Reproductive-Aged Women. Obstetrics & Gynecology [Internet]. 2013 [citado 12 Mayo 2016]; 121(4): p. 891-896. Disponible en: http:/ /DOI: 10.1097 / 01.AOG.0000428646.67925.9aDiagnosis of Abnormal Uterine Bleeding in Reproductive-Aged Women. P RACT IC E BULLETIN. Obstetrics & Gynecology [Internet]. 2012 [citado 12 Mayo 2016]; 120(1): p. 197-206. Disponible en: http://www.uptodate.com.ezproxy.unilibrebaq.edu.co:8084/contents/endometr ial-carcinoma-clinical-features-and-diagnosis/abstract/12?utdPopup=trueSu H, Huang L, Huang KG, Feng ChY, Han ChM, Lee ChL. Accuracy of hysteroscopic biopsy, compared to dilation and curettage, as a predictor of final pathology in patients with endometrial cancer. Taiwanese Journal of Obstetrics and Gynecology [Internet]. 2015 [citado 12 Mayo 2016]; 54(6): p. 757-760. Disponible en: https://www-clinicalkeyes.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S1028455915002454.Bakkum-Gamez JN, Wentzensen N, Maurer MJ, Hawthorne KM, Voss JS, Kroneman TN, et al. Detection of endometrial cancer via molecular analysis of DNA collected with vaginal tampons. Gynecologic Oncology [Internet]. 2015 [citado 12 Mayo 2016]; 137(1): p. 14-22. Disponible en: https://wwwclinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1-s2.0-Lai HCh, Wang YCh, Yu MH, Huang RL, Yuan ChCh, Chen KJ, et al. DNA methylation as a biomarker for the detection of hidden carcinoma in endometrial atypical hyperplasia. Gynecologic Oncology [Internet]. 2014 [citado 12 Mayo 2016]; 135(3): p. 552-559. Disponible en: https://wwwclinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0090825814014024.Timmermans A, Opmeer BC, Khan KS, Bachmann LM, Epstein E, Clark TJ, et al. Endometrial Thickness Measurement for Detecting Endometrial Cancer in Women With Postmenopausal Bleeding: A Systematic Review and MetaAnalysis. Obstetrics & Gynecology [Internet]. 2010 [citado 13 Mayo 2016]; 116(1): p. 160-167: Disponible en: http://DOI: 10.1097 / AOG.0b013e3181e3e7e8.Wolfman W, Leyland N, Wolfman W, Heywood M, Singh SS. Asymptomatic Endometrial Thickening. JOGC [Internet]. 2010 [citado 13 Mayo 2016]; 32(10): p. 990-999. Disponible en: http://www.sciencedirect.com/science/article/pii/S1701216316346904#.Menzies R, Wallace S, Ennis M, Bennett A, Jacobson M, Yip G, et al. Significance of Abnormal Sonographic Findings in Postmenopausal Women With and Without Bleeding. JOGC [Internet]. 2011 [citado 13 Mayo 2016]; 33(9): p. 944-951. Disponible en: http://www.sciencedirect.com/science/article/pii/S1701216316350204uie M, Canavan TP, Mansuria S. Threshold for endometrial sampling among postmenopausal patients without vaginal bleeding. International Journal of Gynecology & Obstetrics [Internet]. 2016 [citado 13 Mayo 2016]; 132(3): p. 314-317. Disponible en: https://www-clinicalkey- 143 es.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S002072921500661XPetru E, Lück HJ, Stuart G, Gaffney D, Millán D, Vergote I. Gynecologic Cancer Intergroup (GCIG) proposals for changes of the current FIGO staging system. ejog [Internet]. 2009 [citado 14 Mayo 2016]; 143(2): p. 69-74. Disponible en: http://dx.doi.org/10.1016/j.ejogrb.2008.12.015.Mannelqvist M, Stefansson IM, Bredholt G, Hellem T, Dyan AM, Jonassen I, et al. Gene Expression Patterns Related to Vascular Invasion and Aggressive Features in Endometrial Cancer. The American Journal of Pathology [Internet]. 2011 [citado 14 Mayo 2016]; 178(2): p. 861-871. Disponible en: http://dx.doi.org/10.1016/j.ajpath.2010.10.040.Kondalsamy-Chennakesavan S, Yu Ch, Kattan MW, Yee L, Sykes P, Nascimento M, et al. Nomograms to predict isolated loco-regional or distant recurrence among women with uterine cancer. GYNECOLOGIC ONCOLOGY [Internet]. 