Physiological mechanisms involved in maintaining the corpus luteum during the first two months of pregnancy
Maintenance of the corpus luteum (CL) during pregnancy is essential for continuing the elevated circulating progesterone (P4) that is required to maintain pregnancy. The mechanisms that protect the CL during early pregnancy when the non-pregnant animal would typically undergo CL regression have been...
- Autores:
-
Wiltbank, Milo
Mezera, Megan
Zucato Toledo, Mateus
Drum, Jessica
Baez, Giovanni
Garcia Guerra, Alvaro
Sartori, Roberto
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2018
- Institución:
- Universidad Francisco de Paula Santander
- Repositorio:
- Repositorio Digital UFPS
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.ufps.edu.co:ufps/594
- Acceso en línea:
- http://repositorio.ufps.edu.co/handle/ufps/594
- Palabra clave:
- corpus luteum
interferon-tau
pregnancy
- Rights
- openAccess
- License
- Atribución 4.0 Internacional (CC BY 4.0)
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Physiological mechanisms involved in maintaining the corpus luteum during the first two months of pregnancy |
| title |
Physiological mechanisms involved in maintaining the corpus luteum during the first two months of pregnancy |
| spellingShingle |
Physiological mechanisms involved in maintaining the corpus luteum during the first two months of pregnancy corpus luteum interferon-tau pregnancy |
| title_short |
Physiological mechanisms involved in maintaining the corpus luteum during the first two months of pregnancy |
| title_full |
Physiological mechanisms involved in maintaining the corpus luteum during the first two months of pregnancy |
| title_fullStr |
Physiological mechanisms involved in maintaining the corpus luteum during the first two months of pregnancy |
| title_full_unstemmed |
Physiological mechanisms involved in maintaining the corpus luteum during the first two months of pregnancy |
| title_sort |
Physiological mechanisms involved in maintaining the corpus luteum during the first two months of pregnancy |
| dc.creator.fl_str_mv |
Wiltbank, Milo Mezera, Megan Zucato Toledo, Mateus Drum, Jessica Baez, Giovanni Garcia Guerra, Alvaro Sartori, Roberto |
| dc.contributor.author.none.fl_str_mv |
Wiltbank, Milo Mezera, Megan Zucato Toledo, Mateus Drum, Jessica Baez, Giovanni Garcia Guerra, Alvaro Sartori, Roberto |
| dc.subject.proposal.eng.fl_str_mv |
corpus luteum interferon-tau pregnancy |
| topic |
corpus luteum interferon-tau pregnancy |
| description |
Maintenance of the corpus luteum (CL) during pregnancy is essential for continuing the elevated circulating progesterone (P4) that is required to maintain pregnancy. The mechanisms that protect the CL during early pregnancy when the non-pregnant animal would typically undergo CL regression have been extensively investigated. It is clear uterine prostaglandin F2α (PGF) causes regression of the CL in non-pregnant ruminants and that maintenance of the CL during early pregnancy is dependent upon secretion of interferon-tau (IFNT) from the elongating embryo. A number of specific mechanisms appear to be activated by IFNT. Most studies indicate that there is an inhibition of oxytocin-induced secretion of uterine PGF. There is also evidence for increased resistance to PGF action, perhaps due to secretion of PGE2 and PGE1 or direct endocrine actions of circulating IFNT. These mechanisms occur concurrently and each may help to maintain the CL during the first month of pregnancy. However, during the second month of pregnancy, IFNT is no longer secreted by the embryo. Attachment of the embryo to the uterus and subsequent placentome development have been linked to silencing of expression from the IFNT gene. In addition, there is some evidence that oxytocin responsiveness of the uterus returns during the second month of pregnancy leading to substantial basal secretion of PGF and perhaps PGF pulses. There is also no evidence that the CL during the second month of pregnancy is resistant to the actions of PGF as observed during the first month. Thus, this manuscript attempts to compare the mechanisms that maintain the CL during the first and second months of pregnancy in ruminants and provides a new, speculative, physiological model for maintenance of the CL during month two of pregnancy that is distinct from the previously-described mechanisms that maintain the CL during the first month of pregnancy. |
