Neuropeptides in the human brainstem
The physiological importance of the brainstem has made it one of the most studied structures of the central nervous system of mammals (in- cluding human). This structure receives somatic and visceral inputs and its neurons send motor efferences by means of the cranial nerves, which innervate the hea...
- Autores:
-
Duque Díaz, Ewing
Martínez Rangel, Diana
Ruiz Roa, Silvia Liliana
- Tipo de recurso:
- Review article
- Fecha de publicación:
- 2018
- Institución:
- Universidad Francisco de Paula Santander
- Repositorio:
- Repositorio Digital UFPS
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.ufps.edu.co:ufps/820
- Palabra clave:
- Neuropeptides
mesencephalon
Pons
Medulla oblongata
Human
- Rights
- openAccess
- License
- Atribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)
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Neuropeptides in the human brainstem |
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Neuropeptides in the human brainstem |
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Neuropeptides in the human brainstem Neuropeptides mesencephalon Pons Medulla oblongata Human |
| title_short |
Neuropeptides in the human brainstem |
| title_full |
Neuropeptides in the human brainstem |
| title_fullStr |
Neuropeptides in the human brainstem |
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Neuropeptides in the human brainstem |
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Neuropeptides in the human brainstem |
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Duque Díaz, Ewing Martínez Rangel, Diana Ruiz Roa, Silvia Liliana |
| dc.contributor.author.none.fl_str_mv |
Duque Díaz, Ewing Martínez Rangel, Diana Ruiz Roa, Silvia Liliana |
| dc.subject.proposal.eng.fl_str_mv |
Neuropeptides mesencephalon Pons Medulla oblongata Human |
| topic |
Neuropeptides mesencephalon Pons Medulla oblongata Human |
| description |
The physiological importance of the brainstem has made it one of the most studied structures of the central nervous system of mammals (in- cluding human). This structure receives somatic and visceral inputs and its neurons send motor efferences by means of the cranial nerves, which innervate the head, neck and sensory organs, and it mediates in several actions such as movement, pain, cardiovascular, respiratory, salivary, sleep, vigil and sexual mechanisms. Most of these actions are mediated by neuroactive substances denominated neuropeptides, which are short amino acid chains widespread dis- tributed in the nervous system, that play a role in neurotransmission, neuro- modulation (paracrine and autocrine actions), and act as neurohormones. In- creased study of these substances has taken place since the 1980s to shed light on both their potential role and the way that they mediate in the organism’s different activities. Thus, our aim is a detailed review of available morphologic and physiologic data regarding some neuropeptides in the human brainstem. To such end, we will discuss aspects like: 1) the distribution of neuropeptides in the human brainstem; 2) their possible physiological actions in the human brainstem; 3) neuropeptide coexistences in the human brainstem; and 4) fu- ture research in neuropeptides in the human brainstem. |
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2018 |
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2018-08-26 |
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2021-11-09T22:26:27Z |
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2021-11-09T22:26:27Z |
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Artículo de revista |
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https//doi.org/1022209/ICv.59n2a06 |
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http://repositorio.ufps.edu.co/handle/ufps/820 https//doi.org/1022209/ICv.59n2a06 |
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eng |
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Investigacion Clinica ISSN: 0535-5133, 2018 vol:59 fasc: N/A págs: 161 - 178, DOI:10.22209/IC.v59n2a06 |