2012 [citado 15 Mayo 2016]; 125(3): p. 520-525. Disponible en: http://dx.doi.org/10.1016/j.ygyno.2012.02.022.Ayeni TA, Bakkum-Gamez JN, Mariani A, McGree ME, Weaver AL, Eglefino MG, et al. Comparative outcomes assessment of uterine grade 3 endometrioid, serous, and clear cell carcinomas. GYNECOLOGIC ONCOLOGY [Internet]. 2013 [citado 15 Mayo 2016]; 129(3): p. 478-485. Disponible en: http://dx.doi.org/10.1016/j.ygyno.2013.03.011.Aristizabal P, Graesslin O, Barranger E, Clavel-Chapelon F, Haddad B, Luton D, et al. A suggested modification to FIGO stage I endometrial cancer. GYNECOLOGIC ONCOLOGY [Internet]. 2014 [citado 13 Mayo 2016]; 133(2): p. 192-196. Disponible en: https://www-clinicalkeyes.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0090825814002418.Torralba AE, González E, Callejo J, Lailla JL. Utilidad de la resonancia magnética en la estadificación prequirúrgica del cáncer de endometrio. Clinica e Investigacion en Ginecologia y Obstetricia [Internet]. 2014 [citado 19 Mayo 2016]; 41(3): p. 104-106. Disponible en: https://www-clinicalkeyes.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0210573X13000282Husby JA, Salvesen DO, Magnussen IJ, Trovik J, Bjørge L, Salvesen HB, et al. Tumour apparent diffusion coefficient is associated with depth of myometrial invasion and is negatively correlated to tumour volume in endometrial carcinomas. Clinical Radiology[Internet]. 2015 [citado 15 Mayo 2016]; 70(5): p. 487-494. Disponible en: https://www-clinicalkeyes.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0009926015000203?scrollTo=%23bib4.Mainenti PP, Pizzuti LM, Segreto S, Comerci M, De Fronzo S, Romano F, et al. Diffusion volume (DV) measurement in endometrial and cervical cancer: A new MRI parameter in the evaluation of the tumor grading and the risk classification. European Journal of Radiology [Internet]. 2016 [citado 19Mayo 2016]; 85(1): p. 113-124. Disponible en: https://www-clinicalkeyes.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0720048X15301340Tuomi T, Pasanen A, Luomaranta A, Leminen A, Bützow R, Loukovaara M. Risk-stratification of endometrial carcinomas revisited: A combined preoperative and intraoperative scoring system for a reliable prediction of an advanced disease. Gynecologic Oncology [Internet]. 2015 [citado 19 Mayo 2016]; 137(1): p. 23-27. Disponible en: https://www-clinicalkeyes.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- 145 S0090825815005880Burgmann E, Yun-Yi H, Armstrong A. The Value of Additional Pathology Comments Indicating Suspicion of Adenocarcinoma Among Women Diagnosed Preoperatively With Complex Atypical Endometrial Hyperplasia. Gynecological Pathology [Internet]. 2012 [citado 18 Mayo 2016]; 31(3): p. 222-226. Disponible en: http://DOI: 10.1097 / PGP.0b013e31823ef8b0.Zhou L, Meng Zh, Wu Y, Zhu H, Wang X. Prediction of endometrial carcinogenesis probability while diagnosed as atypical endometrial hyperplasia: a new risk model based on age, CA199 and CA125 assay. European Journal of Obstetrics & Gynecology and Reproductive Biology [Internet]. 2014 [citado 18 Mayo 2016]; 183(1): p. 5-9. Disponible en: https://www-clinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1- s2.0-S0301211514005302.Kitchener H. To stage or not to stage? That is the question: (with apologies to Shakespeare). Int J Gynecol Cancer.[internet]. 2010 [citado 11 Mayo 2016]; 20(11): p. s55-s56. Disponible en: http://ovidsp.tx.ovid.com.ezproxy.unilibrebaq.edu.co:8084/sp3.20.0b/ovidweb.cgi?WebLinkFrameset=1&S=EOKLFPEJLCDDMMNANCIK OAMCFMGAAA00&returnUrl=ovidweb.cgi%3f%26Titles%3dS.sh.22%257c1 %257c10%26FORMAT%3dtitle%26FIELDS%3dTITLES%26S%3.Frost JA, Webster KE, Bryant A, Morrison J. Lymphadenectomy for the management of endometrial cancer. Cochrane Database Syst Rev. 2015 [citado 11 Mayo 2016].;: p. Disponible en: Cochrane Database Syst Rev. 2015 Sep 21;9:CD007585.Cuadra M, Ceberio N, Rodríguez M, Mendizabal J, Gorostiaga J y Lete I. Tratamiento quirúrgico del cáncer de endometrio: ¿qué pasaría si no 146 realizamos biopsia intraoperatoria? Progresos de obstetricia y ginecología [Internet]. 