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2018 |
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2018-09 |
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2021-11-02T15:30:04Z |
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2021-11-02T15:30:04Z |
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10.21451/1984-3143-AR2018-0045 |
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10.21451/1984-3143-AR2018-0045 |
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eng |
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eng |
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Animal Reproduction ISSN: 1984-3143, 2018 vol:15 fasc: sup.1 págs: 805 - 821, DOI:10.21451/1984-3143-AR2018-0045 |
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Vol. 15, No. 1 (2018) |
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1 (2018) |
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Wiltbank, M. C., Mezera, M. A., Toledo, M. Z., Drum, J. N., Baez, G. M., García-Guerra, A., & Sartori, R. (2018). Physiological mechanisms involved in maintaining the corpus luteum during the first two months of pregnancy. Animal Reproduction (AR), 15(Supplement 1), 805-821. |
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Animal Reproduction |
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Atribución 4.0 Internacional (CC BY 4.0) http://purl.org/coar/access_right/c_abf2 |
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17 páginas |
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Animal Reproduction |
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Brasil |
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Wiltbank, Miloc357466f3c3066f43fa100984cf5f45fMezera, Megan7f575e90285d8d40c00d37e57fcb0727Zucato Toledo, Mateusc5c2554a2c6e873d750f6fb5130a43b3600Drum, Jessicaac3b20e755ce949a364ae2f60a27d3ceBaez, Giovannib18821a2a726f7505ba690b97bd8ba58600Garcia Guerra, Alvaro630fbc1ccf3770d19017048d54c4367b600Sartori, Roberto038eaf6183ee15e35f2ea736e4df9e836002021-11-02T15:30:04Z2021-11-02T15:30:04Z2018-09http://repositorio.ufps.edu.co/handle/ufps/59410.21451/1984-3143-AR2018-0045Maintenance of the corpus luteum (CL) during pregnancy is essential for continuing the elevated circulating progesterone (P4) that is required to maintain pregnancy. The mechanisms that protect the CL during early pregnancy when the non-pregnant animal would typically undergo CL regression have been extensively investigated. It is clear uterine prostaglandin F2α (PGF) causes regression of the CL in non-pregnant ruminants and that maintenance of the CL during early pregnancy is dependent upon secretion of interferon-tau (IFNT) from the elongating embryo. A number of specific mechanisms appear to be activated by IFNT. Most studies indicate that there is an inhibition of oxytocin-induced secretion of uterine PGF. There is also evidence for increased resistance to PGF action, perhaps due to secretion of PGE2 and PGE1 or direct endocrine actions of circulating IFNT. These mechanisms occur concurrently and each may help to maintain the CL during the first month of pregnancy. However, during the second month of pregnancy, IFNT is no longer secreted by the embryo. Attachment of the embryo to the uterus and subsequent placentome development have been linked to silencing of expression from the IFNT gene. In addition, there is some evidence that oxytocin responsiveness of the uterus returns during the second month of pregnancy leading to substantial basal secretion of PGF and perhaps PGF pulses. There is also no evidence that the CL during the second month of pregnancy is resistant to the actions of PGF as observed during the first month. Thus, this manuscript attempts to compare the mechanisms that maintain the CL during the first and second months of pregnancy in ruminants and provides a new, speculative, physiological model for maintenance of the CL during month two of pregnancy that is distinct from the previously-described mechanisms that maintain the CL during the first month of pregnancy.17 páginasapplication/pdfengAnimal ReproductionBrasilAnimal Reproduction ISSN: 1984-3143, 2018 vol:15 fasc: sup.1 págs: 805 - 821, DOI:10.21451/1984-3143-AR2018-0045Vol. 15, No. 1 (2018)8211 (2018)80515Wiltbank, M. C., Mezera, M. A., Toledo, M. Z., Drum, J. N., Baez, G. M., García-Guerra, A., & Sartori, R. (2018). Physiological mechanisms involved in maintaining the corpus luteum during the first two months of pregnancy. Animal Reproduction (AR), 15(Supplement 1), 805-821.Animal ReproductionThe Author(s). Published by CBRA. This is an Open Access article under the Creative Commons Attribution License (CC BY 4.0 license)info:eu-repo/semantics/openAccessAtribución 4.0 Internacional (CC BY 4.0)http://purl.org/coar/access_right/c_abf2https://www.animal-reproduction.org/article/doi/10.21451/1984-3143-AR2018-0045Physiological mechanisms involved in maintaining the corpus luteum during the first two months of pregnancyArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85corpus luteuminterferon-taupregnancyAntoniazzi AQ, Webb BT, Romero JJ, Ashley RL, Smirnova NP, Henkes LE, Bott RC, Oliveira JF, Niswender GD, Bazer FW, Hansen TR. 2013. Endocrine delivery of interferon tau protects the corpus luteum from prostaglandin F2 Alpha-induced luteolysis in ewes. Biol Reprod, 88. doi: 10.1095/biolreprod.112.105684.Araujo RR, Ginther OJ, Ferreira JC, Palhao MM, Beg MA, Wiltbank MC. 2009. Role of follicular estradiol-17beta in timing of luteolysis in heifers. Biol Reprod, 81:426-437.Arnold DR, Binelli M, Vonk J, Alexenko AP, Drost M, Wilcox CJ, Thatcher WW. 2000. Intracellular regulation of endometrial PGF(2a) and PGE(2) production in dairy cows during early pregnancy and following treatment with recombinant interferon-tau. Domest Anim Endocrinol, 18:199-216.Arosh JA, Banu SK, Kimmins S, Chapdelaine P, Maclaren LA, Fortier MA. 2004. Effect of interferon-tau on prostaglandin biosynthesis, transport, and signaling at the time of maternal recognition of pregnancy in cattle: evidence of polycrine actions of prostaglandin E2. Endocrinology, 145:5280-5293.Arosh JA, Banu SK, McCracken JA. 2016. Novel concepts on the role of prostaglandins on luteal maintenance and maternal recognition and establishment of pregnancy in ruminants. J Dairy Sci, 99:5926-5940.Asselin E, Lacroix D, Fortier MA. 1997. IFN-tau increases PGE(2) production and COX-2 gene expression in the bovine endometrium in vitro. Mol Cell Endocrinol, 132:117-126.Atli MO, Bender RW, Mehta V, Bastos MR, Luo WX, Vezina CM, Wiltbank MC. 2012. Patterns of gene expression in the bovine corpus luteum following repeated intrauterine infusions of low doses of prostaglandin F2alpha. Biol Reprod, 86. doi: 10.1095/biolreprod.111.094870.Baez GM, Barletta RV, Guenther JN, Gaska JM, Wiltbank MC. 2016. Effect of uterine size on fertility of lactating dairy cows. Theriogenology, 85:1357-1366.Baez GM, Trevisol E, Barletta RV, Cardoso BO, Ricci A, Guenther JN, Cummings NE, Wiltbank MC. 2017. Proposal of a new model for CL regression or maintenance during pregnancy on the basis of timing of regression of contralateral, accessory CL in pregnant cows. Theriogenology, 89:214-225.Bazer FW, Spencer TE, Ott TL. 1997. Interferon tau: a novel pregnancy recognition signal. Am J Reprod Immunol, 37:412-420.Bonnin P, Huynh L, L'Haridon R, Chene N, Martal J. 1999. Transport of uterine PGF(2 alpha) to the ovaries by systemic circulation and local lymphovenous-arterial diffusion during luteolysis in sheep. J Reprod Fertil, 116:199-210.Bott RC, Ashley RL, Henkes LE, Antoniazzi AQ, Bruemmer JE, Niswender GD, Bazer FW, Spencer TE, Smirnova NP, Anthony RV, Hansen TR. 2010. Uterine vein infusion of interferon Tau (IFNT) extends luteal life span in ewes. Biol Reprod, 82:725-735.Bridges PJ, Wright DJ, Buford WI, Ahmad N, Hernandez-Fonseca H, McCormick ML, Schrick FN, Dailey RA, Lewis PE, Inskeep EK. 2000. Ability of induced corpora lutea to maintain pregnancy in beef cows. J Anim Sci, 78:2942-2949.Burns PD, Graf GA, Hayes SH, Silvia WJ. 1997a. Cellular mechanisms by which oxytocin stimulates uterine PGF(2 alpha) synthesis in bovine endometrium: roles of phospholipases C and A(2). Domest Anim Endocrinol, 14:181-191.Burns PD, Tsai SJ, Wiltbank MC, Hayes SH, Graf GA, Silvia WJ. 1997b. Effect of oxytocin on concentrations of prostaglandin H synthase-2 mRNA in ovine endometrial tissue in vivo. Endocrinology, 138:5637-5640.Chang MC. 1952. Development of bovine blastocyst with a note on implantation. Anat Rec, 113:143-161.Charpigny G, Reinaud P, Tamby J-P, Creminon C, Guillomot M. 1997. Cyclooxygenase-2 unlike cyclooxygenase-1 