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Vol. 59 No. 2 (2018) |
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2 (2018) |
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E. Duque-Díaz, D. Martínez-Rangel, y S. Ruiz-Roa, «Neuropeptides in the human brainstem», Invest Clín, vol. 59, n.º 2, p. 161, ago. 2018. |
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Investigacion Clinica |
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openAccess |
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Atribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0) http://purl.org/coar/access_right/c_abf2 |
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Investigacion Clinica |
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Duque Díaz, Ewing2f894639ec544c354aab26a060062825Martínez Rangel, Dianabd167ff4052531cba8542209470fb9ecRuiz Roa, Silvia Liliana38fb46b80826f9790354abc0b1fd8d7e6002021-11-09T22:26:27Z2021-11-09T22:26:27Z2018-08-26http://repositorio.ufps.edu.co/handle/ufps/820https//doi.org/1022209/ICv.59n2a06The physiological importance of the brainstem has made it one of the most studied structures of the central nervous system of mammals (in- cluding human). This structure receives somatic and visceral inputs and its neurons send motor efferences by means of the cranial nerves, which innervate the head, neck and sensory organs, and it mediates in several actions such as movement, pain, cardiovascular, respiratory, salivary, sleep, vigil and sexual mechanisms. Most of these actions are mediated by neuroactive substances denominated neuropeptides, which are short amino acid chains widespread dis- tributed in the nervous system, that play a role in neurotransmission, neuro- modulation (paracrine and autocrine actions), and act as neurohormones. In- creased study of these substances has taken place since the 1980s to shed light on both their potential role and the way that they mediate in the organism’s different activities. Thus, our aim is a detailed review of available morphologic and physiologic data regarding some neuropeptides in the human brainstem. To such end, we will discuss aspects like: 1) the distribution of neuropeptides in the human brainstem; 2) their possible physiological actions in the human brainstem; 3) neuropeptide coexistences in the human brainstem; and 4) fu- ture research in neuropeptides in the human brainstem.18 Páginasapplication/pdfengInvestigacion ClinicaVenezuelaInvestigacion Clinica ISSN: 0535-5133, 2018 vol:59 fasc: N/A págs: 161 - 178, DOI:10.22209/IC.v59n2a06Vol. 59 No. 2 (2018)1782 (2018)16159E. Duque-Díaz, D. Martínez-Rangel, y S. Ruiz-Roa, «Neuropeptides in the human brainstem», Invest Clín, vol. 59, n.º 2, p. 161, ago. 2018.Investigacion ClinicaEsta obra está bajo la licencia: Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)info:eu-repo/semantics/openAccessAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)http://purl.org/coar/access_right/c_abf2https://produccioncientificaluz.org/index.php/investigacion/article/view/29100Neuropeptides in the human brainstemArtículo de revistahttp://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTREVinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85NeuropeptidesmesencephalonPonsMedulla oblongataHumanCoveñas R, Duque E, Mangas A, Marcos P, Narváez JA . Neuropeptides in the monkey ( Macaca fascicularis ) brainstem. In: Brain Molecules: from Vitamins to Molecules for Axonal Guidance. Mangas, A., Coveñas, R., Geffard, M, eds. Transworld Research Net - work, Trivandrum; 2008; p 131-156Carpentier V, Vaudry H, Laquerrière A, Tayot J, Leroux P . Distribution of somato - statin receptors in the adult human brain - stem. Brain Res 1996; 734: 135-148Carpentier V, Vaudry H, Mallet E, Laquer - rière A, Tayot J, Leroux P . Anatomical dis - tribution of somatostatin receptor in the brainstem of the human fetus. Neurosci - ence 1996; 73: 865-879.Coveñas R, Martín F, Belda M, Smith V, Sali - nas P, Rivada E . Mapping of neurokinin-like