2015; 58(10): p. 446-451. Disponible en: https://www-clinicalkeyes.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0304501315001557?scrollTo=%23bib0200.Siobhan K, Miller D. The Role of Lymphadenectomy in Endometrial Cancer. Clinical Obstetrics and Gynecology [Internet]. 2011 [citado 16 Mayo 2016]; 54(2): p. 235-244. Disponible en: http://ovidsp.tx.ovid.com.ezproxy.unilibrebaq.edu.co:8084/sp3.20.0b/ovidweb.cgi?WebLinkFrameset=1&S=OEBIFPBIDIDDMMKLNCIKN DMCBGAHAA00&returnUrl=ovidweb.cgi%3f%26Full%2bText%3dL%257cS.s h.22.43%257c0%257c00003081-201106000-00007%26S%Lécuru F, Bats A, Ngô C, Bensaid C, Achouri A, Makke L, et al.Linfadenectomías en el cáncer de endometrio. Ginecología – Obstetricia [Internet]. 2015 [citado 11 Mayo 2016].; 51(4): p. 1-6. Disponible en: https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/emc/51- s2.0-S1283081X15747429?scrollTo=%23hl0000357.Plante M, Touhami O, Trinh X, Renaud M, Sebastianelli A, Grondin , et al. Sentinel node mapping with indocyanine green and endoscopic near-infrared fluorescence imaging in endometrial cancer. A pilot study and review of the literature. Gynecologic Oncology [Internet]. 2015 [Citado 11 Mayo 2016]; 137(3): p. 443-447. Disponible en: https://www-clinicalkeyes.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0090825815006794.Lu KH, Loose DS, Yates MS, Nogueras GM, Munsell MF, Chen LM, Lynch H, et al. Prospective multicenter randomized intermediate biomarker study of oral contraceptive versus depo-provera for prevention of endometrial cancer in women with Lynch syndrme. Cancer Prev Res (Phila). [Internet]. 2013 [Citado 11Mayo 2016]; 6(8): p. 774-781. Disponible en: http://cancerpreventionresearch.aacrjournals.org/content/6/8/774.full.pdf+htm l.Morelli M, Di Cello A, Venturella R, Mocciaro R, D'Alessandro P, Zullo F. Efficacy of the levonorgestrel intrauterine system (LNG-IUS) in the prevention of the atypical endometrial hyperplasia and endometrial cancer: retrospective data from selected obese menopausal symptomatic women. Gynecol. Endocrinol.[Internet]. 2013; 29(2): p. 156-159. Disponible en: https://www.researchgate.net/profile/Annalisa_Di_Cello/publication/23332795 1_Efficacy_of_the_levonorgestrel_intrauterine_system_(LNGIUS)_in_the_prevention_of_the_atypical_endometrial_hyperplasia_and_endo metrial_cancer_retrospectiv.Linkov F, Elishaev E, Gloyeske N, Edwards R, Althouse A, Geller M, et al.Bariatric surgery-induced weight loss changes immune markers in the endometrium of morbidly obese women. Surgery for Obesity and Related Diseases [Internet]. 2014; 10(5): p. 921-926. Disponible en: https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/journal/1- s2.0-S1550728914001464.Nasir M, Khan G, Ariffin R, Abu J, Chapman C, Deen S, et al.Preventing endometrial cancer risk in polycystic ovarian syndrome (PCOS) women: Could metformin help?. ecologic Oncology. [Internet]. 2014; 132(1): p. 248- 253. Disponible en: https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/journal/1- s2.0-S0090825813012778.Gressel G, Parkash V y Pal L. Management options and fertility-preserving therapy for premenopausal endometrial hyperplasia and early-stage endometrial cancer. International Journal of Gynecology & Obstetrics [Internet]. 2015 [citado 11 ayo 2016]; 131(3): p. 234-239. Disponible en: https://www-clinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1- s2.0-S002072921500572X.Carlson MJ, Thiel KW, Yang S, Leslie KK. Catch it before it kills: progesterone, obesity, and the prevention of endometrial cancer. Discov Med [Internet]. 