Nitric oxide synthase inhibitor improves de novo and long-term l-DOPA-induced dyskinesia in hemiparkinsonian rats
11 p.
- Autores:
-
Padovan-Neto, Fernando Eduardo
Bermúdez Echeverry, Marcela
Chiavegatto, Silvana
Del-Bel, Elaine
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2011
- Institución:
- Universidad de Santander
- Repositorio:
- Repositorio Universidad de Santander
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.udes.edu.co:001/3284
- Acceso en línea:
- https://repositorio.udes.edu.co/handle/001/3284
- Palabra clave:
- Nitric oxide
Nitric oxide synthase
Parkinson’s disease
L-DOPA-induced dyskinesia
Nitric oxide synthase inhibitors
FosB/ΔFosB
Abnormal involuntary movements
Striatum
- Rights
- openAccess
- License
- Derechos Reservados - Frontiers in Systems Neuroscience, 2011
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Nitric oxide synthase inhibitor improves de novo and long-term l-DOPA-induced dyskinesia in hemiparkinsonian rats |
| title |
Nitric oxide synthase inhibitor improves de novo and long-term l-DOPA-induced dyskinesia in hemiparkinsonian rats |
| spellingShingle |
Nitric oxide synthase inhibitor improves de novo and long-term l-DOPA-induced dyskinesia in hemiparkinsonian rats Nitric oxide Nitric oxide synthase Parkinson’s disease L-DOPA-induced dyskinesia Nitric oxide synthase inhibitors FosB/ΔFosB Abnormal involuntary movements Striatum |
| title_short |
Nitric oxide synthase inhibitor improves de novo and long-term l-DOPA-induced dyskinesia in hemiparkinsonian rats |
| title_full |
Nitric oxide synthase inhibitor improves de novo and long-term l-DOPA-induced dyskinesia in hemiparkinsonian rats |
| title_fullStr |
Nitric oxide synthase inhibitor improves de novo and long-term l-DOPA-induced dyskinesia in hemiparkinsonian rats |
| title_full_unstemmed |
Nitric oxide synthase inhibitor improves de novo and long-term l-DOPA-induced dyskinesia in hemiparkinsonian rats |
| title_sort |
Nitric oxide synthase inhibitor improves de novo and long-term l-DOPA-induced dyskinesia in hemiparkinsonian rats |
| dc.creator.fl_str_mv |
Padovan-Neto, Fernando Eduardo Bermúdez Echeverry, Marcela Chiavegatto, Silvana Del-Bel, Elaine |
| dc.contributor.author.spa.fl_str_mv |
Padovan-Neto, Fernando Eduardo Bermúdez Echeverry, Marcela Chiavegatto, Silvana Del-Bel, Elaine |
| dc.subject.proposal.eng.fl_str_mv |
Nitric oxide Nitric oxide synthase Parkinson’s disease L-DOPA-induced dyskinesia Nitric oxide synthase inhibitors FosB/ΔFosB Abnormal involuntary movements Striatum |
| topic |
Nitric oxide Nitric oxide synthase Parkinson’s disease L-DOPA-induced dyskinesia Nitric oxide synthase inhibitors FosB/ΔFosB Abnormal involuntary movements Striatum |
| description |
11 p. |
| publishDate |
2011 |
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2011-06 |
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2019-07-06T16:39:13Z |
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2019-07-06T16:39:13Z |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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10.3389/fnsys.2011.00040 |
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1662-5137 |
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https://repositorio.udes.edu.co/handle/001/3284 |
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10.3389/fnsys.2011.00040 1662-5137 |
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eng |
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eng |
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Frontiers in Systems Neuroscience |
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Derechos Reservados - Frontiers in Systems Neuroscience, 2011 |
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Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) |
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https://creativecommons.org/licenses/by-nc/4.0/ |
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openAccess |
