Study on Croton sp. genetic diversity in the Department of Norte de Santander using the internal transcribed spacer (ITS) region of ribosomal DNA (rDNA)

Genetic variability studies on species with a pharmacological potential are essential for conserving genetic resources. A genetic characterization of a species can guide efforts to collect and conserve germplasm for future breeding programs. The Croton genus belongs to the Euphorbiaceae family, whic...

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Autores:: Chaves-Bedoya, Giovanni

Tipo de recurso:: Article of journal

Fecha de publicación:: 2022

Institución:: Universidad Francisco de Paula Santander

Repositorio:: Repositorio Digital UFPS

Idioma:: eng

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dc.title.eng.fl_str_mv	Study on Croton sp. genetic diversity in the Department of Norte de Santander using the internal transcribed spacer (ITS) region of ribosomal DNA (rDNA)
title	Study on Croton sp. genetic diversity in the Department of Norte de Santander using the internal transcribed spacer (ITS) region of ribosomal DNA (rDNA)
spellingShingle	Study on Croton sp. genetic diversity in the Department of Norte de Santander using the internal transcribed spacer (ITS) region of ribosomal DNA (rDNA) Euphorbiaceae Medicinal plants Drago's blood Neotropics Genetic variability Molecular systematics
title_short	Study on Croton sp. genetic diversity in the Department of Norte de Santander using the internal transcribed spacer (ITS) region of ribosomal DNA (rDNA)
title_full	Study on Croton sp. genetic diversity in the Department of Norte de Santander using the internal transcribed spacer (ITS) region of ribosomal DNA (rDNA)
title_fullStr	Study on Croton sp. genetic diversity in the Department of Norte de Santander using the internal transcribed spacer (ITS) region of ribosomal DNA (rDNA)
title_full_unstemmed	Study on Croton sp. genetic diversity in the Department of Norte de Santander using the internal transcribed spacer (ITS) region of ribosomal DNA (rDNA)
title_sort	Study on Croton sp. genetic diversity in the Department of Norte de Santander using the internal transcribed spacer (ITS) region of ribosomal DNA (rDNA)
dc.creator.fl_str_mv	Chaves-Bedoya, Giovanni
dc.contributor.author.none.fl_str_mv	Chaves-Bedoya, Giovanni
dc.subject.proposal.eng.fl_str_mv	Euphorbiaceae Medicinal plants Drago's blood Neotropics Genetic variability Molecular systematics
topic	Euphorbiaceae Medicinal plants Drago's blood Neotropics Genetic variability Molecular systematics
description	Genetic variability studies on species with a pharmacological potential are essential for conserving genetic resources. A genetic characterization of a species can guide efforts to collect and conserve germplasm for future breeding programs. The Croton genus belongs to the Euphorbiaceae family, which has approximately 1,300 species, is widely distributed in tropical and subtropical regions of the world, and has a wide range of ethnobotanical and medicinal uses. The aim of this research was to study genetic variability by analyzing sequences of the internal transcribed space region (ITS1 5'-TCCGTAGGGAACCTGCGGC-3' and ITS4 5'-TCCTCCGCTTATGC-3') of ribosomal DNA (rDNA) of a Croton population from forested areas in the Department of Norte de Santander in the municipalities of Chinacota, Pamplona and El Zulia. The results indicated considerable genetic variability in the Croton population, with a nucleotide similarity ranging from 54 to 99% and phylogenetical grouping according to the place of origin. The information gained from the ITS region can be a useful parameter for diversity evaluations and phylogenetic studies since there are no similar studies on Croton in this department in northeastern Colombia.