2012 [Citado 11 Mayo 2016]; 14(76): p. 215-222. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964851/.Scalici J, Laughlin B, Finan M, Wang B y Rocconi R. The trend towards minimally invasive surgery (MIS) for endometrial cancer: An ACS–NSQIP evaluation of surgical outcomes. Gynecologic Oncology [internet]. 2015 [Citado 11 Mayo 2016]; 136(3): p. 512-515. Disponible en: https://wwwclinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0090825814014796Chan J, Gardner A, Taylor K, Thompson C, Blansit K, Yu X, et al.Robotic versus laparoscopic versus open surgery in morbidly obese endometrial cancer patients — A comparative analysis of total charges and complication rates. Gynecologic Oncology. [Internet]. 2015 [Citado 11 Mayo 2016]; 139(2): p. 300-305. Disponible en: https://www-clinicalkeyes.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0090825815301232.Herling S, Møller A, Palle C y Thomsen T. Health-related quality of life after robotic-assisted laparoscopic hysterectomy for women with endometrial cancer — A prospective cohort study. Gynecologic Oncology. [Internet]. 2016 [Citado 11 Mayo 2016]; 140(1): p. 107-113. Disponible en: https://wwwclinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0090825815301712.Corrado G, Chiantera V, Fanfani F, Cutillo G, Lucidi A, Mancini E, et al. Robotic Hysterectomy in Severely Obese Patients With Endometrial Cancer: A Multicenter Stud. Journal of Minimally Invasive Gynecology. [Internet]. 2016 [citado 11 Mayo 2016].; 23(1): p. 94-100. Disponible en: https://wwwclinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S1553465015015101.Favero G, Miglino G, Köhler Ch, Pfiffer T, Silva e Silva A, Ribeiro A, et al. Herramientas para compartir y guardar. Journal of Minimally Invasive Gynecology.[Internet]. 2015[Citado 11 Mayo 2016].; 22(6): p. 938-943. Disponible en: https://www-clinicalkeyes.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S1553465015003258.Boggess J, Kilgore J. Uterine Cancer. In Abeloff's Clinical Oncology. 5th ed.: Saunders; 2014. p. 1575-1591.Homesley H, Filiaci V, Gibbons S, Long H, Cella D, Spirtos N, et al: A randomized phase III trial in advanced endometrial carcinoma of surgery and volume directed radiation followed by cisplatin and doxorubicin with or without paclitaxel: A Gynecologic On. Gynecologic Oncology. [Internet]. 2009 [citado 16 Mayo 2016]; 112(3): p. 543-552. Disponible en: https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/journal/1- s2.0-S0090825808009384.Nout R, van de Poll-Franse L, Lybeert M, Wárlám-Rodenhuis C, Jobsen J, Mens J, et al: Long-term outcome and quality of life of patients with endometrial carcinoma treated with or without pelvic radiotherapy in the post operative radiation therapy in. endometrial carcinoma 1 (PORTEC-1) trial.J Clin Oncol.[Internet]. 2011 [Citado 16 Mayo 2016]; 29(13): p. 1692-1700. Disponible en: https://pure.uvt.nl/portal/files/1379512/MedPst_Pollfranse_longterm__JCO_2011.pdf.Ly D, Soisson P, Dodson M, Sause W y Gaffney D:Adjuvant radiation therapy is associated with improved pelvic control and overall survival in FIGO IB endometrial carcinoma with high grade histology. Gynecologic Oncology [Internet]. 2015. [citado 16 mayo 2016]; 138(3): p. 526-531. Disponible en: https://www-clinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1- s2.0-S0090825815300433Nout R, Smit V, Putter H, Jürgenliemk-Schulz I, Jobsen J, Lutgens L, et al: Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2). an openlabel, non-inferiority, randomised trial. Lancet. [Internet]. 