immunoreactivity in the human brainstem. BMC Neurosc 2003; 4:(3) 1-13.Coveñas R, Martin F, Salinas P, Rivada E, Smith V, Aguilar LA . An immunocytochemi - cal mapping of methionine-enkephalin-arg - 6 gly 7 -leu 8 in the human brainstem. Neuro - science 2004; 128(4): 843-859.Duque E, Mangas A, Salinas P, Díaz-Cabiale Z, Narváez JA, Coveñas R . Mapping of alpha- neo-endorphin-and neurokinin B-immuno - reactivity in the human brainstem. Brain Struct Funct2013; 218(1): 131-149.Duque E, Mangas A, Díaz-Cabiale Z, Narváez JA, Coveñas R . Neuropeptides in the monkey brainstem. In: Monkeys: Bi - ology, behavior and disorders, Rachel M. Williams, editors. Nova Science Publisher 2011; p 151-166.Duque-Díaz E, Díaz-Cabiale Z, Narvaéz JA, Coveñas R. Mapping of enkephalins and adrenocorticotropic hormone in the squir - rel monkey brainstem. Anat Sci Int2017; 92: 275-292.Bouras C, Taban CH, Constantinidis J. Map - ping of enkephalins in human brain: an immunohistofluorescence study on brains from patients with senile and presenile dementia. Neuroscience 1984; 12(1): 179- 190.Belda M, Coveñas R, Narváez JA, Aguirre JA, Tramu G. An immunocytochemical map - ping of methionine-enkephalin-Arg6-Gly 7 - Leu 8 in the cat brainstem. Anat Embryol. 2003; 206(5): 399-408.Rinne JO, Lönnberg P, Marjamäki P, Mölsä P, Säkö E, Paljärvi L . Brain methionine-and leucine-enkephalin receptors in patients with dementia. Neurosci Lett 1993; 161(1): 77-80.Rinne JO . Human brain methionine-and leucine-enkephalins and their receptors during ageing. Brain Res 1993; 624(1): 131-136Del Fiacco M, Dessi ML, Atzori MG, Levanti MC . Substance P in the human brainstem. Preliminary results of its immunohisto - chemical localization. Brain Res 1983; 264(1): 142-147.Del Fiacco M, Dessi ML, Levanti LC . Topo - graphical localization of substance P in the human pot-morten brainstem. An inmuno - histochemical study in the newborn and adult tissue. Neuroscience 1984; 12: 591- 611.Dawbarn D, Hunt SP, Emson PC . Neuro - peptide Y: regional distribution chromato - graphic charatacterization and immuno - histochemicaldemostration in post-morten human brain. Brain Res 1984; 296: 168- 173.Widdwson PS . Quantitative receptor auto - radiography demostrates a differential dis - tribution of neuropeptide-Y Y 1 and Y 2 recep - tor subtypes in the human and rat brain. Brain Res 1993; 631: 27-38.Jacques D, Dumont Y, Fornier A, Quirion R. Characterization of neuropeptide Y receptor subtipe in the normal human brain, including the hypothalamus. Neuroscience 1997; 79 (1): 129-148.Coveñas R, Gonzalez-Fuentes J, Rivas- Infante E, Lagartes-Donato MJ, Mangas A, Geffard M, Arroyo-Jimenez MM, Cebada- Sanchez S, Insausti R, Marcos P. Devel - opmental study vitamin C distribution in children’s brainstem by immnunohisto - chemistry. Ann Anat 2015; 201: 65-78.Mangas A, Coveñas R, Geffard K, Geffard M, Marcos P, Insauti R, Dabadie MP . Folic acid in the monkey brain: An immunocy - tochemical study. Neurosc Lett 2004; 362: 258-261.Mangas A, Coveñas R, Geffard K, Geffard M, Marcos P, Insauti R, Dabadie MP . Thia - mine-like in the monkey brain: An immuno - cytochemical study. Life Sciences 2006; 79: 1121-1128.Mangas A, Coveñas R, Bodet D, Geffard M, Aguilar LA, Yajeya J . Immunocytochemi - cal visualization of D-Glutamate in the rat brain. Neuroscience 2007; 144: 654-666.Mangas A, Coveñas R, Bodet D, Deleu S, Marcos P, Geffard M . Vitamins in the mon - key brain: an immunocytochemical study. J Chem Neuroanat 2009; 38: 1-8.Mangas A, Yajeya J, Gonzalez N, Husson M, Geffard M, Coveñas R. Detection of panto - thenic acid-immunoreactive neurons in the rat lateral septal nucleus by a newly devel - oped antibody . Folia Histochem Cytobiol 2016; 54: 186-192.Striedter GF . Neurobiology: A functional approach. New York (NY): Oxford University Press. 