publishDate	2022
dc.date.issued.none.fl_str_mv	2022-01-01
dc.date.accessioned.none.fl_str_mv	2024-04-15T16:46:20Z
dc.date.available.none.fl_str_mv	2024-04-15T16:46:20Z
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dc.identifier.doi.none.fl_str_mv	https://doi.org/10.17584/rcch.2022v16i1.13592
url	https://repositorio.ufps.edu.co/handle/ufps/6923 https://doi.org/10.17584/rcch.2022v16i1.13592
dc.language.iso.spa.fl_str_mv	eng
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dc.relation.ispartof.none.fl_str_mv	REVISTA COLOMBIANA DE CIENCIAS HORTÍCOLAS - Vol. 16 - No. 1, e13592, January-April 2022e-ISSN: 2422-3719 · ISSN-L: 2011-2173
dc.relation.citationedition.spa.fl_str_mv	Vol.16 No.1 (2022)
dc.relation.citationendpage.spa.fl_str_mv	9
dc.relation.citationissue.spa.fl_str_mv	1. (2022)
dc.relation.citationstartpage.spa.fl_str_mv	1
dc.relation.citationvolume.spa.fl_str_mv	16
dc.relation.cites.none.fl_str_mv	G. Chaves-Bedoya, “Study on Croton sp. genetic diversity in the Department of Norte de Santander using the internal transcribed spacer (ITS) region of ribosomal DNA (rDNA)”, Rev. Colomb. Cienc. Hortic, vol. 16, no. 1, p. e13592, Jan. 2022.
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dc.format.extent.spa.fl_str_mv	9 Páginas
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dc.publisher.spa.fl_str_mv	Revista Colombiana de Ciencias Horticolas
dc.publisher.place.spa.fl_str_mv	Tunja, Colombia
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institution	Universidad Francisco de Paula Santander
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spelling	Chaves-Bedoya, Giovannia2ff1d1930ac907c3572b5d3c6e10b646002024-04-15T16:46:20Z2024-04-15T16:46:20Z2022-01-01https://repositorio.ufps.edu.co/handle/ufps/6923https://doi.org/10.17584/rcch.2022v16i1.13592Genetic variability studies on species with a pharmacological potential are essential for conserving genetic resources. A genetic characterization of a species can guide efforts to collect and conserve germplasm for future breeding programs. The Croton genus belongs to the Euphorbiaceae family, which has approximately 1,300 species, is widely distributed in tropical and subtropical regions of the world, and has a wide range of ethnobotanical and medicinal uses. The aim of this research was to study genetic variability by analyzing sequences of the internal transcribed space region (ITS1 5'-TCCGTAGGGAACCTGCGGC-3' and ITS4 5'-TCCTCCGCTTATGC-3') of ribosomal DNA (rDNA) of a Croton population from forested areas in the Department of Norte de Santander in the municipalities of Chinacota, Pamplona and El Zulia. The results indicated considerable genetic variability in the Croton population, with a nucleotide similarity ranging from 54 to 99% and phylogenetical grouping according to the place of origin. The information gained from the ITS region can be a useful parameter for diversity evaluations and phylogenetic studies since there are no similar studies on Croton in this department in northeastern Colombia.9 Páginasapplication/pdfengRevista Colombiana de Ciencias HorticolasTunja, ColombiaREVISTA COLOMBIANA DE CIENCIAS HORTÍCOLAS - Vol. 16 - No. 1, e13592, January-April 2022e-ISSN: 2422-3719 · ISSN-L: 2011-2173Vol.16 No.1 (2022)91. (2022)116G. Chaves-Bedoya, “Study on Croton sp. genetic diversity in the Department of Norte de Santander using the internal transcribed spacer (ITS) region of ribosomal DNA (rDNA)”, Rev. Colomb. Cienc. Hortic, vol. 16, no. 1, p. e13592, Jan. 2022.This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.https://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)http://purl.org/coar/access_right/c_abf2https://revistas.uptc.edu.co/index.php/ciencias_horticolas/article/view/13592Study on Croton sp. genetic diversity in the Department of Norte de Santander using the internal transcribed spacer (ITS) region of ribosomal DNA (rDNA)Artículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85EuphorbiaceaeMedicinal plantsDrago's bloodNeotropicsGenetic variabilityMolecular systematicsBerry, P.E., A.L. Hipp, K.J. Wurdack, B. Van Ee, and R. Riina. 