is highly expressed in ovine embryos during the implantation period. Biol Reprod, 57:1032-1040.Costine BA, Inskeep EK, Blemings KP, Flores JA, Wilson ME. 2007. Mechanisms of reduced luteal sensitivity to prostaglandin F2alpha during maternal recognition of pregnancy in ewes. Domest Anim Endocrinol, 32:106-121.Danet-Desnoyers G, Meyer MD, Gross TS, Johnson JW, Thatcher WW. 1995. Regulation of endometrial prostaglandin synthesis during early pregnancy in cattle: effects of phospholipases and calcium in vitro. Prostaglandins, 50:313-330.Davis JS, Rueda BR. 2002. The corpus luteum: an ovarian structure with maternal instincts and suicidal tendencies. Front Biosci, 7:D1949-D1978.Del Campo MR, Rowe RF, French LR, Ginther OJ. 1977. Unilateral relationship of embryos and the corpus luteum in cattle. Biol Reprod, 16:580-585.Del Campo MR, Mapletoft RJ, Rowe RF, Critser JK, Ginther OJ. 1980. Unilateral utero-ovarian relationship in pregnant cattle and role of uterine vein. Theriogenology, 14:185-193.Diskin MG, Morris DG. 2008. Embryonic and early foetal losses in cattle and other ruminants. Reprod Domest Anim, 43:260-267.Diskin MG, Waters SM, Parr MH, Kenny DA. 2016. Pregnancy losses in cattle: potential for improvement. Reprod Fertil Dev, 28:83-93.Dorniak P, Bazer FW, Spencer TE. 2011. Prostaglandins regulate conceptus elongation and mediate effects of interferon tau on the ovine uterine endometrium. Biol Reprod, 84:1119-1127.Ealy AD, Larson SF, Liu L, Alexenko AP, Winkelman GL, Kubisch HM, Bixby JA, Roberts RM. 2001. Polymorphic forms of expressed bovine interferon-tau genes: Relative transcript abundance during early placental development, promoter sequences of genes and biological activity of protein products. Endocrinology, 142:2906-2915.Ealy AD, Yang QE. 2009. Control of interferon-tau expression during early pregnancy in ruminants. Am J Reprod Immunol, 61:95-106.Ezashi T, Imakawa K. 2017. Transcriptional control of IFNT expression. Reproduction, 154:F21-F31.Farin CE, Imakawa K, Hansen TR, Mcdonnell JJ, Murphy CN, Farin PW, Roberts RM. 1990. Expression of trophoblastic interferon genes in sheep and cattle. Biol Reprod, 43:210-218.Fleming JGW, Spencer TE, Safe SH, Bazer FW. 2006. Estrogen regulates transcription of the ovine oxytocin receptor gene through GC-rich SP1 promoter elements. 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Vascular anatomy of uterus and ovaries and unilateral luteolytic effect of uterus - cattle. Am J Vet Res, 35:193-203.Ginther OJ, Araujo RR, Palhao MP, Rodrigues BL, Beg MA. 2009. Necessity of sequential pulses of prostaglandin F2alpha for complete physiologic luteolysis in cattle. Biol Reprod, 80:641-648.Ginther OJ, Khan FA, Hannan MA, Beg MA. 2012. Temporal interrelationships at 15-min intervals among oxytocin, LH, and progesterone during a pulse of a prostaglandin F2alpha metabolite in heifers. Anim Reprod Sci, 133:63-70.Giordano JO, Guenther JN, Lopes G, Jr., Fricke PM. 2012. Changes in serum pregnancy-associated glycoprotein, pregnancy-specific protein B, and progesterone concentrations before and after induction of pregnancy loss in lactating dairy cows. J Dairy Sci, 95:683-697.Godkin JD, Bazer FW, Moffatt J, Sessions F, Roberts RM. 1982. Purification and properties of a major, low molecular weight protein released by the trophoblast of sheep blastocysts at day 13-21. J Reprod Fertil, 65:141-150.Godkin JD, Bazer FW, Roberts RM. 1984a. Ovine trophoblast protein 1, an early secreted blastocyst protein, binds specifically to uterine endometrium and affects protein synthesis. Endocrinology, 114:120-130.Godkin JD, Bazer FW, Thatcher WW, Roberts RM. 1984b. Proteins released by cultured day 15-16 conceptuses prolong luteal maintenance when introduced into the uterine lumen of cyclic ewes. J Reprod Fertil, 71:57-64.Godkin JD, Smith SE, Johnson RD, Dore JJ. 1997. The role of trophoblast interferons in the maintenance of early pregnancy in ruminants. Am J Reprod Immunol, 37:137-143.Guillomot M, Michel C, Gaye P, Charlier N, Trojan J, Martal J. 1990. Cellular localization of an embryonic interferon, ovine trophoblastin and its mRNA in sheep embryos during early pregnancy. Biol Cell, 68:205-211.Hansen PJ, Anthony RV, Bazer FW, Baumbach GA, Roberts RM. 1985. In vitro synthesis and secretion of ovine trophoblast protein-1 during the period of maternal recognition