2010 [Citado 16 Mayo 2016].; 375(9717): p. 816-823. Disponible en: https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/journal/1- s2.0-S0140673609621632.Thigpen J.T., Brady M.F., Homesley H.D., Malfetano J., DuBeshter B., Burger R.A., et al: Phase III trial of doxorubicin with or without cisplatin in advanced endometrial carcinoma: a gynecologic oncology group study. J. Clin. Oncol. [Internet]. 2004 [Citado 16 Mayo 2016].; 22(19): p. 3902-3908. Disponible en: http://jco.ascopubs.org/content/22/19/3902.full.Hei-Yu Lau, Min-Yu Chen, Yu-Min Ke, Jen Chen-Ruei, El I-Hui Chen, WenLiou Shiung et al. Outcome of ovarian preservation during surgical treatment for endometrial cancer: A Taiwanese Gynecologic Oncology Group study. Taiwanese Journal of Obstetrics and Gynecology [Internet]. 2015 [citado, 11 Mayo 2016]; 54(5): p. 532-536. Disponible en: https://www-clinicalkeyes.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S102845591500162X.Sun Ch, Chen G, Yang Z, Jiang J, Yang X, Li N, et al. Safety of ovarian preservation in young patients with early-stage endometrial cancer: a retrospective study and meta-analysis. Fertility and Sterility [Internet]. 2013 [Citado 11 Mayo 2016]; 100(3): p. 782-787. Disponible en: https://www.clinicalkey.es.ezproxy.unilibrebaq.edu.co/#!/content/journal/1- s2.0-S0015028213006420.Simpson A, Feigenberg T, Clarke B, Gien L, Ismiil N, Laframboise S, et al.Fertility sparing treatment of complex atypical hyperplasia and low grade endometrial cancer using oral progestin. Gynecologic Oncology [Internet]. 2014 [citado 11 Mayo 2016]; 133(2): p. 229-233. Disponible en: https://wwwclinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0090825814001383Chen M, Jin Y, Li Y, Bi Y, Shan Y y Pan L. Oncologic and reproductive outcomes after fertility-sparing management with oral progestin for women with complex endometrial hyperplasia and endometrial cance. International Journal of Gynecology & Obstetrics [Internet]. 2016 [citado 11 Mayo 2016]; 132(1): p. 34-38. Disponible en: https://www-clinicalkeyes.consultaremota.upb.edu.co/#!/content/journal/1-s2.0- S0020729215005962.Gao Ch, Wang Y, Tian W, Zhu Wy Xue F. The therapeutic significance of aromatase inhibitors in endometrial carcinoma. Gynecologic Oncology [Internet]. 2014 [citado 11 Mayo 2016].; 134(1): p. 190-195. Disponible en: https://www-clinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1- s2.0-S0090825814009214.Schointuch M, Gilliam T, Stine J, Han X, Zhou Ch, Gehrig P, et al.Simvastatin, an HMG-CoA reductase inhibitor, exhibits anti-metastatic and anti-tumorigenic effects in endometrial cancer. Gynecologic Oncology. [Internet]. 2014 [citado 11 Mayo 2016].; 134(2): p. 346-355. Disponible en: https://www-clinicalkey-es.consultaremota.upb.edu.co/#!/content/journal/1- s2.0-S0090825814009755.Crum ChP, Duska LR, Nucci MR. Adenocarcinoma, Carcinosarcoma, and Other Epithelial Tumors of the Endometrium. In Crum ChP, Nucci MR, Lee KR. Diagnostic Gynecologic and Obstetric Pathology. 2a ed. Philadelphia: Elsevier, Inc; 2011. p. 517-581.ORIGINAL94326904.pdf94326904.pdfTrabajo de Gradoapplication/pdf1758501http://repository.unilibre.edu.co/bitstream/10901/10256/1/94326904.pdf4216424b08edd408ec4af7fb53a610d7MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repository.unilibre.edu.co/bitstream/10901/10256/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAIL94326904.pdf.jpg94326904.pdf.jpgIM Thumbnailimage/jpeg6368http://repository.unilibre.edu.co/bitstream/10901/10256/3/94326904.pdf.jpg328e96c3696e7b69e2ded6b1dfe64112MD5310901/10256oai:repository.unilibre.edu.co:10901/102562022-10-11 12:08:25.717Repositorio Institucional Unilibrerepositorio@unilibrebog.edu.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

Publicaciones similares