Non-Newtonian Behavior Effect on Gas-liquid Mass Transfer using an Anchor Impeller for CSTR Bioreactors: A CFD Approach

Objectives: kL a mass transfer coefficient was predicted using CFD (computational fluid dynamics) for analyzing non-newtonian effects on gas liquid mass transfer in a 10 L bioreactor stirred with an Anchor Impeller. Methods/Statistical Analysis: The set up bioreactor configurations were defined by t...

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Autores:
Niño, Lilibeth
Gelves, German
Peñuela, Mariana
Tipo de recurso:
Article of journal
Fecha de publicación:
2018
Institución:
Universidad Francisco de Paula Santander
Repositorio:
Repositorio Digital UFPS
Idioma:
eng
OAI Identifier:
oai:repositorio.ufps.edu.co:ufps/540
Acceso en línea:
http://repositorio.ufps.edu.co/handle/ufps/540
Palabra clave:
Anchor
Bubble Coalescence
Non-Newtonian
Sauter Diameter
CFD
Rights
openAccess
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Description
Summary:Objectives: kL a mass transfer coefficient was predicted using CFD (computational fluid dynamics) for analyzing non-newtonian effects on gas liquid mass transfer in a 10 L bioreactor stirred with an Anchor Impeller. Methods/Statistical Analysis: The set up bioreactor configurations were defined by typical culturing conditions used for fungi organism. Bubble breakage frequency and coalescence rate were simulated using Luo - Colaloglou and Tavlarides models and PBM approaches, respectively. Simulated results from different shear rates due to non-newtonian behaviour are compared by analyzing its influences in bubble size and power input. Findings: A clear relationship between high levels of shear rates and small bubble sizes is found in this work. The later is also associated with the high values of kL a simulated (270 h-1) and compared to levels found at low shear rates (62 h-1). Application/Improvements: Impressed by these findings new design optimizations for non-newtonian bioprocessing applications would be improved using CFD.