of pregnancy. Endocrinology, 117:1424-1430.Hansen TR, Romero JJ, Antoniazzi AQ, Bott RC, Ashley RL, Webb BT, Henkes LE, Smirnova NP. 2013. Endocrine conceptus signaling in ruminants. Anim Reprod, 10:311-321.Henderson K, Scaramuzzi R, Baird D. 1977. Simultaneous infusion of prostaglandin E2 antagonizes the luteolytic action of prostaglandin F2α in vivo. J Endocrinol, 72:379-383.Huie JM, Magness RR, Reynolds LP, Hoyer G, Huecksteadt T, Colcord M, Stalcup B, Whysong GL, Weems CW. 1981. Effect of chronic inpsilateral or contralateral intrauterine infusion of prostaglandin E1 (PGE1) on luteal function of unilaterally ovariectomized ewes. Prostaglandins, 21:945-955.Hyland J, Manns J, Humphrey W. 1982. Prostaglandin production by ovine embryos and endometrium in vitro. J Reprod Fertil, 65:299-304.Inskeep EK, Butcher RL. 1966. Local component of utero-ovarian relationships in ewe. J Anim Sci, 25:1164-1168.Inskeep EK, Smutny WJ, Butcher RL, Pexton JE. 1975. Effects of intrafollicular injections of prostaglandins in non-pregnant and pregnant ewes. J Anim Sci, 41:1098-1104.Ivell R, Fuchs AR, Bathgate R, Tillmann G, Kimura T. 2000. Regulation of the oxytocin receptor in bovine reproductive tissues and the role of steroids. Reprod Domest Anim, 35:134-141.Jenner LJ, Parkinson TJ, Lamming GE. 1991. Uterine oxytocin receptors in cyclic and pregnant cows. J Reprod Fertil, 91:49-58.Johnson GA, Austin KJ, Collins AM, Murdoch WJ, Hansen TR. 1999. Endometrial ISG17 mRNA and a related mRNA are induced by interferon-tau and localized to glandular epithelial and stromal cells from pregnant cows. Endocrine, 10:243-252.Kanai N, Lu R, Satriano JA, Bao Y, Wolkoff AW, Schuster VL. 1995. Identification and characterization of a prostaglandin transporter. Science, 268:866-869.Kieborz-Loos KR, Garverick HA, Keisler DH, Hamilton SA, Salfen BE, Youngquist RS, Smith MF. 2003. Oxytocin-induced secretion of prostaglandin F-2 alpha in postpartum beef cows: effects of progesterone and estradiol-17 beta treatment. J Anim Sci, 81:1830-1836.Kim MS, Min KS, Seong HH, Kim CL, Jeon IS, Kim SW, Imakawa K. 2018. Regulation of conceptus interferon-tau gene subtypes expressed in the uterusduring the peri-implantation period of cattle. Anim Reprod Sci, 190:39-46.Kindahl H, Edqvist L-E, Bane A, Granstrom E. 1976. Blood levels of progesterone and 15-keto-13,14-dihydro-prostaglandin F 2a during the normal oestrous cycle and early pregnancy in heifers. Acta Endocrinol, 82:134-149.Kizaki K, Shichijo-Kizaki A, Furusawa T, Takahashi T, Hosoe M, Hashizume K. 2013. Differential neutrophil gene expression in early bovine pregnancy. Reprod Biol Endocrinol, 11:6. doi: 10.1186/1477-7827-11-6.Knickerbocker JJ, Wiltbank MC, Niswender GD. 1988. Mechanisms of luteolysis in domestic livestock. Domest Anim Endocrinol, 5:91-107.Lamond DR, Drost M, Mccracke.Ja, Lamond DR. 1973. 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 incorporada en las Obras Colectivas.

b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda.

c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas. Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).

4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:

a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).

b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.

c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.

d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:

i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.

ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, los consagrados por la SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.

e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, ACINPRO), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.

5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

7. Término.

a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.

b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.

8. Varios.

a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.

b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.

c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.

d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.
0000-0002-9382-5962b18821a2a726f7505ba690b97bd8ba586000000-0002-4114-5965630fbc1ccf3770d19017048d54c4367b6000000-0001-6917-0057038eaf6183ee15e35f2ea736e4df9e83600 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