Sobre el modelado matemático de la red bioquímica que describe la interacción molecular entre receptores celulares de células dentríticas y el ligando manosa de mycobacterium tuberculosis
A nivel mundial se considera a la tuberculosis (TB) como una enfermedad de gran importancia en la salud pública con grandes impactos socioeconómicos, presentando elevadas tasas de incidencia y mortalidad. El modelamiento matemático en el complejo CD-Mtb (Células dentríticas-Mycobacterium tuberculosi...
- Autores:
-
Ibarguen, Eduardo
Burbano-Rosero, Edith Mariela
Vergel Ortega, Mawency
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2021
- Institución:
- Universidad Francisco de Paula Santander
- Repositorio:
- Repositorio Digital UFPS
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.ufps.edu.co:ufps/1521
- Acceso en línea:
- http://repositorio.ufps.edu.co/handle/ufps/1521
https://doi.org/10.36260/rbr.v10i2.1199
- Palabra clave:
- Tuberculosis
Células dendríticas
Micobacterium tuberculosis
ligandoS
receptores
modelado matemático
Tuberculosis
Dendritic cells
Mycobacterium tuberculosis
ligands
receptors
mathematical modeling
- Rights
- openAccess
- License
- Atribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)
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Sobre el modelado matemático de la red bioquímica que describe la interacción molecular entre receptores celulares de células dentríticas y el ligando manosa de mycobacterium tuberculosis |
| dc.title.translated.none.fl_str_mv |
ON MATHEMATICAL MODELING OF A BIOCHEMICAL NETWORK DESCRIBING THE MOLECULAR INTERACTION BETWEEN DENDRITIC CELL RECEPTORS AND MANNOSE LIGAND OF MYCOBACTERIUM TUBERCULOSIS |
| title |
Sobre el modelado matemático de la red bioquímica que describe la interacción molecular entre receptores celulares de células dentríticas y el ligando manosa de mycobacterium tuberculosis |
| spellingShingle |
Sobre el modelado matemático de la red bioquímica que describe la interacción molecular entre receptores celulares de células dentríticas y el ligando manosa de mycobacterium tuberculosis Tuberculosis Células dendríticas Micobacterium tuberculosis ligandoS receptores modelado matemático Tuberculosis Dendritic cells Mycobacterium tuberculosis ligands receptors mathematical modeling |
| title_short |
Sobre el modelado matemático de la red bioquímica que describe la interacción molecular entre receptores celulares de células dentríticas y el ligando manosa de mycobacterium tuberculosis |
| title_full |
Sobre el modelado matemático de la red bioquímica que describe la interacción molecular entre receptores celulares de células dentríticas y el ligando manosa de mycobacterium tuberculosis |
| title_fullStr |
Sobre el modelado matemático de la red bioquímica que describe la interacción molecular entre receptores celulares de células dentríticas y el ligando manosa de mycobacterium tuberculosis |
| title_full_unstemmed |
Sobre el modelado matemático de la red bioquímica que describe la interacción molecular entre receptores celulares de células dentríticas y el ligando manosa de mycobacterium tuberculosis |
| title_sort |
Sobre el modelado matemático de la red bioquímica que describe la interacción molecular entre receptores celulares de células dentríticas y el ligando manosa de mycobacterium tuberculosis |
| dc.creator.fl_str_mv |
Ibarguen, Eduardo Burbano-Rosero, Edith Mariela Vergel Ortega, Mawency |
| dc.contributor.author.none.fl_str_mv |
Ibarguen, Eduardo Burbano-Rosero, Edith Mariela Vergel Ortega, Mawency |
| dc.subject.proposal.spa.fl_str_mv |
Tuberculosis Células dendríticas Micobacterium tuberculosis ligandoS receptores modelado matemático |
| topic |
Tuberculosis Células dendríticas Micobacterium tuberculosis ligandoS receptores modelado matemático Tuberculosis Dendritic cells Mycobacterium tuberculosis ligands receptors mathematical modeling |
| dc.subject.proposal.eng.fl_str_mv |
Tuberculosis Dendritic cells Mycobacterium tuberculosis ligands receptors mathematical modeling |
| description |