2016; p 58-61.Coveñas R, Mangas A, Narváez JA . Intro - duction to neuropeptide. En: Focus on neu - ropeptide research, Coveñas R, Mangas A, Narváez J, eds. Transworld Research Net - work Trivandrum; 2007; p 1-26.Pammer CS, Fodor M, Palkovits M. Locali - zation of corticotropin-releasing factor, so - matostatin, and vasoactive intestinal poly - peptide in the parabrachial nuclei of the human Brain. J Neurosc Res 1988; 20:109- 114.Chigr F, Najimi M, Leduque P, Charnay Y, Jordan D, Chayvialle JA. Anatomical distri - bution of somatostatin immunoreactivity in he infant brainstem. Neuroscience 1989; 29(3): 615-628.Haines DE . Neuroanatomy. An Atlas of Structure, Section, and Systems. Urban and Schwarzenberg, Baltimore-Munich 1987.Shepperd G . Neurobiology, Oxford Univer - sity press, 3 th ed. New York, USA. 1989Kandel ER, Schwartz JH, Jessell TM . Princi - ples of neural science. New York: McGraw- Hill. 2001; 4: p 1227-1246Raffa RB . The action of FMRFamide (Phe- Met-Arg-Phe-NH2) and related peptides on mammals. Peptides 1988; 9: 915-922.Schwarzer C. 30 years of dynorphins new insights on their functions in neuropsychi - atric diseases. Pharmacol Ther 2009; 123: 353-370.Manso B, Sanche ML, Medina LE, Aguilar LA, Díaz-Cabiale Z, Narváez JA, Coveñas R. Immunohistochemical mapping of pro-opi - omelanocortin- and pro-dynorphin-derived peptides in the alpaca ( Lama pacos ) dien - cephalon. J Chem Neuroanat 2014; 59-60: 36-50.Kowarika, M, Einhäusera J, Jochima B, Büttnerb A, Töllea TR, Riemenschneiderc M, Platzera S, Berthelea A. Impact of the COMT Val1 08/158 Met polymorphism on the mu-opioid receptor system in the human brain: mu-opioid receptor, met-enkephalin and beta-endorphin expression. Neurosc Lett 2012; 506: 214-219.Hollander N . β -endorphin in the brainstem, pituitary, and spinal fluid of infants at au - topsy: relation to sudden infant death syn - drome. Forens Scien Inter 1988; 38: 67-74.Pasi A, Mehraein A, Jehle A, Traub M, Morniroli G, Bär W . β -Endorphin: regional level profile in the brain of the human in - fant. Neurochem Int 1992; 20(1): 93-95Coquerel, A, Buser M, Tayot J, Pfaff F, Ma - tray F, Proust B . Beta-endorphin and neu - rotensin in brainstem and cerebrospinal fluid in the sudden infant death syndrome. Neurochem Int 1992; 20(1): 97-102.Fodor M, Görcs TJ, Palkovits M. Immuno - histochemical study on the distribution of neuropeptides within the pontine tegmen - tum—particularly the parabrachial nuclei and the locus coeruleus of the human brain. Neuroscience 1992; 46(4): 891-908.Mai JK, Estephens TH, Hopf A, Cuello AC . Substance P in the human brain. Neurosci - ence 1986; 3: 109-139.Marcos P, Coveñas R, De León M, Narváez JA, Tramú G, Aguirre JA . Neurokinin A-like immunoreactivity in the cat brainstem. Neuropeptides 1993; 25: 105-114.Muñoz M, Coveñas R. Involvement of sub - stance P and the NK-1 receptor in human pathology. Amino Acids 2014; 46(7): 1727- 1750Bergström L, Lagercrantz H, Terenius, L . Post-mortem analyses of neuropeptides in brains from sudden infant death victims. Brain Res 1984; 323(2): 279-285.Kleiman JE, Hong J, Laradola M, Govoni E, Guilin CJ . Neuropeptides in the human brain-postmorten studies. Prog Neuro- psych Biol Psysich 1985; 9: 91-95.Enman NM, Sabban EL, Mcgonigle P, Van Bockstaele EJ. Targeting the neuropeptide Y system in stress-related psychiatric disor - der. Neurobiol Stress 2015; 1: 33-43.Brené S, Lindefors N, Kopp J, Sedvall G, Persson H. Regional distribution of neu - ropeptide Y mRNA in postmortem human brain. Molec Brain Res 1989; 6(4): 241-249Walter A, Mai JK, Jiménez-Härtel W. Map - ping of neuropeptide Y-like immunoreactiv - ity in the human forebrain. Brain Res Bull 1990; 24(3): 297-311.Yu MC, Luo CB, Lomg L, Yew DT . An immu - nohistochemical study of neuropeptide Y positive site in the developing human hip - pocampal formation. Develop Brain Res 1993; 72: 277-281.Ko L, Rotoli G, Grignol G, Hu W, Merchan - thaler I, Dudas B . A putative morphological substrate of the catecholamine-influenced neuropeptide Y (NPY) release in the human hypothalamus . Neuropeptides 2011; 45: 197-203.Yamazoe M, Shiosaka S, Emson C, Tohy - amaM . Distribution of neuropeptide Y in the lower brainstem: an immunohistochem - ical analysis. Brain Res 