Traditional use and qualitative chemical composition of medicinal plants in the communities of Sardinata and Cúcuta in Norte de Santander - Colombia

Traditional medicine is part of the culture of the people, it is an expression of intangible cultural heritage that combines different traditional knowledge and practices. Medicinal plants have been used as an alternative method to conventional medicine, and their use in developing countries has bee...

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Autores:
Ascanio, Erika Andrea
Chaves-Bedoya, Giovanni
Ortiz Rojas, Luz Yineth
Tipo de recurso:
Article of journal
Fecha de publicación:
2023
Institución:
Universidad Francisco de Paula Santander
Repositorio:
Repositorio Digital UFPS
Idioma:
eng
OAI Identifier:
oai:repositorio.ufps.edu.co:ufps/6816
Acceso en línea:
https://repositorio.ufps.edu.co/handle/ufps/6816
Palabra clave:
Traditional medicine
Ethnobotanic
Herbalist
Secondary
metabolites
Thin layer chromatography
Rights
openAccess
License
https://creativecommons.org/licenses/by-nc-sa/4.0/
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network_acronym_str RUFPS2
network_name_str Repositorio Digital UFPS
repository_id_str
dc.title.eng.fl_str_mv Traditional use and qualitative chemical composition of medicinal plants in the communities of Sardinata and Cúcuta in Norte de Santander - Colombia
dc.title.spa.fl_str_mv Uso tradicional y composición química cualitativa de plantas medicinales en las comunidades de Sardinata y Cúcuta en Norte de Santander - Colombia
title Traditional use and qualitative chemical composition of medicinal plants in the communities of Sardinata and Cúcuta in Norte de Santander - Colombia
spellingShingle Traditional use and qualitative chemical composition of medicinal plants in the communities of Sardinata and Cúcuta in Norte de Santander - Colombia
Traditional medicine
Ethnobotanic
Herbalist
Secondary
metabolites
Thin layer chromatography
title_short Traditional use and qualitative chemical composition of medicinal plants in the communities of Sardinata and Cúcuta in Norte de Santander - Colombia
title_full Traditional use and qualitative chemical composition of medicinal plants in the communities of Sardinata and Cúcuta in Norte de Santander - Colombia
title_fullStr Traditional use and qualitative chemical composition of medicinal plants in the communities of Sardinata and Cúcuta in Norte de Santander - Colombia
title_full_unstemmed Traditional use and qualitative chemical composition of medicinal plants in the communities of Sardinata and Cúcuta in Norte de Santander - Colombia
title_sort Traditional use and qualitative chemical composition of medicinal plants in the communities of Sardinata and Cúcuta in Norte de Santander - Colombia
dc.creator.fl_str_mv Ascanio, Erika Andrea
Chaves-Bedoya, Giovanni
Ortiz Rojas, Luz Yineth
dc.contributor.author.none.fl_str_mv Ascanio, Erika Andrea
Chaves-Bedoya, Giovanni
Ortiz Rojas, Luz Yineth
dc.subject.proposal.eng.fl_str_mv Traditional medicine
Ethnobotanic
Herbalist
Secondary
metabolites
Thin layer chromatography
topic Traditional medicine
Ethnobotanic
Herbalist
Secondary
metabolites
Thin layer chromatography
description Traditional medicine is part of the culture of the people, it is an expression of intangible cultural heritage that combines different traditional knowledge and practices. Medicinal plants have been used as an alternative method to conventional medicine, and their use in developing countries has been inherited generationally. The aim of this study was to determine the prevalence of use in traditional medicine and preliminary identification of secondary metabolites present in medicinal plants used for the treatment of ailments in two municipalities from Norte de Santander-Colombia. The research method used for the development of the project is qualitative and experimental. Interviews were conducted with 40 herbalists in the markets of the municipalities of Sardinata and Cúcuta. Experimentally, the ethanolic extract of 17 medicinal plants was obtained to identify the secondary metabolites present using the technique of thin layer chromatography (TLC). The results suggests that the secondary metabolites of higher prevalence in the most used medicinal plants are flavonoids and terpenes. Information gained from traditional and medicinal plants maintains an important cultural value and represents an alternative use for the management of ailments at low cost, highlighting the importance of phytotherapy for communities. The results of the study not only confirm the relevance of medicinal plants in the region, but also highlight the importance of continuing to research and document the applications and benefits of these plants in traditional and modern medicine.