A nivel mundial se considera a la tuberculosis (TB) como una enfermedad de gran importancia en la salud pública con grandes impactos socioeconómicos, presentando elevadas tasas de incidencia y mortalidad. El modelamiento matemático en el complejo CD-Mtb (Células dentríticas-Mycobacterium tuberculosis) ha sido poco estudiado, lo que representa un problema de investigación que se puede abordar con los avances actuales sobre el modelamiento en escalas moleculares, siendo "el modelo receptor-ligando con representación de estados" el más recomendado para abordar esta dinámica. Adicionalmente, la importancia de estudios en este campo radica en la predicción que permitiría efectuar la modelación en asociación al desarrollo de un estadio de Tb activa o latente. Teniendo en cuenta lo anterior, en esta investigación se enfocó en determinar los principales receptores que se acoplan con el ligando manosa en el proceso molecular de reconocimiento, además de formular a partir de la literatura disponible, una red bioquímica que acople la interacción molecular entre las células dendríticas y el patógeno Mtb en las vías de señalización que implican el reconocimiento de la manosa por los receptores de células dendríticas (DC-SIGN, TLR4, de TLR9, TLR2, MR, Dectin-2, Mincle, FcRy, Dectin-1, SIGNR-3, CR3, SR, Langerin). Se espera que a partir de esta red se desarrollen modelos matemáticos mediante sistemas de ecuaciones diferenciales, esta modelación permitirá manipular variables y parámetros, con el propósito de contestar preguntas acerca de las posibles interacciones mediadas entre doce receptores celulares y el ligando manosa. |
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2021 |
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2021-11-29T15:25:46Z |
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2021-11-29T15:25:46Z |
| dc.date.issued.none.fl_str_mv |
2021-02-01 |
| dc.type.spa.fl_str_mv |
Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/resource_type/c_6501 |
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Text |
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https://doi.org/10.36260/rbr.v10i2.1199 |
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http://repositorio.ufps.edu.co/handle/ufps/1521 https://doi.org/10.36260/rbr.v10i2.1199 |
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spa |
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Revista Boletin Redipe |
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Vol.10 No.2.(2021) |
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130 |
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2 (2021) |
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109 |
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10 |
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Ibarguen Mondragón E, Burbano-Rosero EM, Vergel-Ortega M. Sobre el modelado matemático de la red bioquímica que describe la interacción molecular entre receptores celulares de células dentríticas y el ligando manosa de mycobacterium tuberculosis. bol.redipe [Internet]. 1 de febrero de 2021 [citado 29 de noviembre de 2021];10(2):109-30. Disponible en: https://revista.redipe.org/index.php/1/article/view/1199 |
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Revista Boletin Redipe |
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Atribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0) |
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openAccess |
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Atribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0) http://purl.org/coar/access_right/c_abf2 |
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Revista Boletin Redipe |
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Bogota , Colombia |
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Ibarguen, Eduardo675f6b7fc7b4e5b637011b2de44c532c600Burbano-Rosero, Edith Mariela0f88ad88ca853fa83867483bf7c11959Vergel Ortega, Mawencye1db451514df4d6eb054b4e8e3bf1e426002021-11-29T15:25:46Z2021-11-29T15:25:46Z2021-02-01http://repositorio.ufps.edu.co/handle/ufps/1521https://doi.org/10.36260/rbr.v10i2.1199A nivel mundial se considera a la tuberculosis (TB) como una enfermedad de gran importancia en la salud pública con grandes impactos socioeconómicos, presentando elevadas tasas de incidencia y mortalidad. El modelamiento matemático en el complejo CD-Mtb (Células dentríticas-Mycobacterium tuberculosis) ha sido poco estudiado, lo que representa un problema de investigación que se puede abordar con los avances actuales sobre el modelamiento en escalas moleculares, siendo "el modelo receptor-ligando con representación de estados" el más recomendado para abordar esta dinámica. Adicionalmente, la importancia de estudios en este campo radica en la predicción que permitiría efectuar la modelación en asociación al desarrollo de un estadio de Tb activa o latente. Teniendo en cuenta lo anterior, en esta investigación se enfocó en determinar los principales receptores que se acoplan con el ligando manosa en el proceso molecular de reconocimiento, además de formular a partir de la literatura disponible, una red bioquímica que