Non-Newtonian Behavior Effect on Gas-liquid Mass Transfer using an Anchor Impeller for CSTR Bioreactors: A CFD Approach

Objectives: kL a mass transfer coefficient was predicted using CFD (computational fluid dynamics) for analyzing non-newtonian effects on gas liquid mass transfer in a 10 L bioreactor stirred with an Anchor Impeller. Methods/Statistical Analysis: The set up bioreactor configurations were defined by typical culturing conditions used for fungi organism. Bubble breakage frequency and coalescence rate were simulated using Luo - Colaloglou and Tavlarides models and PBM approaches, respectively. Simulated results from different shear rates due to non-newtonian behaviour are compared by analyzing its influences in bubble size and power input. Findings: A clear relationship between high levels of shear rates and small bubble sizes is found in this work. The later is also associated with the high values of kL a simulated (270 h-1) and compared to levels found at low shear rates (62 h-1). Application/Improvements: Impressed by these findings new design optimizations for non-newtonian bioprocessing applications would be improved using CFD.

• Autores: Niño, Lilibeth; Gelves, German; Peñuela, Mariana
• Tipo de recurso: Article of journal
• Fecha de publicación: 2018
• Institución: UNIVERSIDAD FRANCISCO DE PAULA SANTANDER
• Repositorio: Repositorio Digital UFPS
• Idioma: eng
• OAI Identifier: oai:repositorio.ufps.edu.co:ufps/540
• Acceso en línea: http://repositorio.ufps.edu.co/handle/ufps/540
• Palabra clave: Anchor; Bubble Coalescence; Non-Newtonian; Sauter Diameter; CFD
• Rights: openAccess
• License: This work is licensed under a Creative Commons Attribution 4.0 International License.