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Padovan-Neto, Fernando Eduardo25ddad04-45de-4675-928b-48047b44da13-1Bermúdez Echeverry, Marcela281f95c7-f0cb-40ce-9add-b534ed173fe7-1Chiavegatto, Silvanad49373c9-56e2-4d2c-9470-79b880041e0f-1Del-Bel, Elainecc90022d-e8df-4a13-b0f1-47b6c29ac095-12019-07-06T16:39:13Z2019-07-06T16:39:13Z2011-0611 p.Inhibitors of neuronal and endothelial nitric oxide synthase decrease l-3,4-dihidroxifenilalanine (l-DOPA)-induced dyskinesias in rodents. The mechanism of nitric oxide inhibitor action is unknown. The aims of the present study were to investigate the decrease of l-DOPA-induced abnormal involuntary movements (AIMs) in 6-hydroxydopamine (6-OHDA)-lesioned rats by nitric oxide inhibitors following either acute or chronic treatment. The primary findings of this study were that NG-nitro-l-Arginine, an inhibitor of endothelial and neuronal nitric oxide synthase, attenuated AIMs induced by chronic and acute l-DOPA. In contrast, rotational behavior was attenuated only after chronic l-DOPA. The 6-OHDA lesion and the l-DOPA treatment induced a bilateral increase (1.5 times) in the neuronal nitric oxide synthase (nNOS) protein and nNOS mRNA in the striatum and in the frontal cortex. There was a parallel increase, bilaterally, of the FosB/ΔFosB, primarily in the ipsilateral striatum. The exception was in the contralateral striatum and the ipsilateral frontal cortex, where chronic l-DOPA treatment induced an increase of approximately 10 times the nNOS mRNA. Our results provided further evidence of an anti-dyskinetic effect of NOS inhibitor. The effect appeared under l-DOPA acute and chronic treatment. The l-DOPA treatment also revealed an over-expression of the neuronal NOS in the frontal cortex and striatum. Our results corroborated findings that l-DOPA-induced rotation differs between acute and chronic treatment. The effect of the NOS inhibitor conceivably relied on the l-DOPA structural modifications in the Parkinsonian brain. Taken together, these data provided a rationale for further evaluation of NOS inhibitors in the treatment of l-DOPA-induced dyskinesia.application/pdf10.3389/fnsys.2011.000401662-5137https://repositorio.udes.edu.co/handle/001/3284engFrontiers in Systems NeuroscienceDerechos Reservados - Frontiers in Systems Neuroscience, 2011info:eu-repo/semantics/openAccessAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2https://www.frontiersin.org/articles/10.3389/fnsys.2011.00040/fullNitric oxideNitric oxide synthaseParkinson’s diseaseL-DOPA-induced dyskinesiaNitric oxide synthase inhibitorsFosB/ΔFosBAbnormal involuntary movementsStriatumNitric oxide synthase inhibitor improves de novo and long-term l-DOPA-induced dyskinesia in hemiparkinsonian ratsArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85PublicationTHUMBNAILNitric oxide synthase inhibitor improves de novo and long-term l-DOPA-induced dyskinesia in hemiparkinsonian rats.pdf.jpgNitric oxide synthase inhibitor improves de novo and long-term l-DOPA-induced dyskinesia in hemiparkinsonian rats.pdf.jpgGenerated Thumbnailimage/jpeg1737https://repositorio.udes.edu.co/bitstreams/736e27bf-861f-4cef-ae8c-7ebd20c4baae/downloadc82fe9f19c1ea2ed3ed80e1c87b15a43MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-859https://repositorio.udes.edu.co/bitstreams/538aa51b-d776-44ae-aef4-7869aebfab0d/download38d94cf55aa1bf2dac1a736ac45c881cMD52ORIGINALNitric oxide synthase inhibitor improves de novo and long-term l-DOPA-induced dyskinesia in hemiparkinsonian rats.pdfArtículo Principalapplication/pdf2295706https://repositorio.udes.edu.co/bitstreams/f3fd63a8-5411-4f18-b4a9-b99569eb1581/downloadef6cc26c7d461e3ddb1edf43f033ddd7MD55TEXTNitric oxide synthase inhibitor improves de novo and long-term l-DOPA-induced dyskinesia in hemiparkinsonian rats.pdf.txtNitric oxide synthase inhibitor improves de novo and long-term l-DOPA-induced dyskinesia in hemiparkinsonian rats.pdf.txtExtracted texttext/plain64146https://repositorio.udes.edu.co/bitstreams/9f0f7832-0425-4aa9-9972-00b1f411dc0b/download619ea0ed0ae9254d0cc46a8c3f277bdfMD53001/3284oai:repositorio.udes.edu.co:001/32842023-10-10 09:14:57.619https://creativecommons.org/licenses/by-nc/4.0/Derechos Reservados - Frontiers in Systems Neuroscience, 2011https://repositorio.udes.edu.coRepositorio Universidad de Santandersoporte@metabiblioteca.comTGljZW5jaWEgZGUgUHVibGljYWNpw7NuIFVERVMKRGlyZWN0cmljZXMgZGUgVVNPIHkgQUNDRVNPCgo= |