Peripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis
7 p.
- Autores:
-
Lopez-Jaramillo, Patricio
Raman, Kripa
O’Donnell, Martin J.
Czlonkowska, Anna
Duarte, Yan Carlos
Peñaherrera, Ernesto
Sharma, Mike
Shoamanesh, Ashkan
Skowronska, Marta
Yusuf, Salim
Paré, Guillaume
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2016
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/3239
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/3239
- Palabra clave:
- Biomarkers
Blood
Gene expression profiling
Prognosis
Stroke
- Rights
- openAccess
- License
- Derechos Reservados - American Heart Association, Inc., 2016
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Peripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis |
| title |
Peripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis |
| spellingShingle |
Peripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis Biomarkers Blood Gene expression profiling Prognosis Stroke |
| title_short |
Peripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis |
| title_full |
Peripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis |
| title_fullStr |
Peripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis |
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Peripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis |
| title_sort |
Peripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis |
| dc.creator.fl_str_mv |
Lopez-Jaramillo, Patricio Raman, Kripa O’Donnell, Martin J. Czlonkowska, Anna Duarte, Yan Carlos Peñaherrera, Ernesto Sharma, Mike Shoamanesh, Ashkan Skowronska, Marta Yusuf, Salim Paré, Guillaume |
| dc.contributor.author.spa.fl_str_mv |
Lopez-Jaramillo, Patricio Raman, Kripa O’Donnell, Martin J. Czlonkowska, Anna Duarte, Yan Carlos Peñaherrera, Ernesto Sharma, Mike Shoamanesh, Ashkan Skowronska, Marta Yusuf, Salim Paré, Guillaume |
| dc.subject.proposal.eng.fl_str_mv |
Biomarkers Blood Gene expression profiling Prognosis Stroke |
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Biomarkers Blood Gene expression profiling Prognosis Stroke |
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7 p. |
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2016 |
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2016-01-12 |
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2019-07-02T12:33:44Z |
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2019-07-02T12:33:44Z |
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10.1161/STROKEAHA.115.011854 |
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1524-4628 |
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0039-2499 |
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https://repositorio.udes.edu.co/handle/001/3239 |
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eng |
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eng |
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Stroke |
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Derechos Reservados - American Heart Association, Inc., 2016 |
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Lopez-Jaramillo, Patricio9a71267b-dcb0-4d31-b37d-2d30be58d4d2-1Raman, Kripaeec4f89d-3717-4a20-9b33-b420a8e3fb25-1O’Donnell, Martin J.87baff49-ae1d-46bd-ad8a-0cbd6aecbacd-1Czlonkowska, Anna124b7f21-8a3d-4bf2-900c-bc38601f1982-1Duarte, Yan Carlosa6ecce30-24dc-41cd-a709-cf7b3eaaa9ff-1Peñaherrera, Ernesto035097e8-6ecc-450c-8ad9-0da9770630f3-1Sharma, Mike1ad9f4e4-61dc-4955-acc3-a60a13d889c7-1Shoamanesh, Ashkan653a4cf0-f2cf-4362-8aeb-125e83b846c1-1Skowronska, Marta3713c7ee-f888-43e7-9882-b5897e904de2-1Yusuf, Salim06a836b5-f5e3-41d9-a516-9cc46e5d7948-1Paré, Guillaume4945b341-3adf-49b8-831e-c83f9fae1ccc-12019-07-02T12:33:44Z2019-07-02T12:33:44Z2016-01-127 p.Background and Purpose—A limitation when making early decisions on stroke management is the lack of rapid diagnostic and prognostic testing. Our study sought to identify peripheral blood RNA biomarkers associated with stroke. The secondary aims were to assess the discriminative capacity of RNA biomarkers for primary stroke type and stroke prognosis at 1-month. Methods—Whole-blood gene expression profiling was conducted on the discovery cohort: 129 first-time stroke cases that had blood sampling within 5 days of symptom onset and 170 control participants with no history of stroke. Results—Through multiple regression analysis, we determined that expression of the gene MCEMP1 had the strongest association with stroke of 11181 genes tested. MCEMP1 increased by 2.4-fold in stroke when compared with controls (95% confidence interval, 2.0–2.8; P=8.2×10−22). In addition, expression was elevated in intracerebral hemorrhage when compared with ischemic stroke cases (P=3.9×10−4). MCEMP1 was also highest soon after symptom onset and had no association with stroke risk factors. Furthermore, MCEMP1 expression independently improved discrimination of 1-month outcome. Indeed, discrimination models for disability and mortality that included MCEMP1 expression, baseline modified Rankin Scale score, and primary stroke type improved discrimination when compared with a model without MCEMP1 (disability Net Reclassification Index, 0.76; P=3.0×10−6 and mortality Net Reclassification Index, 1.3; P=1.1×10−9). Significant associations with MCEMP1 were confirmed in an independent validation cohort of 28 stroke cases and 34 controls. Conclusions—This study demonstrates that peripheral blood expression of MCEMP1 may have utility for stroke diagnosis and as a prognostic biomarker of stroke outcome at 1-month.application/pdf10.1161/STROKEAHA.115.0118541524-46280039-2499https://repositorio.udes.edu.co/handle/001/3239engStrokeDerechos Reservados - American Heart Association, Inc., 2016info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.115.011854BiomarkersBloodGene expression profilingPrognosisStrokePeripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke PrognosisArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85PublicationTHUMBNAILPeripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis.pdf.jpgPeripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis.pdf.jpgGenerated Thumbnailimage/jpeg1826https://repositorio.udes.edu.co/bitstreams/53506451-aef1-468a-9356-cdaf8cd0ea53/downloadf050283f3ff672e6d2a381ef58a91885MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/b0ae1d10-3ddb-45ad-a13f-48461d802ecf/download38d94cf55aa1bf2dac1a736ac45c881cMD52ORIGINALPeripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis.pdfArtículo Principalapplication/pdf438132https://repositorio.udes.edu.co/bitstreams/df2328c2-477c-49c7-a167-13e4a390a006/downloadbc6faf21d0a3ff31de3d13cf5d728d42MD55TEXTPeripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis.pdf.txtPeripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis.pdf.txtExtracted texttext/plain39914https://repositorio.udes.edu.co/bitstreams/c4adf246-f926-4581-a028-012088c10a9a/downloada32c6423522611eea8c81390fc3c4357MD56001/3239oai:repositorio.udes.edu.co:001/32392023-10-10 09:23:05.296https://creativecommons.org/licenses/by-nc/4.0/Derechos Reservados - American Heart Association, Inc., 2016https://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo= |