publishDate 2023
dc.date.issued.none.fl_str_mv 2023-01-01
dc.date.accessioned.none.fl_str_mv 2024-04-04T15:05:28Z
dc.date.available.none.fl_str_mv 2024-04-04T15:05:28Z
dc.type.spa.fl_str_mv Artículo de revista
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dc.identifier.uri.none.fl_str_mv https://repositorio.ufps.edu.co/handle/ufps/6816
dc.identifier.doi.none.fl_str_mv 10.17584/rcch.2023v17i1.15527
url https://repositorio.ufps.edu.co/handle/ufps/6816
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dc.relation.ispartof.none.fl_str_mv E. A. Ascanio, G. Chaves-Bedoya, and L. Y. Ortiz-Rojas, “Traditional use and qualitative chemical composition of medicinal plants in the communities of Sardinata and Cúcuta in Norte de Santander - Colombia”, Rev. Colomb. Cienc. Hortic, vol. 17, no. 1, p. e15527, Jan. 2023.
dc.relation.citationedition.spa.fl_str_mv Vol.17 N°. 1(2023)
dc.relation.citationendpage.spa.fl_str_mv 14
dc.relation.citationissue.spa.fl_str_mv 1 (2023)
dc.relation.citationstartpage.spa.fl_str_mv 1
dc.relation.citationvolume.spa.fl_str_mv 17
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dc.format.extent.spa.fl_str_mv 14 Páginas
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dc.publisher.spa.fl_str_mv Revista Colombiana de Ciencias Horticolas
dc.publisher.place.spa.fl_str_mv Tunja, Colombia
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spelling Ascanio, Erika Andreada8842b69e377096042eb3d83f565eb6600Chaves-Bedoya, Giovannia2ff1d1930ac907c3572b5d3c6e10b64600Ortiz Rojas, Luz Yinethd7b1b88daafb9cb19c1fc53b1e89e0cc6002024-04-04T15:05:28Z2024-04-04T15:05:28Z2023-01-01https://repositorio.ufps.edu.co/handle/ufps/681610.17584/rcch.2023v17i1.15527Traditional medicine is part of the culture of the people, it is an expression of intangible cultural heritage that combines different traditional knowledge and practices. Medicinal plants have been used as an alternative method to conventional medicine, and their use in developing countries has been inherited generationally. The aim of this study was to determine the prevalence of use in traditional medicine and preliminary identification of secondary metabolites present in medicinal plants used for the treatment of ailments in two municipalities from Norte de Santander-Colombia. The research method used for the development of the project is qualitative and experimental. Interviews were conducted with 40 herbalists in the markets of the municipalities of Sardinata and Cúcuta. Experimentally, the ethanolic extract of 17 medicinal plants was obtained to identify the secondary metabolites present using the technique of thin layer chromatography (TLC). The results suggests that the secondary metabolites of higher prevalence in the most used medicinal plants are flavonoids and terpenes. Information gained from traditional and medicinal plants maintains an important cultural value and represents an alternative use for the management of ailments at low cost, highlighting the importance of phytotherapy for communities. The results of the study not only confirm the relevance of medicinal plants in the region, but also highlight the importance of continuing to research and document the applications and benefits of these plants in traditional and modern medicine.14 Páginasapplication/pdfengRevista Colombiana de Ciencias HorticolasTunja, ColombiaE. A. Ascanio, G. Chaves-Bedoya, and L. Y. Ortiz-Rojas, “Traditional use and qualitative chemical composition of medicinal plants in the communities of Sardinata and Cúcuta in Norte de Santander - Colombia”, Rev. Colomb. Cienc. Hortic, vol. 17, no. 1, p. e15527, Jan. 2023.Vol.17 N°. 1(2023)141 (2023)117This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.https://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)http://purl.org/coar/access_right/c_abf2https://revistas.uptc.edu.co/index.php/ciencias_horticolas/article/view/15527Traditional use and qualitative chemical composition of medicinal plants in the communities of Sardinata and Cúcuta in Norte de Santander - ColombiaUso tradicional y composición química cualitativa de plantas medicinales en las comunidades de Sardinata y Cúcuta en Norte de Santander - ColombiaArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Traditional medicineEthnobotanicHerbalistSecondarymetabolitesThin layer chromatographyAlbuquerque, U.P., P.M. Medeiros, A.L.S. Almeida, J.M. Monteiro, E.M.F. Lins Neto, J.G. Melo, and J.P. Santos. 