acople la interacción molecular entre las células dendríticas y el patógeno Mtb en las vías de señalización que implican el reconocimiento de la manosa por los receptores de células dendríticas (DC-SIGN, TLR4, de TLR9, TLR2, MR, Dectin-2, Mincle, FcRy, Dectin-1, SIGNR-3, CR3, SR, Langerin). Se espera que a partir de esta red se desarrollen modelos matemáticos mediante sistemas de ecuaciones diferenciales, esta modelación permitirá manipular variables y parámetros, con el propósito de contestar preguntas acerca de las posibles interacciones mediadas entre doce receptores celulares y el ligando manosa.At global level, tuberculosis (TB) is considered a disease of great importance in public health with high incidence and mortality rates. Mathematical modeling in the CD-Mtb complex (Dentritic cells-Mycobacterium tuberculosis) has not been studied a lots, above represents a research problem that can be addressed with current advances on modeling at molecular scales, being “the receptor-ligand model with representation of states “the most recommended to address biding dynamics. Additionally, the importance of studies in this field lies in the prediction that would allow modeling in association with the development of an active or latent TB stage. Taking into account the above, this research focused on determining the main receptors that are coupled with the mannose ligand in the molecular recognition process, in addition to formulating, based on the available literature, a biochemical network that couples the molecular interaction between the dendritic cells and the pathogen Mtb in the signaling pathways involving recognition of mannose by dendritic cell receptors (DC-SIGN, TLR4, de TLR9, TLR2, MR, Dectin-2, Mincle, FcRy, Dectin-1, SIGNR -3, CR3, SR, Langerin). It is expected that from this network, mathematical models will be developed through systems of differential equations. This modeling will allow the manipulation of variables and parameters, in order to answer questions about the possible interactions mediated between twelve cell receptors and the mannose ligandapplication/pdfspaRevista Boletin RedipeBogota , ColombiaRevista Boletin RedipeVol.10 No.2.(2021)1302 (2021)10910Ibarguen Mondragón E, Burbano-Rosero EM, Vergel-Ortega M. Sobre el modelado matemático de la red bioquímica que describe la interacción molecular entre receptores celulares de células dentríticas y el ligando manosa de mycobacterium tuberculosis. bol.redipe [Internet]. 1 de febrero de 2021 [citado 29 de noviembre de 2021];10(2):109-30. Disponible en: https://revista.redipe.org/index.php/1/article/view/1199Revista Boletin RedipeEsta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.info:eu-repo/semantics/openAccessAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)http://purl.org/coar/access_right/c_abf2https://revista.redipe.org/index.php/1/article/view/1199Sobre el modelado matemático de la red bioquímica que describe la interacción molecular entre receptores celulares de células dentríticas y el ligando manosa de mycobacterium tuberculosisON MATHEMATICAL MODELING OF A BIOCHEMICAL NETWORK DESCRIBING THE MOLECULAR INTERACTION BETWEEN DENDRITIC CELL RECEPTORS AND MANNOSE LIGAND OF MYCOBACTERIUM TUBERCULOSISArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85TuberculosisCélulas dendríticasMicobacterium tuberculosisligandoSreceptoresmodelado matemáticoTuberculosisDendritic cellsMycobacterium tuberculosisligandsreceptorsmathematical modelingAbel B., Thieblemont N., Quesniaux V., Brown N., Mpagi J., Miyake K., Bihl F. and Ryffel B. (2002). Toll-Like Receptor 4 Expression Is Required to Control Chronic Mycobacterium tuberculosis Infection in Mice. The Journal of Immunology, 169: 3155-3162Akira S., Takeda K. and Kaisho T. (2001). Toll-like receptors: critical proteins linking innate and acquired immunity. Nature Immunology, 2(8): 675 - 680Balboa L., Romero M., Yokobori N., Schierloh P., Geffner L., Basile J., Musella R., Abbate E., de la Barrera S., Sasiain M. and Alemán M. (2010). Mycobacterium tuberculosis impairs dendritic cell response by altering CD1b, DC-SIGN and MR profile. Immunology and Cell Biology, 88:716-726Banchereau J. and Steinman R. (1998). Dendritic cells and the control of immunity. Nature, 392: 245 - 252Banchereau J., Briere F., Caux C., Davoust J., Lebecque S., Liu Y., Pulendran B. and Palucka K. (2000). Immunobiology Of dendritic cells. Annu. Rev. Immunol, 18:767-811Bansal K., Elluru S., Narayana Y., Chaturvedi R., Patil S., Kaveri S., Bayry J. and Balaji K. (2010). PE_PGRS Antigens of Mycobacterium tuberculosis Induce Maturation