2005. Molecular phylogenetics of the giant genus Croton and tribe Crotoneae (Euphorbiaceae sensu stricto) using ITS and TRNL-TRNF DNA sequence data. Am. J. Bot. 92(9), 1520-1534. Doi: 10.3732/ajb.92.9.1520Block, S., C. Baccelli, B. Tinant, L. Van Meervelt, R. Rozenberg, J.-L. Habib Jiwan, G. Llabrès, M.-C. De Pauw-Gillet, and J. Quetin-Leclercq. 2004. Diterpenes from the leaves of Croton zambesicus. Phytochemistry 65(8), 1165-1171. Doi: 10.1016/j.phytochem.2004.02.023Caruzo, M.B.R., B.W. Van Ee, I. Cordeiro, P.E. Berry, and R. Riina. 2011. Molecular phylogenetics and character evolution of the “sacaca” clade: Novel relationships of Croton section Cleodora (Euphorbiaceae). Mol. Phylogenet. Evol. 60(2), 193-206. Doi: 10.1016/j.ympev.2011.04.013Clark, K., I. Karsch-Mizrachi, D.J. Lipman, J. Ostell, and E.W. Sayers. 2016. GenBank. Nucleic Acids Res. 44(D1), 67-72. Doi: 10.1093/nar/gkv1276Costa, R.B., P. Martin de Moraes, L. Skowronski, C.E. Oliveira, M.L. Nogueira, R.M.S. Yui, A.P. Lorenz, and W.S. Fava. 2020. Genetic diversity and population structure of Croton urucurana Baill. (Euphorbiaceae) in Central Brazil by ISSR markers. Braz. J. Bot. (43), 831-838. Doi: 10.1007/s40415-020-00657-wCoy Barrera, C.A., D.C. Gomez, and F.A. Castiblanco. 2016. Importancia medicinal del género Croton (euphorbiaceae). Rev. Cubana Plant. Med. 21(2), 234-247.Farias, F.R., J.S. Williamson, S.V. Rodriguez, G. Angeles, and V.O. Portugal. 2009. Bark anatomy in Croton draco var. draco (Euphorbiaceae). Am. J. Bot. 96(12), 2155-2167. Doi: 10.3732/ajb.0900035Forough, J.F., T.A. Shivaji, and D.R. Mallikarjun. 2018. Assessment of genetic diversity among different sugarcane genotypes using internal transcribed spacer (ITS) region of the ribosomal DNA (rDNA). GSC Biol. Pharm. Sci. 5(2), 17-25. Doi: 10.30574/gscbps.2018.5.2.0108Godoy, G., L.E. Ojeda, V. Leon, F. Escalona, D. Mansilla, M. Brewer, N.N. Machado. 2020. Antimicrobial potential of Croton gossypiifolius (Euphorbiaceae) latex on species associated with human infections. Arnaldoa 27(1), 247-255.Kumar, S., G. Stecher, M. Li, C. Knyaz, and K. Tamura. 2018. MEGA X: Molecular Evolutionary Genetics Analysis across computing platforms. Mol. Biol. Evol. 35(6), 1547-1549. Doi: 10.1093/molbev/msy096Li, W., A. Cowley, M. Uludag, T. Gur, H. McWilliam, S. Squizzato, Y.M. Park, N. Buso, and R. Lopez. 2015. The EMBL-EBI bioinformatics web and programmatic tools framework. Nucleic Acids Res. 43(W1), W580-584. Doi: 10.1093/nar/gkv279Luján, M., Y. León, and R. Riina. 2015. Sinopsis de Croton (Euphorbiaceae) en los Andes de Mérida, Venezuela. Caldasia 37(1), 73-90. Doi: 10.15446/caldasia.v37n1.50815Mäder, G., P.M. Zamberlan, N.J.R. Fagundes, T. Magnus, F.M. Salzano, S.L. Bonatto, and L.B. Freitas. 2010. The use and limits of ITS data in the analysis of intraspecific variation in Passiflora L. (Passifloraceae). Genet. Mol. Biol. 33(1), 99-108. Doi: 10.1590/S1415-47572009005000101Masa-Iranzo, I., I. Sanmartin, M.B.R. Caruzo, and R. Riina. 2021. Skipping the dry diagonal: Spatio-temporal evolution of Croton section Cleodora (Euphorbiaceae) in the Neotropics. Bot. J. Linn. Soc. 197(1), 61-84. Doi: 10.1093/botlinnean/boab016Milanowski, D.J., R.E.K. Winter, M.P.F. Elvin-Lewis, and W.H. Lewis. 