2007. Medicinal plants of the caatinga (semi-arid) vegetation of NE Brazil: a quantitative approach. J. Ethnopharmacol. 114(3), 325-354. Doi: https://doi.org/10.1016/j.jep.2007.08.017Alonso-Castro, A.J., F. Domínguez, J.J. Maldonado-Miranda, L.J. Castillo-Pérez, C. Carranza-Álvarez, E. Solano, M.A. Isiordia-Espinoza, M.C. Juárez-Vázquez, J.R. Zapata-Morales, M.A. Argueta-Fuertes, A.J. Ruiz-Padilla, C.R. Solorio-Alvarado, J.E. Rangel-Velázquez, R. Ortiz-Andrade, I. González-Sánchez, G. Cruz-Jiménez, and L.M. Orozco-Castellanos. 2017. Use of medicinal plants by health professionals in Mexico. J. Ethnopharmacol. 198, 81-86. Doi: https://doi.org/10.1016/j.jep.2016.12.038Alvarez, L.S. 2007. El uso de medicina alternativa y medicina tradicional en Medellín, 2005. Rev. Fac. Nac. Salud Pública 25(2), 100-109.Bennett, J. and C.M. Brown. 2000. Use of herbal remedies by patients in a health maintenance organization. J. Am. Pharm. Assoc. 40(3), 353-358. Doi: https://doi.org/10.1016/s1086-5802(16)31082-8Bussmann, R.W., D. Sharon, I. Vandebroek, A. Jones, and Z. Revene. 2007. Health for sale: The medicinal plant markets in Trujillo and Chiclayo, Northern Peru. J. Ethnobiol. Ethnomed. 3, 37. Doi: https://doi.org/10.1186/1746-4269-3-37Cámara-Leret, R., N. Paniagua-Zambrana, H. Balslev, and M.J. Macía. 2014. Ethnobotanical knowledge is vastly under-documented in Northwestern South America. PLoS ONE 9(1), e85794. Doi: https://doi.org/10.1371/journal.pone.0085794Carrillo-Fajardo, M., O. Rivera-Díaz, and R. Sánchez-Montaño. 2007. Carcaterización florística y estructural del bosque seco tropical del Cerro Tasajero, San José de Cúcuta (Norte de Santander), Colombia. Actual Biol. 29(86), 55-73. Doi: https://doi.org/10.17533/udea.acbi.329348Chali, B.U., A. Hasho, and N.B. Koricha. 2021. Preference and practice of traditional medicine and associated factors in Jimma Town, Southwest Ethiopia. Evid.-Based Complement. Altern. Med. 2021, 9962892. Doi: https://doi.org/10.1155/2021/9962892Chaves-Bedoya, G., E.J. Vera, and L.Y. Ortiz-Rojas. 2022. Phytochemical characterization of ethanolic extracts of the leaves of Zanthoxylum Caribaeum Lam. and evaluation of antimicrobial activity against Burkholderia Glumae. Rev. Chimie 73(1), 54-61. Doi: https://doi.org/10.37358/RC.22.1.8502Cox-Georgian, D., N. Ramadoss, C. Dona, and C. Basu. 2019. Therapeutic and medicinal uses of terpenes. pp. 333-359. In: Joshee, N., S. Dhekney, and P. Parajuli (eds) Medicinal plants. Springer International Publishing, Cham, Switzerland. Doi: https://doi.org/10.1007/978-3-030-31269-5_15Escalona, L.J., A. Tase, A. Estrada, and M.L. Almaguer. 2015. Uso tradicional de plantas medicinales por el adulto mayor en la comunidad serrana de Corralillo Arriba. Guisa, Granma. Rev. 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 incorporada en las Obras Colectivas.

b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda.

c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas. Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).

4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:

a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).

b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.

c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.

d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:

i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.

ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, los consagrados por la SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.

e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, ACINPRO), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.

5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

7. Término.

a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.

b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.

8. Varios.

a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.

b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.

c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.

d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.
0009-0002-1137-6874da8842b69e377096042eb3d83f565eb66000000-0003-1013-614Xa2ff1d1930ac907c3572b5d3c6e10b64600