and Activation of Human Dendritic Cells. J. Immunol, 184;3495-3504Buschow S., Lasonder E., van Deutekom H., Oud M., Beltrame L., Huynen M., de Vries I., Figdor C. and Cavalieri D. (2010). Dominant Processes during Human Dendritic Cell Maturation Revealed by Integration of Proteome and Transcriptome at the Pathway Level. Journal of Proteome Research, 9:1727- 1737Chávez D. (2007). Receptores Tipo Toll. Rev. latinoam. actual. bioméd., 1(1): 3-9Chavesa M., Sontag E. and Dinerstein R. (2004). Steady-States of Receptor-Ligand Dynamics: A Theoretical Framework. Preprint submitted to Elsevier ScienceChen K., Lu J., Wang L. and Gan YW. (2004). Mycobacterial heat shock protein 65 enhances antigen cross-presentation in dendritic cells independent of Toll-like receptor 4 signaling. J. Leukoc. Biol., 75: 260 -266Dietrich J. and Doherty M. (2009). 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Macrophage-Inducible C-Type Lectin Mincle-Expressing Dendritic Cells Contribute to Control of Splenic Mycobacterium bovis BCG Infection in Mice. Infection and Immunity, 83(1), 184–196. http://doi.org/10.1128/ IAI.02500-14Mihret, A. (2012). The role of dendritic cells in Mycobacterium tuberculosis infection. Virulence, 3(7), 654–659. http://doi.org/10.4161/ viru.22586 .Inaba K, Pack M, Inaba M, Sakuta H, Isdell F, Steinman RM. High levels of a major histocompatibility complex II-self peptide complex on dendritic cells from the T cell areas of lymph nodes. J. Exp. Med. 186: 665-72 (1997).Guery JC, Adorini L. Dendritic cells are the most effi cient in presenting endogenous naturally processed self-epitopes to class IIrestricted T cells. J. Immunol. 154: 536-44 (1995)Sallusto F, Lanzavecchia A. Mobilizing dendritic cells for tolerance, priming, and chronic inflammation. J. Exp. Med. 189: 611-4 (1999); Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, Pulendran B, Palucka K. 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Clin Dev Immunol 2011; 2011:405310; PMID:21603213; http://dx.doi. org/10.1155/2011/405310Balboa, Luciana, Kviatcovsky, Denise, Schierloh, Pablo, Garcia, Marina, de la Barrera, Silvia, del Carmen Sasiain, Maria, Monocyte-derived dendritic cells early exposed to Mycobacterium tuberculosis induce an enhanced T helper 17 response and transfer mycobacterial antigens. 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interacción molecular entre receptores celulares de células dentríticas y el ligando manosa de mycobacterium tuberculosis.pdf.jpgSobre el modelado matemático de la red bioquímica que describe la interacción molecular entre receptores celulares de células dentríticas y el ligando manosa de mycobacterium tuberculosis.pdf.jpgGenerated Thumbnailimage/jpeg14604https://repositorio.ufps.edu.co/bitstream/ufps/1521/4/Sobre%20el%20modelado%20matem%c3%a1tico%20de%20la%20red%20bioqu%c3%admica%20que%20describe%20la%20interacci%c3%b3n%20molecular%20entre%20receptores%20celulares%20de%20c%c3%a9lulas%20dentr%c3%adticas%20y%20el%20ligando%20manosa%20de%20mycobacterium%20tuberculosis.pdf.jpg6422d81ea85f31817eba48736d7670d8MD54open accessufps/1521oai:repositorio.ufps.edu.co:ufps/15212022-05-23 10:50:56.683open accessRepositorio Universidad Francisco de Paula 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 incorporada en las Obras Colectivas.

b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda.

c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas. Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).

4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:

a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).

b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.

c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.

d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:

i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.

ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, los consagrados por la SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.

e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, ACINPRO), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.

5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

7. Término.

a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.

b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.

8. Varios.

a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.

b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.

c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.

d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.
0000-0001-8285-2968e1db451514df4d6eb054b4e8e3bf1e42600 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