2002. Geographic distribution of three alkaloid chemotypes of Croton lechleri. J. Nat. Prod. 65(6), 814-819. Doi: 10.1021/np000270vMurillo Aldana, J.C. 1999. Composición y distribución del genero Croton (Euphorbiaceae) en Colombia, con cuatro especies nuevas. Caldasia, 21(2), 141-166.Perdue, G.P., R.N. Blomster, D.A. Blake, and N.R. Farnsworth. 1979. South American plants II: taspine isolation and anti-inflammatory activity. J. Pharm. Sci. 68(1), 124-126. Doi: 10.1002/jps.2600680145Riina, R., P. Berry, and B. Van Ee. 2009. Molecular phylogenetics of the Dragon’s Blood Croton Section Cyclostigma (Euphorbiaceae): A polyphyletic assemblage unraveled. Syst. Bot. 34(2), 360-374.Salatino, A., M.L.F. Salatino, and G. Negri. 2007. Traditional uses, chemistry and pharmacology of Croton species (Euphorbiaceae). J. Braz. Chem. Soc. 18(1), 11-33. Doi: 10.1590/S0103-50532007000100002Stöver, B.C. and K.F. Müller. 2010. TreeGraph 2: Combining and visualizing evidence from different phylogenetic analyses. BMC Bioinformatics 11, 7. Doi: 10.1186/1471-2105-11-7Van Ee, B.W. and P.E. Berry. 2010. Taxonomy and phylogeny of Croton section Heptallon (Euphorbiaceae). Syst. Bot. 35(1), 151-167. Doi: 10.1600/036364410790862461Van Ee, B.W. and P.E. Berry. 2011. Croton section Pedicellati (Euphorbiaceae), a novel new world group, and a new subsectional classification of Croton section Lamprocroton. Syst. Bot. 36(1), 88-98. Doi: 10.1600/036364411X553162White, T.J., T. Bruns, S. Lee, and J. Taylor. 1990. Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics. pp. 315-322. In: Innis, M.A., D.H. Gelfand, J.J. Sninsky, and T.J. White (eds.). PCR protocols. A guide to methods and applications. Academic Press, San Diego, FL. Doi: 10.1016/B978-0-12-372180-8.50042-1Yang, S., X. Li, F. Huang, Y. Huang, X. Liu, J. Wu, Q. Wang, Z. Deng, R. Chen, and M. Zhang. 2018. A new method based on SNP of nrDNA-ITS to identify Saccharum spontaneum and its progeny in the genus Saccharum. PLoS One 13(5), e0197458. 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 incorporada en las Obras Colectivas.

b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda.

c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas. Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).

4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:

a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).

b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.

c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.

d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:

i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.

ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, los consagrados por la SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.

e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, ACINPRO), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.

5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

7. Término.

a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.

b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.

8. Varios.

a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.

b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.

c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.

d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.
0000-0003-1013-614Xa2ff1d1930ac907c3572b5d3c6e10b64600

Study on Croton sp. genetic diversity in the Department of Norte de Santander using the internal transcribed spacer (ITS) region of ribosomal DNA (rDNA)

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