1985; 355: 109-120.Halliday GM, Li YW, Oliver JR, Joh TH, Cot - ton RGM, Howe PRC, Geffen LB, Blessing WW . The distribution of neuropeptide Y- like inmunoreactive neurons in the human medulla oblongata. Neuroscience 1988; 26 (1): 179-191.Marcos P, Arroyo-Jiménez MM, Lozano G, González-Fuentes J, Lagartos-Donate MJ, Aguilar LA, Coveñas R . Mapping of tyrosine hydroxylase in the diencephalon of alpaca ( Lama Pacos ) and co-distribution with so - matostatin-28 (1-12). J Chem Neuroanat 2013; 50-51: 66-74.Bouras C, Magistretti PJ, Morrison JH, Con - stantinidis J. An immunohistochemical study of pro-somatostatin-derived peptides in the human brain. Neuroscience 1987; 22(3): 781-800.Austin MC, Janosky JE, Murphy HA . In - creased conrticotropin-releasing hormone immunoreactivity in monoamine-contain - ing pontine nuclei of depressed suicide men. Molec Psych 2003; 8: 324-332Hasegawa E, Yanagisawa M, Sakurai T, Mie - da M . Orexin neuron ssuppress narcolepsy via 2 distinct efferent pathways. J Clin In - vest 2014; 124(2):604-616.Goncharuk V, Jhamandas JH. Neuropeptide FF2 receptor distribution in the human brain: an immunohistochemical study. Pep - tides 2008; 25: 1544-1553.Loup F, Tribollet E, Dubois-Dauphin M, Dreifuss JJ. Localization of high-affinity binding sites for oxytocin and vasopressin in the human brain. An autoradiographic study. Brain Res 1991; 555: 220-232.Boccia ML, Petrusz P, Suzuki K, Marson L, Pedersen CA . Inmunohistochemical lo - calitation of oxytocin receptors in human brain. Neuroscience 2013; 253: 155-164.Baer K, Waldvogel HJ, During J, Snell RG, Faull RLM, Rees MI . Association of gephy - rin and glycine receptors in the human brainstem and spinal cord: an immunohis - tochemical analysis. Neuroscience 2003; 122: 773-784Baer K, Waldvogel HJ, Faull RLM, Rees MI . Localization of glycine receptors in the hu - man forebrain, Brainstem, and cervical spi - nal cord: an immunohistochemical review. Front Molec Neurosc 2009; 2 (25): 1-11.Mazzone SB, Geraghty DP. Respiratory ac - tions of tachykinins in the nucleus of the solitary tract: characterization of receptors using selective agonists and antagonists. Br J Pharmacol 2000; 129: 1121-1131.Caberlotto L, Fuxe K, Overstreet DH, Ger - rard P, Hurd YL . Alterations in neuropep -tide Y and Y1 receptor mRNA expression in brains from an animal model of depression: region specific adaptation after fluoxetine treatment. Molec Brain Res 1998; 59(1): 58-65.Kuwaki T. Orexin links emotional stress to autonomic function. Autonom Neurosc Ba - sic Clin 2011; 161: 20-27.Sinto C . Orexin/hypocretin plays a role in the response to physiological disequilibri - um. 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 incorporada en las Obras Colectivas.

b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda.

c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas. Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).

4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:

a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).

b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.

c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.

d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:

i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.

ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, los consagrados por la SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.

e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, ACINPRO), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.

5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

7. Término.

a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.

b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.

8. Varios.

a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.

b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.

c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.

d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.
0000-0002-4649-094438fb46b80826f9790354abc0b1fd8d7e600 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